Published in EMBO Rep on July 03, 2009
The Concise Guide to PHARMACOLOGY 2013/14: ion channels. Br J Pharmacol (2013) 3.03
Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice. Proc Natl Acad Sci U S A (2010) 1.46
Sodium leak channels in neuronal excitability and rhythmic behaviors. Neuron (2011) 1.25
De novo mutations in NALCN cause a syndrome characterized by congenital contractures of the limbs and face, hypotonia, and developmental delay. Am J Hum Genet (2015) 1.17
A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability. Cell (2015) 1.10
Mutations in NALCN cause an autosomal-recessive syndrome with severe hypotonia, speech impairment, and cognitive delay. Am J Hum Genet (2013) 1.03
Conserved role of unc-79 in ethanol responses in lightweight mutant mice. PLoS Genet (2010) 1.00
A sodium leak current regulates pacemaker activity of adult central pattern generator neurons in Lymnaea stagnalis. PLoS One (2011) 0.97
Involvement of Na(+)-leak channel in substance P-induced depolarization of pacemaking activity in interstitial cells of Cajal. Cell Physiol Biochem (2012) 0.95
Phylogeny unites animal sodium leak channels with fungal calcium channels in an ancient, voltage-insensitive clade. Mol Biol Evol (2012) 0.94
Bursting and calcium oscillations in pancreatic beta-cells: specific pacemakers for specific mechanisms. Am J Physiol Endocrinol Metab (2010) 0.93
Genetic analysis of mouse strains with variable serum sodium concentrations identifies the Nalcn sodium channel as a novel player in osmoregulation. Physiol Genomics (2010) 0.92
Rare DNA copy number variants in cardiovascular malformations with extracardiac abnormalities. Eur J Hum Genet (2012) 0.91
The cellular building blocks of breathing. Compr Physiol (2012) 0.91
The sodium leak channel, NALCN, in health and disease. Front Cell Neurosci (2014) 0.90
Selectivity filters and cysteine-rich extracellular loops in voltage-gated sodium, calcium, and NALCN channels. Front Physiol (2015) 0.90
UNC79 and UNC80, putative auxiliary subunits of the NARROW ABDOMEN ion channel, are indispensable for robust circadian locomotor rhythms in Drosophila. PLoS One (2013) 0.88
NALCN ion channels have alternative selectivity filters resembling calcium channels or sodium channels. PLoS One (2013) 0.88
G protein-coupled receptor signaling via Src kinase induces endogenous human transient receptor potential vanilloid type 6 (TRPV6) channel activation. J Biol Chem (2011) 0.87
A uniquely adaptable pore is consistent with NALCN being an ion sensor. Channels (Austin) (2013) 0.87
Mathematical modeling of heterogeneous electrophysiological responses in human β-cells. PLoS Comput Biol (2014) 0.86
NALCN: a regulated leak channel. EMBO Rep (2009) 0.85
A co-operative regulation of neuronal excitability by UNC-7 innexin and NCA/NALCN leak channel. Mol Brain (2011) 0.84
Novel insights into the function of β-cell M3 muscarinic acetylcholine receptors: therapeutic implications. Trends Endocrinol Metab (2010) 0.84
The interplay of seven subthreshold conductances controls the resting membrane potential and the oscillatory behavior of thalamocortical neurons. J Neurophysiol (2014) 0.81
Ion channels and regulation of insulin secretion in human β-cells: a computational systems analysis. Islets (2013) 0.81
Induction of a novel cation current in cardiac ventricular myocytes by flufenamic acid and related drugs. Br J Pharmacol (2010) 0.79
The prelude on novel receptor and ligand targets involved in the treatment of diabetes mellitus. Adv Pharm Bull (2014) 0.78
Insulin/IGF-1 signaling, including class II/III PI3Ks, β-arrestin and SGK-1, is required in C. elegans to maintain pharyngeal muscle performance during starvation. PLoS One (2013) 0.78
Extrasynaptic muscarinic acetylcholine receptors on neuronal cell bodies regulate presynaptic function in Caenorhabditis elegans. J Neurosci (2013) 0.78
The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons. Elife (2016) 0.78
The role of M(3)-muscarinic receptor signaling in insulin secretion. Commun Integr Biol (2011) 0.77
Pancreatic Beta Cell G-Protein Coupled Receptors and Second Messenger Interactions: A Systems Biology Computational Analysis. PLoS One (2016) 0.76
Sodium leak channel, non-selective contributes to the leak current in human myometrial smooth muscle cells from pregnant women. Mol Hum Reprod (2015) 0.75
The NCA-1 and NCA-2 Ion Channels Function Downstream of Gq and Rho To Regulate Locomotion in Caenorhabditis elegans. Genetics (2017) 0.75
The truth in complexes: perspectives on ion channel signaling nexuses in the nervous system. Front Cell Neurosci (2014) 0.75
HEK293 cell line: a vehicle for the expression of recombinant proteins. J Pharmacol Toxicol Methods (2005) 3.41
The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm. Cell (2007) 2.54
Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer. Nature (2001) 2.28
From molecule to malady. Nature (2006) 2.13
Constitutive activity and inverse agonists of G protein-coupled receptors: a current perspective. Mol Pharmacol (2003) 1.72
Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80. Nature (2008) 1.71
A putative cation channel and its novel regulator: cross-species conservation of effects on general anesthesia. Curr Biol (2007) 1.70
GPCR interacting proteins (GIP). Pharmacol Ther (2004) 1.61
A putative cation channel, NCA-1, and a novel protein, UNC-80, transmit neuronal activity in C. elegans. PLoS Biol (2008) 1.61
Signaling protein complexes associated with neuronal ion channels. Nat Neurosci (2006) 1.59
Ion channels as drug targets: the next GPCRs. J Gen Physiol (2008) 1.51
Distinct sequence elements control the specificity of G protein activation by muscarinic acetylcholine receptor subtypes. EMBO J (1990) 1.51
UNC-80 and the NCA ion channels contribute to endocytosis defects in synaptojanin mutants. Curr Biol (2007) 1.36
Cloning of a novel four repeat protein related to voltage-gated sodium and calcium channels. FEBS Lett (1999) 1.36
ERKI/II regulation by the muscarinic acetylcholine receptors in neurons. J Neurosci (2000) 1.23
Activation of a nonselective cationic conductance by metabotropic glutamatergic and muscarinic agonists in CA3 pyramidal neurons of the rat hippocampus. J Neurosci (1995) 1.15
GPCRs signaling directly through Src-family kinases. Sci STKE (2007) 1.10
G protein-independent activation of an inward Na(+) current by muscarinic receptors in mouse pancreatic beta-cells. J Biol Chem (2002) 1.02
The sodium "leak" has finally been plugged. Neuron (2007) 0.90
Multiple structural elements contribute to voltage-dependent facilitation of neuronal alpha 1C (CaV1.2) L-type calcium channels. Neuropharmacology (2001) 0.86
Carbachol-induced sodium current in guinea pig ventricular myocytes is not regulated by guanine nucleotides. J Pharmacol Exp Ther (1993) 0.82
Abnormal development of the hippocampal dentate gyrus in mice lacking the CXCR4 chemokine receptor. Proc Natl Acad Sci U S A (2002) 2.72
Functional role of L-type Cav1.3 Ca2+ channels in cardiac pacemaker activity. Proc Natl Acad Sci U S A (2003) 2.60
Excitatory monocyte chemoattractant protein-1 signaling is up-regulated in sensory neurons after chronic compression of the dorsal root ganglion. Proc Natl Acad Sci U S A (2005) 2.50
Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease. Nat Genet (2002) 2.46
Sequential waves of functionally related proteins are expressed when B cells prepare for antibody secretion. Immunity (2003) 2.40
STIM1-Orai1 interactions and Orai1 conformational changes revealed by live-cell FRET microscopy. J Physiol (2008) 2.29
ORL1 receptor-mediated internalization of N-type calcium channels. Nat Neurosci (2005) 2.24
Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception. EMBO J (2004) 2.15
Chemokine receptors: signposts to brain development and disease. Nat Rev Neurosci (2003) 2.08
Chemokines and the pathophysiology of neuropathic pain. Proc Natl Acad Sci U S A (2007) 2.03
Chemokine receptor expression by neural progenitor cells in neurogenic regions of mouse brain. J Comp Neurol (2007) 2.02
TREK-1, a K+ channel involved in polymodal pain perception. EMBO J (2006) 2.02
Primary cutaneous diffuse large B-cell lymphoma, leg type: clinicopathologic features and prognostic analysis in 60 cases. Arch Dermatol (2007) 2.00
ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family. EMBO J (2002) 1.98
Chemokines regulate the migration of neural progenitors to sites of neuroinflammation. J Neurosci (2006) 1.96
Thiol-mediated protein retention in the endoplasmic reticulum: the role of ERp44. EMBO J (2003) 1.96
Monocyte chemoattractant protein-1 functions as a neuromodulator in dorsal root ganglia neurons. J Neurochem (2007) 1.93
Chemokine receptors are expressed widely by embryonic and adult neural progenitor cells. J Neurosci Res (2004) 1.81
The proteasome load versus capacity balance determines apoptotic sensitivity of multiple myeloma cells to proteasome inhibition. Blood (2009) 1.77
Diagnosis and management of nail pigmentations. J Am Acad Dermatol (2007) 1.73
The chemokine stromal cell-derived factor-1 regulates the migration of sensory neuron progenitors. J Neurosci (2005) 1.69
Chemokines: integrators of pain and inflammation. Nat Rev Drug Discov (2005) 1.68
Abnormalities in hippocampal functioning with persistent pain. J Neurosci (2012) 1.68
Desensitization of mechano-gated K2P channels. Proc Natl Acad Sci U S A (2006) 1.65
Bradycardia and slowing of the atrioventricular conduction in mice lacking CaV3.1/alpha1G T-type calcium channels. Circ Res (2006) 1.62
The chemokine stromal cell-derived factor-1 regulates GABAergic inputs to neural progenitors in the postnatal dentate gyrus. J Neurosci (2008) 1.59
Visualization of chemokine receptor activation in transgenic mice reveals peripheral activation of CCR2 receptors in states of neuropathic pain. J Neurosci (2009) 1.59
Trafficking of L-type calcium channels mediated by the postsynaptic scaffolding protein AKAP79. J Biol Chem (2002) 1.58
Role of adult hippocampal neurogenesis in persistent pain. Pain (2016) 1.56
CXCR4 chemokine receptor signaling mediates pain hypersensitivity in association with antiretroviral toxic neuropathy. Brain Behav Immun (2007) 1.53
Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors. EMBO Mol Med (2011) 1.50
SDF1 in the dorsal corticospinal tract promotes CXCR4+ cell migration after spinal cord injury. J Neuroinflammation (2011) 1.50
Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability. J Physiol (2002) 1.48
Cross-talk between the mechano-gated K2P channel TREK-1 and the actin cytoskeleton. EMBO Rep (2005) 1.41
GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells. J Biol Chem (2009) 1.36
CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis. Proc Natl Acad Sci U S A (2012) 1.34
A Ca(v)3.2/syntaxin-1A signaling complex controls T-type channel activity and low-threshold exocytosis. J Biol Chem (2011) 1.33
The controlled generation of functional basal forebrain cholinergic neurons from human embryonic stem cells. Stem Cells (2011) 1.32
Differential targeting of the L-type Ca2+ channel alpha 1C (CaV1.2) to synaptic and extrasynaptic compartments in hippocampal neurons. Eur J Neurosci (2004) 1.29
Calcium-permeable ion channels in pain signaling. Physiol Rev (2014) 1.28
Akt regulates L-type Ca2+ channel activity by modulating Cavalpha1 protein stability. J Cell Biol (2009) 1.28
Voltage-dependent calcium channels and cardiac pacemaker activity: from ionic currents to genes. Prog Biophys Mol Biol (2005) 1.27
Progressively impaired proteasomal capacity during terminal plasma cell differentiation. EMBO J (2006) 1.27
Ubiquitin homeostasis is critical for synaptic development and function. J Neurosci (2011) 1.26
T-type calcium channels in differentiation and proliferation. Cell Calcium (2006) 1.25
Animal models of chemotherapy-evoked painful peripheral neuropathies. Neurotherapeutics (2009) 1.24
Dermoscopic Features of Onychomatricoma: A Study of 34 Cases. Dermatology (2015) 1.23
A destructive interaction mechanism accounts for dominant-negative effects of misfolded mutants of voltage-gated calcium channels. J Neurosci (2008) 1.22
Increased chemokine signaling in a model of HIV1-associated peripheral neuropathy. Mol Pain (2009) 1.22
Regulation of CXCR4 receptor dimerization by the chemokine SDF-1alpha and the HIV-1 coat protein gp120: a fluorescence resonance energy transfer (FRET) study. J Pharmacol Exp Ther (2004) 1.21
The I-II loop controls plasma membrane expression and gating of Ca(v)3.2 T-type Ca2+ channels: a paradigm for childhood absence epilepsy mutations. J Neurosci (2007) 1.19
Plasma membrane expression of T-type calcium channel alpha(1) subunits is modulated by high voltage-activated auxiliary subunits. J Biol Chem (2004) 1.18
T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids. J Neurosci (2009) 1.18
Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models. Proc Natl Acad Sci U S A (2003) 1.18
Infection of neurons and encephalitis after intracranial inoculation of herpes simplex virus requires the entry receptor nectin-1. Proc Natl Acad Sci U S A (2009) 1.16
CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity. Circ Res (2010) 1.15
Subunit-specific modulation of T-type calcium channels by zinc. J Physiol (2006) 1.14
Agonist-independent modulation of N-type calcium channels by ORL1 receptors. Nat Neurosci (2004) 1.13
ERK1/2 control phosphorylation and protein level of cAMP-responsive element-binding protein: a key role in glucose-mediated pancreatic beta-cell survival. Diabetes (2006) 1.13
Regulation of calcium currents by chemokines and their receptors. J Neuroimmunol (2002) 1.12
Voltage-gated calcium channels in genetic diseases. Biochim Biophys Acta (2006) 1.12
Calcium entry and α-synuclein inclusions elevate dendritic mitochondrial oxidant stress in dopaminergic neurons. J Neurosci (2013) 1.10
Activation of the nuclear factor of activated T-cells (NFAT) mediates upregulation of CCR2 chemokine receptors in dorsal root ganglion (DRG) neurons: a possible mechanism for activity-dependent transcription in DRG neurons in association with neuropathic pain. Mol Cell Neurosci (2007) 1.10
Integrin/Chemokine receptor interactions in the pathogenesis of experimental autoimmune encephalomyelitis. J Neuroimmune Pharmacol (2014) 1.10
I-II loop structural determinants in the gating and surface expression of low voltage-activated calcium channels. PLoS One (2008) 1.09
Distinctive properties of CXC chemokine receptor 4-expressing Cajal-Retzius cells versus GABAergic interneurons of the postnatal hippocampus. J Physiol (2010) 1.08
Role of voltage-gated calcium channels in epilepsy. Pflugers Arch (2009) 1.08
Chemokine signaling and the management of neuropathic pain. Mol Interv (2009) 1.07
Imatinib mesylate as a preoperative therapy in dermatofibrosarcoma: results of a multicenter phase II study on 25 patients. Clin Cancer Res (2010) 1.07
A rapidly activating delayed rectifier K+ current regulates pacemaker activity in adult mouse sinoatrial node cells. Am J Physiol Heart Circ Physiol (2003) 1.07
PI3-kinase promotes TRPV2 activity independently of channel translocation to the plasma membrane. Cell Calcium (2006) 1.06
T-type calcium channels contribute to colonic hypersensitivity in a rat model of irritable bowel syndrome. Proc Natl Acad Sci U S A (2011) 1.06
Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2-aminoethoxydiphenyl borate. Mol Pharmacol (2007) 1.05
CXCR4 signaling mediates morphine-induced tactile hyperalgesia. Brain Behav Immun (2010) 1.05
Mutational analysis of CACNA1G in idiopathic generalized epilepsy. Mutation in brief #962. Online. Hum Mutat (2007) 1.03
Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta-cells and human pancreatic islets. Diabetes (2009) 1.02
TAFA4, a chemokine-like protein, modulates injury-induced mechanical and chemical pain hypersensitivity in mice. Cell Rep (2013) 1.02
A 48-hour exposure of pancreatic islets to calpain inhibitors impairs mitochondrial fuel metabolism and the exocytosis of insulin. Metabolism (2003) 1.02
Comparison of postoperative pain in patients receiving interscalene block or general anesthesia for shoulder surgery. Orthopedics (2002) 1.02
Molecular pathways underlying the modulation of T-type calcium channels by neurotransmitters and hormones. Cell Calcium (2006) 1.01
Beta -Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of beta 2 adrenergic receptor Galpha s signaling in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A (2002) 1.01
Stable membrane expression of postsynaptic CaV1.2 calcium channel clusters is independent of interactions with AKAP79/150 and PDZ proteins. J Neurosci (2008) 1.00
Activation of c-Jun N-terminal kinase mediates gp120IIIB- and nucleoside analogue-induced sensory neuron toxicity. Exp Neurol (2004) 1.00
The role of CXCR4 signaling in the migration of transplanted oligodendrocyte progenitors into the cerebral white matter. Neurobiol Dis (2011) 1.00