Published in Proc Natl Acad Sci U S A on August 09, 2006
Effect of trehalose on protein structure. Protein Sci (2009) 1.97
Surveying polypeptide and protein domain conformation and association with FlAsH and ReAsH. Nat Chem Biol (2007) 1.80
From the test tube to the cell: exploring the folding and aggregation of a beta-clam protein. Biopolymers (2007) 1.67
Proline modulates the intracellular redox environment and protects mammalian cells against oxidative stress. Free Radic Biol Med (2007) 1.54
Genome-wide transcriptional responses of Escherichia coli K-12 to continuous osmotic and heat stresses. J Bacteriol (2008) 1.49
Atomistic simulations of the effects of polyglutamine chain length and solvent quality on conformational equilibria and spontaneous homodimerization. J Mol Biol (2008) 1.43
An expanding arsenal of experimental methods yields an explosion of insights into protein folding mechanisms. Nat Struct Mol Biol (2009) 1.43
Synthesis and uptake of the compatible solutes ectoine and 5-hydroxyectoine by Streptomyces coelicolor A3(2) in response to salt and heat stresses. Appl Environ Microbiol (2008) 1.27
In-cell aggregation of a polyglutamine-containing chimera is a multistep process initiated by the flanking sequence. J Biol Chem (2007) 1.19
Chemical chaperones assist intracellular folding to buffer mutational variations. Nat Chem Biol (2012) 1.12
Functional polymorphisms in PRODH are associated with risk and protection for schizophrenia and fronto-striatal structure and function. PLoS Genet (2008) 1.11
Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs). Chem Rev (2014) 1.10
Proline mechanisms of stress survival. Antioxid Redox Signal (2013) 1.06
Meeting the challenges of on-host and off-host water balance in blood-feeding arthropods. J Insect Physiol (2010) 1.05
Dynamic local unfolding in the serpin α-1 antitrypsin provides a mechanism for loop insertion and polymerization. Nat Struct Mol Biol (2011) 1.04
Synthesis of the compatible solute ectoine in Virgibacillus pantothenticus is triggered by high salinity and low growth temperature. Appl Environ Microbiol (2008) 1.02
Rescue of photoreceptor degeneration by curcumin in transgenic rats with P23H rhodopsin mutation. PLoS One (2011) 1.01
genetic determinants of intrinsic colistin tolerance in Acinetobacter baumannii. Infect Immun (2012) 0.98
Osmotically controlled synthesis of the compatible solute proline is critical for cellular defense of Bacillus subtilis against high osmolarity. J Bacteriol (2011) 0.96
Stabilizing additives added during cell lysis aid in the solubilization of recombinant proteins. PLoS One (2012) 0.93
Artificially evolved Synechococcus PCC6301 Rubisco variants exhibit improvements in folding and catalytic efficiency. Biochem J (2007) 0.92
The SV40 late protein VP4 is a viroporin that forms pores to disrupt membranes for viral release. PLoS Pathog (2011) 0.92
The biological function of the Huntingtin protein and its relevance to Huntington's Disease pathology. Curr Trends Neurol (2011) 0.90
Deletion of v7-3 (SLC6A15) transporter allows assessment of its roles in synaptosomal proline uptake, leucine uptake and behaviors. Brain Res (2007) 0.90
Macromolecular crowding regulates assembly of mRNA stress granules after osmotic stress: new role for compatible osmolytes. J Biol Chem (2011) 0.89
Characterization of the proteostasis roles of glycerol accumulation, protein degradation and protein synthesis during osmotic stress in C. elegans. PLoS One (2012) 0.88
Quantifying additive interactions of the osmolyte proline with individual functional groups of proteins: comparisons with urea and glycine betaine, interpretation of m-values. Biochemistry (2013) 0.87
Crowding alone cannot account for cosolute effect on amyloid aggregation. PLoS One (2011) 0.87
Naturally occurring osmolytes modulate the nanomechanical properties of polycystic kidney disease domains. J Biol Chem (2010) 0.86
Genetic engineering for heat tolerance in plants. Physiol Mol Biol Plants (2008) 0.86
Osmoprotection of Bacillus subtilis through import and proteolysis of proline-containing peptides. Appl Environ Microbiol (2012) 0.86
Orthogonal Analysis Underscores the Relevance of Primary and Secondary Metabolites in Licorice. J Nat Prod (2014) 0.86
Proline biosynthesis is required for endoplasmic reticulum stress tolerance in Saccharomyces cerevisiae. J Biol Chem (2014) 0.85
Huntington's disease: the past, present, and future search for disease modifiers. Yale J Biol Med (2013) 0.85
Ectoine and hydroxyectoine as protectants against osmotic and cold stress: uptake through the SigB-controlled betaine-choline- carnitine transporter-type carrier EctT from Virgibacillus pantothenticus. J Bacteriol (2011) 0.85
Reactive oxygen species homeostasis and virulence of the fungal pathogen Cryptococcus neoformans requires an intact proline catabolism pathway. Genetics (2013) 0.84
Proline to the rescue. Proc Natl Acad Sci U S A (2006) 0.84
Arginine and the Hofmeister Series: the role of ion-ion interactions in protein aggregation suppression. J Phys Chem B (2011) 0.83
On the design of broad based screening assays to identify potential pharmacological chaperones of protein misfolding diseases. Curr Top Med Chem (2012) 0.83
Systems metabolic engineering of Corynebacterium glutamicum for production of the chemical chaperone ectoine. Microb Cell Fact (2013) 0.83
Transcriptional responses of uropathogenic Escherichia coli to increased environmental osmolality caused by salt or urea. Infect Immun (2012) 0.82
The effect of osmolytes on protein fibrillation. Int J Mol Sci (2012) 0.82
Insights into the disparate action of osmolytes and macromolecular crowders on amyloid formation. Prion (2012) 0.81
Crystal structure of the ectoine hydroxylase, a snapshot of the active site. J Biol Chem (2014) 0.80
The green tea polyphenol (-)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios. FEBS Lett (2014) 0.80
Tracking unfolding and refolding reactions of single proteins using atomic force microscopy methods. Methods (2013) 0.80
N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy. PLoS Genet (2016) 0.80
Strategies to stabilize compact folding and minimize aggregation of antibody-based fragments. Adv Biosci Biotechnol (2013) 0.79
Early folding events protect aggregation-prone regions of a β-rich protein. Structure (2013) 0.78
Effects of hydrophobic macromolecular crowders on amyloid β (16-22) aggregation. Biophys J (2015) 0.77
Addressing mechanism of fibrillization/aggregation and its prevention in presence of osmolytes: spectroscopic and calorimetric approach. PLoS One (2014) 0.77
Its preferential interactions with biopolymers account for diverse observed effects of trehalose. Biophys J (2015) 0.77
IgG Fab fragments forming bivalent complexes by a conformational mechanism that is reversible by osmolytes. J Biol Chem (2012) 0.77
A method for direct measurement of protein stability in vivo. Methods Mol Biol (2009) 0.77
How evolving enzymes can beat the heat and avoid defeat. Nat Chem Biol (2009) 0.76
Microorganisms maintain crowding homeostasis. Nat Rev Microbiol (2017) 0.76
Artificial environments for the co-translational stabilization of cell-free expressed proteins. PLoS One (2013) 0.76
EctD-mediated biotransformation of the chemical chaperone ectoine into hydroxyectoine and its mechanosensitive channel-independent excretion. Microb Cell Fact (2016) 0.75
Design and Evaluation of the Highly Concentrated Human IgG Formulation Using Cyclodextrin Polypseudorotaxane Hydrogels. AAPS PharmSciTech (2015) 0.75
Effect of osmolytes on the binding of EGR1 transcription factor to DNA. Biopolymers (2015) 0.75
The Effects of Lipid Membranes, Crowding and Osmolytes on the Aggregation, and Fibrillation Propensity of Human IAPP. J Diabetes Res (2015) 0.75
The Fermentation Analogy: A Point of View for Understanding the Intriguing Role of Proline Accumulation in Stressed Plants. Front Plant Sci (2016) 0.75
Synergistic Inhibition of Protein Fibrillation by Proline and Sorbitol: Biophysical Investigations. PLoS One (2016) 0.75
Formation of neurodegenerative aggresome and death-inducing signaling complex in maternal diabetes-induced neural tube defects. Proc Natl Acad Sci U S A (2017) 0.75
Self-protective responses to norvaline-induced stress in a leucyl-tRNA synthetase editing-deficient yeast strain. Nucleic Acids Res (2017) 0.75
Trimethylamine N-oxide abolishes the chaperone activity of α-casein: an intrinsically disordered protein. Sci Rep (2017) 0.75
Living with water stress: evolution of osmolyte systems. Science (1982) 17.27
Protein aggregation and neurodegenerative disease. Nat Med (2004) 9.51
New biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo: synthesis and biological applications. J Am Chem Soc (2002) 5.83
Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution. J Mol Med (Berl) (2003) 5.15
Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses. J Exp Biol (2005) 3.76
Osmosensing by bacteria: signals and membrane-based sensors. Microbiol Mol Biol Rev (1999) 3.74
Amyloid diseases: abnormal protein aggregation in neurodegeneration. Proc Natl Acad Sci U S A (1999) 3.54
Multiple effects of trehalose on protein folding in vitro and in vivo. Mol Cell (1998) 3.33
Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease. Nat Med (2004) 3.26
Predicting the energetics of osmolyte-induced protein folding/unfolding. Proc Natl Acad Sci U S A (2005) 2.85
The osmophobic effect: natural selection of a thermodynamic force in protein folding. J Mol Biol (2001) 2.61
Monitoring protein stability and aggregation in vivo by real-time fluorescent labeling. Proc Natl Acad Sci U S A (2003) 2.43
Responses of E. coli to osmotic stress: large changes in amounts of cytoplasmic solutes and water. Trends Biochem Sci (1998) 2.25
Vapor pressure osmometry studies of osmolyte-protein interactions: implications for the action of osmoprotectants in vivo and for the interpretation of "osmotic stress" experiments in vitro. Biochemistry (2000) 2.24
The Yin and Yang of protein folding. FEBS J (2005) 1.68
Manipulating the amyloid-beta aggregation pathway with chemical chaperones. J Biol Chem (1999) 1.50
Roles of cytoplasmic osmolytes, water, and crowding in the response of Escherichia coli to osmotic stress: biophysical basis of osmoprotection by glycine betaine. Biochemistry (2003) 1.48
Proline inhibits aggregation during protein refolding. Protein Sci (2000) 1.38
Extended polyglutamine tracts cause aggregation and structural perturbation of an adjacent beta barrel protein. J Biol Chem (2006) 1.37
Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy. Hum Mol Genet (2005) 1.32
Effects of naturally occurring osmolytes on protein stability and solubility: issues important in protein crystallization. Methods (2004) 1.32
Protein aggregation and its consequences for human disease. Protein Pept Lett (2006) 1.31
Aggregation of a slow-folding mutant of a beta-clam protein proceeds through a monomeric nucleus. Biochemistry (2005) 1.29
Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42. Neurobiol Dis (2005) 1.26
Requirements for osmosensing and osmotic activation of transporter ProP from Escherichia coli. Biochemistry (2001) 1.14
Osmosensor ProP of Escherichia coli responds to the concentration, chemistry, and molecular size of osmolytes in the proteoliposome lumen. Biochemistry (2003) 1.10
Ectoine and hydroxyectoine inhibit aggregation and neurotoxicity of Alzheimer's beta-amyloid. FEBS Lett (2005) 1.01
Contribution of simple saccharides to the stabilization of amyloid structure. Biochem Biophys Res Commun (2005) 0.99
TMAO promotes fibrillization and microtubule assembly activity in the C-terminal repeat region of tau. Biochemistry (2006) 0.98
A novel therapeutic strategy for polyglutamine diseases by stabilizing aggregation-prone proteins with small molecules. J Mol Med (Berl) (2005) 0.94
Proline is a protein solubilizing solute. Biochem Mol Biol Int (1997) 0.94
The role of proline in the prevention of aggregation during protein folding in vitro. Biochem Mol Biol Int (1998) 0.88
Sending signals dynamically. Science (2009) 3.64
The changing landscape of protein allostery. Curr Opin Struct Biol (2006) 2.90
Monitoring protein stability and aggregation in vivo by real-time fluorescent labeling. Proc Natl Acad Sci U S A (2003) 2.43
Hsp70 chaperone ligands control domain association via an allosteric mechanism mediated by the interdomain linker. Mol Cell (2007) 2.39
From the test tube to the cell: exploring the folding and aggregation of a beta-clam protein. Biopolymers (2007) 1.67
An interdomain energetic tug-of-war creates the allosterically active state in Hsp70 molecular chaperones. Cell (2012) 1.67
Allosteric signal transmission in the nucleotide-binding domain of 70-kDa heat shock protein (Hsp70) molecular chaperones. Proc Natl Acad Sci U S A (2011) 1.55
Phospholipid-induced monomerization and signal-peptide-induced oligomerization of SecA. J Biol Chem (2002) 1.50
Macromolecular crowding remodels the energy landscape of a protein by favoring a more compact unfolded state. J Am Chem Soc (2010) 1.45
Dependence of endoplasmic reticulum-associated degradation on the peptide binding domain and concentration of BiP. Mol Biol Cell (2003) 1.43
An interdomain sector mediating allostery in Hsp70 molecular chaperones. Mol Syst Biol (2010) 1.42
Extended polyglutamine tracts cause aggregation and structural perturbation of an adjacent beta barrel protein. J Biol Chem (2006) 1.37
Protein folding in the cell: challenges and progress. Curr Opin Struct Biol (2010) 1.32
Aggregation of a slow-folding mutant of a beta-clam protein proceeds through a monomeric nucleus. Biochemistry (2005) 1.29
Direct comparison of a stable isolated Hsp70 substrate-binding domain in the empty and substrate-bound states. J Biol Chem (2005) 1.27
Unique physical properties and interactions of the domains of methylated DNA binding protein 2. Biochemistry (2010) 1.25
In-cell aggregation of a polyglutamine-containing chimera is a multistep process initiated by the flanking sequence. J Biol Chem (2007) 1.19
Rett syndrome-causing mutations in human MeCP2 result in diverse structural changes that impact folding and DNA interactions. J Biol Chem (2008) 1.12
Exploring weak, transient protein--protein interactions in crowded in vivo environments by in-cell nuclear magnetic resonance spectroscopy. Biochemistry (2011) 1.11
Sequence and structural analysis of cellular retinoic acid-binding proteins reveals a network of conserved hydrophobic interactions. Proteins (2004) 1.10
Cross-strand split tetra-Cys motifs as structure sensors in a beta-sheet protein. Chem Biol (2008) 1.07
Role of Hsp70 ATPase domain intrinsic dynamics and sequence evolution in enabling its functional interactions with NEFs. PLoS Comput Biol (2010) 1.07
Mapping the signal sequence-binding site on SRP reveals a significant role for the NG domain. J Biol Chem (2002) 1.07
Roles of beta-turns in protein folding: from peptide models to protein engineering. Biopolymers (2008) 1.06
Dynamic local unfolding in the serpin α-1 antitrypsin provides a mechanism for loop insertion and polymerization. Nat Struct Mol Biol (2011) 1.04
Nucleotide exchange from the high-affinity ATP-binding site in SecA is the rate-limiting step in the ATPase cycle of the soluble enzyme and occurs through a specialized conformational state. Biochemistry (2004) 1.02
Conserved, disordered C terminus of DnaK enhances cellular survival upon stress and DnaK in vitro chaperone activity. J Biol Chem (2011) 0.99
The conformation of a signal peptide bound by Escherichia coli preprotein translocase SecA. J Biol Chem (2005) 0.99
FoldEco: a model for proteostasis in E. coli. Cell Rep (2012) 0.98
Evolutionary coupling of structural and functional sequence information in the intracellular lipid-binding protein family. Proteins (2006) 0.95
JBC is on a mission to facilitate scientific discovery. J Biol Chem (2017) 0.95
Role of local sequence in the folding of cellular retinoic abinding protein I: structural propensities of reverse turns. Biochemistry (2003) 0.93
Functionally significant mobile regions of Escherichia coli SecA ATPase identified by NMR. J Biol Chem (2002) 0.91
Nature's molecular sponges: small heat shock proteins grow into their chaperone roles. Proc Natl Acad Sci U S A (2010) 0.90
Electrophysiological studies in Xenopus oocytes for the opening of Escherichia coli SecA-dependent protein-conducting channels. J Membr Biol (2007) 0.89
Segmental isotopic labeling of the Hsp70 molecular chaperone DnaK using expressed protein ligation. Biopolymers (2010) 0.88
Effects of osmolytes on protein folding and aggregation in cells. Methods Enzymol (2007) 0.87
Site-specific fluorescent labeling of poly-histidine sequences using a metal-chelating cysteine. Chem Biol Drug Des (2007) 0.87
Exploring the interactions between signal sequences and E. coli SRP by two distinct and complementary crosslinking methods. Biopolymers (2009) 0.87
Natural polypeptide scaffolds: beta-sheets, beta-turns, and beta-hairpins. Biopolymers (2006) 0.85
Use of synthetic signal sequences to explore the protein export machinery. Biopolymers (2008) 0.82
The Role of Aromatic-Aromatic Interactions in Strand-Strand Stabilization of β-Sheets. J Mol Biol (2013) 0.82
Orthogonal cross-seeding: an approach to explore protein aggregates in living cells. Biochemistry (2008) 0.82
First glimpses of a chaperonin-bound folding intermediate. Proc Natl Acad Sci U S A (2005) 0.82
Local sequence information in cellular retinoic acid-binding protein I: specific residue roles in beta-turns. Biopolymers (2003) 0.82
A well-defined amphipathic conformation for the calcium-free cyclic lipopeptide antibiotic, daptomycin, in aqueous solution. Biopolymers (2005) 0.82
How bacteria survive an acid trip. Proc Natl Acad Sci U S A (2013) 0.80
Disorder breathes life into a DEAD motor. Nat Struct Mol Biol (2006) 0.80
Native structural propensity in cellular retinoic acid-binding protein I 64-88: the role of locally encoded structure in the folding of a beta-barrel protein. Biophys Chem (2003) 0.79
The structure of Escherichia coli signal recognition particle revealed by scanning transmission electron microscopy. Mol Biol Cell (2006) 0.79
Using a low denaturant model to explore the conformational features of translocation-active SecA. Biochemistry (2012) 0.78
Early folding events protect aggregation-prone regions of a β-rich protein. Structure (2013) 0.78
A method for direct measurement of protein stability in vivo. Methods Mol Biol (2009) 0.77
The molecular dating game: an antibody heavy chain hangs loose with a chaperone while waiting for its life partner. Mol Cell (2009) 0.77
Chapter 3: A fluorescent window into protein folding and aggregation in cells. Methods Cell Biol (2008) 0.77
A new twist for an Hsp70 chaperone. Nat Struct Biol (2002) 0.75
Delicate balance between functionally required flexibility and aggregation risk in a β-rich protein. Biochemistry (2013) 0.75
You got to know when to hold (or unfold) 'em…. Mol Cell (2012) 0.75
A Loyal Friend of ASBMB and JBC: Howard Schachman, 1918-2016. J Biol Chem (2016) 0.75
What Happens When You Submit a Paper to JBC? J Biol Chem (2017) 0.75
On the costs of scientific publishing. J Biol Chem (2017) 0.75
The Journal of Biological Chemistry: 2016 Onward. J Biol Chem (2016) 0.75
Our field is in good hands. Biopolymers (2008) 0.75
Finding the fittest fold: using the evolutionary record to design new proteins. Cell (2005) 0.75
The Sixth Peptide Engineering Meeting PEM6, Emory University Conference Center, Atlanta, Georgia, October 2 to 5, 2012. Biopolymers (2013) 0.75
The Herbert Tabor Best Paper Awards: Celebrating young authors who contribute top content to JBC. J Biol Chem (2017) 0.75
What's in a Name? J Biol Chem (2016) 0.75
A tribute to the career of a gentle giant of peptide science. Biopolymers (2008) 0.75
Editorial: Passing of a gentle giant of peptide science: in memoriam, R. Bruce Merrifield. Biopolymers (2006) 0.75
Celebrating the scientific legacy of Elkan R. Blout. Biopolymers (2008) 0.75