Published in Dev Biol on July 07, 2006
Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol (2010) 1.59
Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear. Hum Mol Genet (2008) 1.25
The ATP-dependent chromatin remodeling enzyme CHD7 regulates pro-neural gene expression and neurogenesis in the inner ear. Development (2010) 1.24
Connecting the ear to the brain: Molecular mechanisms of auditory circuit assembly. Prog Neurobiol (2011) 1.23
Molecular evolution of the vertebrate mechanosensory cell and ear. Int J Dev Biol (2007) 1.23
The Eyes Absent proteins in development and disease. Cell Mol Life Sci (2012) 1.16
Eya1 and Six1 promote neurogenesis in the cranial placodes in a SoxB1-dependent fashion. Dev Biol (2008) 1.12
Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation. BMC Dev Biol (2010) 1.12
EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear. Development (2012) 1.06
Setting appropriate boundaries: fate, patterning and competence at the neural plate border. Dev Biol (2013) 1.02
HERV-mediated genomic rearrangement of EYA1 in an individual with branchio-oto-renal syndrome. Am J Med Genet A (2010) 0.99
The EYA-SO/SIX complex in development and disease. Pediatr Nephrol (2012) 0.96
The SIX1-EYA transcriptional complex as a therapeutic target in cancer. Expert Opin Ther Targets (2015) 0.94
Establishing the pre-placodal region and breaking it into placodes with distinct identities. Dev Biol (2014) 0.92
Catweasel mice: a novel role for Six1 in sensory patch development and a model for branchio-oto-renal syndrome. Dev Biol (2009) 0.91
Six1 transcription factor is critical for coordination of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol (2011) 0.89
Identification and characterization of mouse otic sensory lineage genes. Front Cell Neurosci (2015) 0.84
The phosphatase-transcription activator EYA1 is targeted by anaphase-promoting complex/Cdh1 for degradation at M-to-G1 transition. Mol Cell Biol (2012) 0.84
Segregating neural and mechanosensory fates in the developing ear: patterning, signaling, and transcriptional control. Cell Tissue Res (2014) 0.83
Early steps in inner ear development: induction and morphogenesis of the otic placode. Front Pharmacol (2015) 0.82
Characterization of Lgr5+ progenitor cell transcriptomes in the apical and basal turns of the mouse cochlea. Oncotarget (2016) 0.82
Transcriptional regulation of cranial sensory placode development. Curr Top Dev Biol (2015) 0.82
The Eya1 phosphatase promotes Shh signaling during hindbrain development and oncogenesis. Dev Cell (2015) 0.80
The role of foxi family transcription factors in the development of the ear and jaw. Curr Top Dev Biol (2015) 0.79
Deafness mutation mining using regular expression based pattern matching. BMC Med Inform Decis Mak (2007) 0.79
Redundant functions of Rac GTPases in inner ear morphogenesis. Dev Biol (2011) 0.79
Branchio-Oto-Renal Syndrome (BOR) associated with focal glomerulosclerosis in a patient with a novel EYA1 splice site mutation. BMC Nephrol (2013) 0.79
The molecular basis of craniofacial placode development. Wiley Interdiscip Rev Dev Biol (2016) 0.78
Two-way communication between the metabolic and cell cycle machineries: the molecular basis. Cell Cycle (2015) 0.77
Genetic Correction of Induced Pluripotent Stem Cells From a Deaf Patient With MYO7A Mutation Results in Morphologic and Functional Recovery of the Derived Hair Cell-Like Cells. Stem Cells Transl Med (2016) 0.77
Using Xenopus to discover new genes involved in branchiootorenal spectrum disorders. Comp Biochem Physiol C Toxicol Pharmacol (2015) 0.76
Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafness. PLoS One (2013) 0.76
Cell interactions, signals and transcriptional hierarchy governing placode progenitor induction. Development (2017) 0.75
Pax-2 controls multiple steps of urogenital development. Development (1995) 3.42
Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia. Nat Genet (1999) 3.24
The eyes absent gene: genetic control of cell survival and differentiation in the developing Drosophila eye. Cell (1993) 3.08
Development of the mouse inner ear and origin of its sensory organs. J Neurosci (1998) 2.81
Follicular cells of the thyroid gland require Pax8 gene function. Nat Genet (1998) 2.75
A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family. Nat Genet (1997) 2.68
Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development. Development (1998) 2.56
SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes. Proc Natl Acad Sci U S A (2004) 2.41
Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear. Development (1993) 2.39
The role of Six1 in mammalian auditory system development. Development (2003) 2.22
Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode. Development (1997) 2.18
Transcription factor GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear. J Comp Neurol (2001) 2.02
Expression and function of FGF10 in mammalian inner ear development. Dev Dyn (2003) 1.95
Fgf3 and Fgf10 are required for mouse otic placode induction. Development (2003) 1.84
Revisiting cell fate specification in the inner ear. Curr Opin Neurobiol (2002) 1.82
Specification of the mammalian cochlea is dependent on Sonic hedgehog. Genes Dev (2002) 1.71
Mutations in the transcriptional activator EYA4 cause late-onset deafness at the DFNA10 locus. Hum Mol Genet (2001) 1.68
Characterization of three novel members of the zebrafish Pax2/5/8 family: dependency of Pax5 and Pax8 expression on the Pax2.1 (noi) function. Development (1998) 1.67
FGF/FGFR-2(IIIb) signaling is essential for inner ear morphogenesis. J Neurosci (2000) 1.64
Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice. Development (2003) 1.59
Clustering of mutations responsible for branchio-oto-renal (BOR) syndrome in the eyes absent homologous region (eyaHR) of EYA1. Hum Mol Genet (1997) 1.59
Frequency of the branchio-oto-renal (BOR) syndrome in children with profound hearing loss. Am J Med Genet (1980) 1.55
Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes. Development (2004) 1.54
Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid. Development (2002) 1.49
Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome. Hum Mol Genet (2001) 1.46
The role of Pax2 in mouse inner ear development. Dev Biol (2004) 1.41
Expression of the transcription factors GATA3 and Pax2 during development of the mammalian inner ear. J Comp Neurol (2002) 1.41
Regulation of the spalt/spalt-related gene complex and its function during sensory organ development in the Drosophila thorax. Development (1999) 1.35
Sensory organ generation in the chick inner ear. J Neurosci (1996) 1.34
Whole-mount in situ hybridization in the mouse embryo: gene expression in three dimensions. Trends Genet (1993) 1.32
EYA4, a novel vertebrate gene related to Drosophila eyes absent. Hum Mol Genet (1999) 1.32
Role of Pax genes in eye evolution: a cnidarian PaxB gene uniting Pax2 and Pax6 functions. Dev Cell (2003) 1.31
Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene. Development (1998) 1.30
BOR and BO syndromes are allelic defects of EYA1. Eur J Hum Genet (1998) 1.29
Addition of the BMP4 antagonist, noggin, disrupts avian inner ear development. Development (2000) 1.26
Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene. Genome Res (1997) 1.25
Expression of a truncated Sall1 transcriptional repressor is responsible for Townes-Brocks syndrome birth defects. Hum Mol Genet (2003) 1.25
Phenotypic manifestations of branchio-oto-renal syndrome. Am J Med Genet (1995) 1.23
Ectopic noggin blocks sensory and nonsensory organ morphogenesis in the chicken inner ear. Dev Biol (1999) 1.21
A 4-bp insertion in the eya-homologous region (eyaHR) of EYA4 causes hearing impairment in a Hungarian family linked to DFNA10. Mol Med (2002) 1.14
The zebrafish eya1 gene and its expression pattern during embryogenesis. Dev Genes Evol (1999) 1.14
Nkx5-1 controls semicircular canal formation in the mouse inner ear. Development (1998) 1.13
Eya1 expression in the developing ear and kidney: towards the understanding of the pathogenesis of Branchio-Oto-Renal (BOR) syndrome. Dev Dyn (1998) 1.07
SALL1 mutations in Townes-Brocks syndrome and related disorders. Hum Mutat (2000) 1.07
Identification of three novel mutations in human EYA1 protein associated with branchio-oto-renal syndrome. Hum Mutat (1998) 1.04
Xenopus Eya1 demarcates all neurogenic placodes as well as migrating hypaxial muscle precursors. Mech Dev (2001) 1.00
Eya1 acts upstream of Tbx1, Neurogenin 1, NeuroD and the neurotrophins BDNF and NT-3 during inner ear development. Mech Dev (2005) 0.93
Molecular cloning, chromosomal localization, and expression of the murine SALL1 ortholog Sall1. Cytogenet Cell Genet (2000) 0.93
Drosophila spalt/spalt-related mutants exhibit Townes-Brocks' syndrome phenotypes. Proc Natl Acad Sci U S A (2003) 0.91
DFNA10/EYA4--the clinical picture. Adv Otorhinolaryngol (2002) 0.87
Experimental endolymphatic hydrops. S Afr Med J (1973) 0.86
Homologs of animal eyes absent (eya) genes are found in higher plants. Mol Gen Genet (1999) 0.82
Functional brown adipose tissue in healthy adults. N Engl J Med (2009) 16.22
Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell (2012) 11.03
Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation. Proc Natl Acad Sci U S A (2004) 3.45
Different metabolic responses of human brown adipose tissue to activation by cold and insulin. Cell Metab (2011) 3.40
Evidence for two types of brown adipose tissue in humans. Nat Med (2013) 2.97
Six1 is required for the early organogenesis of mammalian kidney. Development (2003) 2.47
SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes. Proc Natl Acad Sci U S A (2004) 2.41
The role of Six1 in mammalian auditory system development. Development (2003) 2.22
Reduced expression of FOXC2 and brown adipogenic genes in human subjects with insulin resistance. Obes Res (2003) 1.63
Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice. Development (2003) 1.59
Transcriptional control of SLC26A4 is involved in Pendred syndrome and nonsyndromic enlargement of vestibular aqueduct (DFNB4). Am J Hum Genet (2007) 1.59
Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes. Development (2004) 1.54
Distal renal tubular acidosis in mice that lack the forkhead transcription factor Foxi1. J Clin Invest (2004) 1.53
Transcription factor SIX5 is mutated in patients with branchio-oto-renal syndrome. Am J Hum Genet (2007) 1.52
Six1 and Eya1 expression can reprogram adult muscle from the slow-twitch phenotype into the fast-twitch phenotype. Mol Cell Biol (2004) 1.39
Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells and fibroblasts for mammalian internal organs, and their vasculature. Nat Cell Biol (2012) 1.38
Epididymal expression of the forkhead transcription factor Foxi1 is required for male fertility. EMBO J (2006) 1.32
Eya1-Six1 interaction is sufficient to induce hair cell fate in the cochlea by activating Atoh1 expression in cooperation with Sox2. Dev Cell (2012) 1.30
FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue. Proc Natl Acad Sci U S A (2008) 1.27
Foxe3 haploinsufficiency in mice: a model for Peters' anomaly. Invest Ophthalmol Vis Sci (2002) 1.26
Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear. Hum Mol Genet (2008) 1.25
The forkhead transcription factor Foxi1 is a master regulator of vacuolar H-ATPase proton pump subunits in the inner ear, kidney and epididymis. PLoS One (2009) 1.21
Blunted metabolic responses to cold and insulin stimulation in brown adipose tissue of obese humans. Obesity (Silver Spring) (2013) 1.20
Brown adipose tissue--a new role in humans? Nat Rev Endocrinol (2010) 1.18
Spermatogenesis of mice lacking CK2alpha': failure of germ cell survival and characteristic modifications of the spermatid nucleus. Mol Reprod Dev (2003) 1.17
The boundary cap: a source of neural crest stem cells that generate multiple sensory neuron subtypes. Development (2005) 1.17
Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme. Dev Biol (2005) 1.17
Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo. Dev Biol (2006) 1.14
Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1. Dev Biol (2006) 1.13
Mechanisms of FOXC2- and FOXD1-mediated regulation of the RI alpha subunit of cAMP-dependent protein kinase include release of transcriptional repression and activation by protein kinase B alpha and cAMP. J Biol Chem (2002) 1.08
Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4. Dev Biol (2008) 1.06
EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear. Development (2012) 1.06
SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation. Development (2010) 1.04
Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology. J Biol Chem (2004) 1.02
Pilot study of sentinel-node-based adoptive immunotherapy in advanced colorectal cancer. Ann Surg Oncol (2010) 1.01
The adipocyte-expressed forkhead transcription factor Foxc2 regulates metabolism through altered mitochondrial function. Diabetes (2011) 0.98
Insulin and TNF alpha induce expression of the forkhead transcription factor gene Foxc2 in 3T3-L1 adipocytes via PI3K and ERK 1/2-dependent pathways. Mol Endocrinol (2002) 0.97
Hyperthyroidism increases brown fat metabolism in humans. J Clin Endocrinol Metab (2013) 0.96
Comparison of dorsocervical with abdominal subcutaneous adipose tissue in patients with and without antiretroviral therapy-associated lipodystrophy. Diabetes (2011) 0.94
Emergence of the sensory nervous system as defined by Foxs1 expression. Differentiation (2007) 0.93
Biocompatibility of bacterial magnetosomes: acute toxicity, immunotoxicity and cytotoxicity. Nanotoxicology (2010) 0.91
Reduced PDE4 expression and activity contributes to enhanced catecholamine-induced cAMP accumulation in adipocytes from FOXC2 transgenic mice. FEBS Lett (2006) 0.88
Presence of brown adipocytes in retroperitoneal fat from patients with benign adrenal tumors: relationship with outdoor temperature. J Clin Endocrinol Metab (2013) 0.88
FOXC2 mRNA Expression and a 5' untranslated region polymorphism of the gene are associated with insulin resistance. Diabetes (2002) 0.88
Adipocyte mitochondrial genes and the forkhead factor FOXC2 are decreased in type 2 diabetes patients and normalized in response to rosiglitazone. Diabetol Metab Syndr (2011) 0.88
Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis. Dev Biol (2011) 0.87
Therapeutic prospects of metabolically active brown adipose tissue in humans. Front Endocrinol (Lausanne) (2011) 0.86
Spermatid nuclear and sperm periaxonemal anomalies in the mouse Ube2b null mutant. Mol Reprod Dev (2003) 0.85
Lack of the central nervous system- and neural crest-expressed forkhead gene Foxs1 affects motor function and body weight. Mol Cell Biol (2005) 0.85
MGRN1-dependent pigment-type switching requires its ubiquitination activity but not its interaction with TSG101 or NEDD4. Pigment Cell Melanoma Res (2013) 0.84
The phosphatase-transcription activator EYA1 is targeted by anaphase-promoting complex/Cdh1 for degradation at M-to-G1 transition. Mol Cell Biol (2012) 0.84
Insulin resistance and type 2 diabetes--an adipocentric view. Curr Mol Med (2003) 0.83
EYA1-SIX1 complex in neurosensory cell fate induction in the mammalian inner ear. Hear Res (2012) 0.82
Mice with disrupted type I protein kinase A anchoring in T cells resist retrovirus-induced immunodeficiency. J Immunol (2011) 0.80
Developmental cardiac hypertrophy in a mouse model of prolidase deficiency. Birth Defects Res A Clin Mol Teratol (2011) 0.79
"The adipocyte: a multifunctional cell". Cell Metab (2006) 0.79
A winged helix forkhead (FOXD2) tunes sensitivity to cAMP in T lymphocytes through regulation of cAMP-dependent protein kinase RIalpha. J Biol Chem (2003) 0.78
In vitro differentiated adipocytes from a Foxc2 reporter knock-in mouse as screening tool. Transgenic Res (2009) 0.78
Identification and characterization of a novel testis-specific gene CKT2, which encodes a substrate for protein kinase CK2. Nucleic Acids Res (2009) 0.77
Pancreatic beta-cell lipotoxicity induced by overexpression of hormone-sensitive lipase. Diabetes (2003) 0.77
Distribution dynamics of recombinant Lactobacillus in the gastrointestinal tract of neonatal rats. PLoS One (2013) 0.77
Overexpression of Foxf2 in adipose tissue is associated with lower levels of IRS1 and decreased glucose uptake in vivo. Am J Physiol Endocrinol Metab (2009) 0.77
Disrupted SOX10 function causes spongiform neurodegeneration in gray tremor mice. Mamm Genome (2014) 0.75
Use of animals on expiring protocols. No 'ongoing' work. Lab Anim (NY) (2009) 0.75