Published in Development on July 01, 2003
Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression. J Mammary Gland Biol Neoplasia (2010) 3.93
Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney. EMBO J (2006) 3.26
Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development (2007) 2.70
Advances in early kidney specification, development and patterning. Development (2009) 2.62
SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes. Proc Natl Acad Sci U S A (2004) 2.41
The role of Six1 in mammalian auditory system development. Development (2003) 2.22
The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling. J Clin Invest (2009) 2.01
High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population. Dev Biol (2009) 1.84
Mammalian kidney development: principles, progress, and projections. Cold Spring Harb Perspect Biol (2012) 1.80
Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks. Dev Cell (2012) 1.75
Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes. Development (2004) 1.54
The sine oculis homeobox (SIX) family of transcription factors as regulators of development and disease. Cell Mol Life Sci (2009) 1.51
A regulatory program for excretory system regeneration in planarians. Development (2011) 1.43
The ECM protein nephronectin promotes kidney development via integrin alpha8beta1-mediated stimulation of Gdnf expression. Development (2007) 1.42
A Hox-Eya-Pax complex regulates early kidney developmental gene expression. Mol Cell Biol (2007) 1.42
Six1 and Eya1 expression can reprogram adult muscle from the slow-twitch phenotype into the fast-twitch phenotype. Mol Cell Biol (2004) 1.39
A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J Clin Invest (2011) 1.39
Cell and molecular biology of kidney development. Semin Nephrol (2009) 1.32
Eya2 is required to mediate the pro-metastatic functions of Six1 via the induction of TGF-β signaling, epithelial-mesenchymal transition, and cancer stem cell properties. Oncogene (2011) 1.30
Clinicopathological significance of homeoprotein Six1 in hepatocellular carcinoma. Br J Cancer (2006) 1.29
The pro-apoptotic protein Bim is a microRNA target in kidney progenitors. J Am Soc Nephrol (2011) 1.27
Genetic determination of nephrogenesis: the Pax/Eya/Six gene network. Pediatr Nephrol (2003) 1.27
Concise review: Kidney stem/progenitor cells: differentiate, sort out, or reprogram? Stem Cells (2010) 1.23
Defining and redefining the nephron progenitor population. Pediatr Nephrol (2011) 1.23
Identification of transcriptional targets of the dual-function transcription factor/phosphatase eyes absent. Dev Biol (2007) 1.23
Six1 promotes proliferation of pancreatic cancer cells via upregulation of cyclin D1 expression. PLoS One (2013) 1.23
Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors. Cancer Cell (2015) 1.18
Wt1 ablation and Igf2 upregulation in mice result in Wilms tumors with elevated ERK1/2 phosphorylation. J Clin Invest (2010) 1.17
Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme. Dev Biol (2005) 1.17
Homeoprotein Six1 increases TGF-beta type I receptor and converts TGF-beta signaling from suppressive to supportive for tumor growth. Cancer Res (2010) 1.16
The Eyes Absent proteins in development and disease. Cell Mol Life Sci (2012) 1.16
Direct transcriptional reprogramming of adult cells to embryonic nephron progenitors. J Am Soc Nephrol (2013) 1.14
Six proteins regulate the activation of Myf5 expression in embryonic mouse limbs. Proc Natl Acad Sci U S A (2007) 1.14
Tissue-specific roles of Tbx1 in the development of the outer, middle and inner ear, defective in 22q11DS patients. Hum Mol Genet (2006) 1.13
Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1. Dev Biol (2006) 1.13
Wilms tumor--a renal stem cell malignancy? Pediatr Nephrol (2011) 1.11
Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo. Dev Biol (2008) 1.10
Expression of Six1 in luminal breast cancers predicts poor prognosis and promotes increases in tumor initiating cells by activation of extracellular signal-regulated kinase and transforming growth factor-beta signaling pathways. Breast Cancer Res (2012) 1.10
Genetic approaches to human renal agenesis/hypoplasia and dysplasia. Pediatr Nephrol (2007) 1.07
EWS/FLI1 regulates EYA3 in Ewing sarcoma via modulation of miRNA-708, resulting in increased cell survival and chemoresistance. Mol Cancer Res (2012) 1.04
SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation. Development (2010) 1.04
Genetic and developmental basis for urinary tract obstruction. Pediatr Nephrol (2008) 1.01
Discrimination of vanadium from zinc using gene profiling in human bronchial epithelial cells. Environ Health Perspect (2005) 0.99
Fras1, a basement membrane-associated protein mutated in Fraser syndrome, mediates both the initiation of the mammalian kidney and the integrity of renal glomeruli. Hum Mol Genet (2008) 0.99
WT1 and kidney progenitor cells. Organogenesis (2010) 0.97
Elevated amounts of myocilin in the aqueous humor of transgenic mice cause significant changes in ocular gene expression. Exp Eye Res (2008) 0.97
The EYA-SO/SIX complex in development and disease. Pediatr Nephrol (2012) 0.96
Six and Eya promote apoptosis through direct transcriptional activation of the proapoptotic BH3-only gene egl-1 in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2010) 0.96
Eya1 interacts with Six2 and Myc to regulate expansion of the nephron progenitor pool during nephrogenesis. Dev Cell (2014) 0.95
The yin and yang of kidney development and Wilms' tumors. Genes Dev (2015) 0.95
The SIX1-EYA transcriptional complex as a therapeutic target in cancer. Expert Opin Ther Targets (2015) 0.94
Six1 and Eya1 are critical regulators of peri-cloacal mesenchymal progenitors during genitourinary tract development. Dev Biol (2011) 0.94
Betaglycan is required for the establishment of nephron endowment in the mouse. PLoS One (2011) 0.93
Catweasel mice: a novel role for Six1 in sensory patch development and a model for branchio-oto-renal syndrome. Dev Biol (2009) 0.91
Misexpression of Six2 is associated with heritable frontonasal dysplasia and renal hypoplasia in 3H1 Br mice. Dev Dyn (2008) 0.90
Six1 transcription factor is critical for coordination of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol (2011) 0.89
Gene regulatory network of renal primordium development. Pediatr Nephrol (2013) 0.87
COUP-TFII is essential for metanephric mesenchyme formation and kidney precursor cell survival. Development (2012) 0.87
Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis. Dev Biol (2011) 0.87
The genetics of auricular development and malformation: new findings in model systems driving future directions for microtia research. Eur J Med Genet (2014) 0.86
Position dependent responses to discontinuities in the retinal determination network. Dev Biol (2008) 0.86
Characterization of the Six1 homeobox gene in normal mammary gland morphogenesis. BMC Dev Biol (2010) 0.86
Tbx18 is essential for normal development of vasculature network and glomerular mesangium in the mammalian kidney. Dev Biol (2014) 0.85
Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators. Development (2016) 0.84
BMP signaling controls formation of a primordial germ cell niche within the early genital ridges. Dev Biol (2010) 0.84
The phosphatase-transcription activator EYA1 is targeted by anaphase-promoting complex/Cdh1 for degradation at M-to-G1 transition. Mol Cell Biol (2012) 0.84
Transcriptional regulation of cranial sensory placode development. Curr Top Dev Biol (2015) 0.82
Six1 promotes epithelial-mesenchymal transition and malignant conversion in human papillomavirus type 16-immortalized human keratinocytes. Carcinogenesis (2014) 0.82
Eye-specification genes in the bacterial light organ of the bobtail squid Euprymna scolopes, and their expression in response to symbiont cues. Mech Dev (2013) 0.82
Embryonic origin and remodeling of the urinary and digestive outlets. PLoS One (2013) 0.81
The genetics and epigenetics of kidney development. Semin Nephrol (2013) 0.80
Novel dominant-negative mutation within the six domain of the conserved eye specification gene sine oculis inhibits eye development in Drosophila. Dev Dyn (2005) 0.80
Increased expression of Six1 correlates with progression and prognosis of prostate cancer. Cancer Cell Int (2015) 0.80
Chromatin-based mechanisms of renal epithelial differentiation. J Am Soc Nephrol (2011) 0.79
Developmental expression patterns of candidate cofactors for vertebrate six family transcription factors. Dev Dyn (2010) 0.79
Differential selection within the Drosophila retinal determination network and evidence for functional divergence between paralog pairs. Evol Dev (2011) 0.79
MicroRNAs: potential regulators of renal development genes that contribute to CAKUT. Pediatr Nephrol (2013) 0.78
Microarray identification of novel genes downstream of Six1, a critical factor in cranial placode, somite, and kidney development. Dev Dyn (2014) 0.78
Expression profile of SIX family members correlates with clinic-pathological features and prognosis of breast cancer: A systematic review and meta-analysis. Medicine (Baltimore) (2016) 0.78
Signaling during Kidney Development. Cells (2015) 0.78
The KIDSTEM European Research Training Network: Developing a Stem Cell Based Therapy to Replace Nephrons Lost through Reflux Nephropathy. Organogenesis (2007) 0.77
The expression profile and clinic significance of the SIX family in non-small cell lung cancer. J Hematol Oncol (2016) 0.77
Eya-six are necessary for survival of nephrogenic cord progenitors and inducing nephric duct development before ureteric bud formation. Dev Dyn (2015) 0.77
The Eye Specification Network in Drosophila. Proc Indian Natl Sci Acad B Biol Sci (2004) 0.77
SIX1 overexpression in diffuse-type and grade III gastric tumors: Features that are associated with poor prognosis. Adv Biomed Res (2015) 0.76
Using Xenopus to discover new genes involved in branchiootorenal spectrum disorders. Comp Biochem Physiol C Toxicol Pharmacol (2015) 0.76
Expression of Six1 homeobox gene during development of the mouse submandibular salivary gland. Oral Dis (2009) 0.76
GDNF-independent ureteric budding: role of PI3K-independent activation of AKT and FOSB/JUN/AP-1 signaling. Biol Open (2013) 0.76
NRF1 and ZSCAN10 bind to the promoter region of the SIX1 gene and their effects body measurements in Qinchuan cattle. Sci Rep (2017) 0.76
Six1 overexpression at early stages of HPV16-mediated transformation of human keratinocytes promotes differentiation resistance and EMT. Virology (2014) 0.75
Nephron number, hypertension, and CKD: physiological and genetic insight from humans and animal models. Physiol Genomics (2017) 0.75
Developmental Genetics and Congenital Anomalies of the Kidney and Urinary Tract. J Pediatr Genet (2015) 0.75
Increased Six1 expression is associated with poor prognosis in patients with osteosarcoma. Oncol Lett (2017) 0.75
Establishment of a Conditionally Immortalized Wilms Tumor Cell Line with a Homozygous WT1 Deletion within a Heterozygous 11p13 Deletion and UPD Limited to 11p15. PLoS One (2016) 0.75
Tessellation analysis of glomerular spatial arrangement in mice with heritable renal hypoplasia. Anat Rec (Hoboken) (2010) 0.75
The homeoprotein SIX1 controls cellular senescence through the regulation of p16INK4A and differentiation-related genes. Oncogene (2015) 0.75
Osr1 Interacts Synergistically with Wt1 to Regulate Kidney Organogenesis. PLoS One (2016) 0.75
Renal anomalies associated with ectopic neurohypophysis. J Clin Res Pediatr Endocrinol (2011) 0.75
LncRNA-Six1 Encodes a Micropeptide to Activate Six1 in Cis and Is Involved in Cell Proliferation and Muscle Growth. Front Physiol (2017) 0.75
Six1 expression is associated with a poor prognosis in patients with glioma. Oncol Lett (2017) 0.75
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SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes. Proc Natl Acad Sci U S A (2004) 2.41
Pax3 functions at a nodal point in melanocyte stem cell differentiation. Nature (2005) 2.37
The role of Six1 in mammalian auditory system development. Development (2003) 2.22
Muscle contraction is necessary to maintain joint progenitor cell fate. Dev Cell (2009) 2.09
Development of a virus-induced gene-silencing system for hexaploid wheat and its use in functional analysis of the Lr21-mediated leaf rust resistance pathway. Plant Physiol (2005) 2.02
Altered myogenesis in Six1-deficient mice. Development (2003) 1.92
Interleukin-6-driven progranulin expression increases cholangiocarcinoma growth by an Akt-dependent mechanism. Gut (2011) 1.91
Refractive error and visual impairment in school children in rural southern China. Ophthalmology (2006) 1.84
Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo. Development (2005) 1.70
Inhibition of HIV-1 maturation via drug association with the viral Gag protein in immature HIV-1 particles. J Biol Chem (2005) 1.66
MicroRNA-143 as a tumor suppressor for bladder cancer. J Urol (2009) 1.56
The gene Sr33, an ortholog of barley Mla genes, encodes resistance to wheat stem rust race Ug99. Science (2013) 1.55
Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes. Development (2004) 1.54
Thymus, kidney and craniofacial abnormalities in Six 1 deficient mice. Mech Dev (2003) 1.52
Transcription factor SIX5 is mutated in patients with branchio-oto-renal syndrome. Am J Hum Genet (2007) 1.52
Assessment and prognostic significance of mitotic index using the mitosis marker phospho-histone H3 in low and intermediate-grade infiltrating astrocytomas. Am J Surg Pathol (2006) 1.50
Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid. Development (2002) 1.49
Activation of estrogen receptor-alpha by the anion nitrite. Cancer Res (2008) 1.47
Expression and role of neuroglobin in rats with sepsis-associated encephalopathy. Crit Care Med (2014) 1.46
Genome analyses of Icelandic strains of Sulfolobus islandicus, model organisms for genetic and virus-host interaction studies. J Bacteriol (2011) 1.45
Arabidopsis acyl-CoA-binding protein ACBP3 participates in plant response to hypoxia by modulating very-long-chain fatty acid metabolism. Plant J (2014) 1.44
Prognostic role of serum carbohydrate antigen 19-9 levels in patients with resectable hepatocellular carcinoma. Tumour Biol (2015) 1.42
Expression of dopamine 2 receptor subtype mRNA in clinically nonfunctioning pituitary adenomas. Neurol Sci (2011) 1.39
Six1 and Eya1 expression can reprogram adult muscle from the slow-twitch phenotype into the fast-twitch phenotype. Mol Cell Biol (2004) 1.39
The farnesoid X receptor controls gene expression in a ligand- and promoter-selective fashion. J Biol Chem (2003) 1.35
Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump. J Biol Chem (2003) 1.33
Construction of a SNP-based genetic linkage map in cultivated peanut based on large scale marker development using next-generation double-digest restriction-site-associated DNA sequencing (ddRADseq). BMC Genomics (2014) 1.30
Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity. Blood (2007) 1.27
Anti-AIDS agents. 78. Design, synthesis, metabolic stability assessment, and antiviral evaluation of novel betulinic acid derivatives as potent anti-human immunodeficiency virus (HIV) agents. J Med Chem (2009) 1.26
Sulfolobus tengchongensis spindle-shaped virus STSV1: virus-host interactions and genomic features. J Virol (2005) 1.26
Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents. J Med Chem (2006) 1.25
Regulation of the lifespan in dendritic cell subsets. Mol Immunol (2007) 1.23
Cre reporter mouse expressing a nuclear localized fusion of GFP and beta-galactosidase reveals new derivatives of Pax3-expressing precursors. Genesis (2008) 1.23
Ssh10b, a conserved thermophilic archaeal protein, binds RNA in vivo. Mol Microbiol (2003) 1.20
Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers. J Clin Invest (2009) 1.19
Design, synthesis, and preclinical evaluations of novel 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) drug candidates. J Med Chem (2012) 1.18
Silencing cAMP-response element-binding protein (CREB) identifies CYR61 as a tumor suppressor gene in melanoma. J Biol Chem (2009) 1.18
Spermatogenesis of mice lacking CK2alpha': failure of germ cell survival and characteristic modifications of the spermatid nucleus. Mol Reprod Dev (2003) 1.17
Quantitative proteomic identification of six4 as the trex-binding factor in the muscle creatine kinase enhancer. Mol Cell Biol (2004) 1.17
Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme. Dev Biol (2005) 1.17
Metagenomic insights into the fibrolytic microbiome in yak rumen. PLoS One (2012) 1.17
New betulinic acid derivatives for bevirimat-resistant human immunodeficiency virus type-1. J Med Chem (2013) 1.16
H3.3 actively marks enhancers and primes gene transcription via opening higher-ordered chromatin. Genes Dev (2013) 1.14
Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo. Dev Biol (2006) 1.14
Six proteins regulate the activation of Myf5 expression in embryonic mouse limbs. Proc Natl Acad Sci U S A (2007) 1.14
Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity. J Biol Chem (2002) 1.14
Caspase-9-induced mitochondrial disruption through cleavage of anti-apoptotic BCL-2 family members. J Biol Chem (2007) 1.13
Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1. Dev Biol (2006) 1.13
Betulinic acid derivatives as human immunodeficiency virus type 2 (HIV-2) inhibitors. J Med Chem (2009) 1.12
Revealing the essentiality of multiple archaeal pcna genes using a mutant propagation assay based on an improved knockout method. Microbiology (2010) 1.11
Eya1 regulates the growth of otic epithelium and interacts with Pax2 during the development of all sensory areas in the inner ear. Dev Biol (2006) 1.10
Defects in brain patterning and head morphogenesis in the mouse mutant Fused toes. Dev Biol (2006) 1.10
Anti-AIDS agents 79. Design, synthesis, molecular modeling and structure-activity relationships of novel dicamphanoyl-2',2'-dimethyldihydropyranochromone (DCP) analogs as potent anti-HIV agents. Bioorg Med Chem (2010) 1.08
Tanshinone IIA: A Promising Natural Cardioprotective Agent. Evid Based Complement Alternat Med (2012) 1.07
Where self-control comes from: on the development of self-control and its relationship to deviance over time. Dev Psychol (2010) 1.07
Six1 and Six4 gene expression is necessary to activate the fast-type muscle gene program in the mouse primary myotome. Dev Biol (2009) 1.06
Ash2l interacts with Tbx1 and is required during early embryogenesis. Exp Biol Med (Maywood) (2010) 1.06
Diarylaniline derivatives as a distinct class of HIV-1 non-nucleoside reverse transcriptase inhibitors. J Med Chem (2010) 1.06
Reg4 protects against acinar cell necrosis in experimental pancreatitis. Gut (2010) 1.06
YAP/TEAD-mediated transcription controls cellular senescence. Cancer Res (2013) 1.06
Serum starvation induced cell cycle synchronization facilitates human somatic cells reprogramming. PLoS One (2012) 1.06
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1. Antimicrob Agents Chemother (2007) 1.05
Genetic analysis of chikungunya viruses imported to mainland China in 2008. Virol J (2010) 1.05
Six and Eya expression during human somitogenesis and MyoD gene family activation. J Muscle Res Cell Motil (2002) 1.04
Anti-AIDS agents 81. Design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors. J Med Chem (2010) 1.04
Nicotinamidase modulation of NAD+ biosynthesis and nicotinamide levels separately affect reproductive development and cell survival in C. elegans. Development (2009) 1.04
Multivariate statistical analysis of heavy metals in street dust of Baoji, NW China. J Hazard Mater (2009) 1.04
Analysis of 106 kb of contiguous DNA sequence from the D genome of wheat reveals high gene density and a complex arrangement of genes related to disease resistance. Genome (2002) 1.03
Human herpesvirus 6 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus. Am J Pathol (2005) 1.03
Biochemical and structural characterization of Cren7, a novel chromatin protein conserved among Crenarchaea. Nucleic Acids Res (2007) 1.03
Six1 regulates stem cell repair potential and self-renewal during skeletal muscle regeneration. J Cell Biol (2012) 1.03
Protease activated receptor-1 inhibits the Maspin tumor-suppressor gene to determine the melanoma metastatic phenotype. Proc Natl Acad Sci U S A (2010) 1.02
Overexpression of protease-activated receptor-1 contributes to melanoma metastasis via regulation of connexin 43. Cancer Res (2009) 1.02
Biochemical characterization of an ATP-dependent DNA ligase from the hyperthermophilic crenarchaeon Sulfolobus shibatae. Extremophiles (2002) 1.02
A natural small molecule harmine inhibits angiogenesis and suppresses tumour growth through activation of p53 in endothelial cells. PLoS One (2012) 1.00
Anti-AIDS agents 90. novel C-28 modified bevirimat analogues as potent HIV maturation inhibitors. J Med Chem (2012) 1.00
HDL of patients with type 2 diabetes mellitus elevates the capability of promoting breast cancer metastasis. Clin Cancer Res (2012) 0.99
Six1 is not involved in limb tendon development, but is expressed in limb connective tissue under Shh regulation. Mech Dev (2004) 0.99
Sulfolobus tengchongensis sp. nov., a novel thermoacidophilic archaeon isolated from a hot spring in Tengchong, China. Extremophiles (2003) 0.99
Optimization of 2,4-diarylanilines as non-nucleoside HIV-1 reverse transcriptase inhibitors. Bioorg Med Chem Lett (2012) 0.98
Expression of Id-1 is regulated by MCAM/MUC18: a missing link in melanoma progression. Cancer Res (2011) 0.98
Characterization of the human UBE3B gene: structure, expression, evolution, and alternative splicing. Genomics (2003) 0.98
Porcine reproductive and respiratory syndrome virus induces autophagy to promote virus replication. Autophagy (2012) 0.98
Upregulation of barrel GABAergic neurons is associated with cross-modal plasticity in olfactory deficit. PLoS One (2010) 0.98
Dynamics of chloroplast proteome in salt-stressed mangrove Kandelia candel (L.) Druce. J Proteome Res (2013) 0.98
MicroRNA-145 regulates human corneal epithelial differentiation. PLoS One (2011) 0.98
Antioxidant activity of Lactobacillus plantarum strains isolated from traditional Chinese fermented foods. Food Chem (2012) 0.97
Reciprocal interactions between tumor-associated macrophages and CD44-positive cancer cells via osteopontin/CD44 promote tumorigenicity in colorectal cancer. Clin Cancer Res (2012) 0.97