Staphylococcus aureus mutants with increased lysostaphin resistance.

PubWeight™: 1.08‹?› | Rank: Top 10%

🔗 View Article (PMC 1595375)

Published in J Bacteriol on September 01, 2006

Authors

Angelika Gründling1, Dominique M Missiakas, Olaf Schneewind

Author Affiliations

1: Department of Microbiology, University of Chicago, 920 E 58th Street, Chicago, IL 60637, USA.

Articles citing this

Bacteriophage endolysins as novel antimicrobials. Future Microbiol (2012) 1.68

Synergism between a novel chimeric lysin and oxacillin protects against infection by methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother (2010) 1.48

Modulation of cell wall structure and antimicrobial susceptibility by a Staphylococcus aureus eukaryote-like serine/threonine kinase and phosphatase. Infect Immun (2009) 1.47

Chimeric phage lysins act synergistically with lysostaphin to kill mastitis-causing Staphylococcus aureus in murine mammary glands. Appl Environ Microbiol (2012) 1.15

Staphylococcus aureus mutants lacking the LytR-CpsA-Psr family of enzymes release cell wall teichoic acids into the extracellular medium. J Bacteriol (2013) 1.15

Determinants of murein hydrolase targeting to cross-wall of Staphylococcus aureus peptidoglycan. J Biol Chem (2012) 1.06

Lysostaphin-resistant variants of Staphylococcus aureus demonstrate reduced fitness in vitro and in vivo. Antimicrob Agents Chemother (2006) 1.03

Oritavancin binds to isolated protoplast membranes but not intact protoplasts of Staphylococcus aureus. J Mol Biol (2009) 1.00

Expansion of type II CAAX proteases reveals evolutionary origin of γ-secretase subunit APH-1. J Mol Biol (2011) 0.97

Peptidoglycan hydrolases-potential weapons against Staphylococcus aureus. Appl Microbiol Biotechnol (2012) 0.96

ABI domain-containing proteins contribute to surface protein display and cell division in Staphylococcus aureus. Mol Microbiol (2010) 0.93

Compound-gene interaction mapping reveals distinct roles for Staphylococcus aureus teichoic acids. Proc Natl Acad Sci U S A (2014) 0.91

The YjbH adaptor protein enhances proteolysis of the transcriptional regulator Spx in Staphylococcus aureus. J Bacteriol (2011) 0.90

Wall teichoic acids of Staphylococcus aureus limit recognition by the drosophila peptidoglycan recognition protein-SA to promote pathogenicity. PLoS Pathog (2011) 0.90

The Abi-domain protein Abx1 interacts with the CovS histidine kinase to control virulence gene expression in group B Streptococcus. PLoS Pathog (2013) 0.88

Staphylococcus haemolyticus prophage ΦSH2 endolysin relies on cysteine, histidine-dependent amidohydrolases/peptidases activity for lysis 'from without'. J Biotechnol (2012) 0.84

A new platform for ultra-high density Staphylococcus aureus transposon libraries. BMC Genomics (2015) 0.83

Evolutionarily distinct bacteriophage endolysins featuring conserved peptidoglycan cleavage sites protect mice from MRSA infection. J Antimicrob Chemother (2015) 0.82

Bioluminescence and 19F magnetic resonance imaging visualize the efficacy of lysostaphin alone and in combination with oxacillin against Staphylococcus aureus in murine thigh and catheter-associated infection models. Antimicrob Agents Chemother (2013) 0.81

Inactivation of the Ecs ABC transporter of Staphylococcus aureus attenuates virulence by altering composition and function of bacterial wall. PLoS One (2010) 0.80

VimA-dependent modulation of the secretome in Porphyromonas gingivalis. Mol Oral Microbiol (2012) 0.80

Bactericidal synergy of lysostaphin in combination with antimicrobial peptides. Eur J Clin Microbiol Infect Dis (2011) 0.78

The effect of skin fatty acids on Staphylococcus aureus. Arch Microbiol (2014) 0.78

In silico analysis of AHJD-like viruses, Staphylococcus aureus phages S24-1 and S13', and study of phage S24-1 adsorption. Microbiologyopen (2014) 0.76

Lysostaphin: A Staphylococcal Bacteriolysin with Potential Clinical Applications. Pharmaceuticals (Basel) (2010) 0.75

Articles cited by this

Studies on transformation of Escherichia coli with plasmids. J Mol Biol (1983) 116.81

Use of T7 RNA polymerase to direct expression of cloned genes. Methods Enzymol (1990) 61.47

Staphylococcus aureus infections. N Engl J Med (1998) 36.39

The toxic shock syndrome exotoxin structural gene is not detectably transmitted by a prophage. Nature (1983) 19.44

CDD: a Conserved Domain Database for protein classification. Nucleic Acids Res (2005) 18.85

Staphylococcal coagulase; mode of action and antigenicity. J Gen Microbiol (1952) 8.13

Surface proteins of gram-positive bacteria and mechanisms of their targeting to the cell wall envelope. Microbiol Mol Biol Rev (1999) 7.76

The mechanism of genetic recombination in Escherichia coli. Cold Spring Harb Symp Quant Biol (1953) 7.41

LYSOSTAPHIN: A NEW BACTERIOLYTIC AGENT FOR THE STAPHYLOCOCCUS. Proc Natl Acad Sci U S A (1964) 7.06

Genetic approaches to study of biofilms. Methods Enzymol (1999) 6.78

A new vector for high-throughput, ligation-independent cloning encoding a tobacco etch virus protease cleavage site. Protein Expr Purif (2002) 5.72

Peptidoglycan composition of a highly methicillin-resistant Staphylococcus aureus strain. The role of penicillin binding protein 2A. J Biol Chem (1992) 4.92

The composition of the murein of Escherichia coli. J Biol Chem (1988) 4.83

FemA, a host-mediated factor essential for methicillin resistance in Staphylococcus aureus: molecular cloning and characterization. Mol Gen Genet (1989) 4.67

Construction of single-copy integration vectors for Staphylococcus aureus. Gene (1991) 4.43

Structure of the cell wall anchor of surface proteins in Staphylococcus aureus. Science (1995) 4.27

STRUCTURE OF THE CELL WALL OF STAPHYLOCOCCUS AUREUS, STRAIN COPENHAGEN. I. PREPARATION OF FRAGMENTS BY ENZYMATIC HYDROLYSIS. Biochemistry (1964) 4.16

Peptidoglycan transpeptidase and D-alanine carboxypeptidase: penicillin-sensitive enzymatic reactions. Fed Proc (1967) 4.14

Staphylococcus aureus virulence genes identified by bursa aurealis mutagenesis and nematode killing. Proc Natl Acad Sci U S A (2004) 3.89

femA, which encodes a factor essential for expression of methicillin resistance, affects glycine content of peptidoglycan in methicillin-resistant and methicillin-susceptible Staphylococcus aureus strains. J Bacteriol (1991) 3.00

Cell wall monoglycine cross-bridges and methicillin hypersusceptibility in a femAB null mutant of methicillin-resistant Staphylococcus aureus. J Bacteriol (1997) 2.43

Staphylococcal cell wall: morphogenesis and fatal variations in the presence of penicillin. Microbiol Mol Biol Rev (1998) 2.37

Influence of femB on methicillin resistance and peptidoglycan metabolism in Staphylococcus aureus. J Bacteriol (1993) 2.23

Characterization of the locus responsible for the bacteriocin production in Lactobacillus plantarum C11. J Bacteriol (1996) 2.20

Structure of the cell wall of Staphylococcus aureus, strain Copenhagen. VII. Mode of action of the bacteriolytic peptidase from Myxobacter and the isolation of intact cell wall polysaccharides. Biochemistry (1967) 2.18

Multiple enzymatic activities of the murein hydrolase from staphylococcal phage phi11. Identification of a D-alanyl-glycine endopeptidase activity. J Biol Chem (1999) 2.05

STRUCTURE OF THE CELL WALL OF STAPHYLOCOCCUS AUREUS, STRAIN COPENHAGEN. IV. THE TEICHOIC ACID-GLYCOPEPTIDE COMPLEX. Biochemistry (1965) 2.04

Cloning, sequence, and expression of the lysostaphin gene from Staphylococcus simulans. Proc Natl Acad Sci U S A (1987) 2.02

Anchoring of surface proteins to the cell wall of Staphylococcus aureus. III. Lipid II is an in vivo peptidoglycan substrate for sortase-catalyzed surface protein anchoring. J Biol Chem (2002) 1.97

Microarray transcription analysis of clinical Staphylococcus aureus isolates resistant to vancomycin. J Bacteriol (2003) 1.92

Target cell specificity of a bacteriocin molecule: a C-terminal signal directs lysostaphin to the cell wall of Staphylococcus aureus. EMBO J (1996) 1.82

In vitro assembly of a complete, pentaglycine interpeptide bridge containing cell wall precursor (lipid II-Gly5) of Staphylococcus aureus. Mol Microbiol (2004) 1.81

Lysostaphin treatment of experimental methicillin-resistant Staphylococcus aureus aortic valve endocarditis. Antimicrob Agents Chemother (1998) 1.78

STRUCTURE OF THE CELL WALL OF STAPHYLOCOCCUS AUREUS, STRAIN COPENHAGEN. II. SEPARATION AND STRUCTURE OF DISACCHARIDES. Biochemistry (1964) 1.78

Cross-linked peptidoglycan mediates lysostaphin binding to the cell wall envelope of Staphylococcus aureus. J Bacteriol (2006) 1.72

Lysostaphin treatment of experimental aortic valve endocarditis caused by a Staphylococcus aureus isolate with reduced susceptibility to vancomycin. Antimicrob Agents Chemother (1999) 1.69

Anchor structure of staphylococcal surface proteins. A branched peptide that links the carboxyl terminus of proteins to the cell wall. J Biol Chem (1997) 1.68

The essential Staphylococcus aureus gene fmhB is involved in the first step of peptidoglycan pentaglycine interpeptide formation. Proc Natl Acad Sci U S A (1999) 1.66

Staphylococcus aureus bacteremia--consider the source. N Engl J Med (2001) 1.64

Increase in transduction efficiency of Tn551 mediated by the methicillin resistance marker. J Bacteriol (1983) 1.56

Type II CAAX prenyl endopeptidases belong to a novel superfamily of putative membrane-bound metalloproteases. Trends Biochem Sci (2001) 1.55

Cell walls of Streptococcus pyogenes, type 14. C polysaccharide-peptidoglycan and G polysaccharide-peptidoglycan complexes. Biochemistry (1967) 1.54

Lysostaphin cream eradicates Staphylococcus aureus nasal colonization in a cotton rat model. Antimicrob Agents Chemother (2003) 1.48

The molecular organization of the lysostaphin gene and its sequences repeated in tandem. Mol Gen Genet (1987) 1.47

Relationship between lysostaphin endopeptidase production and cell wall composition in Staphylococcus staphylolyticus. J Bacteriol (1979) 1.46

The lysostaphin endopeptidase resistance gene (epr) specifies modification of peptidoglycan cross bridges in Staphylococcus simulans and Staphylococcus aureus. Appl Environ Microbiol (1995) 1.43

Anchor structure of staphylococcal surface proteins. V. Anchor structure of the sortase B substrate IsdC. J Biol Chem (2005) 1.34

AbiG, a genotypically novel abortive infection mechanism encoded by plasmid pCI750 of Lactococcus lactis subsp. cremoris UC653. Appl Environ Microbiol (1996) 1.34

Specificities of FemA and FemB for different glycine residues: FemB cannot substitute for FemA in staphylococcal peptidoglycan pentaglycine side chain formation. J Bacteriol (1997) 1.33

Comparison of four methods for determining lysostaphin susceptibility of various strains of Staphylococcus aureus. Antimicrob Agents Chemother (2005) 1.22

Studies with recombinant Saccharomyces cerevisiae CaaX prenyl protease Rce1p. Biochemistry (2000) 1.18

Cross-linking and O-acetylation of newly synthesized peptidoglycan in Staphylococcus aureus H. J Gen Microbiol (1989) 1.07

Binding of SycH chaperone to YscM1 and YscM2 activates effector yop expression in Yersinia enterocolitica. J Bacteriol (2004) 1.03

Cell wall assembly in Staphylococcus aureus: proposed absence of secondary crosslinking reactions. J Gen Microbiol (1993) 1.00

Newer antistaphylococcal agents. Curr Opin Pediatr (2005) 0.97

Facile penetration of the Staphylococcus aureus capsule by lysostaphin. Infect Immun (1980) 0.86

Effectiveness of the lactococcal abortive infection systems AbiA, AbiE, AbiF and AbiG against P335 type phages. FEMS Microbiol Lett (2002) 0.86

Genetic analysis of 17 genes in Staphylococcus aureus with reduced susceptibility to vancomycin (VISA) and heteroVISA. J Antimicrob Chemother (2004) 0.84

Articles by these authors

Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature (2005) 7.72

Allelic replacement in Staphylococcus aureus with inducible counter-selection. Plasmid (2005) 6.11

Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia. Nat Med (2007) 5.95

Sortases and the art of anchoring proteins to the envelopes of gram-positive bacteria. Microbiol Mol Biol Rev (2006) 4.88

Passage of heme-iron across the envelope of Staphylococcus aureus. Science (2003) 4.83

Iron-source preference of Staphylococcus aureus infections. Science (2004) 4.33

Targeting of alpha-hemolysin by active or passive immunization decreases severity of USA300 skin infection in a mouse model. J Infect Dis (2010) 4.19

Panton-Valentine leukocidin is not a virulence determinant in murine models of community-associated methicillin-resistant Staphylococcus aureus disease. J Infect Dis (2008) 4.16

Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands. J Bacteriol (2007) 4.07

Vaccine protection against Staphylococcus aureus pneumonia. J Exp Med (2008) 4.01

Staphylococcus aureus virulence genes identified by bursa aurealis mutagenesis and nematode killing. Proc Natl Acad Sci U S A (2004) 3.89

Assembly of pili on the surface of Corynebacterium diphtheriae. Mol Microbiol (2003) 3.79

Surface proteins and exotoxins are required for the pathogenesis of Staphylococcus aureus pneumonia. Infect Immun (2006) 3.41

Staphylococcus aureus degrades neutrophil extracellular traps to promote immune cell death. Science (2013) 3.32

Plague bacteria target immune cells during infection. Science (2005) 3.32

An iron-regulated sortase anchors a class of surface protein during Staphylococcus aureus pathogenesis. Proc Natl Acad Sci U S A (2002) 3.23

Genetic requirements for Staphylococcus aureus abscess formation and persistence in host tissues. FASEB J (2009) 2.82

Sortases and pilin elements involved in pilus assembly of Corynebacterium diphtheriae. Mol Microbiol (2004) 2.80

Assembly of pili in Gram-positive bacteria. Trends Microbiol (2004) 2.76

Vaccine assembly from surface proteins of Staphylococcus aureus. Proc Natl Acad Sci U S A (2006) 2.71

Staphylococcus aureus IsdB is a hemoglobin receptor required for heme iron utilization. J Bacteriol (2006) 2.54

Protein sorting to the cell wall envelope of Gram-positive bacteria. Biochim Biophys Acta (2004) 2.42

EsxA and EsxB are secreted by an ESAT-6-like system that is required for the pathogenesis of Staphylococcus aureus infections. Proc Natl Acad Sci U S A (2005) 2.42

IsdG and IsdI, heme-degrading enzymes in the cytoplasm of Staphylococcus aureus. J Biol Chem (2003) 2.39

Iron-regulated surface determinants (Isd) of Staphylococcus aureus: stealing iron from heme. Microbes Infect (2004) 2.37

The Bacillus subtilis quorum-sensing molecule CSF contributes to intestinal homeostasis via OCTN2, a host cell membrane transporter. Cell Host Microbe (2007) 2.26

Prophages of Staphylococcus aureus Newman and their contribution to virulence. Mol Microbiol (2006) 2.20

Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection. J Infect Dis (2011) 2.19

Soluble factors from Lactobacillus GG activate MAPKs and induce cytoprotective heat shock proteins in intestinal epithelial cells. Am J Physiol Cell Physiol (2005) 2.07

Synthesis of glycerol phosphate lipoteichoic acid in Staphylococcus aureus. Proc Natl Acad Sci U S A (2007) 2.06

Anchoring of surface proteins to the cell wall of Staphylococcus aureus. III. Lipid II is an in vivo peptidoglycan substrate for sortase-catalyzed surface protein anchoring. J Biol Chem (2002) 1.97

Substrate recognition by the Yersinia type III protein secretion machinery. Mol Microbiol (2003) 1.93

hPepT1 transports muramyl dipeptide, activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cells. Gastroenterology (2004) 1.91

Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulence. Mol Microbiol (2002) 1.89

Staphylococcus aureus synthesizes adenosine to escape host immune responses. J Exp Med (2009) 1.85

An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus. Nat Chem Biol (2006) 1.83

Rapidly progressive, fatal, inhalation anthrax-like infection in a human: case report, pathogen genome sequencing, pathology, and coordinated response. Arch Pathol Lab Med (2011) 1.83

Architects at the bacterial surface - sortases and the assembly of pili with isopeptide bonds. Nat Rev Microbiol (2011) 1.79

Nontoxigenic protein A vaccine for methicillin-resistant Staphylococcus aureus infections in mice. J Exp Med (2010) 1.77

The structure of sortase B, a cysteine transpeptidase that tethers surface protein to the Staphylococcus aureus cell wall. Structure (2004) 1.76

Contribution of coagulases towards Staphylococcus aureus disease and protective immunity. PLoS Pathog (2010) 1.75

Cross-linked peptidoglycan mediates lysostaphin binding to the cell wall envelope of Staphylococcus aureus. J Bacteriol (2006) 1.72

Assembly of pili on the surface of Bacillus cereus vegetative cells. Mol Microbiol (2007) 1.67

Sortase as a target of anti-infective therapy. Pharmacol Rev (2008) 1.64

Iron acquisition and transport in Staphylococcus aureus. Biometals (2006) 1.61

Protein secretion and surface display in Gram-positive bacteria. Philos Trans R Soc Lond B Biol Sci (2012) 1.61

BslA, a pXO1-encoded adhesin of Bacillus anthracis. Mol Microbiol (2008) 1.60

Crystal structures of Staphylococcus aureus sortase A and its substrate complex. J Biol Chem (2004) 1.60

Surface protein IsdC and Sortase B are required for heme-iron scavenging of Bacillus anthracis. J Bacteriol (2006) 1.59

Toll-like receptor 6 drives differentiation of tolerogenic dendritic cells and contributes to LcrV-mediated plague pathogenesis. Cell Host Microbe (2008) 1.59

Staphylococcus aureus IsdG and IsdI, heme-degrading enzymes with structural similarity to monooxygenases. J Biol Chem (2004) 1.58

Preventing Staphylococcus aureus sepsis through the inhibition of its agglutination in blood. PLoS Pathog (2011) 1.57

LcrV plague vaccine with altered immunomodulatory properties. Infect Immun (2005) 1.57

IsdA and IsdB antibodies protect mice against Staphylococcus aureus abscess formation and lethal challenge. Vaccine (2010) 1.57

Recurrent infections and immune evasion strategies of Staphylococcus aureus. Curr Opin Microbiol (2011) 1.54

A play in four acts: Staphylococcus aureus abscess formation. Trends Microbiol (2011) 1.53

Amide bonds assemble pili on the surface of bacilli. Proc Natl Acad Sci U S A (2008) 1.53

Bacillus anthracis IsdG, a heme-degrading monooxygenase. J Bacteriol (2006) 1.51

Targeting proteins to the cell wall of sporulating Bacillus anthracis. Mol Microbiol (2006) 1.49

Genes required for glycolipid synthesis and lipoteichoic acid anchoring in Staphylococcus aureus. J Bacteriol (2007) 1.48

Bacillus anthracis secretes proteins that mediate heme acquisition from hemoglobin. PLoS Pathog (2008) 1.47

Bacillus anthracis sortase A (SrtA) anchors LPXTG motif-containing surface proteins to the cell wall envelope. J Bacteriol (2005) 1.46

YopD and LcrH regulate expression of Yersinia enterocolitica YopQ by a posttranscriptional mechanism and bind to yopQ RNA. J Bacteriol (2002) 1.44

On the role of Staphylococcus aureus sortase and sortase-catalyzed surface protein anchoring in murine septic arthritis. J Infect Dis (2002) 1.39

In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation. Nat Med (2011) 1.38

Type iii protein secretion in yersinia species. Annu Rev Cell Dev Biol (2002) 1.38

Signal peptides direct surface proteins to two distinct envelope locations of Staphylococcus aureus. EMBO J (2008) 1.35

Anchor structure of staphylococcal surface proteins. V. Anchor structure of the sortase B substrate IsdC. J Biol Chem (2005) 1.34

Anchoring of surface proteins to the cell wall of Staphylococcus aureus. Cysteine 184 and histidine 120 of sortase form a thiolate-imidazolium ion pair for catalysis. J Biol Chem (2001) 1.33

Yersinia pestis caf1 variants and the limits of plague vaccine protection. Infect Immun (2008) 1.32

Intramolecular amide bonds stabilize pili on the surface of bacilli. Proc Natl Acad Sci U S A (2009) 1.31

EsaC substrate for the ESAT-6 secretion pathway and its role in persistent infections of Staphylococcus aureus. Mol Microbiol (2008) 1.30

Structure-based mechanism of lipoteichoic acid synthesis by Staphylococcus aureus LtaS. Proc Natl Acad Sci U S A (2009) 1.30

Characterization of the Yersinia enterocolitica type III secretion ATPase YscN and its regulator, YscL. J Bacteriol (2006) 1.29

Distribution of protein A on the surface of Staphylococcus aureus. J Bacteriol (2007) 1.28

Effect of srtA and srtB gene expression on the virulence of Staphylococcus aureus in animal models of infection. J Antimicrob Chemother (2004) 1.28

The YSIRK-G/S motif of staphylococcal protein A and its role in efficiency of signal peptide processing. J Bacteriol (2003) 1.27

The role of Staphylococcus aureus sortase A and sortase B in murine arthritis. Microbes Infect (2003) 1.26

Role of protein A in the evasion of host adaptive immune responses by Staphylococcus aureus. MBio (2013) 1.26

Sortase D forms the covalent bond that links BcpB to the tip of Bacillus cereus pili. J Biol Chem (2009) 1.25

Secretion signal recognition by YscN, the Yersinia type III secretion ATPase. Proc Natl Acad Sci U S A (2006) 1.23

Bacillus anthracis surface-layer proteins assemble by binding to the secondary cell wall polysaccharide in a manner that requires csaB and tagO. J Mol Biol (2010) 1.21

Immunogenicity and protective immunity against bubonic plague and pneumonic plague by immunization of mice with the recombinant V10 antigen, a variant of LcrV. Infect Immun (2006) 1.21

Racemic crystallography of synthetic protein enantiomers used to determine the X-ray structure of plectasin by direct methods. Protein Sci (2009) 1.20

Generating a collection of insertion mutations in the Staphylococcus aureus genome using bursa aurealis. Methods Mol Biol (2008) 1.19

EsaD, a secretion factor for the Ess pathway in Staphylococcus aureus. J Bacteriol (2011) 1.18

Structures of sortase B from Staphylococcus aureus and Bacillus anthracis reveal catalytic amino acid triad in the active site. Structure (2004) 1.18

Immunization with recombinant V10 protects cynomolgus macaques from lethal pneumonic plague. Infect Immun (2008) 1.18