Microwave-assisted synthesis of thieno[2,3-c]pyridine derivatives as a new series of allosteric enhancers at the adenosine A(1) receptor.

Allosteric modulation of purine and pyrimidine receptors. Adv Pharmacol (2011) 0.84

Allosteric modulation of adenosine receptors. Purinergic Signal (2008) 0.76

Computational studies on the regioselectivity of metal-catalyzed synthesis of 1,2,3 triazoles via click reaction: a review. J Mol Model (2015) 0.75

Hospital mortality, length of stay, and preventable complications among critically ill patients before and after tele-ICU reengineering of critical care processes. JAMA (2011) 3.47

Prevalence and test characteristics of national health safety network ventilator-associated events. Crit Care Med (2014) 3.46

DNA replication origins fire stochastically in fission yeast. Mol Biol Cell (2005) 2.35

Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters. J Neurosci (2007) 2.24

Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J Clin Invest (2008) 2.20

Serine 31 phosphorylation of histone variant H3.3 is specific to regions bordering centromeres in metaphase chromosomes. Proc Natl Acad Sci U S A (2005) 1.91

Ammonia and carbon dioxide concentrations in disposable and reusable ventilated mouse cages. J Am Assoc Lab Anim Sci (2008) 1.75

Molecular determinants of dysregulated GABAergic gene expression in the prefrontal cortex of subjects with schizophrenia. Biol Psychiatry (2009) 1.71

The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Brain (2011) 1.70

DNA minor groove binders as potential antitumor and antimicrobial agents. Med Res Rev (2004) 1.54

A glance at adenosine receptors: novel target for antitumor therapy. Pharmacol Ther (2003) 1.41

Blockade of A2A receptors plus l-DOPA after nigrostriatal lesion results in GAD67 mRNA changes different from l-DOPA alone in the rat globus pallidus and substantia nigra reticulata. Exp Neurol (2003) 1.38

Adenosine signaling contributes to ethanol-induced fatty liver in mice. J Clin Invest (2009) 1.38

Design, synthesis, and biological evaluation of hybrid molecules containing alpha-methylene-gamma-butyrolactones and polypyrrole minor groove binders. J Med Chem (2004) 1.35

Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation. Pain (2011) 1.35

The A3 adenosine receptor: an enigmatic player in cell biology. Pharmacol Ther (2007) 1.32

Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells. Mol Pharmacol (2007) 1.28

Histone methylation at gene promoters is associated with developmental regulation and region-specific expression of ionotropic and metabotropic glutamate receptors in human brain. J Neurochem (2005) 1.27

Adenosine receptors as mediators of both cell proliferation and cell death of cultured human melanoma cells. J Invest Dermatol (2002) 1.27

Adenosine receptors and cancer. Biochim Biophys Acta (2010) 1.23

Human CD4+ T cell epitopes from vaccinia virus induced by vaccination or infection. PLoS Pathog (2007) 1.20

Chromatin alterations associated with down-regulated metabolic gene expression in the prefrontal cortex of subjects with schizophrenia. Arch Gen Psychiatry (2005) 1.17

Disruption of IFT complex A causes cystic kidneys without mitotic spindle misorientation. J Am Soc Nephrol (2012) 1.16

Adenosine receptors in colon carcinoma tissues and colon tumoral cell lines: focus on the A(3) adenosine subtype. J Cell Physiol (2007) 1.15

Adenosine receptor antagonists: translating medicinal chemistry and pharmacology into clinical utility. Chem Rev (2008) 1.14

A3 adenosine receptor activation inhibits cell proliferation via phosphatidylinositol 3-kinase/Akt-dependent inhibition of the extracellular signal-regulated kinase 1/2 phosphorylation in A375 human melanoma cells. J Biol Chem (2005) 1.13

Alteration of adenosine receptors in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2005) 1.13

Hyperspectral imaging for early detection of oxygenation and perfusion changes in irradiated skin. J Biomed Opt (2012) 1.13

Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents. FASEB J (2010) 1.12

Elevated expression of A3 adenosine receptors in human colorectal cancer is reflected in peripheral blood cells. Clin Cancer Res (2004) 1.12

Synthesis and biological characterization of [3H] (2-amino-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)-(4-chlorophenyl)-methanone, the first radiolabelled adenosine A1 allosteric enhancer. Bioorg Med Chem Lett (2006) 1.10

A2A adenosine receptor overexpression and functionality, as well as TNF-alpha levels, correlate with motor symptoms in Parkinson's disease. FASEB J (2009) 1.09

Leukoaraiosis predicts poor 90-day outcome after acute large cerebral artery occlusion. Cerebrovasc Dis (2012) 1.08

Expression of A3 adenosine receptors in human lymphocytes: up-regulation in T cell activation. Mol Pharmacol (2004) 1.08

Flat-panel digital mammography system: contrast-detail comparison between screen-film radiographs and hard-copy images. Radiology (2002) 1.08

Effect of low frequency electromagnetic fields on A2A adenosine receptors in human neutrophils. Br J Pharmacol (2002) 1.07

Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues. J Med Chem (2010) 1.06

A consensus panel review of central nervous system effects of the exposure to low-intensity extremely low-frequency magnetic fields. Brain Stimul (2013) 1.06

Adenosine receptors in health and disease. Adv Pharmacol (2011) 1.05

Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine ligands, new tools to characterize A3 adenosine receptors in human tumor cell lines. Curr Med Chem (2005) 1.05

The P2X7 receptor as a therapeutic target. Expert Opin Ther Targets (2008) 1.05

Leukocyte P2 receptors: a novel target for anti-inflammatory and anti-tumor therapy. Curr Drug Targets Cardiovasc Haematol Disord (2005) 1.05

A2A and A3 adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release. Arthritis Res Ther (2011) 1.04

7-Substituted 5-amino-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as A2A adenosine receptor antagonists: a study on the importance of modifications at the side chain on the activity and solubility. J Med Chem (2002) 1.04

Synthesis and biological evaluation of 2- and 3-aminobenzo[b]thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization. J Med Chem (2007) 1.04

Adult intestinal intussusception: can abdominal MDCT distinguish an intussusception caused by a lead point? Abdom Imaging (2008) 1.04

Activation of TRPA1 on dural afferents: a potential mechanism of headache pain. Pain (2012) 1.03

Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents. J Med Chem (2010) 1.03

Structural features controlling the binding of beta-carbolines to the benzodiazepine receptor. Acta Crystallogr B (2004) 1.03

Dihydropyridine receptors and type 1 ryanodine receptors constitute the molecular machinery for voltage-induced Ca2+ release in nerve terminals. J Neurosci (2006) 1.02

Adenosine modulates vascular endothelial growth factor expression via hypoxia-inducible factor-1 in human glioblastoma cells. Biochem Pharmacol (2006) 1.02

Low risk of ureteral obstruction with "deep" (dorsal/posterior) uterosacral ligament suture placement for transvaginal apical suspension. Am J Obstet Gynecol (2005) 1.01

Role of strong intramolecular N-H...N hydrogen bonds in determining the conformation of adenosine-receptor antagonists. Acta Crystallogr B (2006) 1.01

Design, synthesis, and biological evaluation of C9- and C2-substituted pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as new A2A and A3 adenosine receptors antagonists. J Med Chem (2003) 1.00

Pulsed electromagnetic fields increased the anti-inflammatory effect of A₂A and A₃ adenosine receptors in human T/C-28a2 chondrocytes and hFOB 1.19 osteoblasts. PLoS One (2013) 1.00

Synthesis, biological properties, and molecular modeling investigation of the first potent, selective, and water-soluble human A(3) adenosine receptor antagonist. J Med Chem (2002) 0.99

Hypoxia inhibits paclitaxel-induced apoptosis through adenosine-mediated phosphorylation of bad in glioblastoma cells. Mol Pharmacol (2007) 0.99

Gender-specific reduction of estrogen-sensitive small RNA, miR-30b, in subjects with schizophrenia. Schizophr Bull (2010) 0.98

Normalization of A2A and A3 adenosine receptor up-regulation in rheumatoid arthritis patients by treatment with anti-tumor necrosis factor alpha but not methotrexate. Arthritis Rheum (2009) 0.98

Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists. J Med Chem (2002) 0.98