Published in Brain on October 27, 2011
The transient receptor potential channel TRPA1: from gene to pathophysiology. Pflugers Arch (2012) 1.63
The TRPA1 channel in migraine mechanism and treatment. Br J Pharmacol (2014) 1.50
TRPA1: A gatekeeper for inflammation. Annu Rev Physiol (2012) 1.36
Transient receptor potential (TRP) channels: a clinical perspective. Br J Pharmacol (2014) 1.25
Activation of TRPA1 on dural afferents: a potential mechanism of headache pain. Pain (2012) 1.03
Expression of the transient receptor potential channels TRPV1, TRPA1 and TRPM8 in mouse trigeminal primary afferent neurons innervating the dura. Mol Pain (2012) 1.00
Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release. Proc Natl Acad Sci U S A (2015) 0.96
TRPA1 channels in the vasculature. Br J Pharmacol (2012) 0.92
Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel. Pain (2013) 0.89
Transient receptor potential channels as targets for phytochemicals. ACS Chem Neurosci (2014) 0.88
The pharmacology of TRP channels. Br J Pharmacol (2014) 0.87
Targeting TRP channels for novel migraine therapeutics. ACS Chem Neurosci (2014) 0.87
Modelling headache and migraine and its pharmacological manipulation. Br J Pharmacol (2014) 0.86
Critical role of calcitonin gene-related peptide receptors in cortical spreading depression. Proc Natl Acad Sci U S A (2012) 0.86
TRPA1 and other TRP channels in migraine. J Headache Pain (2013) 0.85
Antidromic vasodilatation and the migraine mechanism. J Headache Pain (2011) 0.85
Molecular and cellular mechanisms that initiate pain and itch. Cell Mol Life Sci (2015) 0.84
Steroidal and non-steroidal third-generation aromatase inhibitors induce pain-like symptoms via TRPA1. Nat Commun (2014) 0.83
Umbellulone modulates TRP channels. Pflugers Arch (2011) 0.83
Ion channels and migraine. Headache (2014) 0.82
The role of chemosensitive afferent nerves and TRP ion channels in the pathomechanism of headaches. Pflugers Arch (2012) 0.80
Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain. Sci Rep (2016) 0.78
Extracranial injections of botulinum neurotoxin type A inhibit intracranial meningeal nociceptors' responses to stimulation of TRPV1 and TRPA1 channels: Are we getting closer to solving this puzzle? Cephalalgia (2016) 0.78
Intraganglionic signaling as a novel nasal-meningeal pathway for TRPA1-dependent trigeminovascular activation by inhaled environmental irritants. PLoS One (2014) 0.77
Leucettamols, bifunctionalized marine sphingoids, act as modulators of TRPA1 and TRPM8 channels. Mar Drugs (2012) 0.77
Sensitization of the trigeminovascular system following environmental irritant exposure. Cephalalgia (2015) 0.76
The Role of Adenosine Signaling in Headache: A Review. Brain Sci (2017) 0.75
Depression of home cage wheel running: a reliable and clinically relevant method to assess migraine pain in rats. J Headache Pain (2017) 0.75
Herbalism helps headache. Brain (2012) 0.75
Action mechanisms of Onabotulinum toxin-A: hints for selection of eligible patients. Neurol Sci (2017) 0.75
The antimigraine butterbur ingredient, isopetasin, desensitises peptidergic nociceptors via the transient receptor potential ankyrin 1 channel. Br J Pharmacol (2017) 0.75
Hydrogen Sulfide Mediating both Excitatory and Inhibitory Effects in a Rat Model of Meningeal Nociception and Headache Generation. Front Neurol (2017) 0.75
The role of the transient receptor potential ankyrin type-1 (TRPA1) channel in migraine pain: evaluation in an animal model. J Headache Pain (2017) 0.75
The endogenous cannabinoid system controls extinction of aversive memories. Nature (2002) 7.19
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature (2004) 5.76
CB1 cannabinoid receptors and on-demand defense against excitotoxicity. Science (2003) 5.22
Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science (2005) 5.12
Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. Nature (2003) 4.45
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A (2007) 4.10
Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. J Cell Biol (2003) 3.60
Effect of β-blockers and other antihypertensive drugs on the risk of melanoma recurrence and death. Mayo Clin Proc (2013) 3.59
The endocannabinoid system and its therapeutic exploitation. Nat Rev Drug Discov (2004) 3.47
TRPA1 acts as a cold sensor in vitro and in vivo. Proc Natl Acad Sci U S A (2009) 3.46
The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses (2009) 3.45
Clinical validation of cutoff target ranges in newborn screening of metabolic disorders by tandem mass spectrometry: a worldwide collaborative project. Genet Med (2011) 3.21
An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors. Proc Natl Acad Sci U S A (2002) 3.16
TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption. J Biol Chem (2003) 3.15
Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem (2002) 3.14
TRP channels: an overview. Cell Calcium (2005) 2.98
Permeation and selectivity of TRP channels. Annu Rev Physiol (2006) 2.96
TRPP2 and TRPV4 form a polymodal sensory channel complex. J Cell Biol (2008) 2.88
Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells. J Biol Chem (2002) 2.87
Bimodal action of menthol on the transient receptor potential channel TRPA1. J Neurosci (2007) 2.78
Unmasking the tonic-aversive state in neuropathic pain. Nat Neurosci (2009) 2.77
Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemia. J Clin Endocrinol Metab (2006) 2.72
Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome. Gastroenterology (2007) 2.63
Calcium absorption across epithelia. Physiol Rev (2005) 2.57
Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol. Br J Pharmacol (2002) 2.54
Treatment with β-blockers and reduced disease progression in patients with thick melanoma. Arch Intern Med (2011) 2.53
Heat activation of TRPM5 underlies thermal sensitivity of sweet taste. Nature (2005) 2.52
Sensing with TRP channels. Nat Chem Biol (2005) 2.51
TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli. Nat Chem Biol (2007) 2.48
Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia. J Neurosci (2004) 2.42
CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids. Proc Natl Acad Sci U S A (2005) 2.36
TRPV4 calcium entry channel: a paradigm for gating diversity. Am J Physiol Cell Physiol (2004) 2.35
Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice. J Physiol (2006) 2.34
Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends Pharmacol Sci (2009) 2.32
TRPM3 is a nociceptor channel involved in the detection of noxious heat. Neuron (2011) 2.31
Gating of TRP channels: a voltage connection? J Physiol (2005) 2.30
Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS. Proc Natl Acad Sci U S A (2003) 2.29
Circulating and hepatic endocannabinoids and endocannabinoid-related molecules in patients with cirrhosis. Liver Int (2009) 2.27
Molecular determinants of permeation through the cation channel TRPV4. J Biol Chem (2002) 2.24
Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia. Nat Genet (2008) 2.24
Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8. Pain (2002) 2.24
Dynorphin A activates bradykinin receptors to maintain neuropathic pain. Nat Neurosci (2006) 2.23
The Ca2+-activated cation channel TRPM4 is regulated by phosphatidylinositol 4,5-biphosphate. EMBO J (2006) 2.22
A newly identified role for superoxide in inflammatory pain. J Pharmacol Exp Ther (2004) 2.21
Voltage dependence of the Ca2+-activated cation channel TRPM4. J Biol Chem (2003) 2.21
Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J Clin Invest (2008) 2.20
Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding. J Clin Invest (2007) 2.19
Molecular determinants of vanilloid sensitivity in TRPV1. J Biol Chem (2004) 2.17
Prostate growth and prevalence of prostate diseases in early onset spinal cord injuries. Eur Urol (2008) 2.15
The vanilloid transient receptor potential channel TRPV4: from structure to disease. Prog Biophys Mol Biol (2009) 2.13
Central modulation of pain. J Clin Invest (2010) 2.12
TRPs in our senses. Curr Biol (2008) 2.12
Multiple actions of systemic artemin in experimental neuropathy. Nat Med (2003) 2.12
Proteinuria impairs podocyte regeneration by sequestering retinoic acid. J Am Soc Nephrol (2013) 2.09
AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. J Pharmacol Exp Ther (2004) 2.08
Mutations in the gene encoding the calcium-permeable ion channel TRPV4 produce spondylometaphyseal dysplasia, Kozlowski type and metatropic dysplasia. Am J Hum Genet (2009) 2.02
Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain. J Neurosci (2002) 2.00
Pharmacology of vanilloid transient receptor potential cation channels. Mol Pharmacol (2009) 2.00
Protease-activated receptor 2 mediates eosinophil infiltration and hyperreactivity in allergic inflammation of the airway. J Immunol (2002) 1.99
Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders. Epilepsia (2014) 1.97
Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex. EMBO J (2003) 1.97
Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. Proc Natl Acad Sci U S A (2010) 1.96
Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics. Anesthesiology (2007) 1.96
Antinociceptive and nociceptive actions of opioids. J Neurobiol (2004) 1.93
Voltage-gated sodium channels and hyperalgesia. Annu Rev Pharmacol Toxicol (2004) 1.93
Possible endocannabinoid control of colorectal cancer growth. Gastroenterology (2003) 1.89
Redistribution of Na(V)1.8 in uninjured axons enables neuropathic pain. J Neurosci (2003) 1.89
Morphine treatment accelerates sarcoma-induced bone pain, bone loss, and spontaneous fracture in a murine model of bone cancer. Pain (2007) 1.88
Endovanilloids. Putative endogenous ligands of transient receptor potential vanilloid 1 channels. Eur J Biochem (2004) 1.87
Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure. Biopolymers (2005) 1.83
Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain. Pain (2011) 1.82
Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4. J Biol Chem (2004) 1.82
Is paradoxical pain induced by sustained opioid exposure an underlying mechanism of opioid antinociceptive tolerance? Neurosignals (2005) 1.80
Outer pore architecture of a Ca2+-selective TRP channel. J Biol Chem (2004) 1.79