HAb18G (CD147), a cancer-associated biomarker and its role in cancer detection.

PubWeight™: 1.45‹?› | Rank: Top 5%

🔗 View Article (PMID 19438743)

Published in Histopathology on May 01, 2009

Authors

Yu Li1, Jing Xu, Ling Chen, Li Chen, Wei-De Zhong, Zheng Zhang, Li Mi, Yang Zhang, Cheng-Gong Liao, Hui-Jie Bian, Jian-Li Jiang, Xiang-Min Yang, Xiao-Yan Li, Chun-Mei Fan, Ping Zhu, Li Fu, Zhi-Nan Chen

Author Affiliations

1: Cell Engineering Research Centre, Department of Cell Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi'an, China.

Articles citing this

Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation. Future Oncol (2010) 1.54

Ultra-sensitive liquid biopsy of circulating extracellular vesicles using ExoScreen. Nat Commun (2014) 1.21

The biological function and clinical utilization of CD147 in human diseases: a review of the current scientific literature. Int J Mol Sci (2014) 1.15

High expression of CD147 and MMP-9 is correlated with poor prognosis of triple-negative breast cancer (TNBC) patients. Med Oncol (2012) 1.07

CD147 induces UPR to inhibit apoptosis and chemosensitivity by increasing the transcription of Bip in hepatocellular carcinoma. Cell Death Differ (2012) 1.04

Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters. J Mol Med (Berl) (2015) 1.02

HAb18G/CD147 promotes pSTAT3-mediated pancreatic cancer development via CD44s. Clin Cancer Res (2013) 1.00

Characterization of basigin isoforms and the inhibitory function of basigin-3 in human hepatocellular carcinoma proliferation and invasion. Mol Cell Biol (2011) 0.99

microRNA-146a inhibits cancer metastasis by downregulating VEGF through dual pathways in hepatocellular carcinoma. Mol Cancer (2015) 0.99

CD147, CD44, and the epidermal growth factor receptor (EGFR) signaling pathway cooperate to regulate breast epithelial cell invasiveness. J Biol Chem (2013) 0.95

Promoter hypomethylation up-regulates CD147 expression through increasing Sp1 binding and associates with poor prognosis in human hepatocellular carcinoma. J Cell Mol Med (2010) 0.94

Increased expression of CD147 and MMP-9 is correlated with poor prognosis of salivary duct carcinoma. J Cancer Res Clin Oncol (2012) 0.93

EMMPRIN promotes angiogenesis, proliferation, invasion and resistance to sunitinib in renal cell carcinoma, and its level predicts patient outcome. PLoS One (2013) 0.91

Increased expression of extracellular matrix metalloproteinase inducer (CD147) in multiple myeloma: role in regulation of myeloma cell proliferation. Leukemia (2012) 0.91

EMMPRIN modulates epithelial barrier function through a MMP-mediated occludin cleavage: implications in dry eye disease. Am J Pathol (2011) 0.91

Role of emmprin in endometrial cancer. BMC Cancer (2012) 0.90

The emerging importance of α-L-fucose in human breast cancer: a review. Am J Transl Res (2011) 0.89

EMMPRIN is associated with S100A4 and predicts patient outcome in colorectal cancer. Br J Cancer (2012) 0.88

CD147 promotes Src-dependent activation of Rac1 signaling through STAT3/DOCK8 during the motility of hepatocellular carcinoma cells. Oncotarget (2015) 0.88

MicroRNA-34a suppresses the breast cancer stem cell-like characteristics by downregulating Notch1 pathway. Cancer Sci (2015) 0.87

How, with whom and when: an overview of CD147-mediated regulatory networks influencing matrix metalloproteinase activity. Biosci Rep (2015) 0.87

A novel small-molecule compound targeting CD147 inhibits the motility and invasion of hepatocellular carcinoma cells. Oncotarget (2016) 0.85

New insights into germ cell migration and survival/apoptosis in spermatogenesis: Lessons from CD147. Spermatogenesis (2012) 0.85

A novel role of EMMPRIN/CD147 in transformation of quiescent fibroblasts to cancer-associated fibroblasts by breast cancer cells. Cancer Lett (2013) 0.84

Prognostic Indications of Elevated MCT4 and CD147 across Cancer Types: A Meta-Analysis. Biomed Res Int (2015) 0.83

EMMPRIN expression in oral squamous cell carcinomas: correlation with tumor proliferation and patient survival. Biomed Res Int (2014) 0.80

Activation of TGF-β1-CD147 positive feedback loop in hepatic stellate cells promotes liver fibrosis. Sci Rep (2015) 0.80

Cell expression patterns of CD147 in N-diethylnitrosamine/phenobarbital-induced mouse hepatocellular carcinoma. J Mol Histol (2014) 0.80

Important functional roles of basigin in thymocyte development and T cell activation. Int J Biol Sci (2013) 0.80

HAb18G/CD147 regulates vinculin-mediated focal adhesion and cytoskeleton organization in cultured human hepatocellular carcinoma cells. PLoS One (2014) 0.80

The roles of CD147 and/or cyclophilin A in kidney diseases. Mediators Inflamm (2014) 0.80

Gemcitabine enhances cell invasion via activating HAb18G/CD147-EGFR-pSTAT3 signaling. Oncotarget (2016) 0.80

CD147/EMMPRIN overexpression and prognosis in cancer: A systematic review and meta-analysis. Sci Rep (2016) 0.79

Epitope mapping of metuximab on CD147 using phage display and molecular docking. Comput Math Methods Med (2013) 0.79

Basigin-mediated redistribution of CD98 promotes cell spreading and tumorigenicity in hepatocellular carcinoma. J Exp Clin Cancer Res (2015) 0.78

Interaction of KLF6 and Sp1 regulates basigin-2 expression mediated proliferation, invasion and metastasis in hepatocellular carcinoma. Oncotarget (2016) 0.78

CD147 reinforces [Ca2+]i oscillations and promotes oncogenic progression in hepatocellular carcinoma. Oncotarget (2015) 0.78

Cytoplasmic fragment of CD147 generated by regulated intramembrane proteolysis contributes to HCC by promoting autophagy. Cell Death Dis (2017) 0.75

CD147 regulates extrinsic apoptosis in spermatocytes by modulating NFκB signaling pathways. Oncotarget (2016) 0.75

N-linked glycosylation at Asn152 on CD147 affects protein folding and stability: promoting tumour metastasis in hepatocellular carcinoma. Sci Rep (2016) 0.75

An oncolytic adenovirus that expresses the HAb18 and interleukin 24 genes exhibits enhanced antitumor activity in hepatocellular carcinoma cells. Oncotarget (2016) 0.75

The inhibition role of miR-22 in hepatocellular carcinoma cell migration and invasion via targeting CD147. Cancer Cell Int (2017) 0.75

The role of CD147 expression in prostate cancer: a systematic review and meta-analysis. Drug Des Devel Ther (2016) 0.75

CD147 as a Novel Prognostic Biomarker for Hepatocellular Carcinoma: A Meta-Analysis. Biomed Res Int (2017) 0.75

The altered glucose metabolism in tumor and a tumor acidic microenvironment associated with extracellular matrix metalloproteinase inducer and monocarboxylate transporters. Oncotarget (2016) 0.75

Hispidulin induces mitochondrial apoptosis in acute myeloid leukemia cells by targeting extracellular matrix metalloproteinase inducer. Am J Transl Res (2016) 0.75

Metuzumab enhanced chemosensitivity and apoptosis in non-small cell lung carcinoma. Cancer Biol Ther (2017) 0.75

[EMMPRIN (CD147). A prognostic and potentially therapeutic marker in urothelial cancer]. Pathologe (2010) 0.75

Overexpression of CD147 is associated with poor prognosis, tumor cell migration and ERK signaling pathway activation in hepatocellular carcinoma. Exp Ther Med (2017) 0.75

Comparative proteomic investigation of metastatic and non-metastatic osteosarcoma cells of human and canine origin. PLoS One (2017) 0.75

Articles by these authors

Human-mouse alignments with BLASTZ. Genome Res (2003) 35.49

Genome-wide atlas of gene expression in the adult mouse brain. Nature (2006) 28.02

I-TASSER: a unified platform for automated protein structure and function prediction. Nat Protoc (2010) 22.66

Prevalence of diabetes among men and women in China. N Engl J Med (2010) 19.98

Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature (2012) 15.91

Sequence and structural variation in a human genome uncovered by short-read, massively parallel ligation sequencing using two-base encoding. Genome Res (2009) 15.15

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25

Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity. Nature (2002) 12.49

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10

The Protein Data Bank and structural genomics. Nucleic Acids Res (2003) 8.34

Genomewide association study of leprosy. N Engl J Med (2009) 8.17

Rapid whole-genome mutational profiling using next-generation sequencing technologies. Genome Res (2008) 8.01

The RCSB Protein Data Bank: a redesigned query system and relational database based on the mmCIF schema. Nucleic Acids Res (2005) 7.81

Randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion. Ophthalmology (2010) 7.30

The distribution and query systems of the RCSB Protein Data Bank. Nucleic Acids Res (2004) 7.03

Antibody domain exchange is an immunological solution to carbohydrate cluster recognition. Science (2003) 6.68

Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer. Nat Med (2009) 6.61

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet (2009) 6.42

The RCSB PDB information portal for structural genomics. Nucleic Acids Res (2006) 6.36

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet (2009) 6.31

Multi-platform next-generation sequencing of the domestic turkey (Meleagris gallopavo): genome assembly and analysis. PLoS Biol (2010) 5.39

LOMETS: a local meta-threading-server for protein structure prediction. Nucleic Acids Res (2007) 5.30

The oyster genome reveals stress adaptation and complexity of shell formation. Nature (2012) 5.30

Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. Proc Natl Acad Sci U S A (2006) 5.16

Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm. Cell (2012) 5.16

Ab initio modeling of small proteins by iterative TASSER simulations. BMC Biol (2007) 5.07

MIF signal transduction initiated by binding to CD74. J Exp Med (2003) 4.79

Vedolizumab as induction and maintenance therapy for ulcerative colitis. N Engl J Med (2013) 4.75

An outbreak of hand, foot, and mouth disease associated with subgenotype C4 of human enterovirus 71 in Shandong, China. J Clin Virol (2009) 4.62

Dexamethasone intravitreal implant in patients with macular edema related to branch or central retinal vein occlusion twelve-month study results. Ophthalmology (2011) 4.61

Temporal dynamics of the human vaginal microbiota. Sci Transl Med (2012) 4.58

A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Nat Cell Biol (2006) 4.55

Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant vaccinia virus, and replication-defective adenovirus vectors expressing a human immunodeficiency virus type 1 gag gene. J Virol (2003) 4.41

Sequence and analysis of rice chromosome 4. Nature (2002) 4.39

Detection of breast cancer with addition of annual screening ultrasound or a single screening MRI to mammography in women with elevated breast cancer risk. JAMA (2012) 4.25

The global burden of liver disease: the major impact of China. Hepatology (2014) 4.23

Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature (2007) 4.12

Tools for the automatic identification and classification of RNA base pairs. Nucleic Acids Res (2003) 4.12

Consequences of motor copy number on the intracellular transport of kinesin-1-driven lipid droplets. Cell (2008) 4.11

Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol (2010) 4.08

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med (2010) 4.04

Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. Nat Genet (2010) 4.01

Vedolizumab as induction and maintenance therapy for Crohn's disease. N Engl J Med (2013) 3.98

RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer. J Clin Oncol (2012) 3.72

Dexamethasone intravitreal implant for noninfectious intermediate or posterior uveitis. Arch Ophthalmol (2011) 3.63

Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat Genet (2009) 3.59

Association between changes in air pollution levels during the Beijing Olympics and biomarkers of inflammation and thrombosis in healthy young adults. JAMA (2012) 3.52

MUSTER: Improving protein sequence profile-profile alignments by using multiple sources of structure information. Proteins (2008) 3.38

Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients. Gastroenterology (2007) 3.34

Nature of nonfunctional envelope proteins on the surface of human immunodeficiency virus type 1. J Virol (2006) 3.34

Deep RNA sequencing at single base-pair resolution reveals high complexity of the rice transcriptome. Genome Res (2010) 3.34

How significant is a protein structure similarity with TM-score = 0.5? Bioinformatics (2010) 3.22

Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature (2011) 3.19

Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation. Mol Cell (2008) 3.18

Asymmetric mating interactions drive widespread invasion and displacement in a whitefly. Science (2007) 3.17

Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls. Circ Cardiovasc Genet (2010) 3.15

A comparison of three highly active antiretroviral treatment strategies consisting of non-nucleoside reverse transcriptase inhibitors, protease inhibitors, or both in the presence of nucleoside reverse transcriptase inhibitors as initial therapy (CPCRA 058 FIRST Study): a long-term randomised trial. Lancet (2006) 3.10

Gene dosage of the common variant 9p21 predicts severity of coronary artery disease. J Am Coll Cardiol (2010) 3.07

Dexamethasone intravitreal implant for treatment of diabetic macular edema in vitrectomized patients. Retina (2011) 3.04

Wnt-dependent regulation of the E-cadherin repressor snail. J Biol Chem (2005) 3.03

Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus. Anesthesiology (2007) 3.02

Epidemiology of schistosomiasis in the People's Republic of China, 2004. Emerg Infect Dis (2007) 3.00

Atomic-level protein structure refinement using fragment-guided molecular dynamics conformation sampling. Structure (2011) 2.97

Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nat Genet (2010) 2.95

Ab initio protein structure assembly using continuous structure fragments and optimized knowledge-based force field. Proteins (2012) 2.94

PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors. Blood (2007) 2.93

Three-field or two-field resection for thoracic esophageal cancer: a meta-analysis. Ann Thorac Surg (2013) 2.92

Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients. J Hepatol (2009) 2.84

The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2. EMBO J (2003) 2.81

A cancer cell metalloprotease triad regulates the basement membrane transmigration program. Genes Dev (2006) 2.78

Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4. Cardiovasc Res (2010) 2.77

Potential clinical and economic consequences of noncardiac incidental findings on cardiac computed tomography. J Am Coll Cardiol (2009) 2.76

COFACTOR: an accurate comparative algorithm for structure-based protein function annotation. Nucleic Acids Res (2012) 2.75

Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1. J Exp Med (2009) 2.73

Long noncoding RNAs with snoRNA ends. Mol Cell (2012) 2.71

Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial VEGF signaling. Cell (2012) 2.71

Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma. Nat Med (2013) 2.70

A randomized controlled trial of Licartin for preventing hepatoma recurrence after liver transplantation. Hepatology (2007) 2.66

Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors. Cancer Discov (2014) 2.64

Ambient air pollution, birth weight and preterm birth: a systematic review and meta-analysis. Environ Res (2012) 2.63

Darbepoetin alpha for the treatment of anemia in patients with active cancer not receiving chemotherapy or radiotherapy: results of a phase III, multicenter, randomized, double-blind, placebo-controlled study. J Clin Oncol (2008) 2.60

Prevalence of cardiovascular disease risk factor in the Chinese population: the 2007-2008 China National Diabetes and Metabolic Disorders Study. Eur Heart J (2011) 2.57

BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions. Nucleic Acids Res (2012) 2.56

An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide). Cancer Discov (2013) 2.52

Activation of the cardiac proteasome during pressure overload promotes ventricular hypertrophy. Circulation (2006) 2.50

Rapid mitochondrial DNA segregation in primate preimplantation embryos precedes somatic and germline bottleneck. Cell Rep (2012) 2.50

Interleukin-17-producing CD4(+) T cells increase with severity of liver damage in patients with chronic hepatitis B. Hepatology (2010) 2.44

Surface contact stimulates the just-in-time deployment of bacterial adhesins. Mol Microbiol (2011) 2.44

Protein-ligand binding site recognition using complementary binding-specific substructure comparison and sequence profile alignment. Bioinformatics (2013) 2.43

Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway. Nature (2003) 2.42

Horizontal transfer of an adaptive chimeric photoreceptor from bryophytes to ferns. Proc Natl Acad Sci U S A (2014) 2.42

Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice. Circulation (2010) 2.39

Arsenic detoxification and evolution of trimethylarsine gas by a microbial arsenite S-adenosylmethionine methyltransferase. Proc Natl Acad Sci U S A (2006) 2.37

Cryo-EM study of the chromatin fiber reveals a double helix twisted by tetranucleosomal units. Science (2014) 2.37