Published in J Biochem on August 01, 2006
Autophagy, immunity, and microbial adaptations. Cell Host Microbe (2009) 5.84
Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells. Nat Med (2009) 3.17
Eating the enemy within: autophagy in infectious diseases. Cell Death Differ (2008) 2.17
IRGM is a common target of RNA viruses that subvert the autophagy network. PLoS Pathog (2011) 2.09
Cytoprotective roles for autophagy. Curr Opin Cell Biol (2010) 1.81
Liver autophagy contributes to the maintenance of blood glucose and amino acid levels. Autophagy (2011) 1.59
Anaplasma phagocytophilum and Ehrlichia chaffeensis: subversive manipulators of host cells. Nat Rev Microbiol (2010) 1.57
Multiple roles of the cytoskeleton in autophagy. Biol Rev Camb Philos Soc (2009) 1.43
Viral Bcl-2-mediated evasion of autophagy aids chronic infection of gammaherpesvirus 68. PLoS Pathog (2009) 1.31
Pseudomonas aeruginosa induces membrane blebs in epithelial cells, which are utilized as a niche for intracellular replication and motility. Infect Immun (2008) 1.22
TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation. J Biol Chem (2011) 1.21
Yersinia pestis can reside in autophagosomes and avoid xenophagy in murine macrophages by preventing vacuole acidification. Infect Immun (2009) 1.17
Specific behavior of intracellular Streptococcus pyogenes that has undergone autophagic degradation is associated with bacterial streptolysin O and host small G proteins Rab5 and Rab7. J Biol Chem (2010) 1.02
Autophagy induced by calcium phosphate precipitates targets damaged endosomes. J Biol Chem (2014) 0.99
Sigma Factor SigB Is Crucial to Mediate Staphylococcus aureus Adaptation during Chronic Infections. PLoS Pathog (2015) 0.97
Intracellular recognition of pathogens and autophagy as an innate immune host defence. J Biochem (2011) 0.95
Multi-species bacterial biofilm and intracellular infection in otitis media. BMC Pediatr (2011) 0.94
Antibiotic resistance breakers: can repurposed drugs fill the antibiotic discovery void? Nat Rev Drug Discov (2015) 0.92
Natural occurrence of Mycobacterium as an endosymbiont of Acanthamoeba isolated from a contact lens storage case. Korean J Parasitol (2007) 0.87
Methicillin-resistant Staphylococcus aureus adaptation to human keratinocytes. MBio (2015) 0.82
IsaB Inhibits Autophagic Flux to Promote Host Transmission of Methicillin-Resistant Staphylococcus aureus. J Invest Dermatol (2015) 0.81
Pseudomonas aeruginosa eliminates natural killer cells via phagocytosis-induced apoptosis. PLoS Pathog (2009) 0.81
Insufficient Acidification of Autophagosomes Facilitates Group A Streptococcus Survival and Growth in Endothelial Cells. MBio (2015) 0.79
Endosymbiont Tolerance and Control within Insect Hosts. Insects (2012) 0.79
Fusobacterium nucleatum-Induced Impairment of Autophagic Flux Enhances the Expression of Proinflammatory Cytokines via ROS in Caco-2 Cells. PLoS One (2016) 0.77
Variant in the 5' untranslated region of insulin-like growth factor 1 receptor is associated with susceptibility to mastitis in cattle. G3 (Bethesda) (2012) 0.77
microRNA-17-5p Modulates Bacille Calmette-Guerin Growth in RAW264.7 Cells by Targeting ULK1. PLoS One (2015) 0.77
Vacuolar pathogens value membrane integrity. Proc Natl Acad Sci U S A (2012) 0.77
Autophagy in toxicology: self-consumption in times of stress and plenty. J Appl Toxicol (2012) 0.77
Autophagy as an antimicrobial strategy. Expert Rev Anti Infect Ther (2009) 0.76
Role of Autophagy and Apoptosis in the Postinfluenza Bacterial Pneumonia. Biomed Res Int (2016) 0.75
Escherichia coli-host macrophage interactions in the pathogenesis of inflammatory bowel disease. World J Gastroenterol (2014) 0.75
Mir-30d increases intracellular survival of Helicobacter pylori through inhibition of autophagy pathway. World J Gastroenterol (2016) 0.75
Galectin-3 Inhibits Galectin-8/Parkin-Mediated Ubiquitination of Group A Streptococcus. MBio (2017) 0.75
Bacterial toxins: Offensive, defensive, or something else altogether? PLoS Pathog (2017) 0.75
The role of autophagy during the early neonatal starvation period. Nature (2004) 22.40
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Methods in mammalian autophagy research. Cell (2010) 20.08
In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell (2003) 17.55
How to interpret LC3 immunoblotting. Autophagy (2007) 12.30
Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy (2007) 11.74
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature (2008) 11.39
Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol (2005) 10.27
Autophagy defends cells against invading group A Streptococcus. Science (2004) 9.53
LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci (2004) 9.20
The role of Atg proteins in autophagosome formation. Annu Rev Cell Dev Biol (2011) 8.18
A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation. Nat Cell Biol (2009) 7.84
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat Cell Biol (2009) 7.35
The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy. Mol Biol Cell (2008) 6.66
Escape of intracellular Shigella from autophagy. Science (2004) 6.64
Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate. J Cell Sci (2003) 6.50
Autophagosome formation in mammalian cells. Cell Struct Funct (2002) 5.58
Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuole. J Biol Chem (2006) 5.50
Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. Proc Natl Acad Sci U S A (2009) 4.48
Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability. Am J Pathol (2007) 4.45
Autophagosomes form at ER-mitochondria contact sites. Nature (2013) 4.32
An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure. Mol Biol Cell (2008) 4.00
Autophagic control of listeria through intracellular innate immune recognition in drosophila. Nat Immunol (2008) 3.78
Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem (2006) 3.77
The origin of the autophagosomal membrane. Nat Cell Biol (2010) 3.20
Listeria monocytogenes ActA-mediated escape from autophagic recognition. Nat Cell Biol (2009) 3.05
The autophagosome: origins unknown, biogenesis complex. Nat Rev Mol Cell Biol (2013) 3.04
Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L. J Cell Biol (2010) 2.98
Coronavirus replication complex formation utilizes components of cellular autophagy. J Biol Chem (2003) 2.96
A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery. Chem Biol (2011) 2.81
Intracellular inclusions containing mutant alpha1-antitrypsin Z are propagated in the absence of autophagic activity. J Biol Chem (2005) 2.60
Dynein-dependent movement of autophagosomes mediates efficient encounters with lysosomes. Cell Struct Funct (2008) 2.47
Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes. J Cell Sci (2004) 2.35
Regulation of epidermal growth factor receptor down-regulation by UBPY-mediated deubiquitination at endosomes. Mol Biol Cell (2005) 2.31
Protective role of autophagy against Vibrio cholerae cytolysin, a pore-forming toxin from V. cholerae. Proc Natl Acad Sci U S A (2007) 2.27
The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting. J Biol Chem (2003) 2.19
Listeria monocytogenes evades killing by autophagy during colonization of host cells. Autophagy (2007) 2.13
Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation. Mol Biol Cell (2008) 2.08
Monitoring autophagy in mammalian cultured cells through the dynamics of LC3. Methods Enzymol (2009) 1.99
Host cell autophagy activated by antibiotics is required for their effective antimycobacterial drug action. Cell Host Microbe (2012) 1.99
Chemical modulators of autophagy as biological probes and potential therapeutics. Nat Chem Biol (2011) 1.97
ALIS are stress-induced protein storage compartments for substrates of the proteasome and autophagy. Autophagy (2006) 1.97
GFP-like proteins stably accumulate in lysosomes. Cell Struct Funct (2008) 1.97
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Mol Cell (2013) 1.95
The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella. Mol Biol Cell (2011) 1.79
Modulation of local PtdIns3P levels by the PI phosphatase MTMR3 regulates constitutive autophagy. Traffic (2010) 1.59
SKD1 AAA ATPase-dependent endosomal transport is involved in autolysosome formation. Cell Struct Funct (2002) 1.58
Variations of Porphyromonas gingivalis fimbriae in relation to microbial pathogenesis. J Periodontal Res (2004) 1.57
Autophagy guards against cisplatin-induced acute kidney injury. Am J Pathol (2012) 1.56
Autophagic elimination of misfolded procollagen aggregates in the endoplasmic reticulum as a means of cell protection. Mol Biol Cell (2009) 1.55
Combinational soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins VAMP8 and Vti1b mediate fusion of antimicrobial and canonical autophagosomes with lysosomes. Mol Biol Cell (2010) 1.55
A dominant negative form of the AAA ATPase SKD1/VPS4 impairs membrane trafficking out of endosomal/lysosomal compartments: class E vps phenotype in mammalian cells. J Cell Sci (2003) 1.52
Endothelial nitric-oxide synthase antisense (NOS3AS) gene encodes an autophagy-related protein (APG9-like2) highly expressed in trophoblast. J Biol Chem (2005) 1.46
Effect of Helicobacter pylori's vacuolating cytotoxin on the autophagy pathway in gastric epithelial cells. Autophagy (2009) 1.45
Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin. J Cell Biol (2013) 1.44
Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma. Int J Cancer (2011) 1.43
An initial step of GAS-containing autophagosome-like vacuoles formation requires Rab7. PLoS Pathog (2009) 1.43
Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic proteins Bax and Bak, leading to cytochrome c release and cell death, independent of vacuolation. J Biol Chem (2006) 1.43
Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin. J Biol Chem (2003) 1.37
Differential involvement of Atg16L1 in Crohn disease and canonical autophagy: analysis of the organization of the Atg16L1 complex in fibroblasts. J Biol Chem (2009) 1.36
Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation. Mol Biol Cell (2008) 1.34
Where do they come from? Insights into autophagosome formation. FEBS Lett (2010) 1.32
Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury. EMBO J (2013) 1.31
Comparative genomic analyses of Streptococcus mutans provide insights into chromosomal shuffling and species-specific content. BMC Genomics (2009) 1.29
Virulence of Porphyromonas gingivalis is altered by substitution of fimbria gene with different genotype. Cell Microbiol (2006) 1.28
Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B. J Cell Sci (2004) 1.27
Complete genome sequence of the bacterium Porphyromonas gingivalis TDC60, which causes periodontal disease. J Bacteriol (2011) 1.25
CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis. J Cell Biol (2006) 1.25
The collagen-binding protein of Streptococcus mutans is involved in haemorrhagic stroke. Nat Commun (2011) 1.25
The first molecular evidence that autophagy relates rimmed vacuole formation in chloroquine myopathy. J Biochem (2002) 1.24
Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method. FEBS Lett (2002) 1.22
Genetic analysis of capsular polysaccharide synthesis gene clusters from all serotypes of Streptococcus suis: potential mechanisms for generation of capsular variation. Appl Environ Microbiol (2013) 1.22
Novel laminin-binding protein of Streptococcus pyogenes, Lbp, is involved in adhesion to epithelial cells. Infect Immun (2002) 1.21
Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagy. J Clin Invest (2014) 1.19
Regulation of membrane biogenesis in autophagy via PI3P dynamics. Semin Cell Dev Biol (2010) 1.19
Molecular characterization of a novel fibronectin-binding protein of Streptococcus pyogenes strains isolated from toxic shock-like syndrome patients. J Biol Chem (2002) 1.17
Demonstration of Streptococcus mutans with a cell wall polysaccharide specific to a new serotype, k, in the human oral cavity. J Clin Microbiol (2004) 1.17
Role of Hrs in maturation of autophagosomes in mammalian cells. Biochem Biophys Res Commun (2007) 1.16
Autophagosomes can support Yersinia pseudotuberculosis replication in macrophages. Cell Microbiol (2010) 1.16
The C/EBP beta isoform 34-kDa LAP is responsible for NF-IL-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing. J Immunol (2007) 1.16
Streptococcus mutans clonal variation revealed by multilocus sequence typing. J Clin Microbiol (2007) 1.15
Porphyromonas gingivalis outer membrane vesicles enter human epithelial cells via an endocytic pathway and are sorted to lysosomal compartments. Infect Immun (2009) 1.15
Up-to-date membrane biogenesis in the autophagosome formation. Curr Opin Cell Biol (2013) 1.15
Role of the Apg12 conjugation system in mammalian autophagy. Int J Biochem Cell Biol (2003) 1.15
CRISPR inhibition of prophage acquisition in Streptococcus pyogenes. PLoS One (2011) 1.14
Ubiquitination-mediated autophagy against invading bacteria. Curr Opin Cell Biol (2011) 1.13
Influenza A virus-infected hosts boost an invasive type of Streptococcus pyogenes infection in mice. J Virol (2003) 1.13
Electron tomography reveals the endoplasmic reticulum as a membrane source for autophagosome formation. Autophagy (2010) 1.13
Genotypic and PFGE/MLVA analyses of Vibrio cholerae O1: geographical spread and temporal changes during the 2007-2010 cholera outbreaks in Thailand. PLoS One (2012) 1.12
Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans. Gastroenterology (2012) 1.12
Rubicon and PLEKHM1 negatively regulate the endocytic/autophagic pathway via a novel Rab7-binding domain. Mol Biol Cell (2010) 1.10
Molecular basis of canonical and bactericidal autophagy. Int Immunol (2009) 1.09
Survival of parvovirus B19-infected cells by cellular autophagy. Virology (2006) 1.08
Artificial induction of autophagy around polystyrene beads in nonphagocytic cells. Autophagy (2010) 1.06
Bornavirus closely associates and segregates with host chromosomes to ensure persistent intranuclear infection. Cell Host Microbe (2012) 1.03
Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells. Cancer Sci (2011) 1.03