Published in J Biol Chem on March 06, 2006
Autophagy in the pathogenesis of disease. Cell (2008) 34.68
Role of autophagy in cancer. Nat Rev Cancer (2007) 10.88
Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat Cell Biol (2009) 6.69
The double-edged sword of autophagy modulation in cancer. Clin Cancer Res (2009) 5.46
Autophagy modulation as a potential therapeutic target for diverse diseases. Nat Rev Drug Discov (2012) 5.26
Autophagy gone awry in neurodegenerative diseases. Nat Neurosci (2010) 4.72
The role of autophagy in neurodegenerative disease. Nat Med (2013) 4.46
Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability. Am J Pathol (2007) 4.45
Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease. Nat Neurosci (2010) 4.22
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat Chem Biol (2008) 4.19
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest (2008) 4.09
Neural mechanisms of ageing and cognitive decline. Nature (2010) 3.59
TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity. Proc Natl Acad Sci U S A (2013) 3.33
Autophagy and aging: keeping that old broom working. Trends Genet (2008) 3.09
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. Genes Dev (2009) 3.03
Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL. Cell Death Differ (2009) 2.85
Role of autophagy in suppression of inflammation and cancer. Curr Opin Cell Biol (2010) 2.58
Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease. J Cell Sci (2008) 2.55
Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis. Arthritis Rheum (2010) 2.43
A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions. Dev Cell (2010) 2.40
Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human disease. Annu Rev Pathol (2012) 2.20
The aging stress response. Mol Cell (2010) 2.19
Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proc Natl Acad Sci U S A (2010) 2.10
Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night. Curr Opin Genet Dev (2011) 2.09
Early autophagic response in a novel knock-in model of Huntington disease. Hum Mol Genet (2010) 1.99
Protein homeostasis and aging: The importance of exquisite quality control. Ageing Res Rev (2010) 1.84
Autophagy activation by rapamycin reduces severity of experimental osteoarthritis. Ann Rheum Dis (2011) 1.78
Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3. Brain (2009) 1.66
Autophagy: for better or for worse. Cell Res (2011) 1.65
Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways. Hum Mol Genet (2008) 1.63
All-you-can-eat: autophagy in neurodegeneration and neuroprotection. Mol Neurodegener (2009) 1.60
Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes. Arthritis Rheumatol (2015) 1.54
OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells. Mol Pharmacol (2008) 1.52
Aggrephagy: selective disposal of protein aggregates by macroautophagy. Int J Cell Biol (2012) 1.52
Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. J Biol Chem (2010) 1.50
Mitochondrial electron transport chain complex III is required for antimycin A to inhibit autophagy. Chem Biol (2011) 1.50
MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner. EMBO J (2010) 1.49
Polyglutamine tracts regulate beclin 1-dependent autophagy. Nature (2017) 1.48
Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells. Mol Cancer Ther (2008) 1.48
Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders. Pharmacol Ther (2010) 1.39
TOR-mediated autophagy regulates cell death in Drosophila neurodegenerative disease. J Cell Biol (2009) 1.38
Autophagy in neurodegeneration and development. Biochim Biophys Acta (2008) 1.38
Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Hum Mol Genet (2010) 1.38
Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy. Hum Mol Genet (2012) 1.36
Protein misfolding disorders and macroautophagy. Curr Opin Cell Biol (2010) 1.36
Parkin-mediated ubiquitin signalling in aggresome formation and autophagy. Biochem Soc Trans (2010) 1.31
Autophagy in neuroprotection and neurodegeneration: A question of balance. Future Neurol (2008) 1.31
Autophagy in neurodegenerative disorders: pathogenic roles and therapeutic implications. Trends Neurosci (2010) 1.30
Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies. Exp Mol Med (2015) 1.29
Neuronal autophagy and neurodegenerative diseases. Exp Mol Med (2012) 1.28
Autophagy: a critical regulator of cellular metabolism and homeostasis. Mol Cells (2013) 1.24
Autophagy and neurodegeneration. J Clin Invest (2015) 1.24
Protein quality control and degradation in cardiomyocytes. J Mol Cell Cardiol (2008) 1.22
The regulation of aging: does autophagy underlie longevity? Trends Cell Biol (2009) 1.22
Review: autophagy and neurodegeneration: survival at a cost? Neuropathol Appl Neurobiol (2010) 1.17
Autophagy takes flight in Drosophila. FEBS Lett (2010) 1.15
Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated Abeta in AD models. Hum Mol Genet (2011) 1.12
Translational evidence that impaired autophagy contributes to arterial ageing. J Physiol (2012) 1.12
A role for Toll-like receptor 3 variants in host susceptibility to enteroviral myocarditis and dilated cardiomyopathy. J Biol Chem (2010) 1.11
Autophagy and misfolded proteins in neurodegeneration. Exp Neurol (2010) 1.10
Autophagy for the avoidance of neurodegeneration. Genes Dev (2009) 1.09
Neuronal aggregates: formation, clearance, and spreading. Dev Cell (2015) 1.09
Autophagy in axonal and dendritic degeneration. Trends Neurosci (2013) 1.08
Autophagy and neuronal cell death in neurological disorders. Cold Spring Harb Perspect Biol (2012) 1.08
Kainic acid induces early and transient autophagic stress in mouse hippocampus. Neurosci Lett (2006) 1.07
PERK-dependent regulation of MDA-7/IL-24-induced autophagy in primary human glioma cells. Autophagy (2008) 1.06
Glucocorticoid dose determines osteocyte cell fate. FASEB J (2011) 1.06
Potential function for the Huntingtin protein as a scaffold for selective autophagy. Proc Natl Acad Sci U S A (2014) 1.05
Autophagy and polyglutamine diseases. Prog Neurobiol (2011) 1.02
Autophagy - An Emerging Anti-Aging Mechanism. J Clin Exp Pathol (2012) 1.01
Autophagy in inflammation, infection, neurodegeneration and cancer. Int Immunopharmacol (2013) 1.00
Intracellular degradation of misfolded proteins in polyglutamine neurodegenerative diseases. Brain Res Rev (2008) 0.96
Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis. Autophagy (2014) 0.96
The Function of Autophagy in Neurodegenerative Diseases. Int J Mol Sci (2015) 0.95
BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria. Autophagy (2014) 0.95
Autophagy in dementias. Brain Pathol (2012) 0.95
Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy. Hum Mol Genet (2010) 0.94
Autophagosome dynamics in neurodegeneration at a glance. J Cell Sci (2015) 0.94
Age at onset in Huntington's disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7. Hum Genet (2010) 0.94
Angiogenesis impairment in diabetes: role of methylglyoxal-induced receptor for advanced glycation endproducts, autophagy and vascular endothelial growth factor receptor 2. PLoS One (2012) 0.93
Rhes, a striatal-selective protein implicated in Huntington disease, binds beclin-1 and activates autophagy. J Biol Chem (2013) 0.92
Interplay between the ubiquitin-proteasome system and autophagy in proteinopathies. Int J Physiol Pathophysiol Pharmacol (2009) 0.92
Distinct biological effects of different nanoparticles commonly used in cosmetics and medicine coatings. Cell Biosci (2011) 0.92
The many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapy. Drug Discov Today (2014) 0.92
Autophagy in neurodegenerative diseases: from mechanism to therapeutic approach. Mol Cells (2015) 0.92
Melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways. Int J Mol Sci (2014) 0.91
Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic. Hum Mol Genet (2012) 0.91
Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis. Autophagy (2015) 0.90
Autophagy in the myocardium: Dying for survival? Exp Clin Cardiol (2006) 0.89
Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development. Nat Rev Drug Discov (2011) 0.87
Nrbf2 protein suppresses autophagy by modulating Atg14L protein-containing Beclin 1-Vps34 complex architecture and reducing intracellular phosphatidylinositol-3 phosphate levels. J Biol Chem (2014) 0.87
The Autophagy-Lysosomal Pathway in Neurodegeneration: A TFEB Perspective. Trends Neurosci (2016) 0.87
Autophagic activity in neuronal cell death. Neurosci Bull (2015) 0.86
Murine Mesenchymal Stem Cell Commitment to Differentiation Is Regulated by Mitochondrial Dynamics. Stem Cells (2015) 0.86
Autophagy in Drosophila: from historical studies to current knowledge. Biomed Res Int (2014) 0.85
Autophagy in polyglutamine disease: Imposing order on disorder or contributing to the chaos? Mol Cell Neurosci (2015) 0.85
Regulation of Abeta pathology by beclin 1: a protective role for autophagy? J Clin Invest (2008) 0.84
The regulation of N-terminal Huntingtin (Htt552) accumulation by Beclin1. Acta Pharmacol Sin (2012) 0.83
A new autophagy-related checkpoint in the degradation of an ERAD-M target. J Biol Chem (2011) 0.82
The Interplay between Autophagy and Aging. Diabetes Metab J (2013) 0.82
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature (2006) 24.39
The role of autophagy during the early neonatal starvation period. Nature (2004) 22.40
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell (2005) 21.01
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Methods in mammalian autophagy research. Cell (2010) 20.08
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol (2005) 18.60
In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell (2003) 17.55
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest (2003) 16.67
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell (2007) 14.63
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J (2008) 12.89
How to interpret LC3 immunoblotting. Autophagy (2007) 12.30
Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy (2007) 11.74
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol (2005) 11.63
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature (2008) 11.39
Autophagy in immunity and inflammation. Nature (2011) 11.16
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature (2008) 10.84
Autophagy in cell death: an innocent convict? J Clin Invest (2005) 10.70
Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol (2005) 10.27
Autophagy defends cells against invading group A Streptococcus. Science (2004) 9.53
Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol (2008) 9.24
LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci (2004) 9.20
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell (2009) 9.14
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol (2004) 8.85
The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med (2007) 8.82
The role of Atg proteins in autophagosome formation. Annu Rev Cell Dev Biol (2011) 8.18
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science (2005) 7.98
A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation. Nat Cell Biol (2009) 7.84
Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science (2007) 7.65
Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell (2008) 7.61
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat Cell Biol (2009) 7.35
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell (2008) 7.32
FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J Cell Biol (2008) 7.16
The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy. Mol Biol Cell (2008) 6.66
Escape of intracellular Shigella from autophagy. Science (2004) 6.64
Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate. J Cell Sci (2003) 6.50
A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med (2006) 6.01
Autophagosome formation in mammalian cells. Cell Struct Funct (2002) 5.58
Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuole. J Biol Chem (2006) 5.50
De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood. Nat Genet (2013) 4.71
Autophagy-deficient mice develop multiple liver tumors. Genes Dev (2011) 4.64
Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. J Biol Chem (2005) 4.56
Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. Proc Natl Acad Sci U S A (2009) 4.48
Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability. Am J Pathol (2007) 4.45
The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. Cell (2012) 4.40
Autophagosomes form at ER-mitochondria contact sites. Nature (2013) 4.32
Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. J Biol Chem (2002) 4.27
Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Biol Chem (2007) 4.22
Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens. Cell Host Microbe (2008) 4.16
The dynamics of autophagy visualized in live cells: from autophagosome formation to fusion with endo/lysosomes. Autophagy (2005) 4.08
An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure. Mol Biol Cell (2008) 4.00
Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins. Autophagy (2010) 3.99
LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localization. Autophagy (2007) 3.91
Autophagic control of listeria through intracellular innate immune recognition in drosophila. Nat Immunol (2008) 3.78
Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset. Proc Natl Acad Sci U S A (2004) 3.73
The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol Biol Cell (2008) 3.72
Expansion and evolution of cell death programmes. Nat Rev Mol Cell Biol (2008) 3.59
Neural mechanisms of ageing and cognitive decline. Nature (2010) 3.59
Autophagy is essential for preimplantation development of mouse embryos. Science (2008) 3.55
A decade of caspases. Oncogene (2003) 3.55
Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. J Cell Biol (2003) 3.52
Necroptosis as an alternative form of programmed cell death. Curr Opin Cell Biol (2010) 3.51
Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size. FEBS Lett (2006) 3.49
Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest (2010) 3.44
Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc Natl Acad Sci U S A (2007) 3.37
The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell (2003) 3.36
The aging brain. Annu Rev Pathol (2008) 3.28
Induction of autophagy in axonal dystrophy and degeneration. J Neurosci (2006) 3.28
Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell (2007) 3.21
The origin of the autophagosomal membrane. Nat Cell Biol (2010) 3.20
In vivo requirement for Atg5 in antigen presentation by dendritic cells. Immunity (2010) 3.19
Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature (2011) 3.18
Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy. Am J Pathol (2006) 3.18
Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance. Nature (2008) 3.09
Two ubiquitin-like conjugation systems essential for autophagy. Semin Cell Dev Biol (2004) 3.04
The autophagosome: origins unknown, biogenesis complex. Nat Rev Mol Cell Biol (2013) 3.04
Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane. J Biol Chem (2011) 2.99
Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L. J Cell Biol (2010) 2.98
Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival. Cell (2011) 2.98
Coronavirus replication complex formation utilizes components of cellular autophagy. J Biol Chem (2003) 2.96
A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery. Chem Biol (2011) 2.81
Diversity in the mechanisms of neuronal cell death. Neuron (2003) 2.79
Atg101, a novel mammalian autophagy protein interacting with Atg13. Autophagy (2009) 2.78
Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. EMBO J (2009) 2.72
Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders. Nature (2003) 2.60
Intracellular inclusions containing mutant alpha1-antitrypsin Z are propagated in the absence of autophagic activity. J Biol Chem (2005) 2.60
Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell (2011) 2.58