Published in J Biol Chem on March 08, 2005
Autophagy: molecular machinery for self-eating. Cell Death Differ (2005) 8.46
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy (2016) 7.05
mTOR regulation of autophagy. FEBS Lett (2010) 6.59
The hallmarks of cancer: a long non-coding RNA point of view. RNA Biol (2012) 5.60
An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure. Mol Biol Cell (2008) 4.00
An overview of the molecular mechanism of autophagy. Curr Top Microbiol Immunol (2009) 3.29
The machinery of macroautophagy. Cell Res (2013) 3.13
Atg9 cycles between mitochondria and the pre-autophagosomal structure in yeasts. Autophagy (2005) 2.52
A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy (2011) 2.02
Regulation of innate immune responses by autophagy-related proteins. J Cell Biol (2010) 1.94
Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP. EMBO J (2009) 1.91
The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella. Mol Biol Cell (2011) 1.79
Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise. Exp Gerontol (2009) 1.74
Bif-1/endophilin B1: a candidate for crescent driving force in autophagy. Cell Death Differ (2009) 1.46
Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy. Autophagy (2011) 1.44
Biochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartment. J Biol Chem (2009) 1.41
Autophagy: regulation and role in development. Autophagy (2013) 1.28
The emerging role of autophagy in alcoholic liver disease. Exp Biol Med (Maywood) (2011) 1.13
Atg9 vesicles recruit vesicle-tethering proteins Trs85 and Ypt1 to the autophagosome formation site. J Biol Chem (2012) 1.07
PpATG9 encodes a novel membrane protein that traffics to vacuolar membranes, which sequester peroxisomes during pexophagy in Pichia pastoris. Mol Biol Cell (2005) 1.03
Posttranslational modification of autophagy-related proteins in macroautophagy. Autophagy (2015) 1.01
Predicting housekeeping genes based on Fourier analysis. PLoS One (2011) 0.90
Survival by self-destruction: a role for autophagy in the placenta? Placenta (2012) 0.90
Active stabilization of human endothelial nitric oxide synthase mRNA by hnRNP E1 protects against antisense RNA and microRNAs. Mol Cell Biol (2013) 0.87
Atg9A protein, an autophagy-related membrane protein, is localized in the neurons of mouse brains. J Histochem Cytochem (2010) 0.85
Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy. Nat Commun (2015) 0.83
Phosphorylation of Atg9 regulates movement to the phagophore assembly site and the rate of autophagosome formation. Autophagy (2016) 0.83
Three-Axis Model for Atg Recruitment in Autophagy against Salmonella. Int J Cell Biol (2012) 0.79
Atg9 is required for intraluminal vesicles in amphisomes and autolysosomes. Biol Open (2015) 0.78
Excess sphingomyelin disturbs ATG9A trafficking and autophagosome closure. Autophagy (2016) 0.78
Region-specific changes in the immunoreactivity of Atg9A in the central nervous system of SOD1(G93A) transgenic mice. Anat Cell Biol (2014) 0.77
Bif-1 is overexpressed in hepatocellular carcinoma and correlates with shortened patient survival. Oncol Lett (2012) 0.77
ATG9A overexpression is associated with disease recurrence and poor survival in patients with oral squamous cell carcinoma. Virchows Arch (2013) 0.77
Autophagy in Dictyostelium: Mechanisms, regulation and disease in a simple biomedical model. Autophagy (2016) 0.75
Global variation in copy number in the human genome. Nature (2006) 57.50
Detection of large-scale variation in the human genome. Nat Genet (2004) 49.18
The diploid genome sequence of an individual human. PLoS Biol (2007) 44.80
Origins and functional impact of copy number variation in the human genome. Nature (2009) 23.63
Relative impact of nucleotide and copy number variation on gene expression phenotypes. Science (2007) 23.38
The role of autophagy during the early neonatal starvation period. Nature (2004) 22.40
Structural variation in the human genome. Nat Rev Genet (2006) 21.40
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Methods in mammalian autophagy research. Cell (2010) 20.08
In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell (2003) 17.55
Structural variation of chromosomes in autism spectrum disorder. Am J Hum Genet (2008) 15.51
Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66
Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet (2007) 14.05
Consensus statement: chromosomal microarray is a first-tier clinical diagnostic test for individuals with developmental disabilities or congenital anomalies. Am J Hum Genet (2010) 13.70
How to interpret LC3 immunoblotting. Autophagy (2007) 12.30
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Prepublication data sharing. Nature (2009) 12.24
Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy (2007) 11.74
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature (2008) 11.39
Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol (2005) 10.27
Autophagy defends cells against invading group A Streptococcus. Science (2004) 9.53
LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci (2004) 9.20
Copy number variation: new insights in genome diversity. Genome Res (2006) 8.66
The role of Atg proteins in autophagosome formation. Annu Rev Cell Dev Biol (2011) 8.18
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation. Nat Cell Biol (2009) 7.84
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat Cell Biol (2009) 7.35
Genome assembly comparison identifies structural variants in the human genome. Nat Genet (2006) 6.93
Copy-number variations associated with neuropsychiatric conditions. Nature (2008) 6.78
The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy. Mol Biol Cell (2008) 6.66
Escape of intracellular Shigella from autophagy. Science (2004) 6.64
Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate. J Cell Sci (2003) 6.50
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nat Genet (2009) 6.02
Genome-wide detection of human copy number variations using high-density DNA oligonucleotide arrays. Genome Res (2006) 5.97
Autophagosome formation in mammalian cells. Cell Struct Funct (2002) 5.58
Accurate and reliable high-throughput detection of copy number variation in the human genome. Genome Res (2006) 5.50
Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuole. J Biol Chem (2006) 5.50
Severe expressive-language delay related to duplication of the Williams-Beuren locus. N Engl J Med (2005) 5.37
Synaptic, transcriptional and chromatin genes disrupted in autism. Nature (2014) 5.30
Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly. Proc Natl Acad Sci U S A (2002) 5.18
Contribution of SHANK3 mutations to autism spectrum disorder. Am J Hum Genet (2007) 5.04
Structural variants: changing the landscape of chromosomes and design of disease studies. Hum Mol Genet (2006) 4.60
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. Nat Genet (2009) 4.52
Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. Proc Natl Acad Sci U S A (2009) 4.48
Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability. Am J Pathol (2007) 4.45
The Database of Genomic Variants: a curated collection of structural variation in the human genome. Nucleic Acids Res (2013) 4.42
Autophagosomes form at ER-mitochondria contact sites. Nature (2013) 4.32
Genome-wide detection of segmental duplications and potential assembly errors in the human genome sequence. Genome Biol (2003) 4.32
Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature (2012) 4.13
An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure. Mol Biol Cell (2008) 4.00
Public data archives for genomic structural variation. Nat Genet (2010) 3.92
Copy-number variation in control population cohorts. Hum Mol Genet (2007) 3.88
Autophagic control of listeria through intracellular innate immune recognition in drosophila. Nat Immunol (2008) 3.78
Mutations in SUFU predispose to medulloblastoma. Nat Genet (2002) 3.78
Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem (2006) 3.77
Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation. Nat Genet (2010) 3.73
Hotspots for copy number variation in chimpanzees and humans. Proc Natl Acad Sci U S A (2006) 3.68
Discovery of common Asian copy number variants using integrated high-resolution array CGH and massively parallel DNA sequencing. Nat Genet (2010) 3.49
A genome-wide scan for common alleles affecting risk for autism. Hum Mol Genet (2010) 3.42
Comprehensive assessment of array-based platforms and calling algorithms for detection of copy number variants. Nat Biotechnol (2011) 3.25
The origin of the autophagosomal membrane. Nat Cell Biol (2010) 3.20
Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data. PLoS Genet (2010) 3.11
The autophagosome: origins unknown, biogenesis complex. Nat Rev Mol Cell Biol (2013) 3.04
Human chromosome 7: DNA sequence and biology. Science (2003) 3.02
Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L. J Cell Biol (2010) 2.98
Clonal selection drives genetic divergence of metastatic medulloblastoma. Nature (2012) 2.96
Coronavirus replication complex formation utilizes components of cellular autophagy. J Biol Chem (2003) 2.96
Germ-line DNA copy number variation frequencies in a large North American population. Hum Genet (2007) 2.94
Contribution of intragenic DNA methylation in mouse gametic DNA methylomes to establish oocyte-specific heritable marks. PLoS Genet (2012) 2.89
Genetic architecture in autism spectrum disorder. Curr Opin Genet Dev (2012) 2.86
A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery. Chem Biol (2011) 2.81
Towards a comprehensive structural variation map of an individual human genome. Genome Biol (2010) 2.79
Copy number variations and risk for schizophrenia in 22q11.2 deletion syndrome. Hum Mol Genet (2008) 2.76
Genetic and functional analyses of SHANK2 mutations suggest a multiple hit model of autism spectrum disorders. PLoS Genet (2012) 2.65
A role for common fragile site induction in amplification of human oncogenes. Cancer Cell (2002) 2.63
Intracellular inclusions containing mutant alpha1-antitrypsin Z are propagated in the absence of autophagic activity. J Biol Chem (2005) 2.60
Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus. Nature (2011) 2.59
Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3. Am J Psychiatry (2012) 2.48
Detection of clinically relevant genetic variants in autism spectrum disorder by whole-genome sequencing. Am J Hum Genet (2013) 2.47
Dynein-dependent movement of autophagosomes mediates efficient encounters with lysosomes. Cell Struct Funct (2008) 2.47
Individual common variants exert weak effects on the risk for autism spectrum disorderspi. Hum Mol Genet (2012) 2.46
Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes. J Cell Sci (2004) 2.35
Chromosomal regions containing high-density and ambiguously mapped putative single nucleotide polymorphisms (SNPs) correlate with segmental duplications in the human genome. Hum Mol Genet (2002) 2.34
Regulation of epidermal growth factor receptor down-regulation by UBPY-mediated deubiquitination at endosomes. Mol Biol Cell (2005) 2.31
Rare copy number variation discovery and cross-disorder comparisons identify risk genes for ADHD. Sci Transl Med (2011) 2.29
Protective role of autophagy against Vibrio cholerae cytolysin, a pore-forming toxin from V. cholerae. Proc Natl Acad Sci U S A (2007) 2.27
Phenotypic spectrum associated with de novo and inherited deletions and duplications at 16p11.2 in individuals ascertained for diagnosis of autism spectrum disorder. J Med Genet (2009) 2.27
Excessive genomic DNA copy number variation in the Li-Fraumeni cancer predisposition syndrome. Proc Natl Acad Sci U S A (2008) 2.22
The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting. J Biol Chem (2003) 2.19
Genetic analysis of patients with the Saethre-Chotzen phenotype. Am J Med Genet (2002) 2.17