Published in Proc Natl Acad Sci U S A on September 14, 2006
Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp. Nature (2014) 6.94
A one pot, one step, precision cloning method with high throughput capability. PLoS One (2008) 5.94
Therapeutic antibodies: successes, limitations and hopes for the future. Br J Pharmacol (2009) 3.05
Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques. Proc Natl Acad Sci U S A (2012) 2.83
Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection. J Clin Invest (2013) 2.15
Plant-made vaccine antigens and biopharmaceuticals. Trends Plant Sci (2009) 1.81
Enhanced potency of a fucose-free monoclonal antibody being developed as an Ebola virus immunoprotectant. Proc Natl Acad Sci U S A (2011) 1.80
In planta protein sialylation through overexpression of the respective mammalian pathway. J Biol Chem (2010) 1.52
Improved virus neutralization by plant-produced anti-HIV antibodies with a homogeneous beta1,4-galactosylated N-glycan profile. J Biol Chem (2009) 1.49
Extremely high-level and rapid transient protein production in plants without the use of viral replication. Plant Physiol (2008) 1.48
Plant-expressed recombinant mountain cedar allergen Jun a 1 is allergenic and has limited pectate lyase activity. Int Arch Allergy Immunol (2010) 1.45
Structures of protective antibodies reveal sites of vulnerability on Ebola virus. Proc Natl Acad Sci U S A (2014) 1.44
High-level rapid production of full-size monoclonal antibodies in plants by a single-vector DNA replicon system. Biotechnol Bioeng (2010) 1.44
Large bottleneck size in Cauliflower Mosaic Virus populations during host plant colonization. PLoS Pathog (2008) 1.28
Bioprocessing of plant-derived virus-like particles of Norwalk virus capsid protein under current Good Manufacture Practice regulations. Plant Cell Rep (2011) 1.26
Geminiviral vectors based on bean yellow dwarf virus for production of vaccine antigens and monoclonal antibodies in plants. Hum Vaccin (2011) 1.24
Monoclonal antibody produced in plants efficiently treats West Nile virus infection in mice. Proc Natl Acad Sci U S A (2010) 1.23
Cost-effective production of a vaginal protein microbicide to prevent HIV transmission. Proc Natl Acad Sci U S A (2008) 1.23
Efficient agroinfiltration of plants for high-level transient expression of recombinant proteins. J Vis Exp (2013) 1.23
Expression of an immunogenic Ebola immune complex in Nicotiana benthamiana. Plant Biotechnol J (2011) 1.21
Dynamics of the multiplicity of cellular infection in a plant virus. PLoS Pathog (2010) 1.19
Plant-derived virus-like particles as vaccines. Hum Vaccin Immunother (2012) 1.18
Hydrophobin fusions for high-level transient protein expression and purification in Nicotiana benthamiana. Plant Physiol (2009) 1.17
High-efficiency protein expression in plants from agroinfection-compatible Tobacco mosaic virus expression vectors. BMC Biotechnol (2007) 1.14
Robust production of virus-like particles and monoclonal antibodies with geminiviral replicon vectors in lettuce. Plant Biotechnol J (2011) 1.12
N-glycosylation engineering of plants for the biosynthesis of glycoproteins with bisected and branched complex N-glycans. Glycobiology (2011) 1.10
Monoclonal antibodies from plants: a new speed record. Proc Natl Acad Sci U S A (2006) 1.08
Emerging antibody products and Nicotiana manufacturing. Hum Vaccin (2011) 1.08
SNAREs: cogs and coordinators in signaling and development. Plant Physiol (2008) 1.08
Expression of recombinant antibodies. Front Immunol (2013) 1.06
Agroinfiltration as an Effective and Scalable Strategy of Gene Delivery for Production of Pharmaceutical Proteins. Adv Tech Biol Med (2013) 1.03
Chimeric plantibody passively protects mice against aerosolized ricin challenge. Clin Vaccine Immunol (2014) 1.03
Generation and analysis of novel plant-derived antibody-based therapeutic molecules against West Nile virus. PLoS One (2014) 1.03
Efficient single tobamoviral vector-based bioproduction of broadly neutralizing anti-HIV-1 monoclonal antibody VRC01 in Nicotiana benthamiana plants and utility of VRC01 in combination microbicides. Antimicrob Agents Chemother (2013) 1.00
Nicotiana benthamiana as a production platform for artemisinin precursors. PLoS One (2010) 1.00
Manufacturing economics of plant-made biologics: case studies in therapeutic and industrial enzymes. Biomed Res Int (2014) 0.99
A novel system for rapid and cost-effective production of detection and diagnostic reagents of West Nile virus in plants. J Biomed Biotechnol (2011) 0.98
Rapid transient production in plants by replicating and non-replicating vectors yields high quality functional anti-HIV antibody. PLoS One (2010) 0.98
Alga-produced cholera toxin-Pfs25 fusion proteins as oral vaccines. Appl Environ Microbiol (2013) 0.96
Glycan variants of a respiratory syncytial virus antibody with enhanced effector function and in vivo efficacy. Proc Natl Acad Sci U S A (2014) 0.94
Immunoabsorbent nanoparticles based on a tobamovirus displaying protein A. Proc Natl Acad Sci U S A (2006) 0.93
Generation of biologically active multi-sialylated recombinant human EPOFc in plants. PLoS One (2013) 0.93
Structural and functional characterization of an anti-West Nile virus monoclonal antibody and its single-chain variant produced in glycoengineered plants. Plant Biotechnol J (2014) 0.93
Expression and glycoengineering of functionally active heteromultimeric IgM in plants. Proc Natl Acad Sci U S A (2014) 0.93
Immunization with plant-expressed hemagglutinin protects chickens from lethal highly pathogenic avian influenza virus H5N1 challenge infection. J Virol (2010) 0.92
In plant activation: an inducible, hyperexpression platform for recombinant protein production in plants. Plant Cell (2013) 0.92
Efficient production of chimeric human papillomavirus 16 L1 protein bearing the M2e influenza epitope in Nicotiana benthamiana plants. BMC Biotechnol (2011) 0.91
In vivo neutralization of α-cobratoxin with high-affinity llama single-domain antibodies (VHHs) and a VHH-Fc antibody. PLoS One (2013) 0.90
Antibody expressing pea seeds as fodder for prevention of gastrointestinal parasitic infections in chickens. BMC Biotechnol (2009) 0.88
Broad and efficient control of major foodborne pathogenic strains of Escherichia coli by mixtures of plant-produced colicins. Proc Natl Acad Sci U S A (2015) 0.86
When plant virology met Agrobacterium: the rise of the deconstructed clones. Plant Biotechnol J (2015) 0.86
Expression and subcellular targeting of human complement factor C5a in Nicotiana species. PLoS One (2012) 0.85
Evolution of plant-made pharmaceuticals. Int J Mol Sci (2011) 0.85
A tripartite cocktail of chimeric monoclonal antibodies passively protects mice against ricin, staphylococcal enterotoxin B and Clostridium perfringens epsilon toxin. Toxicon (2014) 0.85
High-level transient expression of ER-targeted human interleukin 6 in Nicotiana benthamiana. PLoS One (2012) 0.85
Expression of functionally active sialylated human erythropoietin in plants. Biotechnol J (2013) 0.84
Transient co-expression of post-transcriptional gene silencing suppressors for increased in planta expression of a recombinant anthrax receptor fusion protein. Int J Mol Sci (2011) 0.84
A plant-produced antigen elicits potent immune responses against West Nile virus in mice. Biomed Res Int (2014) 0.83
Lepidopteran cells, an alternative for the production of recombinant antibodies? MAbs (2012) 0.83
Ebola Virus Infection: Overview and Update on Prevention and Treatment. Infect Dis Ther (2015) 0.83
An efficient Foxtail mosaic virus vector system with reduced environmental risk. BMC Biotechnol (2010) 0.81
Recombinant protein production of earthworm lumbrokinase for potential antithrombotic application. Evid Based Complement Alternat Med (2013) 0.81
The Multiplicity of Cellular Infection Changes Depending on the Route of Cell Infection in a Plant Virus. J Virol (2015) 0.81
The role of the plant-specific ALTERED XYLOGLUCAN9 protein in Arabidopsis cell wall polysaccharide O-acetylation. Plant Physiol (2015) 0.81
Production in yeast of pseudotype virus-like particles harboring functionally active antibody fragments neutralizing the cytolytic activity of vaginolysin. Microb Cell Fact (2011) 0.81
Clinical Safety and Immunogenicity of Tumor-Targeted, Plant-Made Id-KLH Conjugate Vaccines for Follicular Lymphoma. Biomed Res Int (2015) 0.80
Production of recombinant allergens in plants. Phytochem Rev (2008) 0.80
Optimization, validation, and application of a real-time PCR protocol for quantification of viable bacterial cells in municipal sewage sludge and biosolids using reporter genes and Escherichia coli. J Ind Microbiol Biotechnol (2013) 0.79
An efficient Potato virus X -based microRNA silencing in Nicotiana benthamiana. Sci Rep (2016) 0.79
Development of expression vectors based on pepino mosaic virus. Plant Methods (2011) 0.79
Plant-made trastuzumab (herceptin) inhibits HER2/Neu+ cell proliferation and retards tumor growth. PLoS One (2011) 0.79
Monoclonal antibody therapy for Junin virus infection. Proc Natl Acad Sci U S A (2016) 0.79
Multiantibody strategies for HIV. Clin Dev Immunol (2013) 0.78
Prevention and treatment of Clostridium perfringens epsilon toxin intoxication in mice with a neutralizing monoclonal antibody (c4D7) produced in Nicotiana benthamiana. Toxicon (2014) 0.78
RNA viral vectors for improved Agrobacterium-mediated transient expression of heterologous proteins in Nicotiana benthamiana cell suspensions and hairy roots. BMC Biotechnol (2012) 0.78
3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012. Virology (2016) 0.78
Comparison of Expression Vectors for Transient Expression of Recombinant Proteins in Plants. Plant Mol Biol Report (2013) 0.78
5' and 3' Untranslated Regions Strongly Enhance Performance of Geminiviral Replicons in Nicotiana benthamiana Leaves. Front Plant Sci (2016) 0.78
Design of virus-based nanomaterials for medicine, biotechnology, and energy. Chem Soc Rev (2016) 0.77
Gene delivery into plant cells for recombinant protein production. Biomed Res Int (2015) 0.77
Fast track antibody V-gene rescue, recombinant expression in plants and characterization of a PfMSP4-specific antibody. Malar J (2015) 0.77
Post-translational control of genetic circuits using Potyvirus proteases. Nucleic Acids Res (2016) 0.77
Biomanufacturing of protective antibodies and other therapeutics in edible plant tissues for oral applications. Plant Biotechnol J (2016) 0.77
Antibody-based concepts for multipurpose prevention technologies. Antiviral Res (2013) 0.76
Chemically Modified Human Serum Albumin Potently Blocks Entry of Ebola Pseudoviruses and Viruslike Particles. Antimicrob Agents Chemother (2017) 0.75
Designed IgM from glycoengineering. Proc Natl Acad Sci U S A (2014) 0.75
Intracellular Localization, Interactions and Functions of Capsicum Chlorosis Virus Proteins. Front Microbiol (2017) 0.75
Efficient In Vitro and In Vivo Activity of Glyco-Engineered Plant-Produced Rabies Monoclonal Antibodies E559 and 62-71-3. PLoS One (2016) 0.75
The Omics Revolution in Agricultural Research. J Agric Food Chem (2015) 0.75
Experimental countermeasures against Ebola virus: current progress and an ethical conundrum. CMAJ (2014) 0.75
Monoclonal Antibody Purification (Nicotiana benthamiana Plants). Bio Protoc (2014) 0.75
Production of Hybrid Chimeric PVX Particles Using a Combination of TMV and PVX-Based Expression Vectors. Front Bioeng Biotechnol (2015) 0.75
Developments in high-yield system expressed vaccines and immunotherapy. Recent Pat Biotechnol (2010) 0.75
Virus-like particles that display Zika virus envelope protein domain III induce potent neutralizing immune responses in mice. Sci Rep (2017) 0.75
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
Jellyfish green fluorescent protein as a reporter for virus infections. Plant J (1995) 3.95
Systemic Agrobacterium tumefaciens-mediated transfection of viral replicons for efficient transient expression in plants. Nat Biotechnol (2005) 3.39
Production of antibodies in transgenic plants. Nature (1989) 2.78
In planta engineering of viral RNA replicons: efficient assembly by recombination of DNA modules delivered by Agrobacterium. Proc Natl Acad Sci U S A (2004) 2.77
Generation and assembly of secretory antibodies in plants. Science (1995) 2.45
Cell-to-cell and phloem-mediated transport of potato virus X. The role of virions Plant Cell (1998) 1.78
Magnifection--a new platform for expressing recombinant vaccines in plants. Vaccine (2005) 1.69
Fluorescent labelling reveals spatial separation of potyvirus populations in mixed infected Nicotiana benthamiana plants. J Gen Virol (2003) 1.56
Synthesis and self-assembly of a functional monoclonal antibody in transgenic Nicotiana tabacum. Plant Mol Biol (1990) 1.25
On the optimal ratio of heavy to light chain genes for efficient recombinant antibody production by CHO cells. Biotechnol Prog (2005) 1.21
The coat protein of white clover mosaic potexvirus has a role in facilitating cell-to-cell transport in plants. Virology (1992) 1.17
Transient expression of a tumor-specific single-chain fragment and a chimeric antibody in tobacco leaves. Proc Natl Acad Sci U S A (1999) 1.14
Electron microscopy on the behavior of two strains of alfalfa mosaic virus in mixed infections. Virology (1970) 1.13
Inhibition of tumor growth by plant-derived mAb. Proc Natl Acad Sci U S A (2005) 1.08
ER-resident chaperone interactions with recombinant antibodies in transgenic plants. Eur J Biochem (2002) 1.06
Efficacy of plant-produced recombinant antibodies against HCG. Hum Reprod (2002) 1.04
Monoclonal antibody form and function: manufacturing the right antibodies for treating drug abuse. AAPS J (2006) 1.03
Limited utility of blue fluorescent protein (BFP) in monitoring plant virus movement. Biochimie (2002) 1.00
Cell-to-cell movement of potato virus X involves distinct functions of the coat protein. J Gen Virol (2001) 1.00
Expression and assembly of a full-length monoclonal antibody in plants using a plant virus vector. J Immunol Methods (1998) 0.99
Recent progress in plantibody technology. Curr Pharm Des (2005) 0.96
Antibody processing and engineering in plants, and new strategies for vaccine production. Vaccine (2005) 0.95
Enhancement of potato virus X synthesis in doubly infected tobacco occurs in doubly infected cells. Virology (1974) 0.95
Molecular farming of recombinant antibodies in plants. Cell Mol Life Sci (2003) 0.92
Transient expression in tobacco leaves of an aglycosylated recombinant antibody against the epidermal growth factor receptor. Biotechnol Bioeng (2005) 0.91
A one pot, one step, precision cloning method with high throughput capability. PLoS One (2008) 5.94
Golden gate shuffling: a one-pot DNA shuffling method based on type IIs restriction enzymes. PLoS One (2009) 5.24
The auxin influx carrier LAX3 promotes lateral root emergence. Nat Cell Biol (2008) 3.69
Systemic Agrobacterium tumefaciens-mediated transfection of viral replicons for efficient transient expression in plants. Nat Biotechnol (2005) 3.39
Assembly of designer TAL effectors by Golden Gate cloning. PLoS One (2011) 3.05
In planta engineering of viral RNA replicons: efficient assembly by recombination of DNA modules delivered by Agrobacterium. Proc Natl Acad Sci U S A (2004) 2.77
A modular cloning system for standardized assembly of multigene constructs. PLoS One (2011) 2.39
Encoding technical information in GM organisms. Nat Biotechnol (2003) 1.97
Viral vectors for the expression of proteins in plants. Curr Opin Biotechnol (2007) 1.80
Glucosinolate and amino acid biosynthesis in Arabidopsis. Plant Physiol (2004) 1.47
Protection conferred by recombinant Yersinia pestis antigens produced by a rapid and highly scalable plant expression system. Proc Natl Acad Sci U S A (2006) 1.15
Engineering viral expression vectors for plants: the 'full virus' and the 'deconstructed virus' strategies. Curr Opin Plant Biol (2004) 1.13
A golden gate modular cloning toolbox for plants. ACS Synth Biol (2014) 1.11
Conservation of RNA structures enables TNV and BYDV 5' and 3' elements to cooperate synergistically in cap-independent translation. Nucleic Acids Res (2004) 1.04
Fast track assembly of multigene constructs using Golden Gate cloning and the MoClo system. Bioeng Bugs (2012) 1.04
Quick and clean cloning: a ligation-independent cloning strategy for selective cloning of specific PCR products from non-specific mixes. PLoS One (2011) 1.01
CD28 aptamers as powerful immune response modulators. Mol Ther Nucleic Acids (2013) 0.98
Golden Gate cloning. Methods Mol Biol (2014) 0.97
High-level recombinant protein expression in transgenic plants by using a double-inducible viral vector. Proc Natl Acad Sci U S A (2011) 0.96
Generation of families of construct variants using golden gate shuffling. Methods Mol Biol (2011) 0.95
Immunoabsorbent nanoparticles based on a tobamovirus displaying protein A. Proc Natl Acad Sci U S A (2006) 0.93
Immunization with plant-expressed hemagglutinin protects chickens from lethal highly pathogenic avian influenza virus H5N1 challenge infection. J Virol (2010) 0.92
Smallpox subunit vaccine produced in Planta confers protection in mice. Proc Natl Acad Sci U S A (2007) 0.90
High-yield production of authentic human growth hormone using a plant virus-based expression system. Plant Biotechnol J (2005) 0.89
A novel hybrid seed system for plants. Plant Biotechnol J (2007) 0.87
Translation initiation factors eIF4E and eIFiso4E are required for polysome formation and regulate plant growth in tobacco. Plant Mol Biol (2005) 0.86
Design of safe and biologically contained transgenic plants: tools and technologies for controlled transgene flow and expression. Biotechnol Genet Eng Rev (2004) 0.86
Combinatorial DNA assembly using Golden Gate cloning. Methods Mol Biol (2013) 0.81
Oligomerization status influences subcellular deposition and glycosylation of recombinant butyrylcholinesterase in Nicotiana benthamiana. Plant Biotechnol J (2014) 0.81
Translocation of aprotinin, a therapeutic protease inhibitor, into the thylakoid lumen of genetically engineered tobacco chloroplasts. Plant Biotechnol J (2008) 0.80
Emerging antibody-based products. Curr Top Microbiol Immunol (2014) 0.79
Quick and clean cloning. Methods Mol Biol (2014) 0.79
Transfer of transformed chloroplasts from Nicotiana tabacum to the Lycium barbarum plants. Cell Biol Int (2005) 0.79
Identity tags revisited. Nat Biotechnol (2003) 0.77
Affinity purification of streptavidin using tobacco mosaic virus particles as purification tags. Anal Biochem (2004) 0.77
A case study for plant-made pharmaceuticals comparing different plant expression and production systems. Methods Mol Biol (2009) 0.76
Genetic transformation of plastids of different Solanaceae species using tobacco cells as organelle hosts. Theor Appl Genet (2006) 0.76
Production of cybrids in Brassicaceae species. Methods Mol Biol (2006) 0.75