Published in Circ Res on September 14, 2006
Molecular mechanics of cardiac myosin-binding protein C in native thick filaments. Science (2012) 2.48
Acceleration of crossbridge kinetics by protein kinase A phosphorylation of cardiac myosin binding protein C modulates cardiac function. Circ Res (2008) 2.07
In the thick of it: HCM-causing mutations in myosin binding proteins of the thick filament. Circ Res (2011) 1.81
Differential roles of regulatory light chain and myosin binding protein-C phosphorylations in the modulation of cardiac force development. J Physiol (2010) 1.76
Characterization of the cardiac myosin binding protein-C phosphoproteome in healthy and failing human hearts. J Mol Cell Cardiol (2013) 1.75
Protein kinase A-mediated phosphorylation of cMyBP-C increases proximity of myosin heads to actin in resting myocardium. Circ Res (2008) 1.55
Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutations. Circ Res (2013) 1.44
Radial displacement of myosin cross-bridges in mouse myocardium due to ablation of myosin binding protein-C. J Mol Biol (2006) 1.33
The contribution of cardiac myosin binding protein-c Ser282 phosphorylation to the rate of force generation and in vivo cardiac contractility. J Physiol (2014) 1.20
Cardiac myosin binding protein-C: redefining its structure and function. Biophys Rev (2012) 1.15
Model representation of the nonlinear step response in cardiac muscle. J Gen Physiol (2010) 1.15
Effect of troponin I Ser23/24 phosphorylation on Ca2+-sensitivity in human myocardium depends on the phosphorylation background. J Mol Cell Cardiol (2010) 1.14
Myosin binding protein-C phosphorylation is the principal mediator of protein kinase A effects on thick filament structure in myocardium. J Mol Cell Cardiol (2012) 1.13
Roles for cardiac MyBP-C in maintaining myofilament lattice rigidity and prolonging myosin cross-bridge lifetime. Biophys J (2011) 1.11
Protein kinase A-induced myofilament desensitization to Ca(2+) as a result of phosphorylation of cardiac myosin-binding protein C. J Gen Physiol (2010) 1.10
Cardiac MyBP-C regulates the rate and force of contraction in mammalian myocardium. Circ Res (2015) 1.08
The contributions of cardiac myosin binding protein C and troponin I phosphorylation to β-adrenergic enhancement of in vivo cardiac function. J Physiol (2016) 1.08
GSK3β phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human: short communication. Circ Res (2012) 1.07
Diastolic myofilament dysfunction in the failing human heart. Pflugers Arch (2011) 1.05
Transmural variation in myosin heavy chain isoform expression modulates the timing of myocardial force generation in porcine left ventricle. J Physiol (2008) 1.03
Mechanical unfolding of cardiac myosin binding protein-C by atomic force microscopy. Biophys J (2011) 1.03
Neonatal mouse-derived engineered cardiac tissue: a novel model system for studying genetic heart disease. Circ Res (2011) 1.02
Sarcomere length dependence of power output is increased after PKA treatment in rat cardiac myocytes. Am J Physiol Heart Circ Physiol (2009) 1.00
Regulation of contraction in mammalian striated muscles--the plot thick-ens. J Gen Physiol (2010) 0.99
Cardiac myosin binding protein C phosphorylation in cardiac disease. J Muscle Res Cell Motil (2011) 0.98
The extent of cardiac myosin binding protein-C phosphorylation modulates actomyosin function in a graded manner. J Muscle Res Cell Motil (2012) 0.97
Acute atrial tachyarrhythmia induces angiotensin II type 1 receptor-mediated oxidative stress and microvascular flow abnormalities in the ventricles. Eur Heart J (2009) 0.96
Magnitude of length-dependent changes in contractile properties varies with titin isoform in rat ventricles. Am J Physiol Heart Circ Physiol (2011) 0.96
Effects of contractile protein phosphorylation on force development in permeabilized rat cardiac myocytes. Basic Res Cardiol (2007) 0.95
Post-translational control of cardiac hemodynamics through myosin binding protein C. Pflugers Arch (2013) 0.95
The dilated cardiomyopathy-causing mutation ACTC E361G in cardiac muscle myofibrils specifically abolishes modulation of Ca(2+) regulation by phosphorylation of troponin I. Biophys J (2014) 0.92
A gain-of-function mutation in the M-domain of cardiac myosin-binding protein-C increases binding to actin. J Biol Chem (2013) 0.91
Myocardial infarction-induced N-terminal fragment of cardiac myosin-binding protein C (cMyBP-C) impairs myofilament function in human myocardium. J Biol Chem (2014) 0.90
Cardiac Myosin-binding protein C modulates the tuning of the molecular motor in the heart. Biophys J (2008) 0.90
Phospholemman is a negative feed-forward regulator of Ca2+ in β-adrenergic signaling, accelerating β-adrenergic inotropy. J Mol Cell Cardiol (2012) 0.88
Phosphorylation modulates the mechanical stability of the cardiac myosin-binding protein C motif. Biophys J (2013) 0.88
Ablation of cardiac myosin-binding protein-C accelerates contractile kinetics in engineered cardiac tissue. J Gen Physiol (2013) 0.85
Phosphorylation and calcium antagonistically tune myosin-binding protein C's structure and function. Proc Natl Acad Sci U S A (2016) 0.84
Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-C. J Mol Cell Cardiol (2015) 0.84
Cardiac Myosin Binding Protein-C Phosphorylation Modulates Myofilament Length-Dependent Activation. Front Physiol (2016) 0.81
Cardiac myosin-binding protein C: hypertrophic cardiomyopathy mutations and structure-function relationships. Pflugers Arch (2013) 0.81
New insights in the role of cardiac myosin binding protein C as a regulator of cardiac contractility. Circ Res (2006) 0.81
Enhanced cardiac function in Gravin mutant mice involves alterations in the β-adrenergic receptor signaling cascade. PLoS One (2013) 0.81
Titin-mediated control of cardiac myofibrillar function. Arch Biochem Biophys (2013) 0.81
Molecule specific effects of PKA-mediated phosphorylation on rat isolated heart and cardiac myofibrillar function. Arch Biochem Biophys (2016) 0.80
ADP-stimulated contraction: A predictor of thin-filament activation in cardiac disease. Proc Natl Acad Sci U S A (2015) 0.78
Insights into length-dependent regulation of cardiac cross-bridge cycling kinetics in human myocardium. Arch Biochem Biophys (2016) 0.78
Preserved cross-bridge kinetics in human hypertrophic cardiomyopathy patients with MYBPC3 mutations. Pflugers Arch (2013) 0.77
Cross-species mechanical fingerprinting of cardiac myosin binding protein-C. Biophys J (2013) 0.77
Cardiac myosin-binding protein C: A protein once at loose ends finds its regulatory groove. Proc Natl Acad Sci U S A (2016) 0.76
Cardiomyopathy-related mutation (A30V) in mouse cardiac troponin T divergently alters the magnitude of stretch activation in α- and β-myosin heavy chain fibers. Am J Physiol Heart Circ Physiol (2016) 0.75
Historical perspective on heart function: the Frank-Starling Law. Biophys Rev (2015) 0.75
The role of protein kinase C-mediated phosphorylation of sarcomeric proteins in the heart-detrimental or beneficial? Biophys Rev (2011) 0.75
Cardiac myosin binding protein-C Ser(302) phosphorylation regulates cardiac β-adrenergic reserve. Sci Adv (2017) 0.75
MYBPC1, an Emerging Myopathic Gene: What We Know and What We Need to Learn. Front Physiol (2016) 0.75
Sarcomeric protein modification during adrenergic stress enhances cross-bridge kinetics and cardiac output. J Appl Physiol (1985) (2016) 0.75
Cardiac Myofibrillar Contractile Properties During the Progression from Hypertension to Decompensated Heart Failure. Am J Physiol Heart Circ Physiol (2017) 0.75
Force development and intracellular Ca(2+) in intact cardiac muscles from gravin mutant mice. Eur J Pharmacol (2017) 0.75
Hypertrophic cardiomyopathy in cardiac myosin binding protein-C knockout mice. Circ Res (2002) 2.82
Three-dimensional structure of vertebrate cardiac muscle myosin filaments. Proc Natl Acad Sci U S A (2008) 2.39
Top-down quantitative proteomics identified phosphorylation of cardiac troponin I as a candidate biomarker for chronic heart failure. J Proteome Res (2011) 2.17
Differential roles of cardiac myosin-binding protein C and cardiac troponin I in the myofibrillar force responses to protein kinase A phosphorylation. Circ Res (2007) 2.11
Ablation of cardiac myosin-binding protein-C accelerates stretch activation in murine skinned myocardium. Circ Res (2006) 2.10
Top-down high-resolution mass spectrometry of cardiac myosin binding protein C revealed that truncation alters protein phosphorylation state. Proc Natl Acad Sci U S A (2009) 2.10
Acceleration of crossbridge kinetics by protein kinase A phosphorylation of cardiac myosin binding protein C modulates cardiac function. Circ Res (2008) 2.07
Basal myosin light chain phosphorylation is a determinant of Ca2+ sensitivity of force and activation dependence of the kinetics of myocardial force development. Am J Physiol Heart Circ Physiol (2004) 1.93
Loaded shortening, power output, and rate of force redevelopment are increased with knockout of cardiac myosin binding protein-C. Circ Res (2003) 1.81
Differential roles of regulatory light chain and myosin binding protein-C phosphorylations in the modulation of cardiac force development. J Physiol (2010) 1.76
Ablation of myosin-binding protein-C accelerates force development in mouse myocardium. Biophys J (2006) 1.69
Cytoplasmic gamma-actin contributes to a compensatory remodeling response in dystrophin-deficient muscle. Proc Natl Acad Sci U S A (2006) 1.68
Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease. J Clin Invest (2012) 1.59
Understanding the organisation and role of myosin binding protein C in normal striated muscle by comparison with MyBP-C knockout cardiac muscle. J Mol Biol (2008) 1.57
Protein kinase A-mediated phosphorylation of cMyBP-C increases proximity of myosin heads to actin in resting myocardium. Circ Res (2008) 1.55
Acceleration of stretch activation in murine myocardium due to phosphorylation of myosin regulatory light chain. J Gen Physiol (2006) 1.53
Role of cardiac myosin binding protein C in sustaining left ventricular systolic stiffening. Circ Res (2004) 1.52
Utrophin binds laterally along actin filaments and can couple costameric actin with sarcolemma when overexpressed in dystrophin-deficient muscle. Mol Biol Cell (2002) 1.44
Cytoplasmic gamma-actin is not required for skeletal muscle development but its absence leads to a progressive myopathy. Dev Cell (2006) 1.43
SLControl: PC-based data acquisition and analysis for muscle mechanics. Am J Physiol Heart Circ Physiol (2003) 1.36
Activation dependence of stretch activation in mouse skinned myocardium: implications for ventricular function. J Gen Physiol (2006) 1.35
Radial displacement of myosin cross-bridges in mouse myocardium due to ablation of myosin binding protein-C. J Mol Biol (2006) 1.33
Binding of myosin binding protein-C to myosin subfragment S2 affects contractility independent of a tether mechanism. Circ Res (2004) 1.33
Role of myosin heavy chain composition in the stretch activation response of rat myocardium. J Physiol (2006) 1.29
History-dependent mechanical properties of permeabilized rat soleus muscle fibers. Biophys J (2002) 1.29
Myosin binding protein C interaction with actin: characterization and mapping of the binding site. J Biol Chem (2010) 1.27
Mutation that dramatically alters rat titin isoform expression and cardiomyocyte passive tension. J Mol Cell Cardiol (2008) 1.20
Myosin light chain phosphorylation is critical for adaptation to cardiac stress. Circulation (2012) 1.19
Titin isoform changes in rat myocardium during development. Mech Dev (2004) 1.18
Myosin binding protein-C phosphorylation is the principal mediator of protein kinase A effects on thick filament structure in myocardium. J Mol Cell Cardiol (2012) 1.13
Expression of Dp260 in muscle tethers the actin cytoskeleton to the dystrophin-glycoprotein complex and partially prevents dystrophy. Hum Mol Genet (2002) 1.10
Protein kinase A-induced myofilament desensitization to Ca(2+) as a result of phosphorylation of cardiac myosin-binding protein C. J Gen Physiol (2010) 1.10
Developmental changes in rat cardiac titin/connectin: transitions in normal animals and in mutants with a delayed pattern of isoform transition. J Muscle Res Cell Motil (2005) 1.09
Myosin light chain 2 into the mainstream of cardiac development and contractility. Circ Res (2006) 1.05
Frank-Starling relationship: long on importance, short on mechanism. Circ Res (2002) 1.04
Transmural variation in myosin heavy chain isoform expression modulates the timing of myocardial force generation in porcine left ventricle. J Physiol (2008) 1.03
Cooperativity in the regulation of force and the kinetics of force development in heart and skeletal muscles: cross-bridge activation of force. Adv Exp Med Biol (2007) 1.03
Contributions of stretch activation to length-dependent contraction in murine myocardium. J Gen Physiol (2006) 1.00
Expression of cardiac troponin T with COOH-terminal truncation accelerates cross-bridge interaction kinetics in mouse myocardium. Am J Physiol Heart Circ Physiol (2004) 0.97
Magnitude of length-dependent changes in contractile properties varies with titin isoform in rat ventricles. Am J Physiol Heart Circ Physiol (2011) 0.96
Cycling cross-bridges increase myocardial stiffness at submaximal levels of Ca2+ activation. Biophys J (2003) 0.95
Cardiac myosin binding protein-C restricts intrafilament torsional dynamics of actin in a phosphorylation-dependent manner. Proc Natl Acad Sci U S A (2012) 0.94
Determination of rate constants for turnover of myosin isoforms in rat myocardium: implications for in vivo contractile kinetics. Am J Physiol Heart Circ Physiol (2009) 0.91
Dissociation of structural and functional phenotypes in cardiac myosin-binding protein C conditional knockout mice. Circulation (2012) 0.89
Overexpression of TEAD-1 in transgenic mouse striated muscles produces a slower skeletal muscle contractile phenotype. J Biol Chem (2008) 0.89
Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy. PLoS One (2012) 0.88
Expression patterns of cardiac myofilament proteins: genomic and protein analysis of surgical myectomy tissue from patients with obstructive hypertrophic cardiomyopathy. Circ Heart Fail (2009) 0.86
Solution structure of heavy meromyosin by small-angle scattering. J Biol Chem (2002) 0.85
Effects of low-level α-myosin heavy chain expression on contractile kinetics in porcine myocardium. Am J Physiol Heart Circ Physiol (2011) 0.85
Resolving myoarchitectural disarray in the mouse ventricular wall with diffusion spectrum magnetic resonance imaging. Ann Biomed Eng (2010) 0.84
Intramolecular interactions in the N-domain of cardiac troponin C are important determinants of calcium sensitivity of force development. Biochemistry (2008) 0.82
Nitroxyl, redox switches, cardiac myofilaments, and heart failure: a prequel to novel therapeutics? Circ Res (2012) 0.78
Dissecting human skeletal muscle troponin proteoforms by top-down mass spectrometry. J Muscle Res Cell Motil (2015) 0.77
Cardiac tissue structure, properties, and performance: a materials science perspective. Ann Biomed Eng (2014) 0.77
Medicine. Chemically tuned myosin motors. Science (2011) 0.75
Removal of contaminating calcium from buffer solutions used in calcium binding assays. Anal Biochem (2007) 0.75