Antifungal activity from 14-helical beta-peptides.

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Hydrophobicity of Antifungal β-Peptides Is Associated with Their Cytotoxic Effect on In Vitro Human Colon Caco-2 and Liver HepG2 Cells. PLoS One (2016) 1.39

Lipidated cyclic γ-AApeptides display both antimicrobial and anti-inflammatory activity. ACS Chem Biol (2013) 0.94

Nylon-3 polymers with selective antifungal activity. J Am Chem Soc (2013) 0.91

Structure-activity relationships among antifungal nylon-3 polymers: identification of materials active against drug-resistant strains of Candida albicans. J Am Chem Soc (2014) 0.89

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Polymer multilayers loaded with antifungal β-peptides kill planktonic Candida albicans and reduce formation of fungal biofilms on the surfaces of flexible catheter tubes. J Control Release (2014) 0.85

Comparison of design strategies for promotion of beta-peptide 14-helix stability in water. Chembiochem (2008) 0.85

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Mechanical stability of helical beta-peptides and a comparison of explicit and implicit solvent models. Biophys J (2008) 0.83

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Hydrophobicity and helicity regulate the antifungal activity of 14-helical β-peptides. ACS Chem Biol (2014) 0.82

The development of antimicrobial a-AApeptides that suppress proinflammatory immune responses. Chembiochem (2014) 0.82

Nylon-3 polymers active against drug-resistant Candida albicans biofilms. J Am Chem Soc (2015) 0.81

Antifungal Activity of 14-Helical β-Peptides against Planktonic Cells and Biofilms of Candida Species. Pharmaceuticals (Basel) (2015) 0.80

γ-AApeptides: Design, Structure, and Applications. Acc Chem Res (2016) 0.79

Novel antimicrobial peptide-modified azithromycin-loaded liposomes against methicillin-resistant Staphylococcus aureus. Int J Nanomedicine (2016) 0.77

Intraluminal Release of an Antifungal β-Peptide Enhances the Antifungal and Anti-Biofilm Activities of Multilayer-Coated Catheters in a Rat Model of Venous Catheter Infection. ACS Biomater Sci Eng (2015) 0.77

Correlating antimicrobial activity and model membrane leakage induced by nylon-3 polymers and detergents. Soft Matter (2015) 0.77

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Helical 1:1 α/Sulfono-γ-AA Heterogeneous Peptides with Antibacterial Activity. Biomacromolecules (2016) 0.76

Antifungal activity of a β-peptide in synthetic urine media: Toward materials-based approaches to reducing catheter-associated urinary tract fungal infections. Acta Biomater (2016) 0.75

Antimicrobial AA Peptides. Curr Top Med Chem (2016) 0.75

A cationic polymer that shows high antifungal activity against diverse human pathogens. Antimicrob Agents Chemother (2017) 0.75

Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature (2011) 13.92

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor. Nature (2011) 9.61

Functional cardiomyocytes derived from human induced pluripotent stem cells. Circ Res (2009) 7.09

Structure and function of an irreversible agonist-β(2) adrenoceptor complex. Nature (2011) 5.35

Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc Natl Acad Sci U S A (2012) 4.85

Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions. Nat Protoc (2012) 3.22

Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells: the matrix sandwich method. Circ Res (2012) 2.91

Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins. Nat Methods (2010) 2.77

Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells. Nat Biotechnol (2012) 2.33

Mimicry of antimicrobial host-defense peptides by random copolymers. J Am Chem Soc (2007) 2.12

Foldamers with heterogeneous backbones. Acc Chem Res (2008) 1.96

Structural and biological mimicry of protein surface recognition by alpha/beta-peptide foldamers. Proc Natl Acad Sci U S A (2009) 1.87

3-D microwell culture of human embryonic stem cells. Biomaterials (2006) 1.77

Retinoic acid and bone morphogenetic protein signaling synergize to efficiently direct epithelial differentiation of human embryonic stem cells. Stem Cells (2007) 1.71

Targeting protein-protein interactions: lessons from p53/MDM2. Biopolymers (2007) 1.67

Mimicry of host-defense peptides by unnatural oligomers: antimicrobial beta-peptides. J Am Chem Soc (2002) 1.66

Effects of substrate mechanics on contractility of cardiomyocytes generated from human pluripotent stem cells. Int J Cell Biol (2012) 1.63

Cytoplasmic and nuclear delivery of a TAT-derived peptide and a beta-peptide after endocytic uptake into HeLa cells. J Biol Chem (2003) 1.57

(alpha/beta+alpha)-peptide antagonists of BH3 domain/Bcl-x(L) recognition: toward general strategies for foldamer-based inhibition of protein-protein interactions. J Am Chem Soc (2007) 1.56

Translocation of a beta-peptide across cell membranes. J Am Chem Soc (2002) 1.55

Helix bundle quaternary structure from alpha/beta-peptide foldamers. J Am Chem Soc (2007) 1.54

Evaluation of diverse α/β-backbone patterns for functional α-helix mimicry: analogues of the Bim BH3 domain. J Am Chem Soc (2011) 1.49

The microwell control of embryoid body size in order to regulate cardiac differentiation of human embryonic stem cells. Biomaterials (2009) 1.46

Interplay among folding, sequence, and lipophilicity in the antibacterial and hemolytic activities of alpha/beta-peptides. J Am Chem Soc (2007) 1.40

EAP1, a Candida albicans gene involved in binding human epithelial cells. Eukaryot Cell (2003) 1.40

Chimeric (alpha/beta + alpha)-peptide ligands for the BH3-recognition cleft of Bcl-XL: critical role of the molecular scaffold in protein surface recognition. J Am Chem Soc (2005) 1.39

A global assessment of stem cell engineering. Tissue Eng Part A (2014) 1.38

Dual mechanism of bacterial lethality for a cationic sequence-random copolymer that mimics host-defense antimicrobial peptides. J Mol Biol (2008) 1.37

Inhibition of human embryonic stem cell differentiation by mechanical strain. J Cell Physiol (2006) 1.36

Sequence-based design of alpha/beta-peptide foldamers that mimic BH3 domains. Angew Chem Int Ed Engl (2008) 1.35

Interplay among side chain sequence, backbone composition, and residue rigidification in polypeptide folding and assembly. Proc Natl Acad Sci U S A (2008) 1.35

High-resolution structural characterization of a helical alpha/beta-peptide foldamer bound to the anti-apoptotic protein Bcl-xL. Angew Chem Int Ed Engl (2009) 1.34

Regulation of iron transport in Streptococcus pneumoniae by RitR, an orphan response regulator. J Bacteriol (2004) 1.34

Eap1p, an adhesin that mediates Candida albicans biofilm formation in vitro and in vivo. Eukaryot Cell (2007) 1.32

Rational development of beta-peptide inhibitors of human cytomegalovirus entry. J Biol Chem (2005) 1.32

Structure-activity studies of 14-helical antimicrobial beta-peptides: probing the relationship between conformational stability and antimicrobial potency. J Am Chem Soc (2002) 1.27

Structure-activity relationships among random nylon-3 copolymers that mimic antibacterial host-defense peptides. J Am Chem Soc (2009) 1.26

Preferred side-chain constellations at antiparallel coiled-coil interfaces. Proc Natl Acad Sci U S A (2008) 1.26

Application of microwave irradiation to the synthesis of 14-helical beta-peptides. Org Lett (2005) 1.24

Role of membrane lipids in the mechanism of bacterial species selective toxicity by two alpha/beta-antimicrobial peptides. Biochim Biophys Acta (2006) 1.23

Engineering the stem cell microenvironment. Biotechnol Prog (2007) 1.23

TGFbeta/Activin/Nodal pathway in inhibition of human embryonic stem cell differentiation by mechanical strain. Biophys J (2008) 1.22

Diphenylprolinol methyl ether: a highly enantioselective catalyst for Michael addition of aldehydes to simple enones. Org Lett (2005) 1.22

Scalable culture and cryopreservation of human embryonic stem cells on microcarriers. Biotechnol Prog (2009) 1.21

Protein prosthesis: a semisynthetic enzyme with a beta-peptide reverse turn. J Am Chem Soc (2002) 1.20

Innovation in the culture and derivation of pluripotent human stem cells. Curr Opin Biotechnol (2008) 1.18

Two helical conformations from a single foldamer backbone: "split personality" in short alpha/beta-peptides. Angew Chem Int Ed Engl (2004) 1.17

Access to poly-beta-peptides with functionalized side chains and end groups via controlled ring-opening polymerization of beta-lactams. J Am Chem Soc (2009) 1.17

Residue requirements for helical folding in short alpha/beta-peptides: crystallographic characterization of the 11-helix in an optimized sequence. J Am Chem Soc (2005) 1.17

Modulation of Wnt/β-catenin signaling in human embryonic stem cells using a 3-D microwell array. Biomaterials (2011) 1.16

Exploration of backbone space in foldamers containing alpha- and beta-amino acid residues: developing protease-resistant oligomers that bind tightly to the BH3-recognition cleft of Bcl-xL. Chembiochem (2007) 1.16

Analysis of the factors that stabilize a designed two-stranded antiparallel beta-sheet. Protein Sci (2002) 1.14

Phosphorylation of yellow fever virus NS5 alters methyltransferase activity. Virology (2008) 1.13

Cryopreservation of adherent human embryonic stem cells. Biotechnol Bioeng (2004) 1.13

Efficient synthesis of a beta-peptide combinatorial library with microwave irradiation. J Am Chem Soc (2005) 1.13

Directed differentiation of human embryonic stem cells to epidermal progenitors. Methods Mol Biol (2010) 1.12

Distinct domains of the Candida albicans adhesin Eap1p mediate cell-cell and cell-substrate interactions. Microbiology (2008) 1.12

Biocidal activity of polystyrenes that are cationic by virtue of protonation. Org Lett (2004) 1.10

Electrostatic versus steric effects in peptidomimicry: synthesis and secondary structure analysis of gramicidin S analogues with (E)-alkene peptide isosteres. J Am Chem Soc (2005) 1.10

Design of non-cysteine-containing antimicrobial beta-hairpins: structure-activity relationship studies with linear protegrin-1 analogues. Biochemistry (2002) 1.10

Environment-independent 14-helix formation in short beta-peptides: striking a balance between shape control and functional diversity. J Am Chem Soc (2003) 1.09

A rationally designed aldolase foldamer. Angew Chem Int Ed Engl (2009) 1.08

Short alkylated peptoid mimics of antimicrobial lipopeptides. Antimicrob Agents Chemother (2010) 1.08

Identification of Candida albicans genes that induce Saccharomyces cerevisiae cell adhesion and morphogenesis. Biotechnol Prog (2005) 1.08

Hydrophile scanning as a complement to alanine scanning for exploring and manipulating protein-protein recognition: application to the Bim BH3 domain. Protein Sci (2008) 1.08

α-Helix mimicry with α/β-peptides. Methods Enzymol (2013) 1.07

Stabilizing and destabilizing effects of phenylalanine --> F5-phenylalanine mutations on the folding of a small protein. J Am Chem Soc (2006) 1.06

Efficient synthesis of enantiomerically pure beta2-amino acids via chiral isoxazolidinones. J Org Chem (2003) 1.06

Catalytic transamidation reactions compatible with tertiary amide metathesis under ambient conditions. J Am Chem Soc (2009) 1.06

Molecular architecture with functionalized beta-peptide helices. Angew Chem Int Ed Engl (2003) 1.06

Tandem facial amphiphiles for membrane protein stabilization. J Am Chem Soc (2010) 1.05

Phosphorylation of the RitR DNA-binding domain by a Ser-Thr phosphokinase: implications for global gene regulation in the streptococci. Mol Microbiol (2008) 1.04

Structural basis of Bcl-xL recognition by a BH3-mimetic α/β-peptide generated by sequence-based design. Chembiochem (2011) 1.04

Unexpected relationships between structure and function in alpha,beta-peptides: antimicrobial foldamers with heterogeneous backbones. J Am Chem Soc (2004) 1.03

Analyzing the dose-dependence of the Saccharomyces cerevisiae global transcriptional response to methyl methanesulfonate and ionizing radiation. BMC Genomics (2006) 1.02

Enantioselective organocatalytic Michael additions of aldehydes to enones with imidazolidinones: cocatalyst effects and evidence for an enamine intermediate. J Am Chem Soc (2005) 1.02

Catalytic transamidation under moderate conditions. J Am Chem Soc (2003) 1.01

Glycotripod amphiphiles for solubilization and stabilization of a membrane-protein superassembly: importance of branching in the hydrophilic portion. Chembiochem (2008) 1.01

Discrete heterogeneous quaternary structure formed by alpha/beta-peptide foldamers and alpha-peptides. J Am Chem Soc (2007) 1.00

Origins of the high 14-helix propensity of cyclohexyl-rigidified residues in beta-peptides. Org Lett (2007) 1.00

Antimicrobial 14-helical beta-peptides: potent bilayer disrupting agents. Biochemistry (2004) 1.00

Parallel β-sheet vibrational couplings revealed by 2D IR spectroscopy of an isotopically labeled macrocycle: quantitative benchmark for the interpretation of amyloid and protein infrared spectra. J Am Chem Soc (2012) 0.99

An antiparallel alpha-helical coiled-coil model system for rapid assessment of side-chain recognition at the hydrophobic interface. J Am Chem Soc (2006) 0.98

Effect of sequence and structural properties on 14-helical beta-peptide activity against Candida albicans planktonic cells and biofilms. ACS Chem Biol (2009) 0.97

Ordering a dynamic protein via a small-molecule stabilizer. J Am Chem Soc (2013) 0.97

H/D exchange- and mass spectrometry-based strategy for the thermodynamic analysis of protein-ligand binding. Anal Chem (2007) 0.97

Parallel synthesis of peptide libraries using microwave irradiation. Nat Protoc (2007) 0.97

Insulin inhibits cardiac mesoderm, not mesendoderm, formation during cardiac differentiation of human pluripotent stem cells and modulation of canonical Wnt signaling can rescue this inhibition. Stem Cells (2013) 0.97