Published in J Mol Biol on September 01, 2006
Exploiting bacterial DNA gyrase as a drug target: current state and perspectives. Appl Microbiol Biotechnol (2011) 1.85
MqsR, a crucial regulator for quorum sensing and biofilm formation, is a GCU-specific mRNA interferase in Escherichia coli. J Biol Chem (2009) 1.74
Doc of prophage P1 is inhibited by its antitoxin partner Phd through fold complementation. J Biol Chem (2008) 1.62
Toxin-antitoxin systems as multilevel interaction systems. Toxins (Basel) (2014) 1.36
RelB and RelE of Escherichia coli form a tight complex that represses transcription via the ribbon-helix-helix motif in RelB. J Mol Biol (2009) 1.35
The solution structure of ParD, the antidote of the ParDE toxin antitoxin module, provides the structural basis for DNA and toxin binding. Protein Sci (2007) 1.14
Structure of the Escherichia coli antitoxin MqsA (YgiT/b3021) bound to its gene promoter reveals extensive domain rearrangements and the specificity of transcriptional regulation. J Biol Chem (2010) 1.11
A conserved mode of protein recognition and binding in a ParD-ParE toxin-antitoxin complex. Biochemistry (2010) 1.05
Regulating toxin-antitoxin expression: controlled detonation of intracellular molecular timebombs. Toxins (Basel) (2014) 1.00
Influence of operator site geometry on transcriptional control by the YefM-YoeB toxin-antitoxin complex. J Bacteriol (2008) 0.96
VapC6, a ribonucleolytic toxin regulates thermophilicity in the crenarchaeote Sulfolobus solfataricus. RNA (2011) 0.96
Structural studies of E73 from a hyperthermophilic archaeal virus identify the "RH3" domain, an elaborated ribbon-helix-helix motif involved in DNA recognition. Biochemistry (2012) 0.94
The transcription factor AmrZ utilizes multiple DNA binding modes to recognize activator and repressor sequences of Pseudomonas aeruginosa virulence genes. PLoS Pathog (2012) 0.94
Vibrio cholerae ParE2 poisons DNA gyrase via a mechanism distinct from other gyrase inhibitors. J Biol Chem (2010) 0.92
Interactions of Kid-Kis toxin-antitoxin complexes with the parD operator-promoter region of plasmid R1 are piloted by the Kis antitoxin and tuned by the stoichiometry of Kid-Kis oligomers. Nucleic Acids Res (2007) 0.91
Modeling of the structure and interactions of the B. anthracis antitoxin, MoxX: deletion mutant studies highlight its modular structure and repressor function. J Comput Aided Mol Des (2011) 0.90
Structural basis of mRNA recognition and cleavage by toxin MazF and its regulation by antitoxin MazE in Bacillus subtilis. Mol Cell (2013) 0.89
The Escherichia coli toxin MqsR destabilizes the transcriptional repression complex formed between the antitoxin MqsA and the mqsRA operon promoter. J Biol Chem (2012) 0.89
Solution structure and membrane binding of the toxin fst of the par addiction module. Biochemistry (2010) 0.86
Keeping the Wolves at Bay: Antitoxins of Prokaryotic Type II Toxin-Antitoxin Systems. Front Mol Biosci (2016) 0.85
Recent advancements in toxin and antitoxin systems involved in bacterial programmed cell death. Int J Microbiol (2010) 0.85
Additional role for the ccd operon of F-plasmid as a transmissible persistence factor. Proc Natl Acad Sci U S A (2012) 0.85
Maintenance forced by a restriction-modification system can be modulated by a region in its modification enzyme not essential for methyltransferase activity. J Bacteriol (2008) 0.84
A general model for toxin-antitoxin module dynamics can explain persister cell formation in E. coli. PLoS Comput Biol (2013) 0.84
Crystallization of Doc and the Phd-Doc toxin-antitoxin complex. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.83
A common origin for the bacterial toxin-antitoxin systems parD and ccd, suggested by analyses of toxin/target and toxin/antitoxin interactions. PLoS One (2012) 0.80
Linkage, mobility, and selfishness in the MazF family of bacterial toxins: a snapshot of bacterial evolution. Genome Biol Evol (2013) 0.79
Structure and function of AvtR, a novel transcriptional regulator from a hyperthermophilic archaeal lipothrixvirus. J Virol (2012) 0.79
Helicobacter pylori NikR protein exhibits distinct conformations when bound to different promoters. J Biol Chem (2011) 0.79
Plasmids of carotenoid-producing Paracoccus spp. (Alphaproteobacteria) - structure, diversity and evolution. PLoS One (2013) 0.78
Unrelated toxin-antitoxin systems cooperate to induce persistence. J R Soc Interface (2015) 0.78
Crystallization of the HigBA2 toxin-antitoxin complex from Vibrio cholerae. Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 0.78
Combinatorial targeting of ribbon-helix-helix artificial transcription factors to chimeric recognition sites. Nucleic Acids Res (2012) 0.77
The Pseudomonas aeruginosa AmrZ C-terminal domain mediates tetramerization and is required for its activator and repressor functions. Environ Microbiol Rep (2015) 0.77
Wake me when it's over - Bacterial toxin-antitoxin proteins and induced dormancy. Exp Biol Med (Maywood) (2016) 0.76
Developing Universal Genetic Tools for Rapid and Efficient Deletion Mutation in Vibrio Species Based on Suicide T-Vectors Carrying a Novel Counterselectable Marker, vmi480. PLoS One (2015) 0.75
Stabilization of the Virulence Plasmid pSLT of Salmonella Typhimurium by Three Maintenance Systems and Its Evaluation by Using a New Stability Test. Front Mol Biosci (2016) 0.75
Stability of the GraA Antitoxin Depends on Growth Phase, ATP Level, and Global Regulator MexT. J Bacteriol (2015) 0.75
Crystallization and preliminary X-ray analysis of two variants of the Escherichia coli O157 ParE2-PaaA2 toxin-antitoxin complex. Acta Crystallogr F Struct Biol Commun (2014) 0.75
A Structure-free Method for Quantifying Conformational Flexibility in proteins. Sci Rep (2016) 0.75
Molecular mechanism governing ratio-dependent transcription regulation in the ccdAB operon. Nucleic Acids Res (2017) 0.75
Purification and crystallization of Phd, the antitoxin of the phd/doc operon. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.75
Resonance assignment of disordered protein with repetitive and overlapping sequence using combinatorial approach reveals initial structural propensities and local restrictions in the denatured state. J Biomol NMR (2016) 0.75
A new yeast poly(A) polymerase complex involved in RNA quality control. PLoS Biol (2005) 5.43
Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A. Nat Chem Biol (2006) 3.89
Lipolysis - a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores. Prog Lipid Res (2010) 2.60
Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation. Cell (2009) 2.60
What is the benefit to Escherichia coli of having multiple toxin-antitoxin systems in its genome? J Bacteriol (2007) 2.29
Overproduction of the Lon protease triggers inhibition of translation in Escherichia coli: involvement of the yefM-yoeB toxin-antitoxin system. Mol Microbiol (2004) 2.29
Diversity of bacterial type II toxin-antitoxin systems: a comprehensive search and functional analysis of novel families. Nucleic Acids Res (2011) 2.19
RNA-specific ribonucleotidyl transferases. RNA (2007) 2.15
Genome-wide analysis of pre-mRNA 3' end processing reveals a decisive role of human cleavage factor I in the regulation of 3' UTR length. Cell Rep (2012) 2.07
A role for SSU72 in balancing RNA polymerase II transcription elongation and termination. Mol Cell (2002) 2.06
WW domains provide a platform for the assembly of multiprotein networks. Mol Cell Biol (2005) 1.97
Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions. J Lipid Res (2008) 1.95
Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. EMBO J (2004) 1.92
Direct interactions between subunits of CPSF and the U2 snRNP contribute to the coupling of pre-mRNA 3' end processing and splicing. Mol Cell (2006) 1.86
The C-terminal region of human adipose triglyceride lipase affects enzyme activity and lipid droplet binding. J Biol Chem (2008) 1.80
An interaction between U2AF 65 and CF I(m) links the splicing and 3' end processing machineries. EMBO J (2006) 1.79
Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization. J Biol Chem (2004) 1.78
Toxins-antitoxins: diversity, evolution and function. Crit Rev Biochem Mol Biol (2011) 1.74
The structure and binding behavior of the bacterial cell surface layer protein SbsC. Structure (2008) 1.72
Independent functions of yeast Pcf11p in pre-mRNA 3' end processing and in transcription termination. EMBO J (2003) 1.72
Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase. Cell Metab (2012) 1.71
RNA-mediated sequestration of the RNA helicase eIF4A by Pateamine A inhibits translation initiation. Chem Biol (2006) 1.71
Yhh1p/Cft1p directly links poly(A) site recognition and RNA polymerase II transcription termination. EMBO J (2002) 1.71
Biological roles of the Lon ATP-dependent protease. Res Microbiol (2006) 1.65
RNA editing by adenosine deaminases generates RNA and protein diversity. Biochimie (2002) 1.64
The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments. Dev Cell (2012) 1.54
Post-transcriptional global regulation by CsrA in bacteria. Cell Mol Life Sci (2010) 1.53
Selective pharmacological targeting of a DEAD box RNA helicase. PLoS One (2008) 1.49
Functional analysis of yeast snoRNA and snRNA 3'-end formation mediated by uncoupling of cleavage and polyadenylation. Mol Cell Biol (2002) 1.49
Chromosomal toxin-antitoxin systems may act as antiaddiction modules. J Bacteriol (2008) 1.46
Molecular basis of gyrase poisoning by the addiction toxin CcdB. J Mol Biol (2005) 1.43
The Staphylococci phages family: an overview. Viruses (2012) 1.41
Different modes of IgE binding to CD23 revealed with major birch allergen, Bet v 1-specific monoclonal IgE. Immunol Cell Biol (2012) 1.41
tadA, an essential tRNA-specific adenosine deaminase from Escherichia coli. EMBO J (2002) 1.38
Distinct roles of non-canonical poly(A) polymerases in RNA metabolism. PLoS Genet (2009) 1.33
G0/G1 switch gene-2 regulates human adipocyte lipolysis by affecting activity and localization of adipose triglyceride lipase. J Lipid Res (2012) 1.32
The N-terminal region of comparative gene identification-58 (CGI-58) is important for lipid droplet binding and activation of adipose triglyceride lipase. J Biol Chem (2010) 1.30
Splicing factors stimulate polyadenylation via USEs at non-canonical 3' end formation signals. EMBO J (2007) 1.27
Biochemical and structural insights into substrate binding and catalytic mechanism of mammalian poly(A) polymerase. J Mol Biol (2004) 1.26
New toxins homologous to ParE belonging to three-component toxin-antitoxin systems in Escherichia coli O157:H7. Mol Microbiol (2010) 1.25
Rejuvenation of CcdB-poisoned gyrase by an intrinsically disordered protein domain. Mol Cell (2009) 1.22
Dimerization of the major birch pollen allergen Bet v 1 is important for its in vivo IgE-cross-linking potential in mice. J Immunol (2005) 1.22
Functions for S. cerevisiae Swd2p in 3' end formation of specific mRNAs and snoRNAs and global histone 3 lysine 4 methylation. RNA (2004) 1.22
Mapping the orientation of helices in micelle-bound peptides by paramagnetic relaxation waves. J Am Chem Soc (2007) 1.22
Functional interactions between coexisting toxin-antitoxin systems of the ccd family in Escherichia coli O157:H7. J Bacteriol (2007) 1.22
The role of the yeast cleavage and polyadenylation factor subunit Ydh1p/Cft2p in pre-mRNA 3'-end formation. Nucleic Acids Res (2003) 1.15
Identification of Der p 23, a peritrophin-like protein, as a new major Dermatophagoides pteronyssinus allergen associated with the peritrophic matrix of mite fecal pellets. J Immunol (2013) 1.14
The solution structure of ParD, the antidote of the ParDE toxin antitoxin module, provides the structural basis for DNA and toxin binding. Protein Sci (2007) 1.14
Use of relaxation enhancements in a paramagnetic environment for the structure determination of proteins using NMR spectroscopy. Angew Chem Int Ed Engl (2009) 1.14
The minimal domain of adipose triglyceride lipase (ATGL) ranges until leucine 254 and can be activated and inhibited by CGI-58 and G0S2, respectively. PLoS One (2011) 1.14
Sequence motifs that distinguish ATP(CTP):tRNA nucleotidyl transferases from eubacterial poly(A) polymerases. RNA (2004) 1.14
Conditional essentiality of the csrA gene in Escherichia coli. J Bacteriol (2008) 1.13
Bacterial toxin-antitoxin systems: Translation inhibitors everywhere. Mob Genet Elements (2011) 1.11
The decay of the chromosomally encoded ccdO157 toxin-antitoxin system in the Escherichia coli species. Genetics (2009) 1.08
Sequential multiplex PCR assay for determining capsular serotypes of colonizing S. pneumoniae. BMC Infect Dis (2011) 1.06
The anti-toxin ParD of plasmid RK2 consists of two structurally distinct moieties and belongs to the ribbon-helix-helix family of DNA-binding proteins. Biochem J (2002) 1.06
Genetic diversity of Group A Streptococcus M protein: implications for typing and vaccine development. Vaccine (2008) 1.05
Gene regulation: reviving the message. Nature (2002) 1.05
The molecular chaperone Hsp90 modulates intermediate steps of amyloid assembly of the Parkinson-related protein alpha-synuclein. J Biol Chem (2009) 1.05
Pharyngitis in low-resources settings: a pragmatic clinical approach to reduce unnecessary antibiotic use. Pediatrics (2006) 1.05
Formation of disulfide bonds and homodimers of the major cat allergen Fel d 1 equivalent to the natural allergen by expression in Escherichia coli. J Biol Chem (2003) 1.04
Identification of Yju3p as functional orthologue of mammalian monoglyceride lipase in the yeast Saccharomycescerevisiae. Biochim Biophys Acta (2010) 1.03
Recombinant carp parvalbumin, the major cross-reactive fish allergen: a tool for diagnosis and therapy of fish allergy. J Immunol (2002) 1.03
The highly conserved TldD and TldE proteins of Escherichia coli are involved in microcin B17 processing and in CcdA degradation. J Bacteriol (2002) 1.03
Myeloperoxidase-derived chlorinating species induce protein carbamylation through decomposition of thiocyanate and urea: novel pathways generating dysfunctional high-density lipoprotein. Antioxid Redox Signal (2012) 1.02
Simplifying proton NMR spectra by instant homonuclear broadband decoupling. Angew Chem Int Ed Engl (2013) 1.02
Differences between Belgian and Brazilian group A Streptococcus epidemiologic landscape. PLoS One (2006) 1.00
Cleavage factor Im is a key regulator of 3' UTR length. RNA Biol (2012) 1.00
Crystal structure of the 25 kDa subunit of human cleavage factor Im. Nucleic Acids Res (2008) 0.99
Reduction of the in vivo allergenicity of Der p 2, the major house-dust mite allergen, by genetic engineering. Mol Immunol (2008) 0.99
PAPD5, a noncanonical poly(A) polymerase with an unusual RNA-binding motif. RNA (2011) 0.99
A hybrid molecule resembling the epitope spectrum of grass pollen for allergy vaccination. J Allergy Clin Immunol (2005) 0.99
TraA and its N-terminal relaxase domain of the Gram-positive plasmid pIP501 show specific oriT binding and behave as dimers in solution. Biochem J (2005) 0.98
Prediction of IgE-binding epitopes by means of allergen surface comparison and correlation to cross-reactivity. J Allergy Clin Immunol (2011) 0.97
The emm-type diversity does not always reflect the M protein genetic diversity--is there a case for designer vaccine against GAS. Vaccine (2009) 0.96
Characterization of folded recombinant Der p 5, a potential diagnostic marker allergen for house dust mite allergy. Int Arch Allergy Immunol (2008) 0.95
Antiparasitic compounds from Cupania cinerea with activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense. J Nat Prod (2011) 0.95
The 2.5 Å structure of the enterococcus conjugation protein TraM resembles VirB8 type IV secretion proteins. J Biol Chem (2012) 0.94
Positioning of micelle-bound peptides by paramagnetic relaxation enhancements. J Phys Chem B (2009) 0.94
Characterization of a novel temperate phage originating from a cereulide-producing Bacillus cereus strain. Res Microbiol (2011) 0.94
Identification of polyhydroxyalkanoates in Halococcus and other haloarchaeal species. Appl Microbiol Biotechnol (2010) 0.93
Conjugative type IV secretion systems in Gram-positive bacteria. Plasmid (2013) 0.92
The TraA relaxase autoregulates the putative type IV secretion-like system encoded by the broad-host-range Streptococcus agalactiae plasmid pIP501. Microbiology (2006) 0.92
Relaxed cleavage specificity within the RelE toxin family. J Bacteriol (2013) 0.92
Mimotopes identify conformational B-cell epitopes on the two major house dust mite allergens Der p 1 and Der p 2. Mol Immunol (2007) 0.91
TraG encoded by the pIP501 type IV secretion system is a two-domain peptidoglycan-degrading enzyme essential for conjugative transfer. J Bacteriol (2013) 0.91
Means to an end: mechanisms of alternative polyadenylation of messenger RNA precursors. Wiley Interdiscip Rev RNA (2013) 0.91
A recombinant hypoallergenic parvalbumin mutant for immunotherapy of IgE-mediated fish allergy. J Immunol (2007) 0.91
Determinants of substrate specificity in RNA-dependent nucleotidyl transferases. Biochim Biophys Acta (2007) 0.91
Monitoring fast reactions by spatially-selective and frequency-shifted continuous NMR spectroscopy: application to rapid-injection protein unfolding. Chem Commun (Camb) (2013) 0.90
An activation domain of plasmid R1 TraI protein delineates stages of gene transfer initiation. Mol Microbiol (2011) 0.90
Cooking birch pollen-related food: divergent consequences for IgE- and T cell-mediated reactivity in vitro and in vivo. J Allergy Clin Immunol (2006) 0.90