Published in Toxins (Basel) on January 10, 2014
The Role of Efflux and Physiological Adaptation in Biofilm Tolerance and Resistance. J Biol Chem (2016) 0.91
de novo synthesis of a bacterial toxin/antitoxin system. Sci Rep (2014) 0.89
sRNA antitoxins: more than one way to repress a toxin. Toxins (Basel) (2014) 0.88
Toxin-Antitoxin Systems in Clinical Pathogens. Toxins (Basel) (2016) 0.86
RNA Futile Cycling in Model Persisters Derived from MazF Accumulation. MBio (2015) 0.83
Functional validation of putative toxin-antitoxin genes from the Gram-positive pathogen Streptococcus pneumoniae: phd-doc is the fourth bona-fide operon. Front Microbiol (2014) 0.83
Type II toxin: antitoxin systems. More than small selfish entities? Curr Genet (2015) 0.82
Rae1/YacP, a new endoribonuclease involved in ribosome-dependent mRNA decay in Bacillus subtilis. EMBO J (2017) 0.81
Evolutionary Paths That Expand Plasmid Host-Range: Implications for Spread of Antibiotic Resistance. Mol Biol Evol (2015) 0.81
What Is the Link between Stringent Response, Endoribonuclease Encoding Type II Toxin-Antitoxin Systems and Persistence? Front Microbiol (2016) 0.81
Identification and Characterization of the HicAB Toxin-Antitoxin System in the Opportunistic Pathogen Pseudomonas aeruginosa. Toxins (Basel) (2016) 0.80
Multitasking SecB chaperones in bacteria. Front Microbiol (2014) 0.79
CDI Systems Are Stably Maintained by a Cell-Contact Mediated Surveillance Mechanism. PLoS Genet (2016) 0.79
Discovery of a conjugative megaplasmid in Bifidobacterium breve. Appl Environ Microbiol (2014) 0.78
Type II Toxin-Antitoxin Distribution and Adaptive Aspects on Xanthomonas Genomes: Focus on Xanthomonas citri. Front Microbiol (2016) 0.78
Orphan toxin OrtT (YdcX) of Escherichia coli reduces growth during the stringent response. Toxins (Basel) (2015) 0.78
Structure-function analysis of VapB4 antitoxin identifies critical features of a minimal VapC4 toxin-binding module. J Bacteriol (2015) 0.78
Activation of Toxin-Antitoxin System Toxins Suppresses Lethality Caused by the Loss of σE in Escherichia coli. J Bacteriol (2015) 0.78
YoeB toxin is activated during thermal stress. Microbiologyopen (2015) 0.78
Fluorescence based primer extension technique to determine transcriptional starting points and cleavage sites of RNases in vivo. J Vis Exp (2014) 0.78
A toxin antitoxin system promotes the maintenance of the IncA/C-mobilizable Salmonella Genomic Island 1. Sci Rep (2016) 0.77
Analysis of the Bacillus cereus SpoIIS antitoxin-toxin system reveals its three-component nature. Front Microbiol (2015) 0.77
Structure, Evolution, and Functions of Bacterial Type III Toxin-Antitoxin Systems. Toxins (Basel) (2016) 0.77
Toxins vapC and pasB from prokaryotic TA modules remain active in mammalian cancer cells. Toxins (Basel) (2014) 0.77
Human Granulocyte Macrophage Colony-Stimulating Factor Enhances Antibiotic Susceptibility of Pseudomonas aeruginosa Persister Cells. Sci Rep (2015) 0.77
The 5' UTR of the type I toxin ZorO can both inhibit and enhance translation. Nucleic Acids Res (2016) 0.76
Toxin-Antitoxin Modules Are Pliable Switches Activated by Multiple Protease Pathways. Toxins (Basel) (2016) 0.76
Identification and characterization of chromosomal relBE toxin-antitoxin locus in Streptomyces cattleya DSM46488. Sci Rep (2016) 0.76
Regulatory crosstalk between type I and type II toxin-antitoxin systems in the human pathogen Enterococcus faecalis. RNA Biol (2015) 0.76
Stability of the GraA Antitoxin Depends on Growth Phase, ATP Level, and Global Regulator MexT. J Bacteriol (2015) 0.75
Mapping Protein-Protein Interactions of the Resistance-Related Bacterial Zeta Toxin-Epsilon Antitoxin Complex (ε₂ζ₂) with High Affinity Peptide Ligands Using Fluorescence Polarization. Toxins (Basel) (2016) 0.75
Plasmid interference for curing antibiotic resistance plasmids in vivo. PLoS One (2017) 0.75
Evolution of the SpoIISABC Toxin-Antitoxin-Antitoxin System in Bacilli. Toxins (Basel) (2016) 0.75
Till stress do us ataRT: a novel toxin-antitoxin system targeting translation initiation. Cell Death Differ (2017) 0.75
Diverse distribution of Toxin-Antitoxin II systems in Salmonella enterica serovars. Sci Rep (2016) 0.75
Toxin MqsR cleaves single-stranded mRNA with various 5' ends. Microbiologyopen (2016) 0.75
Heterologous Expression of Toxins from Bacterial Toxin-Antitoxin Systems in Eukaryotic Cells: Strategies and Applications. Toxins (Basel) (2016) 0.75
Structural Determinants for Antitoxin Identity and Insulation of Cross Talk between Homologous Toxin-Antitoxin Systems. J Bacteriol (2016) 0.75
Mechanistic insights into type I toxin antitoxin systems in Helicobacter pylori: the importance of mRNA folding in controlling toxin expression. Nucleic Acids Res (2017) 0.75
Chaperone addiction of toxin-antitoxin systems. Nat Commun (2016) 0.75
Convenient broad-host-range unstable vectors for studying stabilization cassettes in diverse bacteria. BMC Microbiol (2016) 0.75
Desperate times call for desperate measures: benefits and costs of toxin-antitoxin systems. Curr Genet (2016) 0.75
Development of an antibiotic marker-free platform for heterologous protein production in Streptomyces. Microb Cell Fact (2017) 0.75
Mechanisms for Differential Protein Production in Toxin-Antitoxin Systems. Toxins (Basel) (2017) 0.75
MazF activation promotes translational heterogeneity of the grcA mRNA in Escherichia coli populations. PeerJ (2017) 0.75
MazF cleaves cellular mRNAs specifically at ACA to block protein synthesis in Escherichia coli. Mol Cell (2003) 4.63
Cell killing by the F plasmid CcdB protein involves poisoning of DNA-topoisomerase II complexes. J Mol Biol (1992) 4.13
Mini-F plasmid genes that couple host cell division to plasmid proliferation. Proc Natl Acad Sci U S A (1983) 4.07
Crystal structure of the MazE/MazF complex: molecular bases of antidote-toxin recognition. Mol Cell (2003) 3.66
Bacterial persistence by RNA endonucleases. Proc Natl Acad Sci U S A (2011) 3.52
(p)ppGpp controls bacterial persistence by stochastic induction of toxin-antitoxin activity. Cell (2013) 3.28
The Escherichia coli relBE genes belong to a new toxin-antitoxin gene family. Mol Microbiol (1998) 3.26
Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes. Biol Direct (2009) 3.17
chpA and chpB, Escherichia coli chromosomal homologs of the pem locus responsible for stable maintenance of plasmid R100. J Bacteriol (1993) 3.17
Effects of the ccd function of the F plasmid on bacterial growth. J Bacteriol (1985) 3.10
Bacterial toxin-antitoxin systems: more than selfish entities? PLoS Genet (2009) 3.03
Toxin-antitoxin systems in bacteria and archaea. Annu Rev Genet (2011) 2.99
Characterization of the hipA7 allele of Escherichia coli and evidence that high persistence is governed by (p)ppGpp synthesis. Mol Microbiol (2003) 2.92
Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution. PLoS Genet (2009) 2.89
New connections in the prokaryotic toxin-antitoxin network: relationship with the eukaryotic nonsense-mediated RNA decay system. Genome Biol (2003) 2.77
Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB. Science (2009) 2.74
The phage abortive infection system, ToxIN, functions as a protein-RNA toxin-antitoxin pair. Proc Natl Acad Sci U S A (2009) 2.69
Small toxic proteins and the antisense RNAs that repress them. Microbiol Mol Biol Rev (2008) 2.42
Antitoxin MqsA helps mediate the bacterial general stress response. Nat Chem Biol (2011) 2.30
A novel mechanism of programmed cell death in bacteria by toxin-antitoxin systems corrupts peptidoglycan synthesis. PLoS Biol (2011) 2.27
ParE toxin encoded by the broad-host-range plasmid RK2 is an inhibitor of Escherichia coli gyrase. Mol Microbiol (2002) 2.25
Diversity of bacterial type II toxin-antitoxin systems: a comprehensive search and functional analysis of novel families. Nucleic Acids Res (2011) 2.19
An antisense RNA controls synthesis of an SOS-induced toxin evolved from an antitoxin. Mol Microbiol (2007) 2.11
Abundance of type I toxin-antitoxin systems in bacteria: searches for new candidates and discovery of novel families. Nucleic Acids Res (2010) 1.93
Enteric virulence associated protein VapC inhibits translation by cleavage of initiator tRNA. Proc Natl Acad Sci U S A (2011) 1.92
Identification of components of a new stability system of plasmid R1, ParD, that is close to the origin of replication of this plasmid. Mol Gen Genet (1987) 1.88
Comparative genomics of defense systems in archaea and bacteria. Nucleic Acids Res (2013) 1.82
Three new RelE-homologous mRNA interferases of Escherichia coli differentially induced by environmental stresses. Mol Microbiol (2009) 1.76
Toxins-antitoxins: diversity, evolution and function. Crit Rev Biochem Mol Biol (2011) 1.74
MqsR, a crucial regulator for quorum sensing and biofilm formation, is a GCU-specific mRNA interferase in Escherichia coli. J Biol Chem (2009) 1.74
Two genes, pemK and pemI, responsible for stable maintenance of resistance plasmid R100. J Bacteriol (1988) 1.74
Exclusion of T4 phage by the hok/sok killer locus from plasmid R1. J Bacteriol (1996) 1.72
Bacterial toxin YafQ is an endoribonuclease that associates with the ribosome and blocks translation elongation through sequence-specific and frame-dependent mRNA cleavage. Mol Microbiol (2009) 1.71
A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS. Nat Chem Biol (2012) 1.67
Three dimensional structure of the MqsR:MqsA complex: a novel TA pair comprised of a toxin homologous to RelE and an antitoxin with unique properties. PLoS Pathog (2009) 1.65
Allostery and intrinsic disorder mediate transcription regulation by conditional cooperativity. Cell (2010) 1.65
Crystal structure of the plasmid maintenance system epsilon/zeta: functional mechanism of toxin zeta and inactivation by epsilon 2 zeta 2 complex formation. Proc Natl Acad Sci U S A (2003) 1.64
Viral evasion of a bacterial suicide system by RNA-based molecular mimicry enables infectious altruism. PLoS Genet (2012) 1.62
Doc of prophage P1 is inhibited by its antitoxin partner Phd through fold complementation. J Biol Chem (2008) 1.62
Messenger RNA interferase RelE controls relBE transcription by conditional cooperativity. Mol Microbiol (2008) 1.59
prlF and yhaV encode a new toxin-antitoxin system in Escherichia coli. J Mol Biol (2007) 1.57
ATP-dependent degradation of CcdA by Lon protease. Effects of secondary structure and heterologous subunit interactions. J Biol Chem (1996) 1.55
The mRNA interferases, MazF-mt3 and MazF-mt7 from Mycobacterium tuberculosis target unique pentad sequences in single-stranded RNA. Mol Microbiol (2008) 1.53
Mechanism of killer gene activation. Antisense RNA-dependent RNase III cleavage ensures rapid turn-over of the stable hok, srnB and pndA effector messenger RNAs. J Mol Biol (1992) 1.52
Small untranslated RNA antitoxin in Bacillus subtilis. J Bacteriol (2005) 1.49
A small SOS-induced toxin is targeted against the inner membrane in Escherichia coli. Mol Microbiol (2008) 1.48
Molecular mechanism of bacterial persistence by HipA. Mol Cell (2013) 1.48
YeeU enhances the bundling of cytoskeletal polymers of MreB and FtsZ, antagonizing the CbtA (YeeV) toxicity in Escherichia coli. Mol Microbiol (2012) 1.47
Characterization of MazFSa, an endoribonuclease from Staphylococcus aureus. J Bacteriol (2007) 1.47
The inhibitory mechanism of protein synthesis by YoeB, an Escherichia coli toxin. J Biol Chem (2009) 1.47
Escherichia coli toxin/antitoxin pair MqsR/MqsA regulate toxin CspD. Environ Microbiol (2010) 1.46
Chromosomal toxin-antitoxin systems may act as antiaddiction modules. J Bacteriol (2008) 1.46
Bacterial toxin HigB associates with ribosomes and mediates translation-dependent mRNA cleavage at A-rich sites. J Biol Chem (2009) 1.44
Molecular basis of gyrase poisoning by the addiction toxin CcdB. J Mol Biol (2005) 1.43
To be or not to be: regulation of restriction-modification systems and other toxin-antitoxin systems. Nucleic Acids Res (2013) 1.42
Identification and classification of bacterial Type III toxin-antitoxin systems encoded in chromosomal and plasmid genomes. Nucleic Acids Res (2012) 1.40
The regulation of the Escherichia coli mazEF promoter involves an unusual alternating palindrome. J Biol Chem (2000) 1.37
The ratio between CcdA and CcdB modulates the transcriptional repression of the ccd poison-antidote system. Mol Microbiol (2001) 1.35
The Fic protein Doc uses an inverted substrate to phosphorylate and inactivate EF-Tu. Nat Chem Biol (2013) 1.33
Structural basis for nucleic acid and toxin recognition of the bacterial antitoxin CcdA. J Mol Biol (2006) 1.32
YeeV is an Escherichia coli toxin that inhibits cell division by targeting the cytoskeleton proteins, FtsZ and MreB. Mol Microbiol (2010) 1.31
Staphylococcus aureus MazF specifically cleaves a pentad sequence, UACAU, which is unusually abundant in the mRNA for pathogenic adhesive factor SraP. J Bacteriol (2009) 1.31
The toxin-antitoxin system of the streptococcal plasmid pSM19035. J Bacteriol (2005) 1.29
Structural mechanism of transcriptional autorepression of the Escherichia coli RelB/RelE antitoxin/toxin module. J Mol Biol (2008) 1.26
Toxin-antitoxin systems: Biology, identification, and application. Mob Genet Elements (2013) 1.25
New toxins homologous to ParE belonging to three-component toxin-antitoxin systems in Escherichia coli O157:H7. Mol Microbiol (2010) 1.25
Interaction specificity, toxicity and regulation of a paralogous set of ParE/RelE-family toxin-antitoxin systems. Mol Microbiol (2010) 1.24
A processed noncoding RNA regulates an altruistic bacterial antiviral system. Nat Struct Mol Biol (2011) 1.24
Modulation of DNA supercoiling activity of Escherichia coli DNA gyrase by F plasmid proteins. Antagonistic actions of LetA (CcdA) and LetD (CcdB) proteins. J Biol Chem (1992) 1.22
Characterization of the interaction and cross-regulation of three Mycobacterium tuberculosis RelBE modules. PLoS One (2010) 1.22
Functional interactions between coexisting toxin-antitoxin systems of the ccd family in Escherichia coli O157:H7. J Bacteriol (2007) 1.22
The three RelE homologs of Mycobacterium tuberculosis have individual, drug-specific effects on bacterial antibiotic tolerance. J Bacteriol (2010) 1.21
Balancing at survival's edge: the structure and adaptive benefits of prokaryotic toxin-antitoxin partners. Curr Opin Struct Biol (2011) 1.20
Ectopic production of VapCs from Enterobacteria inhibits translation and trans-activates YoeB mRNA interferase. Mol Microbiol (2009) 1.19
Sok antisense RNA from plasmid R1 is functionally inactivated by RNase E and polyadenylated by poly(A) polymerase I. Mol Microbiol (1997) 1.19
Three Mycobacterium tuberculosis Rel toxin-antitoxin modules inhibit mycobacterial growth and are expressed in infected human macrophages. J Bacteriol (2008) 1.17
Dmd of bacteriophage T4 functions as an antitoxin against Escherichia coli LsoA and RnlA toxins. Mol Microbiol (2012) 1.17
Mycobacterial toxin MazF-mt6 inhibits translation through cleavage of 23S rRNA at the ribosomal A site. Proc Natl Acad Sci U S A (2013) 1.14
The solution structure of ParD, the antidote of the ParDE toxin antitoxin module, provides the structural basis for DNA and toxin binding. Protein Sci (2007) 1.14
VapC toxins from Mycobacterium tuberculosis are ribonucleases that differentially inhibit growth and are neutralized by cognate VapB antitoxins. PLoS One (2011) 1.13
Noncognate Mycobacterium tuberculosis toxin-antitoxins can physically and functionally interact. J Biol Chem (2010) 1.11
Modular organization of the Phd repressor/antitoxin protein. J Bacteriol (2004) 1.09
The decay of the chromosomally encoded ccdO157 toxin-antitoxin system in the Escherichia coli species. Genetics (2009) 1.08
Escherichia coli rnlA and rnlB compose a novel toxin-antitoxin system. Genetics (2010) 1.08
Bacterial toxin RelE mediates frequent codon-independent mRNA cleavage from the 5' end of coding regions in vivo. J Biol Chem (2011) 1.08
Functional interactions between chpB and parD, two homologous conditional killer systems found in the Escherichia coli chromosome and in plasmid R1. FEMS Microbiol Lett (1998) 1.07
Killing activity and rescue function of genome-wide toxin-antitoxin loci of Mycobacterium tuberculosis. FEMS Microbiol Lett (2008) 1.06
Discovery of functional toxin/antitoxin systems in bacteria by shotgun cloning. Mol Cell (2013) 1.05
BsrG/SR4 from Bacillus subtilis--the first temperature-dependent type I toxin-antitoxin system. Mol Microbiol (2012) 1.05
Antitoxin DinJ influences the general stress response through transcript stabilizer CspE. Environ Microbiol (2011) 1.03
Type II toxin/antitoxin MqsR/MqsA controls type V toxin/antitoxin GhoT/GhoS. Environ Microbiol (2013) 1.03
The essential function of B. subtilis RNase III is to silence foreign toxin genes. PLoS Genet (2012) 1.01
Kid cleaves specific mRNAs at UUACU sites to rescue the copy number of plasmid R1. EMBO J (2005) 1.01
Crystal structure of the VapBC toxin-antitoxin complex from Shigella flexneri reveals a hetero-octameric DNA-binding assembly. J Mol Biol (2011) 1.01
The 41 carboxy-terminal residues of the miniF plasmid CcdA protein are sufficient to antagonize the killer activity of the CcdB protein. Mol Gen Genet (1991) 1.01
SecB-like chaperone controls a toxin-antitoxin stress-responsive system in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2011) 1.00
Inhibition of specific gene expressions by protein-mediated mRNA interference. Nat Commun (2012) 1.00
RatA (YfjG), an Escherichia coli toxin, inhibits 70S ribosome association to block translation initiation. Mol Microbiol (2011) 0.99
Crystal structures of Phd-Doc, HigA, and YeeU establish multiple evolutionary links between microbial growth-regulating toxin-antitoxin systems. Structure (2010) 0.99
TasA-tasB, a new putative toxin-antitoxin (TA) system from Bacillus thuringiensis pGI1 plasmid is a widely distributed composite mazE-doc TA system. BMC Genomics (2006) 0.98