Published in Eur J Biochem on September 01, 1975
Homology between a prolyl hydroxylase subunit and a tissue protein that crossreacts immunologically with the enzyme. Proc Natl Acad Sci U S A (1977) 1.30
Cell-free synthesis and assembly of prolyl 4-hydroxylase: the role of the beta-subunit (PDI) in preventing misfolding and aggregation of the alpha-subunit. EMBO J (1993) 1.19
Isolation of lysyl hydroxylase, an enzyme of collagen synthesis, from chick embryos as a homogeneous protein. Biochem J (1980) 1.11
Partial purification and characterization of chick-embryo prolyl 3-hydroxylase. Biochem J (1979) 1.08
The assembly of tetrameric prolyl hydroxylase in tendon fibroblasts from newly synthesized alpha-subunits and from preformed cross-reacting protein. Biochem J (1980) 1.01
Regulation of collagen post-translational modification in transformed human and chick-embryo cells. Biochem J (1981) 0.98
Turnover of prolyl hydroxylase tetramers and the monomer-size protein in chick-embryo cartilaginous bone and lung in vivo. Biochem J (1979) 0.91
Immunological characterization of lysyl hydroxylase, an enzyme of collagen synthesis. Biochem J (1981) 0.82
The effects of long-term local PUVA treatment on collagen metabolism in human skin. Arch Dermatol Res (1980) 0.79
Multiple forms of gamma-butyrobetaine hydroxylase (EC 1.14.11.1). Biochem J (1984) 0.76
Serum immunoreactive prolyl hydroxylase in inflammatory rheumatic diseases. Ann Rheum Dis (1980) 0.75
Collagens: molecular biology, diseases, and potentials for therapy. Annu Rev Biochem (1995) 5.52
Modifications of a specific assay for hydroxyproline in urine. Anal Biochem (1967) 5.48
Heritable diseases of collagen. N Engl J Med (1984) 4.39
The biosynthesis of collagen and its disorders (first of two parts). N Engl J Med (1979) 3.87
Molecular cloning of the beta-subunit of human prolyl 4-hydroxylase. This subunit and protein disulphide isomerase are products of the same gene. EMBO J (1987) 2.79
Posttranslational enzymes in the biosynthesis of collagen: intracellular enzymes. Methods Enzymol (1982) 2.77
The biosynthesis of collagen and its disorders (second of two parts). N Engl J Med (1979) 2.76
Ultrastructural identification of extension aminopropeptides of type I and III collagens in human skin. Proc Natl Acad Sci U S A (1981) 2.03
Collagens and collagen-related diseases. Ann Med (2001) 1.98
A single polypeptide acts both as the beta subunit of prolyl 4-hydroxylase and as a protein disulfide-isomerase. J Biol Chem (1987) 1.92
Mechanism of the prolyl hydroxylase reaction. 1. Role of co-substrates. Eur J Biochem (1977) 1.83
An affinity-column procedure using poly(L-proline) for the purification of prolyl hydroxylase. Purification of the enzyme from chick embryos. Eur J Biochem (1975) 1.80
Mechanism of the prolyl hydroxylase reaction. 2. Kinetic analysis of the reaction sequence. Eur J Biochem (1977) 1.77
Partial identity of the 2-oxoglutarate and ascorbate binding sites of prolyl 4-hydroxylase. J Biol Chem (1986) 1.75
Urinary excretion of hydroxyproline in health and disease. Int Rev Connect Tissue Res (1970) 1.70
Evidence for a structural mutation of procollagen type I in a patient with the Ehlers-Danlos syndrome type VII. J Biol Chem (1980) 1.69
The 2-oxoglutarate binding site of prolyl 4-hydroxylase. Identification of distinct subsites and evidence for 2-oxoglutarate decarboxylation in a ligand reaction at the enzyme-bound ferrous ion. Eur J Biochem (1984) 1.56
Ascorbate is consumed stoichiometrically in the uncoupled reactions catalyzed by prolyl 4-hydroxylase and lysyl hydroxylase. J Biol Chem (1984) 1.50
Gene expression of type I, III and IV collagens in hepatic fibrosis induced by dimethylnitrosamine in the rat. Biochem J (1987) 1.46
The role of ascorbate in the prolyl hydroxylase reaction. Biochem Biophys Res Commun (1978) 1.45
Biosynthesis of collagen and its alterations in pathological states. Med Biol (1976) 1.42
Further evaluation of the significance of urinary hydroxyproline determinations in the diagnosis of thyroid disorders. Clin Chim Acta (1968) 1.41
Characterization of the human prolyl 4-hydroxylase tetramer and its multifunctional protein disulfide-isomerase subunit synthesized in a baculovirus expression system. Proc Natl Acad Sci U S A (1992) 1.40
Characterization of the iron- and 2-oxoglutarate-binding sites of human prolyl 4-hydroxylase. EMBO J (1997) 1.37
Molecular cloning of the alpha-subunit of human prolyl 4-hydroxylase: the complete cDNA-derived amino acid sequence and evidence for alternative splicing of RNA transcripts. Proc Natl Acad Sci U S A (1989) 1.36
Cloning of the human prolyl 4-hydroxylase alpha subunit isoform alpha(II) and characterization of the type II enzyme tetramer. The alpha(I) and alpha(II) subunits do not form a mixed alpha(I)alpha(II)beta2 tetramer. J Biol Chem (1997) 1.34
Assay of collagen-galactosyltransferase and collagen-glucosyltransferase activities and preliminary characterization of enzymic reactions with transferases from chick-embryo cartilage. Eur J Biochem (1975) 1.32
Studies on the lysyl hydroxylase reaction. I. Initial velocity kinetics and related aspects. Biochim Biophys Acta (1980) 1.31
Post-translational processing of procollagens. Ann N Y Acad Sci (1985) 1.30
Protocollagen proline hydroxylase activity in the skin of normal human subjects and of patients with scleroderma. Scand J Clin Lab Invest (1969) 1.30
Hydroxyproline in the serum and urine. Normal values and clinical significance. Acta Med Scand (1966) 1.30
Recent developments in posttranslational modification: intracellular processing. Methods Enzymol (1987) 1.29
Hydroxylation of proline in synthetic polypeptides with purified protocollagen hydroxylase. J Biol Chem (1967) 1.28
Partial purification and characterization of protocollagen lysine hydroxylase from chick embryos. Biochim Biophys Acta (1972) 1.28
ERp60 does not substitute for protein disulphide isomerase as the beta-subunit of prolyl 4-hydroxylase. Biochem J (1996) 1.27
Activities of prolyl hydroxylase, lysyl hydroxylase, collagen galactosyltransferase and collagen glucosyltransferase in the liver of rats with hepatic injury. Biochem J (1974) 1.25
Collagen glycosyltransferases. Int Rev Connect Tissue Res (1979) 1.25
Expression and site-directed mutagenesis of human protein disulfide isomerase in Escherichia coli. This multifunctional polypeptide has two independently acting catalytic sites for the isomerase activity. J Biol Chem (1992) 1.23
Synthesis and degradation of type I procollagen mRNAs in cultured human skin fibroblasts and the effect of cortisol. J Biol Chem (1985) 1.22
A homozygous stop codon in the lysyl hydroxylase gene in two siblings with Ehlers-Danlos syndrome type VI. Nat Genet (1992) 1.20
Partial purification and characterization of a neutral protease which cleaves the N-terminal propeptides from procollagen. Biochemistry (1978) 1.18
Radiommunoassay for human and chick prolyl hydroxylases. Eur J Biochem (1975) 1.17
Prolyl 3-hydroxylase: partial characterization of the enzyme from rat kidney cortex. Eur J Biochem (1977) 1.15
p-HMW-collagen, a minor collagen obtained from chick embryo cartilage without proteolytic treatment of the tissue. Eur J Biochem (1983) 1.14
Differences between collagen hydroxylases and 2-oxoglutarate dehydrogenase in their inhibition by structural analogues of 2-oxoglutarate. Biochem J (1985) 1.13
Molecular cloning of chick lysyl hydroxylase. Little homology in primary structure to the two types of subunit of prolyl 4-hydroxylase. J Biol Chem (1991) 1.12
Isolation of lysyl hydroxylase, an enzyme of collagen synthesis, from chick embryos as a homogeneous protein. Biochem J (1980) 1.11
Site-directed mutagenesis of human lysyl hydroxylase expressed in insect cells. Identification of histidine residues and an aspartic acid residue critical for catalytic activity. J Biol Chem (1996) 1.11
Monoclonal antibodies to human prolyl 4-hydroxylase. Eur J Biochem (1984) 1.10
High-level production of human type I collagen in the yeast Pichia pastoris. Yeast (2001) 1.10
Posttranslational modifications in the biosynthesis of type IV collagen by a human tumor cell line. Biochemistry (1981) 1.09
Assay of protocollagen lysyl hydroxylase activity in the skin of human subjects and changes in the activity with age. Clin Chim Acta (1973) 1.08
Human placental lysyl oxidase. Purification, partial characterization, and preparation of two specific antisera to the enzyme. J Biol Chem (1984) 1.08
Cloning, baculovirus expression, and characterization of a second mouse prolyl 4-hydroxylase alpha-subunit isoform: formation of an alpha 2 beta 2 tetramer with the protein disulfide-isomerase/beta subunit. Proc Natl Acad Sci U S A (1995) 1.08
Partial purification and characterization of chick-embryo prolyl 3-hydroxylase. Biochem J (1979) 1.08
Clinical significance of urinary hydroxyproline determinations in children. Ann Paediatr Fenn (1965) 1.07
Studies on protocollagen lysine hydroxylase. Hydroxylation of synthetic peptides and the stoichiometric decarboxylation of -ketoglutarate. Biochemistry (1972) 1.07
Evidence for 4-hydroxyproline in viral proteins. Characterization of a viral prolyl 4-hydroxylase and its peptide substrates. J Biol Chem (1999) 1.07
The novel type II prolyl 4-hydroxylase is the main enzyme form in chondrocytes and capillary endothelial cells, whereas the type I enzyme predominates in most cells. J Biol Chem (1998) 1.06
Cloning and characterization of a fifth human lysyl oxidase isoenzyme: the third member of the lysyl oxidase-related subfamily with four scavenger receptor cysteine-rich domains. Matrix Biol (2001) 1.06
Site-directed mutagenesis of the alpha subunit of human prolyl 4-hydroxylase. Identification of three histidine residues critical for catalytic activity. J Biol Chem (1995) 1.06
A large duplication in the gene for lysyl hydroxylase accounts for the type VI variant of Ehlers-Danlos syndrome in two siblings. Genomics (1993) 1.05
Collagen biosynthesis enzymes in serum and hepatic tissue in liver disease. I. Prolyl hydroxylase. Eur J Clin Invest (1979) 1.05
Kinetic patterns of protocollagen hydroxylase and further studies on the polypeptide substrate. Biochim Biophys Acta (1968) 1.05
Characterization of human type III collagen expressed in a baculovirus system. Production of a protein with a stable triple helix requires coexpression with the two types of recombinant prolyl 4-hydroxylase subunit. J Biol Chem (1996) 1.04
Hydroxylation of lysine and glycosylation of hydroxylysine during collagen biosynthesis in isolated chick-embryo cartilage cells. Biochem J (1976) 1.03
Glucosylation of galactosylhydroxylysyl residues in collagen in vitro by collagen glucosyltransferase. Inhibition by triple-helical conformation of the substrate. Eur J Biochem (1975) 1.03
Collagen glucosyltransferase. Partial purification and characterization of the enzyme from whole chick embryos and chick-embryo cartilage. Eur J Biochem (1976) 1.03
Cloning of human lysyl hydroxylase: complete cDNA-derived amino acid sequence and assignment of the gene (PLOD) to chromosome 1p36.3----p36.2. Genomics (1992) 1.02
Studies on the lysyl hydroxylase reaction. II. Inhibition kinetics and the reaction mechanism. Biochim Biophys Acta (1980) 1.02
Expression and characterization of recombinant human type II collagens with low and high contents of hydroxylysine and its glycosylated forms. Matrix Biol (1998) 1.01
Isolation and partial characterization of highly purified protocollagen proline hydroxylase. Biochim Biophys Acta (1970) 1.01
Hydroxyprolinemia: an apparently harmless familial metabolic disorder. N Engl J Med (1970) 1.01
Time-dependent inactivation of chick-embryo prolyl 4-hydroxylase by coumalic acid. Evidence for a syncatalytic mechanism. Biochem J (1987) 1.01
Hydroxylation of lysyl residues in native and denatured protocollagen by protocollagen lysyl hydroxylase in vitro. Biochim Biophys Acta (1974) 1.00
Collagen metabolism of the skin in Marfan's syndrome. Clin Chim Acta (1968) 1.00
Cloning and characterization of a third human lysyl hydroxylase isoform. Proc Natl Acad Sci U S A (1998) 1.00
Separation of prolyl 3-hydroxylase and 4-hydroxylase activities and the 4-hydroxyproline requirement for synthesis of 3-hydroxyproline. Biochem Biophys Res Commun (1976) 0.99
Cloning and characterization of a fourth human lysyl oxidase isoenzyme. Biochem J (2001) 0.98
Affinity chromatography of lysyl hydroxylase on concanavalin A-agarose. Biochim Biophys Acta (1977) 0.98