Published in Nat Cell Biol on October 08, 2006
Regulation of cancer cell metabolism. Nat Rev Cancer (2011) 15.44
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov (2009) 10.32
The essence of senescence. Genes Dev (2010) 8.21
Aging, cellular senescence, and cancer. Annu Rev Physiol (2012) 5.08
Bmi1 regulates mitochondrial function and the DNA damage response pathway. Nature (2009) 3.90
Feedback between p21 and reactive oxygen production is necessary for cell senescence. Mol Syst Biol (2010) 3.27
The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Cell (2014) 2.65
Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix. Osteoarthritis Cartilage (2009) 2.65
ROS and p53: a versatile partnership. Free Radic Biol Med (2008) 2.52
Cellular senescence and tumor suppressor gene p16. Int J Cancer (2011) 2.14
Upsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapy. Antioxid Redox Signal (2012) 2.05
Molecular pathogenesis of emphysema. J Clin Invest (2008) 2.03
Cellular senescence in aging and age-related disease: from mechanisms to therapy. Nat Med (2015) 1.82
Free radicals and senescence. Exp Cell Res (2008) 1.79
Real-time in vivo imaging of p16Ink4a reveals cross talk with p53. J Cell Biol (2009) 1.66
Rb-dependent cellular senescence, multinucleation and susceptibility to oncogenic transformation through PKC scaffolding by SSeCKS/AKAP12. Cell Cycle (2010) 1.63
Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging (Albany NY) (2012) 1.57
Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria. Aging Cell (2010) 1.47
ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence. Oncogene (2011) 1.45
Adult-onset, short-term dietary restriction reduces cell senescence in mice. Aging (Albany NY) (2010) 1.45
Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. Proc Natl Acad Sci U S A (2008) 1.41
The proto-oncogene LRF is under post-transcriptional control of MiR-20a: implications for senescence. PLoS One (2008) 1.37
ROS as a tumour suppressor? Nat Cell Biol (2006) 1.33
Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. EMBO J (2009) 1.33
The M-type receptor PLA2R regulates senescence through the p53 pathway. EMBO Rep (2009) 1.29
Nucleostemin rejuvenates cardiac progenitor cells and antagonizes myocardial aging. J Am Coll Cardiol (2015) 1.28
Phosphorylation of angiomotin by Lats1/2 kinases inhibits F-actin binding, cell migration, and angiogenesis. J Biol Chem (2013) 1.27
Mitochondria are required for pro-ageing features of the senescent phenotype. EMBO J (2016) 1.27
Cellular senescence and chromatin structure. Chromosoma (2007) 1.26
Noncatalytic function of ERK1/2 can promote Raf/MEK/ERK-mediated growth arrest signaling. J Biol Chem (2009) 1.18
Visualizing the dynamics of p21(Waf1/Cip1) cyclin-dependent kinase inhibitor expression in living animals. Proc Natl Acad Sci U S A (2007) 1.14
The p16(INK4A) tumor suppressor regulates cellular oxidative stress. Oncogene (2010) 1.12
CENP-A reduction induces a p53-dependent cellular senescence response to protect cells from executing defective mitoses. Mol Cell Biol (2010) 1.11
Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging. Aging Cell (2014) 1.11
Wood smoke exposure and gene promoter methylation are associated with increased risk for COPD in smokers. Am J Respir Crit Care Med (2010) 1.10
Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling. Cell Biosci (2013) 1.09
Hypoxia induces heart regeneration in adult mice. Nature (2016) 1.06
Sustained proliferation in cancer: Mechanisms and novel therapeutic targets. Semin Cancer Biol (2015) 1.01
MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways. Oncogene (2014) 1.01
DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosis. J Zhejiang Univ Sci B (2007) 0.99
Tumor mechanics and metabolic dysfunction. Free Radic Biol Med (2014) 0.97
Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells. Int J Mol Med (2012) 0.96
Carbon source metabolism and its regulation in cancer cells. Crit Rev Eukaryot Gene Expr (2012) 0.94
p16(INK4a) suppression by glucose restriction contributes to human cellular lifespan extension through SIRT1-mediated epigenetic and genetic mechanisms. PLoS One (2011) 0.94
Cellular senescence: unravelling complexity. Age (Dordr) (2009) 0.93
The rb pathway and cancer therapeutics. Curr Drug Targets (2009) 0.93
Oncogene-induced senescence: an essential role for Runx. Cell Cycle (2008) 0.92
c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression. Nat Cell Biol (2012) 0.92
Androgen receptor drives cellular senescence. PLoS One (2012) 0.89
The p53/p21(WAF/CIP) pathway mediates oxidative stress and senescence in dyskeratosis congenita cells with telomerase insufficiency. Antioxid Redox Signal (2011) 0.89
Real-time in vivo imaging of p16gene expression: a new approach to study senescence stress signaling in living animals. Cell Div (2010) 0.89
Cleaved high-molecular-weight kininogen accelerates the onset of endothelial progenitor cell senescence by induction of reactive oxygen species. Arterioscler Thromb Vasc Biol (2011) 0.88
Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence? Longev Healthspan (2014) 0.87
Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis. Cell Death Dis (2013) 0.86
Irreversibility of cellular senescence: dual roles of p16INK4a/Rb-pathway in cell cycle control. Cell Div (2007) 0.86
Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence. Redox Biol (2016) 0.86
Nutritional countermeasures targeting reactive oxygen species in cancer: from mechanisms to biomarkers and clinical evidence. Antioxid Redox Signal (2013) 0.86
A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3. Cell Cycle (2013) 0.85
Micropatterning of 3D Microenvironments for Living Biosensor Applications. Biosensors (Basel) (2014) 0.85
Curcuminoid binding to embryonal carcinoma cells: reductive metabolism, induction of apoptosis, senescence, and inhibition of cell proliferation. PLoS One (2012) 0.84
A stochastic step model of replicative senescence explains ROS production rate in ageing cell populations. PLoS One (2012) 0.84
GDF15 contributes to radiation-induced senescence through the ROS-mediated p16 pathway in human endothelial cells. Oncotarget (2016) 0.84
Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence. Cell Cycle (2015) 0.83
Familial melanoma-associated mutations in p16 uncouple its tumor-suppressor functions. J Invest Dermatol (2012) 0.83
Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation. Proc Natl Acad Sci U S A (2014) 0.83
The protein kinase Cdelta catalytic fragment is critical for maintenance of the G2/M DNA damage checkpoint. J Biol Chem (2009) 0.82
Sensitization of cervix cancer cells to Adriamycin by Pentoxifylline induces an increase in apoptosis and decrease senescence. Mol Cancer (2010) 0.82
ROS-PIASγ cross talk channelizes ATM signaling from resistance to apoptosis during chemosensitization of resistant tumors. Cell Death Dis (2014) 0.82
The role of p21 in regulating mammalian regeneration. Stem Cell Res Ther (2011) 0.81
Metabolomic alterations in human cancer cells by vitamin C-induced oxidative stress. Sci Rep (2015) 0.81
Amyloid-β(1-42) oligomer accelerates senescence in adult hippocampal neural stem/progenitor cells via formylpeptide receptor 2. Cell Death Dis (2013) 0.80
Cellular Senescence as the Causal Nexus of Aging. Front Genet (2016) 0.80
Expression of coxsackie and adenovirus receptor distinguishes transitional cancer states in therapy-induced cellular senescence. Cell Death Dis (2010) 0.80
Selenoprotein H suppresses cellular senescence through genome maintenance and redox regulation. J Biol Chem (2014) 0.80
Low-dose etoposide-treatment induces endoreplication and cell death accompanied by cytoskeletal alterations in A549 cells: Does the response involve senescence? The possible role of vimentin. Cancer Cell Int (2013) 0.79
The Intricate Interplay between Mechanisms Underlying Aging and Cancer. Aging Dis (2014) 0.79
Current Management Strategies in Breast Cancer by Targeting Key Altered Molecular Players. Front Oncol (2016) 0.78
Cancer-targeted IL-12 controls human rhabdomyosarcoma by senescence induction and myogenic differentiation. Oncoimmunology (2015) 0.78
Loss of ARID1A expression leads to sensitivity to ROS-inducing agent elesclomol in gynecologic cancer cells. Oncotarget (2016) 0.77
RAC3 more than a nuclear receptor coactivator: a key inhibitor of senescence that is downregulated in aging. Cell Death Dis (2015) 0.77
Life-history Constraints on the Mechanisms that Control the Rate of ROS Production. Curr Genomics (2014) 0.77
NUAK1 links genomic instability and senescence. Aging (Albany NY) (2010) 0.77
Cellular senescence in livers from children with end stage liver disease. PLoS One (2010) 0.76
Temporally distinct roles for tumor suppressor pathways in cell cycle arrest and cellular senescence in Cyclin D1-driven tumor. Mol Cancer (2012) 0.76
Mitotic Stress Is an Integral Part of the Oncogene-Induced Senescence Program that Promotes Multinucleation and Cell Cycle Arrest. Cell Rep (2015) 0.76
Foxp1 Regulates the Proliferation of Hair Follicle Stem Cells in Response to Oxidative Stress during Hair Cycling. PLoS One (2015) 0.76
Potential roles of DNA methylation in the initiation and establishment of replicative senescence revealed by array-based methylome and transcriptome analyses. PLoS One (2017) 0.75
Exosomes maintain cellular homeostasis by excreting harmful DNA from cells. Nat Commun (2017) 0.75
Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy. Chem Soc Rev (2016) 0.75
Role of p16(INK4a) and BMI-1 in oxidative stress-induced premature senescence in human dental pulp stem cells. Redox Biol (2017) 0.75
DUOX1 silencing in lung cancer promotes EMT, cancer stem cell characteristics and invasive properties. Oncogenesis (2016) 0.75
Cellular conservation of endangered midget buffalo (Lowland Anoa, Bubalus quarlesi) by establishment of primary cultured cell, and its immortalization with expression of cell cycle regulators. Cytotechnology (2016) 0.75
The eIF2α serine 51 phosphorylation-ATF4 arm promotes HIPPO signaling and cell death under oxidative stress. Oncotarget (2016) 0.75
MSK1 triggers the expression of the INK4AB/ARF locus in oncogene-induced senescence. Mol Biol Cell (2016) 0.75
Peritoneal carcinomatosis of colorectal cancer is characterized by structural and functional reorganization of the tumor microenvironment inducing senescence and proliferation arrest in cancer cells. Oncoimmunology (2016) 0.75
Cellular senescence in aging and osteoarthritis. Acta Orthop (2016) 0.75
Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures. Mol Syst Biol (2017) 0.75
Impact of senescence-associated secretory phenotype and its potential as a therapeutic target for senescence-associated diseases. Cancer Sci (2017) 0.75
The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway. Cell Death Differ (2017) 0.75
Senescence in Health and Disease. Cell (2017) 0.75
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature (2013) 7.51
Ubiquitin ligases: cell-cycle control and cancer. Nat Rev Cancer (2006) 6.76
Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell (2007) 5.94
Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell (2003) 5.68
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J (2004) 4.95
Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Nature (2004) 4.35
Aurora-A - a guardian of poles. Nat Rev Cancer (2005) 4.11
The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription. Mol Cell (2003) 3.87
VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. Genes Dev (2004) 3.82
SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature (2011) 3.69
Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase. J Biol Chem (2003) 3.68
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis. EMBO J (2006) 3.53
CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth. Cancer Cell (2011) 3.41
Skp2-mediated degradation of p27 regulates progression into mitosis. Dev Cell (2004) 3.27
Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme. Cancer Res (2003) 3.25
A diacylglycerol-dependent signaling pathway contributes to regulation of antibacterial autophagy. Cell Host Microbe (2010) 3.18
Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase. Nat Cell Biol (2004) 3.14
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. Nature (2010) 3.09
Regulation of the cell cycle by SCF-type ubiquitin ligases. Semin Cell Dev Biol (2005) 3.08
Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation. Cell (2009) 2.99
Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB. Nat Cell Biol (2009) 2.91
Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells. J Biol Chem (2003) 2.89
Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice. J Biol Chem (2004) 2.73
Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature (2002) 2.68
Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis. Nat Cell Biol (2003) 2.64
Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination. Mol Cell Biol (2005) 2.62
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J Biol Chem (2003) 2.59
p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70. Cell Stem Cell (2011) 2.58
p57 is required for quiescence and maintenance of adult hematopoietic stem cells. Cell Stem Cell (2011) 2.54
ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway. Nat Cell Biol (2004) 2.50
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation. Proc Natl Acad Sci U S A (2003) 2.45
Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Dev Cell (2007) 2.41
Targeting the p27 E3 ligase SCF(Skp2) results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy. Blood (2008) 2.36
The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis. Cell (2012) 2.30
M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis. J Exp Med (2009) 2.29
An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation. Proc Natl Acad Sci U S A (2005) 2.18
Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. Nat Med (2005) 2.18
Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export. J Biol Chem (2002) 2.12
Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL. Genes Dev (2008) 2.12
RNA interference targeting aurora kinase a suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells. Cancer Res (2005) 2.11
Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells. EMBO J (2008) 2.05
Dependence of paclitaxel sensitivity on a functional spindle assembly checkpoint. Cancer Res (2004) 2.03
Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus. J Med Chem (2010) 2.03
Large-scale analysis of the human ubiquitin-related proteome. Proteomics (2005) 2.00
Mechanism and biological significance of CD44 cleavage. Cancer Sci (2004) 2.00
Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis. J Exp Med (2007) 1.99
Chfr is required for tumor suppression and Aurora A regulation. Nat Genet (2005) 1.97
Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis. J Biol Chem (2004) 1.97
CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function. Dev Cell (2003) 1.91
Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation. J Cell Biol (2004) 1.90
Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function. Oncogene (2004) 1.86
Protrudin induces neurite formation by directional membrane trafficking. Science (2006) 1.84
Roles of aurora-A kinase in mitotic entry and G2 checkpoint in mammalian cells. Genes Cells (2002) 1.83
Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells. J Clin Invest (2007) 1.78
miR-22 represses cancer progression by inducing cellular senescence. J Cell Biol (2011) 1.78
CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis. Nat Cell Biol (2009) 1.75
The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo. Cell Metab (2011) 1.74
miR-221 and miR-155 regulate human dendritic cell development, apoptosis, and IL-12 production through targeting of p27kip1, KPC1, and SOCS-1. Blood (2011) 1.73
The p16INK4a-RB pathway: molecular link between cellular senescence and tumor suppression. J Med Invest (2004) 1.72
Induction of ZEB proteins by inactivation of RB protein is key determinant of mesenchymal phenotype of breast cancer. J Biol Chem (2012) 1.72
Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell. Nat Commun (2012) 1.71
Gain-of-function mutations in RIT1 cause Noonan syndrome, a RAS/MAPK pathway syndrome. Am J Hum Genet (2013) 1.71
NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment. Mol Cell Biol (2006) 1.69
Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition. Cancer Res (2008) 1.68
Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria. J Biol Chem (2005) 1.67
POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination. EMBO J (2006) 1.66
Real-time in vivo imaging of p16Ink4a reveals cross talk with p53. J Cell Biol (2009) 1.66
Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice. Nat Genet (2009) 1.62
Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response. J Biol Chem (2001) 1.62
Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury. J Clin Invest (2005) 1.61
Suppression of apoptosis in the protein kinase Cdelta null mouse in vivo. J Biol Chem (2006) 1.61
Steps involved in immortalization and tumorigenesis in human B-lymphoblastoid cell lines transformed by Epstein-Barr virus. Cancer Res (2004) 1.60
The UHRF family: oncogenes that are drugable targets for cancer therapy in the near future? Pharmacol Ther (2007) 1.59
Molecular basis for the association of human E4B U box ubiquitin ligase with E2-conjugating enzymes UbcH5c and Ubc4. Structure (2010) 1.58
Cardiomyocyte proliferation and protection against post-myocardial infarction heart failure by cyclin D1 and Skp2 ubiquitin ligase. Cardiovasc Res (2008) 1.57
Molecular clearance of ataxin-3 is regulated by a mammalian E4. EMBO J (2004) 1.57
A case of Mikulicz's disease complicated by malignant lymphoma: a postmortem histopathological finding. Intern Med (2012) 1.56
Tumor necrosis factor-alpha regulates transforming growth factor-beta-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD44-moesin interaction. J Biol Chem (2009) 1.56
Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice. J Clin Invest (2006) 1.52