Engagement of the natural killer cell IgG Fc receptor results in tyrosine phosphorylation of the zeta chain.

PubWeight™: 1.39‹?› | Rank: Top 5%

🔗 View Article (PMC 50808)

Published in Proc Natl Acad Sci U S A on January 15, 1991

Authors

J J O'Shea1, A M Weissman, I C Kennedy, J R Ortaldo

Author Affiliations

1: Laboratory of Experimental Immunology, National Cancer Institute-Frederick Cancer Research and Development Center, MD 21702-1201.

Articles citing this

Tyrosine phosphorylation is required for Fc receptor-mediated phagocytosis in mouse macrophages. J Exp Med (1993) 1.91

Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes. Proc Natl Acad Sci U S A (1994) 1.84

Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation. Proc Natl Acad Sci U S A (1992) 1.55

Tyrosine phosphorylation provides an early and requisite signal for the activation of natural killer cell cytotoxic function. Proc Natl Acad Sci U S A (1991) 1.53

Control of lytic function by mitogen-activated protein kinase/extracellular regulatory kinase 2 (ERK2) in a human natural killer cell line: identification of perforin and granzyme B mobilization by functional ERK2. J Exp Med (1998) 1.48

Stimulation of Fc gamma RIIIA results in phospholipase C-gamma 1 tyrosine phosphorylation and p56lck activation. J Exp Med (1992) 1.41

Inhibition of selective signaling events in natural killer cells recognizing major histocompatibility complex class I. Proc Natl Acad Sci U S A (1995) 1.25

Human immunodeficiency-causing mutation defines CD16 in spontaneous NK cell cytotoxicity. J Clin Invest (2012) 1.22

Signal transduction by the CD2 antigen in T cells and natural killer cells: requirement for expression of a functional T cell receptor or binding of antibody Fc to the Fc receptor, Fc gamma RIIIA (CD16). J Exp Med (1991) 1.18

Functional role for Syk tyrosine kinase in natural killer cell-mediated natural cytotoxicity. J Exp Med (1997) 1.18

Receptor-induced death in human natural killer cells: involvement of CD16. J Exp Med (1995) 1.14

Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils. Proc Natl Acad Sci U S A (1993) 1.12

CD8+ T-cell clones deficient in the expression of the CD45 protein tyrosine phosphatase have impaired responses to T-cell receptor stimuli. Mol Cell Biol (1991) 1.11

Phosphatidylinositol-3 kinase activation induced upon Fc gamma RIIIA-ligand interaction. J Exp Med (1994) 1.08

Identification of human NK cells that are deficient for signaling adaptor FcRγ and specialized for antibody-dependent immune functions. Int Immunol (2012) 1.08

CD16-mediated p21ras activation is associated with Shc and p36 tyrosine phosphorylation and their binding with Grb2 in human natural killer cells. J Exp Med (1996) 0.95

Analysis of competition binding between soluble and membrane-bound ligands for cell surface receptors. Biophys J (1999) 0.95

Triggering through CD16 or phorbol esters enhances adhesion of NK cells to laminin via very late antigen 6. J Exp Med (1992) 0.89

Tetrabromobisphenol A decreases cell-surface proteins involved in human natural killer (NK) cell-dependent target cell lysis. J Immunotoxicol (2011) 0.84

Endocytosis and intracellular trafficking of human natural killer cell receptors. Traffic (2009) 0.81

Decreased expression of FcgammaRIII (CD16) by gammadelta T cells in patients with rheumatoid arthritis. Immunology (2000) 0.79

Transmembrane T-cell receptor peptides inhibit B- and natural killer-cell function. Immunology (2003) 0.77

Expansion of CD16 positive and negative human NK cells in response to tumor stimulation. Eur J Immunol (2014) 0.77

The Fc Domain of Immunoglobulin Is Sufficient to Bridge NK Cells with Virally Infected Cells. Immunity (2017) 0.75

Articles cited by this

The role of the T3/antigen receptor complex in T-cell activation. Annu Rev Immunol (1986) 5.67

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor. Proc Natl Acad Sci U S A (1990) 5.35

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA. Cell (1985) 5.21

The T cell receptor/CD3 complex: a dynamic protein ensemble. Annu Rev Immunol (1988) 5.10

Identification of the components of the murine T cell antigen receptor complex. Cell (1985) 4.20

Failure to synthesize the T cell CD3-zeta chain: structure and function of a partial T cell receptor complex. Cell (1988) 3.59

Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions. J Exp Med (1989) 3.36

Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor. Cell (1986) 3.30

Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion. Nature (1986) 3.00

Human natural killer cells: biologic and pathologic aspects. Lab Invest (1984) 2.99

Complete structure and expression in transfected cells of high affinity IgE receptor. Nature (1989) 2.97

Co-association of CD3 zeta with a receptor (CD16) for IgG Fc on human natural killer cells. Nature (1989) 2.91

Lymphokine-activated killer cells. Analysis of progenitors and effectors. J Exp Med (1986) 2.70

Heterogeneity of natural killer cells. Annu Rev Immunol (1984) 2.59

Molecular cloning of the zeta chain of the T cell antigen receptor. Science (1988) 2.58

T cell activation induces rapid tyrosine phosphorylation of a limited number of cellular substrates. J Biol Chem (1989) 2.50

Genetic and mutational analysis of the T-cell antigen receptor. Annu Rev Immunol (1990) 2.38

Fc gamma R(CD16) interaction with ligand induces Ca2+ mobilization and phosphoinositide turnover in human natural killer cells. Role of Ca2+ in Fc gamma R(CD16)-induced transcription and expression of lymphokine genes. J Exp Med (1989) 2.16

Family of disulphide-linked dimers containing the zeta and eta chains of the T-cell receptor and the gamma chain of Fc receptors. Nature (1990) 2.14

The T cell antigen receptor zeta chain is tyrosine phosphorylated upon activation. J Biol Chem (1988) 2.04

src-related tyrosine protein kinases as signaling components in hematopoietic cells. Cancer Cells (1990) 1.92

A single amino acid in the glycosyl phosphatidylinositol attachment domain determines the membrane topology of Fc gamma RIII. Nature (1989) 1.91

CD3-negative natural killer cells express zeta TCR as part of a novel molecular complex. Nature (1989) 1.82

Activation of a tyrosine protein kinase is an early event in the stimulation of T lymphocytes by interleukin-2. J Biol Chem (1988) 1.70

Fc gamma receptor type III (CD16) is included in the zeta NK receptor complex expressed by human natural killer cells. Proc Natl Acad Sci U S A (1990) 1.66

Mechanisms for regulating expression of membrane isoforms of Fc gamma RIII (CD16). Science (1989) 1.63

Multiple kinases and signal transduction. Phosphorylation of the T cell antigen receptor complex. J Biol Chem (1987) 1.63

Biochemical characterization of the eta chain of the T-cell receptor. A unique subunit related to zeta. J Biol Chem (1989) 1.55

Structural mutations of the T cell receptor zeta chain and its role in T cell activation. Science (1990) 1.44

A new subunit of the human T-cell antigen receptor complex. Nature (1987) 1.38

IL-2 regulation of tyrosine kinase activity is mediated through the p70-75 beta-subunit of the IL-2 receptor. J Immunol (1989) 1.33

Architectural editing: determining the fate of newly synthesized membrane proteins. New Biol (1989) 1.28

Activation-driven programmed cell death and T cell receptor zeta eta expression. Science (1989) 1.27

T cell receptor tyrosine phosphorylation. Variable coupling for different activating ligands. J Biol Chem (1987) 1.17

T cell antigen receptor phosphorylation induced by an anti-receptor antibody. J Immunol (1987) 1.08

T cell antigen receptor: structure, assembly and function. Year Immunol (1989) 1.01

Lysis of tumor cells by CD3+4-8-16+ T cell receptor alpha beta- clones, regulated via CD3 and CD16 activation sites, recombinant interleukin 2, and interferon beta 1. J Immunol (1987) 0.96

Specific expression of human c-fgr in natural immunity effector cells. Mol Cell Biol (1990) 0.92

Tyrosine phosphorylation of the human T cell antigen receptor zeta-chain: activation via CD3 but not CD2. J Immunol (1988) 0.92

Cytotoxic T lymphocyte triggering via CD16 is regulated by CD3 and CD8 antigens. Studies with T cell receptor (TCR)-alpha beta+/CD3+16+ and TCR-gamma delta+/CD3+16+ granular lymphocytes. J Immunol (1990) 0.80

Modulation of CD3- large granular lymphocyte functions by agonist and antagonists of protein kinase C: effects on NK and lymphokine-activated killer activity and production of IFN-gamma. J Immunol (1989) 0.80

Articles by these authors

RING finger proteins: mediators of ubiquitin ligase activity. Cell (2000) 7.75

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Proc Natl Acad Sci U S A (1999) 7.32

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J Biol Chem (2000) 6.92

Characteristics of human large granular lymphocytes and relationship to natural killer and K cells. J Exp Med (1981) 5.76

Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli. Science (2000) 5.22

Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells. J Exp Med (1993) 4.94

Natural killer cells: their roles in defenses against disease. Science (1981) 4.59

Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin. J Biol Chem (1997) 4.28

Ubiquitin and the control of protein fate in the secretory and endocytic pathways. Annu Rev Cell Dev Biol (1998) 4.15

Failure to synthesize the T cell CD3-zeta chain: structure and function of a partial T cell receptor complex. Cell (1988) 3.59

The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum. Proc Natl Acad Sci U S A (2001) 3.39

Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. Nature (1994) 3.31

Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor. Cell (1986) 3.30

Natural killer cells: characteristics and regulation of activity. Immunol Rev (1979) 3.14

Effects of natural and recombinant IL 2 on regulation of IFN gamma production and natural killer activity: lack of involvement of the Tac antigen for these immunoregulatory effects. J Immunol (1984) 3.07

Determination of surface antigens on highly purified human NK cells by flow cytometry with monoclonal antibodies. J Immunol (1981) 3.05

Augmentation by interferon of human natural and antibody-dependent cell-mediated cytotoxicity. Nature (1979) 2.94

Lymphokine-activated killer cells. Analysis of progenitors and effectors. J Exp Med (1986) 2.70

Pre-Golgi degradation of newly synthesized T-cell antigen receptor chains: intrinsic sensitivity and the role of subunit assembly. J Cell Biol (1989) 2.65

Heterogeneity of natural killer cells. Annu Rev Immunol (1984) 2.59

Building a multichain receptor: synthesis, degradation, and assembly of the T-cell antigen receptor. Proc Natl Acad Sci U S A (1987) 2.58

Alpha and beta chemokines induce NK cell migration and enhance NK-mediated cytolysis. J Immunol (1995) 2.52

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. Proc Natl Acad Sci U S A (1995) 2.52

Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15. Proc Natl Acad Sci U S A (1995) 2.19

Only high-affinity receptors for interleukin 2 mediate internalization of ligand. Proc Natl Acad Sci U S A (1986) 2.12

DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase. J Biol Chem (1998) 2.10

A field guide to ubiquitylation. Cell Mol Life Sci (2004) 2.09

Natural killer-sensitive targets stimulate production of TNF-alpha but not TNF-beta (lymphotoxin) by highly purified human peripheral blood large granular lymphocytes. J Immunol (1986) 2.05

Characterization of an anti-peptide antibody that recognizes the murine analogue of the human T cell antigen receptor-T3 delta-chain. J Immunol (1986) 1.91

Identification of a family of closely related human ubiquitin conjugating enzymes. J Biol Chem (1995) 1.89

Cytotoxic reactivity of human lymphocytes cultured in vitro. J Immunol (1977) 1.88

Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes. Proc Natl Acad Sci U S A (1994) 1.84

Novel aspects of degradation of T cell receptor subunits from the endoplasmic reticulum (ER) in T cells: importance of oligosaccharide processing, ubiquitination, and proteasome-dependent removal from ER membranes. J Exp Med (1998) 1.80

Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases. J Biol Chem (1997) 1.79

Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12. J Exp Med (1995) 1.78

Activation-induced ubiquitination of the T cell antigen receptor. Science (1992) 1.75

Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s). J Biol Chem (2001) 1.74

Mechanism of cytotoxicity by natural killer (NK) cells. Annu Rev Immunol (1986) 1.72

Beta chemokines costimulate lymphocyte cytolysis, proliferation, and lymphokine production. J Leukoc Biol (1996) 1.70

Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: implications for degradation of oxidized proteins. Proc Natl Acad Sci U S A (1998) 1.66

The transmembrane domain of a carboxyl-terminal anchored protein determines localization to the endoplasmic reticulum. J Biol Chem (1997) 1.57

In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand (CD154) expression on CD4+ T cells. Eur J Immunol (2000) 1.57

Biochemical characterization of the eta chain of the T-cell receptor. A unique subunit related to zeta. J Biol Chem (1989) 1.55

Natural killer activity in the rat. II. Analysis of surface antigens on LGL by flow cytometry. J Immunol (1981) 1.51

Exposure of K562 cells to anti-receptor monoclonal antibody OKT9 results in rapid redistribution and enhanced degradation of the transferrin receptor. J Cell Biol (1986) 1.50

Cbl-b-dependent coordinated degradation of the epidermal growth factor receptor signaling complex. J Biol Chem (2001) 1.50

Activation-dependent ubiquitination of a T cell antigen receptor subunit on multiple intracellular lysines. J Biol Chem (1994) 1.49

One-signal requirement for interferon-gamma production by human large granular lymphocytes. J Immunol (1987) 1.49

Characterization of the family of dimers associated with Fc receptors (Fc epsilon RI and Fc gamma RIII). J Immunol (1991) 1.48

Augmentation of organ-associated natural killer activity by biological response modifiers. Isolation and characterization of large granular lymphocytes from the liver. J Exp Med (1984) 1.41

Epidural patient-controlled analgesia after cesarean section: buprenorphine-0.015% bupivacaine with epinephrine versus fentanyl-0.015% bupivacaine with and without epinephrine. Anesth Analg (1992) 1.41

Production of interleukin 1 activity by normal human peripheral blood B lymphocytes. J Immunol (1985) 1.40

Mediation of mouse natural cytotoxic activity by tumour necrosis factor. Nature (1986) 1.39

The Ly-49D receptor activates murine natural killer cells. J Exp Med (1996) 1.39

Isolation of human and rat natural killer cells. J Immunol Methods (1982) 1.39

A new subunit of the human T-cell antigen receptor complex. Nature (1987) 1.38

T cell antigen receptor ubiquitination is a consequence of receptor-mediated tyrosine kinase activation. J Biol Chem (1996) 1.38

Analysis of effector mechanisms against HTLV-I- and HTLV-III/LAV-infected lymphoid cells. J Immunol (1986) 1.37

Positive recognition of MHC class I molecules by the Ly49D receptor of murine NK cells. J Immunol (1999) 1.37

Specificity of natural cytotoxic reactivity of normal human lymphocytes against a myeloid leukemia cell line. J Natl Cancer Inst (1977) 1.36

Cloning and functional characteristics of murine large granular lymphocyte-1: a member of the Ly-49 gene family (Ly-49G2) J Exp Med (1995) 1.35

Analysis by a single cell cytotoxicity assay of natural killer (NK) cells frequencies among human large granular lymphocytes and of the effects of interferon on their activity. J Immunol (1982) 1.34

IL-2 regulation of tyrosine kinase activity is mediated through the p70-75 beta-subunit of the IL-2 receptor. J Immunol (1989) 1.33

Cytotoxicity by cultured human lymphocytes: characteristics of effector cells and specificity of cytotoxicity. J Immunol (1979) 1.32

Mechanistic studies of transforming growth factor-beta inhibition of IL-2-dependent activation of CD3- large granular lymphocyte functions. Regulation of IL-2R beta (p75) signal transduction. J Immunol (1991) 1.31

Selective depletion of human natural killer cells on monolayers of target cells. J Immunol (1980) 1.29

Mouse Ly-49D recognizes H-2Dd and activates natural killer cell cytotoxicity. J Exp Med (1999) 1.27

Activation-driven programmed cell death and T cell receptor zeta eta expression. Science (1989) 1.27

The nuclear factor YY1 suppresses the human gamma interferon promoter through two mechanisms: inhibition of AP1 binding and activation of a silencer element. Mol Cell Biol (1996) 1.26

The ever-expanding Ly49 gene family: repertoire and signaling. Immunol Rev (2001) 1.26

A species of human alpha interferon that lacks the ability to boost human natural killer activity. Proc Natl Acad Sci U S A (1984) 1.23

Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation. Immunity (1997) 1.22

Interleukin 2 induction of pore-forming protein gene expression in human peripheral blood CD8+ T cells. J Exp Med (1990) 1.22

Expression and role of p75 interleukin 2 receptor on human monocytes. J Exp Med (1990) 1.19

Human large granular lymphocytes are potent producers of interleukin-1. Nature (1984) 1.18

IL-8 gene expression and production in human peripheral blood lymphocyte subsets. J Immunol (1991) 1.18

A cyclophilin-related protein involved in the function of natural killer cells. Proc Natl Acad Sci U S A (1993) 1.17

Regulation of lymphokine-activated killer activity and pore-forming protein gene expression in human peripheral blood CD8+ T lymphocytes. Inhibition by transforming growth factor-beta. J Immunol (1991) 1.17

Analysis of effector cells in human antibody-dependent cellular cytotoxicity with murine monoclonal antibodies. J Immunol (1987) 1.17

A role for protein tyrosine kinase activity in natural cytotoxicity as well as antibody-dependent cellular cytotoxicity. Effects of herbimycin A. J Immunol (1992) 1.17

Role of organ-associated NK cells in decreased formation of experimental metastases in lung and liver. J Immunol (1985) 1.17

Class I MHC-binding characteristics of the 129/J Ly49 repertoire. J Immunol (2001) 1.15

Transformation of owl monkey T cells in vitro with Herpesvirus saimiri. Proc Natl Acad Sci U S A (1984) 1.14

Analysis of T cell receptors in highly purified rat and human large granular lymphocytes (LGL): lack of functional 1.3 kb beta-chain mRNA. J Immunol (1986) 1.14

Transcriptional coregulator SNURF (RNF4) possesses ubiquitin E3 ligase activity. FEBS Lett (2004) 1.13

Effects of metabolic inhibitors on spontaneous and interferon-boosted human natural killer cell activity. J Immunol (1980) 1.12

Effects of several species of human leukocyte interferon on cytotoxic activity of NK cells and monocytes. Int J Cancer (1983) 1.12

IL-2 and IL-6 synergize to augment the pore-forming protein gene expression and cytotoxic potential of human peripheral blood T cells. J Immunol (1990) 1.09

NK cell infiltration into lung, liver, and subcutaneous B16 melanoma is mediated by VCAM-1/VLA-4 interaction. J Immunol (1996) 1.09

Cellular and molecular mechanisms of IFN-gamma production induced by IL-2 and IL-12 in a human NK cell line. J Leukoc Biol (1995) 1.09

Tolerance and alloreactivity of the Ly49D subset of murine NK cells. J Immunol (1999) 1.09

Effect of human recombinant interferon on cytotoxic activity of natural killer (NK) cells and monocytes. Cell Immunol (1982) 1.08

Induction of DAP12 phosphorylation, calcium mobilization, and cytokine secretion by Ly49H. J Leukoc Biol (1999) 1.08

Characterization of a suppressor T-cell chronic lymphocytic leukemia with ADCC but not NK activity. Blood (1980) 1.08

IL-13 production by NK cells: IL-13-producing NK and T cells are present in vivo in the absence of IFN-gamma. J Immunol (1999) 1.07

Role of a STAT binding site in the regulation of the human perforin promoter. J Immunol (1999) 1.07

Regulation of TCR signaling by CD45 lacking transmembrane and extracellular domains. Science (1993) 1.07

Characterization of an associated 16-kDa tyrosine phosphoprotein required for Ly-49D signal transduction. J Immunol (1998) 1.06

The role of LY49 NK cell subsets in the regulation of murine cytomegalovirus infections. J Immunol (1999) 1.05