Published in Nature on January 18, 1979
Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry. Sci Transl Med (2013) 3.41
Interleukin-2 enhances the depressed natural killer and cytomegalovirus-specific cytotoxic activities of lymphocytes from patients with the acquired immune deficiency syndrome. J Clin Invest (1983) 2.32
Positive self regulation of cytotoxicity in human natural killer cells by production of interferon upon exposure to influenza and herpes viruses. J Exp Med (1982) 1.81
Chédiak-Higashi gene in humans I. Impairment of natural-killer function. J Exp Med (1980) 1.79
Role of alloantigens in natural killing. Allogeneic but not autologous tumor biopsy cells are sensitive for interferon-induced cytotoxicity of human blood lymphcoytes. J Exp Med (1980) 1.48
Dysfunction of natural killer cells in multiple sclerosis: a possible pathogenetic factor. Clin Exp Immunol (1980) 1.47
Release of cytokines induced by Salmonella typhimurium porins. Infect Immun (1993) 1.41
A model for the differentiation of human natural killer cells. Studies on the in vitro activation of Leu-11+ granular lymphocytes with a natural killer-sensitive tumor cell, K562. J Exp Med (1985) 1.41
A species of human alpha interferon that lacks the ability to boost human natural killer activity. Proc Natl Acad Sci U S A (1984) 1.23
Chemiluminescence response of human natural killer cells. I. The relationship between target cell binding, chemiluminescence, and cytolysis. J Exp Med (1982) 1.23
Role of human natural killer cells in health and disease. Clin Diagn Lab Immunol (1994) 1.19
Investigation of the biological effects of anti-cell adhesive synthetic peptides that inhibit experimental metastasis of B16-F10 murine melanoma cells. J Clin Invest (1988) 1.18
Enhancement of human natural cell-mediated cytotoxicity by interferon. Br J Cancer (1980) 1.11
Activation of a suppressor T-cell pathway by interferon. Proc Natl Acad Sci U S A (1982) 1.10
Induction of interferon alpha from human lymphocytes by autologous, dengue virus-infected monocytes. J Exp Med (1987) 1.03
Human B lymphocytes produce leukocyte interferon after interaction with foreign cells. Infect Immun (1981) 1.02
Determination of natural killer cell function by flow cytometry. Clin Diagn Lab Immunol (1996) 1.01
Regulation by recombinant interleukin-2 of protective immunity against recurrent herpes simplex virus type 2 genital infection in guinea pigs. J Virol (1987) 0.97
Use of bone marrow fibroblasts to prepare targets for an HLA restricted-cytotoxicity assay system. J Clin Microbiol (1984) 0.97
Alphaviral vector-transduced dendritic cells are successful therapeutic vaccines against neu-overexpressing tumors in wild-type mice. Vaccine (2007) 0.97
Inhibition of herpes simplex virus type 1 replication in fibroblast cultures by human blood mononuclear cells. J Virol (1986) 0.93
Destruction of the multicellular parasite Schistosoma mansoni by T lymphocytes. J Clin Invest (1982) 0.90
Lysis of varicella zoster virus infected cells by lymphocytes from normal humans and immunosuppressed pediatric leukaemic patients. Clin Exp Immunol (1985) 0.89
Interferon-induced changes in the monocyte membrane: inhibition by retinol and retinoic acid. Immunology (1982) 0.89
Cellular cytotoxicity to measles virus during natural measles infection. Clin Exp Immunol (1980) 0.88
Insensitivity to interferon of NK cells from patients with systemic lupus erythematosus. Clin Exp Immunol (1982) 0.87
The antitumor and immunoadjuvant effects of IFN-alpha in combination with recombinant poxvirus vaccines. Clin Cancer Res (2009) 0.86
De novo synthesis and secretion of a 36-kD protein by cells that form lupus inclusions in response to alpha-interferon. J Clin Invest (1995) 0.86
Inhibition of interferon-mediated induction of indoleamine 2,3-dioxygenase in mouse lung by inhibitors of prostaglandin biosynthesis. Proc Natl Acad Sci U S A (1981) 0.86
Processing and presentation of cell-associated varicella-zoster virus antigens by human monocytes. Clin Exp Immunol (1987) 0.85
Interleukin 2 augmentation of natural killer cell activity in homosexual men with acquired immune deficiency syndrome. Infect Immun (1984) 0.85
NK cell activity and skin test antigen stimulation of NK like CMC in vitro are decreased to different degrees in pregnancy and sarcoidosis. Clin Exp Immunol (1984) 0.85
Lectin-binding characteristics of human natural killer cells. Immunology (1982) 0.84
Enhanced expression in vivo of HLA-ABC antigens and beta 2-microglobulin on human lymphoid cells induced by human interferon-alpha in patients with lung cancer. Enhanced expression of class I major histocompatibility antigens prior to treatment. Clin Exp Immunol (1985) 0.84
Proliferative and functional aspects of interferon-treated human normal and neoplastic T and B cells. Br J Cancer (1980) 0.83
Cathepsin G enhances human natural killer cytotoxicity. Immunology (1998) 0.82
Cellular interactions in the lysis of varicella-zoster virus infected human fibroblasts. Clin Exp Immunol (1986) 0.81
Activation of human natural killer cells by lipopolysaccharide and generation of interleukin-1 alpha, beta, tumour necrosis factor and interleukin-6. Effect of IL-1 receptor antagonist. Immunology (1991) 0.81
Receptors for immunoglobulin isotype on T and B lymphocytes from untreated patients with chronic lymphocytic leukaemia. Clin Exp Immunol (1980) 0.80
Induction of the 2B9 antigen/dipeptidyl peptidase IV/CD26 on human natural killer cells by IL-2, IL-12 or IL-15. Immunology (1997) 0.80
Human polymorphonuclear neutrophil functions are unaffected by human interferon-alpha 2. Infect Immun (1983) 0.80
Recombinant gamma interferon provokes resistance of human breast cancer cells to spontaneous and IL-2 activated non-MHC restricted cytotoxicity. Br J Cancer (1990) 0.79
Selective impairment of alpha-interferon-mediated natural killer augmentation in Sjögren's syndrome: differential effects of alpha-interferon, gamma-interferon, and interleukin 2 on cytolytic activity. Clin Exp Immunol (1987) 0.78
Modulation of in vitro porcine natural killer cell activity by recombinant interleukin-1 alpha, interleukin-2 and interleukin-4. Immunology (1992) 0.78
Regulation of natural and antibody-dependent cellular cytotoxicity by staphylococcal enterotoxin A. Clin Exp Immunol (1983) 0.78
Human immune responses to Plasmodium falciparum infection: molecular evidence for a suboptimal THαβ and TH17 bias over ideal and effective traditional TH1 immune response. Malar J (2013) 0.78
In vitro modulation of human natural killer cell activity by interferon: generation of adherent suppressor cells. Br J Cancer (1984) 0.77
Enhancement of human ADCC with interferon. Clin Exp Immunol (1982) 0.77
Association of human leucocyte low responsiveness to inducers of interferon alpha with HLA-DR 2. Immunology (1983) 0.77
The nature of enhanced natural killer lymphocyte cytotoxicity during anesthesia and surgery in patients with benign disease and cancer. Ann Surg (1984) 0.76
Increased sensitivity to natural killing in Raji cells is due to effector recognition of molecules appearing on target cell membranes following EBV cycle induction. Clin Exp Immunol (1983) 0.75
Natural killer cell activity in atopic dermatitis. Arch Dermatol Res (1982) 0.75
The effect of recombinant interferon-alpha on lymphocyte subpopulations and HLA-DR expression on liver tissue of HBV-positive individuals. Clin Exp Immunol (1990) 0.75
Stimulation natural cytotoxic activity in mixed cell cultures and by culture supernatants containing interferon. Immunology (1982) 0.75
Biosynthetic human interferon treatment of herpetic keratitis. Trans Am Ophthalmol Soc (1983) 0.75
Immunological studies in patients with HBsAg-positive chronic active hepatitis--spontaneous lymphocyte transformation and natural killer cell activity. Korean J Intern Med (1987) 0.75
Multiple biological activities of homogeneous human alpha interferon. Infect Immun (1981) 0.75
Spontaneous cytotoxicity of murine cells treated with the interferon inducers BRL 5907 and BRL 10739. Immunology (1980) 0.75
Therapy with high dose recombinant alpha 2 interferon (IFN-alpha 2) produces a depression in natural killer cell cytotoxicity. Br J Cancer (1984) 0.75
In vitro boost of human NK activity by a triethylphosphine gold derivative. Clin Exp Immunol (1984) 0.75
"Multi-Omics" Analyses of the Development and Function of Natural Killer Cells. Front Immunol (2017) 0.75
Characteristics of human large granular lymphocytes and relationship to natural killer and K cells. J Exp Med (1981) 5.76
Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells. J Exp Med (1993) 4.94
Natural killer cells: their roles in defenses against disease. Science (1981) 4.59
Natural cytotoxic reactivity of human lymphocytes against a myeloid cell line: characterization of effector cells. J Immunol (1977) 3.52
Ligand-activated T cell growth factor-induced proliferation: absorption of T cell growth factor by activated T cells. J Immunol (1979) 3.37
Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. Nature (1994) 3.31
Natural killer cells: characteristics and regulation of activity. Immunol Rev (1979) 3.14
Effects of natural and recombinant IL 2 on regulation of IFN gamma production and natural killer activity: lack of involvement of the Tac antigen for these immunoregulatory effects. J Immunol (1984) 3.07
Determination of surface antigens on highly purified human NK cells by flow cytometry with monoclonal antibodies. J Immunol (1981) 3.05
Lymphokine-activated killer cells. Analysis of progenitors and effectors. J Exp Med (1986) 2.70
Transplantation antigens: introductory symposium. Mixed leukocyte cultures and HL-A antigens. I. Reactivity of young fetuses, newborns and mothers at delivery. Transplant Proc (1971) 2.63
A functional comparison of human Fc-receptor-bearing lymphocytes active in natural cytotoxicity and antibody-dependent cellular cytotoxicity. J Immunol (1977) 2.60
Heterogeneity of natural killer cells. Annu Rev Immunol (1984) 2.59
Alpha and beta chemokines induce NK cell migration and enhance NK-mediated cytolysis. J Immunol (1995) 2.52
Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. Proc Natl Acad Sci U S A (1995) 2.52
Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15. Proc Natl Acad Sci U S A (1995) 2.19
DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase. J Biol Chem (1998) 2.10
Natural killer-sensitive targets stimulate production of TNF-alpha but not TNF-beta (lymphotoxin) by highly purified human peripheral blood large granular lymphocytes. J Immunol (1986) 2.05
Immunosuppressive activity of a subline of the mouse EL-4 lymphoma. Evidence for minute virus of mice causing the inhibition. J Exp Med (1976) 2.01
Antibody-dependent cell-mediated cytotoxicity: heterogeneity of effector cells in human peripheral blood. Scand J Immunol (1975) 1.94
Cytotoxic reactivity of human lymphocytes cultured in vitro. J Immunol (1977) 1.88
Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes. Proc Natl Acad Sci U S A (1994) 1.84
Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12. J Exp Med (1995) 1.78
Mechanism of cytotoxicity by natural killer (NK) cells. Annu Rev Immunol (1986) 1.72
Beta chemokines costimulate lymphocyte cytolysis, proliferation, and lymphokine production. J Leukoc Biol (1996) 1.70
Continued growth of functional human T lymphocytes: production of human T-cell growth factor. Cell Immunol (1980) 1.63
In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand (CD154) expression on CD4+ T cells. Eur J Immunol (2000) 1.57
Natural killer activity in the rat. II. Analysis of surface antigens on LGL by flow cytometry. J Immunol (1981) 1.51
One-signal requirement for interferon-gamma production by human large granular lymphocytes. J Immunol (1987) 1.49
Characterization of the family of dimers associated with Fc receptors (Fc epsilon RI and Fc gamma RIII). J Immunol (1991) 1.48
Augmentation of organ-associated natural killer activity by biological response modifiers. Isolation and characterization of large granular lymphocytes from the liver. J Exp Med (1984) 1.41
Production of interleukin 1 activity by normal human peripheral blood B lymphocytes. J Immunol (1985) 1.40
Monocyte-mediated antibody-dependent cellular cytotoxicity: a clinical test of monocyte function. Blood (1976) 1.40
Mediation of mouse natural cytotoxic activity by tumour necrosis factor. Nature (1986) 1.39
Engagement of the natural killer cell IgG Fc receptor results in tyrosine phosphorylation of the zeta chain. Proc Natl Acad Sci U S A (1991) 1.39
The Ly-49D receptor activates murine natural killer cells. J Exp Med (1996) 1.39
Isolation of human and rat natural killer cells. J Immunol Methods (1982) 1.39
Analysis of effector mechanisms against HTLV-I- and HTLV-III/LAV-infected lymphoid cells. J Immunol (1986) 1.37
Positive recognition of MHC class I molecules by the Ly49D receptor of murine NK cells. J Immunol (1999) 1.37
Specificity of natural cytotoxic reactivity of normal human lymphocytes against a myeloid leukemia cell line. J Natl Cancer Inst (1977) 1.36
Cloning and functional characteristics of murine large granular lymphocyte-1: a member of the Ly-49 gene family (Ly-49G2) J Exp Med (1995) 1.35
Analysis by a single cell cytotoxicity assay of natural killer (NK) cells frequencies among human large granular lymphocytes and of the effects of interferon on their activity. J Immunol (1982) 1.34
Detection of HLA-DRw (Ia-like) antigens on human T lymphocytes grown in tissue culture. J Immunol (1979) 1.33
IL-2 regulation of tyrosine kinase activity is mediated through the p70-75 beta-subunit of the IL-2 receptor. J Immunol (1989) 1.33
Cytotoxicity by cultured human lymphocytes: characteristics of effector cells and specificity of cytotoxicity. J Immunol (1979) 1.32
Selective depletion of human natural killer cells on monolayers of target cells. J Immunol (1980) 1.29
Mouse Ly-49D recognizes H-2Dd and activates natural killer cell cytotoxicity. J Exp Med (1999) 1.27
The nuclear factor YY1 suppresses the human gamma interferon promoter through two mechanisms: inhibition of AP1 binding and activation of a silencer element. Mol Cell Biol (1996) 1.26
The ever-expanding Ly49 gene family: repertoire and signaling. Immunol Rev (2001) 1.26
A species of human alpha interferon that lacks the ability to boost human natural killer activity. Proc Natl Acad Sci U S A (1984) 1.23
Interleukin 2 induction of pore-forming protein gene expression in human peripheral blood CD8+ T cells. J Exp Med (1990) 1.22
Expression and role of p75 interleukin 2 receptor on human monocytes. J Exp Med (1990) 1.19
Human large granular lymphocytes are potent producers of interleukin-1. Nature (1984) 1.18
IL-8 gene expression and production in human peripheral blood lymphocyte subsets. J Immunol (1991) 1.18
A cyclophilin-related protein involved in the function of natural killer cells. Proc Natl Acad Sci U S A (1993) 1.17
Regulation of lymphokine-activated killer activity and pore-forming protein gene expression in human peripheral blood CD8+ T lymphocytes. Inhibition by transforming growth factor-beta. J Immunol (1991) 1.17
Analysis of effector cells in human antibody-dependent cellular cytotoxicity with murine monoclonal antibodies. J Immunol (1987) 1.17
Cytotoxicity against the K562 erythroleukemia cell line by human natural killer (NK) cells which do not bear free Fc receptors for IgG. Int J Cancer (1979) 1.17
A role for protein tyrosine kinase activity in natural cytotoxicity as well as antibody-dependent cellular cytotoxicity. Effects of herbimycin A. J Immunol (1992) 1.17
Role of organ-associated NK cells in decreased formation of experimental metastases in lung and liver. J Immunol (1985) 1.17
Lymphokine regulation of activated (G1) lymphocytes. II. Glucocorticoid and anti-Tac-induced inhibition of human T lymphocyte proliferation. J Immunol (1984) 1.16
Cortical thickness and diaphysial diameter of the metacarpal bones from the age of three months to eleven years. Helv Paediatr Acta (1968) 1.16
Class I MHC-binding characteristics of the 129/J Ly49 repertoire. J Immunol (2001) 1.15
Transformation of owl monkey T cells in vitro with Herpesvirus saimiri. Proc Natl Acad Sci U S A (1984) 1.14
Analysis of T cell receptors in highly purified rat and human large granular lymphocytes (LGL): lack of functional 1.3 kb beta-chain mRNA. J Immunol (1986) 1.14
Inhibition of in vitro lymphoproliferative responses by in vivo passaged rat 13762 mammary adenocarcinoma cells. II. Evidenceth Kilham rat virus is responsible for the inhibitory effect. Cell Immunol (1977) 1.13
Cytotoxic activities of normal cultured human T cells. J Immunol (1978) 1.12
Effects of several species of human leukocyte interferon on cytotoxic activity of NK cells and monocytes. Int J Cancer (1983) 1.12
Effects of metabolic inhibitors on spontaneous and interferon-boosted human natural killer cell activity. J Immunol (1980) 1.12
The suppression of mitogen- and alloantigen-stimulated peripheral blood lymphocytes by cultured human T lymphocytes. J Immunol (1979) 1.09
NK cell infiltration into lung, liver, and subcutaneous B16 melanoma is mediated by VCAM-1/VLA-4 interaction. J Immunol (1996) 1.09
IL-2 and IL-6 synergize to augment the pore-forming protein gene expression and cytotoxic potential of human peripheral blood T cells. J Immunol (1990) 1.09
Cellular and molecular mechanisms of IFN-gamma production induced by IL-2 and IL-12 in a human NK cell line. J Leukoc Biol (1995) 1.09
Tolerance and alloreactivity of the Ly49D subset of murine NK cells. J Immunol (1999) 1.09
Effect of human recombinant interferon on cytotoxic activity of natural killer (NK) cells and monocytes. Cell Immunol (1982) 1.08
Induction of DAP12 phosphorylation, calcium mobilization, and cytokine secretion by Ly49H. J Leukoc Biol (1999) 1.08
Characterization of a suppressor T-cell chronic lymphocytic leukemia with ADCC but not NK activity. Blood (1980) 1.08
IL-13 production by NK cells: IL-13-producing NK and T cells are present in vivo in the absence of IFN-gamma. J Immunol (1999) 1.07
Role of a STAT binding site in the regulation of the human perforin promoter. J Immunol (1999) 1.07
Characterization of an associated 16-kDa tyrosine phosphoprotein required for Ly-49D signal transduction. J Immunol (1998) 1.06
The role of LY49 NK cell subsets in the regulation of murine cytomegalovirus infections. J Immunol (1999) 1.05
The natural killer gene complex genetic locus Chok encodes Ly-49D, a target recognition receptor that activates natural killing. Proc Natl Acad Sci U S A (1999) 1.05
Human tumour antigens defined by cytotoxicity and proliferative responses of cultured lymphoid cells. Nature (1982) 1.03
Characteristics of human NK clones: target specificity and phenotype. J Immunol (1984) 1.03
Characterization of a silencer regulatory element in the human interferon-gamma promoter. J Biol Chem (1994) 1.02
Differential regulation of the Janus kinase-STAT pathway and biologic function of IL-13 in primary human NK and T cells: a comparative study with IL-4. J Immunol (1998) 1.02
Augmentation of mouse liver-associated natural killer activity by biologic response modifiers occurs largely via rapid recruitment of large granular lymphocytes from the bone marrow. J Immunol (1989) 1.02
Regulation of local host-mediated anti-tumor mechanisms by cytokines: direct and indirect effects on leukocyte recruitment and angiogenesis. Am J Pathol (1997) 0.98
Cultures of purified human natural killer cells: growth in the presence of interleukin 2. Cell Immunol (1982) 0.98
Flavone acetic acid directly induces expression of cytokine genes in mouse splenic leukocytes but not in human peripheral blood leukocytes. Cancer Res (1991) 0.98
Modulation of fetal antigen(s) in mouse leukemia cells. Cancer Res (1974) 0.98
Depression of natural killer cytotoxicity after in vivo administration of recombinant leukocyte interferon. J Immunol (1983) 0.97
Interaction of Ly-49D+ NK cells with H-2Dd target cells leads to Dap-12 phosphorylation and IFN-gamma secretion. J Immunol (2000) 0.97
Engraftment and activity of anti-CD3-activated human peripheral blood lymphocytes transferred into mice with severe combined immune deficiency. J Immunol (1993) 0.97