Published in Cancer Res on October 15, 2006
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Chemistry and antihypertensive effects of tempol and other nitroxides. Pharmacol Rev (2008) 1.91
Radioprotectors and mitigators of radiation-induced normal tissue injury. Oncologist (2010) 1.71
Advances in quantitative UV-visible spectroscopy for clinical and pre-clinical application in cancer. Curr Opin Biotechnol (2009) 1.44
Pulsed EPR imaging of nitroxides in mice. J Magn Reson (2008) 1.09
Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice. Proc Natl Acad Sci U S A (2008) 1.07
Brain redox imaging using blood-brain barrier-permeable nitroxide MRI contrast agent. J Cereb Blood Flow Metab (2008) 1.06
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Imaging heterogeneity in the mitochondrial redox state of premalignant pancreas in the pancreas-specific PTEN-null transgenic mouse model. Biomark Res (2013) 0.92
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Oxidative stress imaging in live animals with techniques based on electron paramagnetic resonance. Radiat Res (2012) 0.86
Synthesis and reduction kinetics of sterically shielded pyrrolidine nitroxides. Org Lett (2012) 0.84
Tumor Xenograft Response to Redox-Active Therapies Assessed by Magnetic Resonance Imaging Using a Thiol-Bearing DOTA Complex of Gadolinium. Transl Oncol (2012) 0.83
In vivo evaluation of different alterations of redox status by studying pharmacokinetics of nitroxides using magnetic resonance techniques. Redox Biol (2015) 0.81
In vivo imaging of tumor physiological, metabolic, and redox changes in response to the anti-angiogenic agent sunitinib: longitudinal assessment to identify transient vascular renormalization. Antioxid Redox Signal (2014) 0.79
The relationship between tissue oxygenation and redox status using magnetic resonance imaging. Int J Oncol (2012) 0.78
Imaging of superoxide generation in the dopaminergic area of the brain in Parkinson's disease, using mito-TEMPO. ACS Chem Neurosci (2013) 0.78
Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications. Chem Rev (2017) 0.76
Unique oxidation of imidazolidine nitroxides by potassium ferricyanide: strategy for designing paramagnetic probes with enhanced sensitivity to oxidative stress. Free Radic Res (2012) 0.76
Imaging Reactive Oxygen Species-Induced Modifications in Living Systems. Antioxid Redox Signal (2016) 0.75
Selective enhancement of hypoxic cell killing by tempol-regulated suicide gene expression. Oncol Rep (2015) 0.75
Accelerated dynamic EPR imaging using fast acquisition and compressive recovery. J Magn Reson (2016) 0.75
Nitroxide-Based Macromolecular Contrast Agents with Unprecedented Transverse Relaxivity and Stability for Magnetic Resonance Imaging of Tumors. ACS Cent Sci (2017) 0.75
Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proc Natl Acad Sci U S A (2005) 3.30
The chemistry and biology of nitroxide compounds. Free Radic Biol Med (2007) 2.76
Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach. Cancer Cell (2004) 2.73
Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo. Proc Natl Acad Sci U S A (2007) 2.71
Overhauser enhanced magnetic resonance imaging for tumor oximetry: coregistration of tumor anatomy and tissue oxygen concentration. Proc Natl Acad Sci U S A (2002) 2.62
Noninvasive imaging of tumor redox status and its modification by tissue glutathione levels. Cancer Res (2002) 2.56
The immunogenicity of human adipose-derived cells: temporal changes in vitro. Stem Cells (2006) 2.50
Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. Proc Natl Acad Sci U S A (2008) 2.50
Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation. Am J Pathol (2002) 2.23
Human bone marrow stromal cell treatment improves neurological functional recovery in EAE mice. Exp Neurol (2005) 2.11
mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis. Cell Stem Cell (2012) 1.99
Ionizing radiation-induced oxidative stress alters miRNA expression. PLoS One (2009) 1.94
Gene expression profiling of breast, prostate, and glioma cells following single versus fractionated doses of radiation. Cancer Res (2007) 1.91
Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity. Nat Commun (2013) 1.84
Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers. Int J Radiat Oncol Biol Phys (2010) 1.84
Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy. Circulation (2008) 1.82
PI3K/mTOR inhibitor PF-04691502 antitumor activity is enhanced with induction of wild-type TP53 in human xenograft and murine knockout models of head and neck cancer. Clin Cancer Res (2013) 1.81
Low-field paramagnetic resonance imaging of tumor oxygenation and glycolytic activity in mice. J Clin Invest (2008) 1.71
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Molecular and cellular biology of moderate-dose (1-10 Gy) radiation and potential mechanisms of radiation protection: report of a workshop at Bethesda, Maryland, December 17-18, 2001. Radiat Res (2003) 1.69
Detecting response of rat C6 glioma tumors to radiotherapy using hyperpolarized [1- 13C]pyruvate and 13C magnetic resonance spectroscopic imaging. Magn Reson Med (2010) 1.65
Nuclear factor-kappaB is an important modulator of the altered gene expression profile and malignant phenotype in squamous cell carcinoma. Cancer Res (2004) 1.65
Interference with transforming growth factor-beta/ Smad3 signaling results in accelerated healing of wounds in previously irradiated skin. Am J Pathol (2003) 1.64
Absolute oxygen tension (pO(2)) in murine fatty and muscle tissue as determined by EPR. Magn Reson Med (2005) 1.63
Single-point (constant-time) imaging in radiofrequency Fourier transform electron paramagnetic resonance. Magn Reson Med (2002) 1.56
Thrombospondin-1 limits ischemic tissue survival by inhibiting nitric oxide-mediated vascular smooth muscle relaxation. Blood (2006) 1.56
Electron paramagnetic resonance imaging of tumor hypoxia: enhanced spatial and temporal resolution for in vivo pO2 determination. Magn Reson Med (2006) 1.50
Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice. Hum Mol Genet (2004) 1.50
Low-field magnetic resonance imaging to visualize chronic and cycling hypoxia in tumor-bearing mice. Cancer Res (2010) 1.49
Fludarabine treatment of patients with chronic lymphocytic leukemia induces a p53-dependent gene expression response. Blood (2004) 1.48
Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone. J Biol Chem (2004) 1.46
Inhibition of nuclear factor-kappaB and target genes during combined therapy with proteasome inhibitor bortezomib and reirradiation in patients with recurrent head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys (2005) 1.44
A new strategy for fast radiofrequency CW EPR imaging: direct detection with rapid scan and rotating gradients. J Magn Reson (2007) 1.41
Noninvasive in vivo oximetric imaging by radiofrequency FT EPR. Magn Reson Med (2002) 1.39
Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction. Proc Natl Acad Sci U S A (2012) 1.38
Oxidative stress, redox, and the tumor microenvironment. Semin Radiat Oncol (2004) 1.38
High-resolution mapping of tumor redox status by magnetic resonance imaging using nitroxides as redox-sensitive contrast agents. Clin Cancer Res (2006) 1.38
Strategies for improved temporal and spectral resolution in in vivo oximetric imaging using time-domain EPR. Magn Reson Med (2007) 1.37
Differential radiation protection of salivary glands versus tumor by Tempol with accompanying tissue assessment of Tempol by magnetic resonance imaging. Clin Cancer Res (2007) 1.34
Imaging cycling tumor hypoxia. Cancer Res (2010) 1.32
Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res (2002) 1.32
Kinetics of tempol for prevention of xerostomia following head and neck irradiation in a mouse model. Clin Cancer Res (2005) 1.27
Blocking thrombospondin-1/CD47 signaling alleviates deleterious effects of aging on tissue responses to ischemia. Arterioscler Thromb Vasc Biol (2007) 1.25
Superoxide fluxes limit nitric oxide-induced signaling. J Biol Chem (2006) 1.22
Pharmacokinetics of a triarylmethyl-type paramagnetic spin probe used in EPR oximetry. Magn Reson Med (2004) 1.22
Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia mice. Cancer Res (2008) 1.22
MR assessment of changes of tumor in response to hyperbaric oxygen treatment. Magn Reson Med (2006) 1.21
Antiangiogenic agent sunitinib transiently increases tumor oxygenation and suppresses cycling hypoxia. Cancer Res (2011) 1.19
Simultaneous imaging of tumor oxygenation and microvascular permeability using Overhauser enhanced MRI. Proc Natl Acad Sci U S A (2009) 1.18
A low molecular weight antioxidant decreases weight and lowers tumor incidence. Free Radic Biol Med (2003) 1.18
Prevention of irradiation-induced salivary hypofunction by microvessel protection in mouse salivary glands. Mol Ther (2007) 1.18
Characterization of Salmonella enterica serovar Typhimurium isolates harboring a chromosomally encoded CMY-2 beta-lactamase gene located on a multidrug resistance genomic island. Antimicrob Agents Chemother (2011) 1.14
Evaluation and comparison of pulsed and continuous wave radiofrequency electron paramagnetic resonance techniques for in vivo detection and imaging of free radicals. J Magn Reson (2002) 1.13
PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells. Int J Cancer (2008) 1.12
The stable nitroxide tempol facilitates salivary gland protection during head and neck irradiation in a mouse model. Clin Cancer Res (2004) 1.10
Pulsed EPR imaging of nitroxides in mice. J Magn Reson (2008) 1.09
Cellular stress induced alterations in microRNA let-7a and let-7b expression are dependent on p53. PLoS One (2011) 1.08
Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice. Proc Natl Acad Sci U S A (2008) 1.07
Prevention of radiation-induced oral mucositis after adenoviral vector-mediated transfer of the keratinocyte growth factor cDNA to mouse submandibular glands. Clin Cancer Res (2009) 1.07
Guadinomines, Type III secretion system inhibitors, produced by Streptomyces sp. K01-0509. I: taxonomy, fermentation, isolation and biological properties. J Antibiot (Tokyo) (2008) 1.07
Prevention of radiation-induced salivary hypofunction following hKGF gene delivery to murine submandibular glands. Clin Cancer Res (2011) 1.07
Stochastic excitation and Hadamard correlation spectroscopy with bandwidth extension in RF FT-EPR. J Magn Reson (2003) 1.07
Brain redox imaging using blood-brain barrier-permeable nitroxide MRI contrast agent. J Cereb Blood Flow Metab (2008) 1.06
Application of a macromolecular contrast agent for detection of alterations of tumor vessel permeability induced by radiation. Clin Cancer Res (2004) 1.04
In vivo spectral fluorescence imaging of submillimeter peritoneal cancer implants using a lectin-targeted optical agent. Neoplasia (2006) 1.04
Assessment of tissue redox status using metabolic responsive contrast agents and magnetic resonance imaging. J Pharm Pharmacol (2008) 1.02