Published in Blood on October 31, 2006
Globin switches in yolk sac-like primitive and fetal-like definitive red blood cells produced from human embryonic stem cells. Blood (2007) 1.76
The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development. Development (2007) 1.49
Noncoding transcription controls downstream promoters to regulate T-cell receptor alpha recombination. EMBO J (2007) 1.46
Transcriptional interference by RNA polymerase pausing and dislodgement of transcription factors. Transcription (2012) 1.11
Histone hyperacetylation within the beta-globin locus is context-dependent and precedes high-level gene expression. Blood (2009) 0.89
CpG hypomethylation in a large domain encompassing the embryonic beta-like globin genes in primitive erythrocytes. Mol Cell Biol (2007) 0.88
Nuclear RNA sequencing of the mouse erythroid cell transcriptome. PLoS One (2012) 0.88
A mouse gene that coordinates epigenetic controls and transcriptional interference to achieve tissue-specific expression. Mol Cell Biol (2007) 0.85
Linear distance from the locus control region determines epsilon-globin transcriptional activity. Mol Cell Biol (2007) 0.83
An embryonic stage-specific enhancer within the murine β-globin locus mediates domain-wide histone hyperacetylation. Blood (2011) 0.80
All of the human beta-type globin genes compete for LCR enhancer activity in embryonic erythroid cells of yeast artificial chromosome transgenic mice. FASEB J (2009) 0.77
Replacement of Igamma3 germ-line promoter by Igamma1 inhibits class-switch recombination to IgG3. Proc Natl Acad Sci U S A (2007) 0.77
High Fractional Occupancy of a Tandem Maf Recognition Element and Its Role in Long-Range β-Globin Gene Regulation. Mol Cell Biol (2015) 0.75
The chromatin "landscape" of a murine adult β-globin gene is unaffected by deletion of either the gene promoter or a downstream enhancer. PLoS One (2014) 0.75
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Transcriptional interference perturbs the binding of Sp1 to the HIV-1 promoter. Nucleic Acids Res (1998) 1.86
Enhanced analysis of metastatic prostate cancer using stable isotopes and high mass accuracy instrumentation. J Proteome Res (2006) 1.82
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Transgenic analysis of a 100-kb human beta-globin cluster-containing DNA fragment propagated as a bacterial artificial chromosome. Blood (1999) 1.32
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The mouse beta h1 gene codes for the z chain of embryonic hemoglobin. J Biol Chem (1984) 0.97
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Promoters of the murine embryonic beta-like globin genes Ey and betah1 do not compete for interaction with the beta-globin locus control region. Proc Natl Acad Sci U S A (2003) 0.86
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Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science (2009) 29.83
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat Biotechnol (2006) 12.13
Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol (2008) 9.24
Controlling the double helix. Nature (2003) 8.61
The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. Genes Dev (2004) 7.57
An expansive human regulatory lexicon encoded in transcription factor footprints. Nature (2012) 7.27
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nat Genet (2003) 6.69
Histone H1 depletion in mammals alters global chromatin structure but causes specific changes in gene regulation. Cell (2005) 6.17
Large-scale phosphorylation analysis of mouse liver. Proc Natl Acad Sci U S A (2007) 6.08
Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1. Mol Cell (2005) 5.77
Functional and mechanistic diversity of distal transcription enhancers. Cell (2011) 5.22
Genome-wide DNA replication profile for Drosophila melanogaster: a link between transcription and replication timing. Nat Genet (2002) 4.68
Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1. Nat Genet (2004) 4.45
Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs. Cell (2004) 4.34
Optimization and use of peptide mass measurement accuracy in shotgun proteomics. Mol Cell Proteomics (2006) 4.25
Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor. J Immunol (2005) 4.18
An encyclopedia of mouse DNA elements (Mouse ENCODE). Genome Biol (2012) 4.15
Intragenic DNA methylation alters chromatin structure and elongation efficiency in mammalian cells. Nat Struct Mol Biol (2004) 4.00
The locus control region is required for association of the murine beta-globin locus with engaged transcription factories during erythroid maturation. Genes Dev (2006) 3.91
The absolute quantification strategy: a general procedure for the quantification of proteins and post-translational modifications. Methods (2005) 3.71
Developmental and species-divergent globin switching are driven by BCL11A. Nature (2009) 3.49
Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors. Gene (2002) 3.33
Form follows function: The genomic organization of cellular differentiation. Genes Dev (2004) 3.20
Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae. J Proteome Res (2007) 3.13
A complex chromatin landscape revealed by patterns of nuclease sensitivity and histone modification within the mouse beta-globin locus. Mol Cell Biol (2003) 3.09
Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. Proc Natl Acad Sci U S A (2008) 3.03
Steps in assembly of silent chromatin in yeast: Sir3-independent binding of a Sir2/Sir4 complex to silencers and role for Sir2-dependent deacetylation. Mol Cell Biol (2002) 2.93
Ovarian cancer progression is controlled by phenotypic changes in dendritic cells. J Exp Med (2012) 2.85
MafA is a key regulator of glucose-stimulated insulin secretion. Mol Cell Biol (2005) 2.85
DNA replication-timing analysis of human chromosome 22 at high resolution and different developmental states. Proc Natl Acad Sci U S A (2004) 2.66
The beta -globin locus control region (LCR) functions primarily by enhancing the transition from transcription initiation to elongation. Genes Dev (2003) 2.65
A proteomic strategy for gaining insights into protein sumoylation in yeast. Mol Cell Proteomics (2004) 2.58
Enhancers: the abundance and function of regulatory sequences beyond promoters. Dev Biol (2009) 2.50
CG dinucleotide clustering is a species-specific property of the genome. Nucleic Acids Res (2007) 2.48
Quantitative phosphoproteomics identifies substrates and functional modules of Aurora and Polo-like kinase activities in mitotic cells. Sci Signal (2011) 2.33
A functional element necessary for fetal hemoglobin silencing. N Engl J Med (2011) 2.25
Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors. Proc Natl Acad Sci U S A (2005) 2.23
The human beta-globin locus control region can silence as well as activate gene expression. Mol Cell Biol (2005) 2.19
Uncovering growth-suppressive MicroRNAs in lung cancer. Clin Cancer Res (2009) 2.19
Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease. Blood (2010) 2.16
An unmethylated 3' promoter-proximal region is required for efficient transcription initiation. PLoS Genet (2007) 2.11
The impact of peptide abundance and dynamic range on stable-isotope-based quantitative proteomic analyses. J Proteome Res (2008) 2.11
Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus. Mol Cell (2007) 2.05
"Maturational" globin switching in primary primitive erythroid cells. Blood (2005) 2.04
Transferrin therapy ameliorates disease in beta-thalassemic mice. Nat Med (2010) 2.04
Dynamic changes in transcription factor complexes during erythroid differentiation revealed by quantitative proteomics. Nat Struct Mol Biol (2003) 2.00
Type 3 deiodinase is critical for the maturation and function of the thyroid axis. J Clin Invest (2006) 1.95
Radiation-induced IFN-gamma production within the tumor microenvironment influences antitumor immunity. J Immunol (2008) 1.93
Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction. Nat Med (2013) 1.92
Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network. Proc Natl Acad Sci U S A (2004) 1.92
Differentiation of human embryonic stem cells into bipotent mesenchymal stem cells. Stem Cells (2006) 1.92
Thalassaemia. Lancet (2011) 1.89
Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway. Proc Natl Acad Sci U S A (2004) 1.88
Gene order and dynamic domains. Science (2004) 1.86
Preventing gene silencing with human replicators. Nat Biotechnol (2006) 1.84
Enhanced analysis of metastatic prostate cancer using stable isotopes and high mass accuracy instrumentation. J Proteome Res (2006) 1.82
Quantitative proteomics reveals a dynamic interactome and phase-specific phosphorylation in the Neurospora circadian clock. Mol Cell (2009) 1.80
High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers. Nucleic Acids Res (2009) 1.80
Transcriptional interference by independently regulated genes occurs in any relative arrangement of the genes and is influenced by chromosomal integration position. Mol Cell Biol (2002) 1.78
FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells. Blood (2010) 1.78
The emergence of lineage-specific chromosomal topologies from coordinate gene regulation. Proc Natl Acad Sci U S A (2009) 1.78
On emerging nuclear order. J Cell Biol (2011) 1.77
Coordinate gene regulation during hematopoiesis is related to genomic organization. PLoS Biol (2007) 1.77
Globin switches in yolk sac-like primitive and fetal-like definitive red blood cells produced from human embryonic stem cells. Blood (2007) 1.76
INF2 is an endoplasmic reticulum-associated formin protein. J Cell Sci (2009) 1.67
A genetic analysis of chromosome territory looping: diverse roles for distal regulatory elements. Chromosome Res (2003) 1.67
Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes. Mol Cell Biol (2005) 1.66
Differentiation of human embryonic stem cells into hematopoietic cells by coculture with human fetal liver cells recapitulates the globin switch that occurs early in development. Exp Hematol (2005) 1.65
Flanking HS-62.5 and 3' HS1, and regions upstream of the LCR, are not required for beta-globin transcription. Blood (2006) 1.65
Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas. Proc Natl Acad Sci U S A (2007) 1.61
Large-scale production of embryonic red blood cells from human embryonic stem cells. Exp Hematol (2006) 1.61
Permanent and panerythroid correction of murine beta thalassemia by multiple lentiviral integration in hematopoietic stem cells. Proc Natl Acad Sci U S A (2002) 1.61
Embryonic and fetal beta-globin gene repression by the orphan nuclear receptors, TR2 and TR4. EMBO J (2007) 1.59
An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer. EMBO J (2002) 1.57
DNA methylation density influences the stability of an epigenetic imprint and Dnmt3a/b-independent de novo methylation. Mol Cell Biol (2002) 1.57
GATA-3 is required for early T lineage progenitor development. J Exp Med (2009) 1.56
Comparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid/gammac-/-, Balb/c-Rag1-/-gammac-/-, and C.B-17-scid/bg immunodeficient mice. Hum Immunol (2009) 1.53
Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery. J Cell Biol (2008) 1.52
Characterization of mouse spleen cells by subtractive proteomics. Mol Cell Proteomics (2005) 1.51
A Gata2 intronic enhancer confers its pan-endothelia-specific regulation. Development (2007) 1.50
ADAMTS13 is expressed in hepatic stellate cells. Lab Invest (2005) 1.49
MafB is essential for renal development and F4/80 expression in macrophages. Mol Cell Biol (2006) 1.48
Gene length and proximity to neighbors affect genome-wide expression levels. Genome Res (2003) 1.47
Predictable dynamic program of timing of DNA replication in human cells. Genome Res (2009) 1.47
Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells. Genes Dev (2010) 1.46
Methylation protects cytidines from AID-mediated deamination. Mol Immunol (2005) 1.46
The gene locus encoding iodothyronine deiodinase type 3 (Dio3) is imprinted in the fetus and expresses antisense transcripts. Endocrinology (2002) 1.45
ChIPs of the beta-globin locus: unraveling gene regulation within an active domain. Curr Opin Genet Dev (2002) 1.45
MMFPh: a maximal motif finder for phosphoproteomics datasets. Bioinformatics (2012) 1.44
Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells. Mol Cell Biol (2011) 1.42
Conditional Gata2 inactivation results in HSC loss and lymphatic mispatterning. J Clin Invest (2012) 1.41
Rapid and reproducible single-stage phosphopeptide enrichment of complex peptide mixtures: application to general and phosphotyrosine-specific phosphoproteomics experiments. Anal Chem (2011) 1.40
Budding yeast silencing complexes and regulation of Sir2 activity by protein-protein interactions. Mol Cell Biol (2004) 1.37
Mammalian linker-histone subtypes differentially affect gene expression in vivo. Proc Natl Acad Sci U S A (2003) 1.37
Bivalent domains enforce transcriptional memory of DNA methylated genes in cancer cells. Proc Natl Acad Sci U S A (2008) 1.36
GATA motifs regulate early hematopoietic lineage-specific expression of the Gata2 gene. Mol Cell Biol (2005) 1.35