Published in J Cell Biol on March 10, 2008
The primary cilium as a complex signaling center. Curr Biol (2009) 3.73
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Functional interaction between autophagy and ciliogenesis. Nature (2013) 2.21
Primary cilia and signaling pathways in mammalian development, health and disease. Nephron Physiol (2009) 2.09
Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation. Proc Natl Acad Sci U S A (2009) 2.04
MicroRNA and gene expression patterns in the differentiation of human embryonic stem cells. J Transl Med (2009) 1.85
Joubert syndrome: congenital cerebellar ataxia with the molar tooth. Lancet Neurol (2013) 1.83
Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation. Mol Cell Biol (2010) 1.81
Cilia in vertebrate development and disease. Development (2012) 1.50
Structure and function of mammalian cilia. Histochem Cell Biol (2008) 1.37
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Temporal relationship between primary and motile ciliogenesis in airway epithelial cells. Am J Respir Cell Mol Biol (2010) 1.28
Primary cilia and coordination of receptor tyrosine kinase (RTK) signalling. J Pathol (2011) 1.27
The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursors. Nat Cell Biol (2009) 1.23
Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleus. BMC Biol (2011) 1.21
Reduced ciliary polycystin-2 in induced pluripotent stem cells from polycystic kidney disease patients with PKD1 mutations. J Am Soc Nephrol (2013) 1.14
Glypican-5 stimulates rhabdomyosarcoma cell proliferation by activating Hedgehog signaling. J Cell Biol (2011) 1.14
Left-right determination: involvement of molecular motor KIF3, cilia, and nodal flow. Cold Spring Harb Perspect Biol (2009) 1.13
The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation. J Cell Sci (2009) 1.12
Primary cilia-mediated mechanotransduction in human mesenchymal stem cells. Stem Cells (2012) 1.11
Gli-similar (Glis) Krüppel-like zinc finger proteins: insights into their physiological functions and critical roles in neonatal diabetes and cystic renal disease. Histol Histopathol (2010) 1.04
Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling. EMBO Rep (2013) 0.89
Hedgehog signaling in skin cancers. Cell Signal (2011) 0.87
Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide. Mol Biol Cell (2014) 0.87
A central region of Gli2 regulates its localization to the primary cilium and transcriptional activity. J Cell Sci (2014) 0.87
Ciliogenesis in normal human kidney development and post-natal life. Pediatr Nephrol (2011) 0.85
Ciliary abnormalities in senescent human fibroblasts impair proliferative capacity. Cell Cycle (2014) 0.85
Ins and outs of GPCR signaling in primary cilia. EMBO Rep (2015) 0.84
Ofd1 controls dorso-ventral patterning and axoneme elongation during embryonic brain development. PLoS One (2012) 0.83
A model of early human embryonic stem cell differentiation reveals inter- and intracellular changes on transition to squamous epithelium. Stem Cells Dev (2011) 0.81
The hedgehog receptor patched1 in T cells is dispensable for adaptive immunity in mice. PLoS One (2013) 0.80
Primary cilia found on HeLa and other cancer cells. Cell Biol Int (2015) 0.80
A network-based approach to dissect the cilia/centrosome complex interactome. BMC Genomics (2014) 0.80
Using the avian mutant talpid2 as a disease model for understanding the oral-facial phenotypes of oral-facial-digital syndrome. Dis Model Mech (2015) 0.79
Inhibition of autophagy suppresses sertraline-mediated primary ciliogenesis in retinal pigment epithelium cells. PLoS One (2015) 0.79
Adult Stem Cell Responses to Nanostimuli. J Funct Biomater (2015) 0.78
Directed differentiation of pluripotent stem cells to kidney cells. Semin Nephrol (2014) 0.78
Primary cilia and autophagic dysfunction in Huntington's disease. Cell Death Differ (2015) 0.78
Autophagy Regulates Formation of Primary Cilia in Mefloquine-Treated Cells. Biomol Ther (Seoul) (2015) 0.77
Modeling Kidney Disease with iPS Cells. Biomark Insights (2015) 0.76
Centriole splitting caused by loss of the centrosomal linker protein C-NAP1 reduces centriolar satellite density and impedes centrosome amplification. Mol Biol Cell (2017) 0.76
Cellular Mechanisms of Ciliary Length Control. Cells (2016) 0.76
The ciliary proteins Meckelin and Jouberin are required for retinoic acid-dependent neural differentiation of mouse embryonic stem cells. Differentiation (2014) 0.75
TGFβ1 - induced recruitment of human bone mesenchymal stem cells is mediated by the primary cilium in a SMAD3-dependent manner. Sci Rep (2016) 0.75
Onward from the cradle. Mol Biol Cell (2014) 0.75
Various facets of vertebrate cilia: motility, signaling, and role in adult neurogenesis. Proc Jpn Acad Ser B Phys Biol Sci (2009) 0.75
Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease. PLoS One (2017) 0.75
Using Primary Neurosphere Cultures to Study Primary Cilia. J Vis Exp (2017) 0.75
The ciliopathies: an emerging class of human genetic disorders. Annu Rev Genomics Hum Genet (2006) 9.56
Vertebrate Smoothened functions at the primary cilium. Nature (2005) 9.24
Patched1 regulates hedgehog signaling at the primary cilium. Science (2007) 9.21
The primary cilium as the cell's antenna: signaling at a sensory organelle. Science (2006) 6.79
Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A (2002) 6.55
Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet (2005) 6.15
Cilia and Hedgehog responsiveness in the mouse. Proc Natl Acad Sci U S A (2005) 5.87
Overview of structure and function of mammalian cilia. Annu Rev Physiol (2007) 4.90
Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development (2005) 4.32
Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response. Nat Genet (2007) 4.24
PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblasts. Curr Biol (2005) 4.04
Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions. Proc Natl Acad Sci U S A (2006) 3.90
Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Dev Biol (2005) 3.63
Nanog and transcriptional networks in embryonic stem cell pluripotency. Cell Res (2007) 3.56
Nodal flow and the generation of left-right asymmetry. Cell (2006) 3.52
FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination. Nature (2005) 3.50
Sensory cilia and integration of signal transduction in human health and disease. Traffic (2007) 2.67
Movement of motor and cargo along cilia. Nature (1999) 2.21
Midbody and primary cilium of neural progenitors release extracellular membrane particles enriched in the stem cell marker prominin-1. J Cell Biol (2007) 2.19
Bardet-Biedl syndrome: an emerging pathomechanism of intracellular transport. Cell Mol Life Sci (2006) 2.19
The primary cilium in cell signaling and cancer. Cancer Res (2006) 1.97
Intraflagellar transport and cilia-dependent renal disease: the ciliary hypothesis of polycystic kidney disease. J Am Soc Nephrol (2004) 1.86
The primary cilium: keeper of the key to cell division. Cell (2007) 1.62
Large-scale production of embryonic red blood cells from human embryonic stem cells. Exp Hematol (2006) 1.61
Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling. Exp Cell Res (2006) 1.59
Transcriptional profiling of the developmentally important signalling pathways in human embryonic stem cells. Hum Reprod (2005) 1.00
Regional differences in expression of specific markers for human embryonic stem cells. Reprod Biomed Online (2007) 0.82
Histone H1 depletion in mammals alters global chromatin structure but causes specific changes in gene regulation. Cell (2005) 6.17
Parental periconceptional smoking and male: female ratio of newborn infants. Lancet (2002) 4.52
PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblasts. Curr Biol (2005) 4.04
Sensory cilia and integration of signal transduction in human health and disease. Traffic (2007) 2.67
The primary cilium at a glance. J Cell Sci (2010) 2.55
CG dinucleotide clustering is a species-specific property of the genome. Nucleic Acids Res (2007) 2.48
Functional interaction between autophagy and ciliogenesis. Nature (2013) 2.21
The human beta-globin locus control region can silence as well as activate gene expression. Mol Cell Biol (2005) 2.19
Primary cilia and signaling pathways in mammalian development, health and disease. Nephron Physiol (2009) 2.09
Transferrin therapy ameliorates disease in beta-thalassemic mice. Nat Med (2010) 2.04
Genome-scale analysis of metazoan replication origins reveals their organization in specific but flexible sites defined by conserved features. Genome Res (2011) 1.94
Differentiation of human embryonic stem cells into bipotent mesenchymal stem cells. Stem Cells (2006) 1.92
Two successful pregnancies following autotransplantation of frozen/thawed ovarian tissue. Hum Reprod (2008) 1.86
Assembly of primary cilia. Dev Dyn (2008) 1.84
Preventing gene silencing with human replicators. Nat Biotechnol (2006) 1.84
High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers. Nucleic Acids Res (2009) 1.80
Transcriptional interference by independently regulated genes occurs in any relative arrangement of the genes and is influenced by chromosomal integration position. Mol Cell Biol (2002) 1.78
Globin switches in yolk sac-like primitive and fetal-like definitive red blood cells produced from human embryonic stem cells. Blood (2007) 1.76
On regenerating the ovary and generating controversy. Cell (2005) 1.76
Differentiation of human embryonic stem cells into hematopoietic cells by coculture with human fetal liver cells recapitulates the globin switch that occurs early in development. Exp Hematol (2005) 1.65
Directional cell migration and chemotaxis in wound healing response to PDGF-AA are coordinated by the primary cilium in fibroblasts. Cell Physiol Biochem (2010) 1.63
Large-scale production of embryonic red blood cells from human embryonic stem cells. Exp Hematol (2006) 1.61
Permanent and panerythroid correction of murine beta thalassemia by multiple lentiviral integration in hematopoietic stem cells. Proc Natl Acad Sci U S A (2002) 1.61
The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking. J Cell Biol (2012) 1.54
Microtubule-dependent movement of late endocytic vesicles in vitro: requirements for Dynein and Kinesin. Mol Biol Cell (2004) 1.50
Liquid-liquid separation in solutions of normal and sickle cell hemoglobin. Proc Natl Acad Sci U S A (2002) 1.50
ADAMTS13 is expressed in hepatic stellate cells. Lab Invest (2005) 1.49
The primary cilium coordinates signaling pathways in cell cycle control and migration during development and tissue repair. Curr Top Dev Biol (2008) 1.49
Gene length and proximity to neighbors affect genome-wide expression levels. Genome Res (2003) 1.47
Predictable dynamic program of timing of DNA replication in human cells. Genome Res (2009) 1.47
Methylation protects cytidines from AID-mediated deamination. Mol Immunol (2005) 1.46
Structure and function of mammalian cilia. Histochem Cell Biol (2008) 1.37
Mammalian linker-histone subtypes differentially affect gene expression in vivo. Proc Natl Acad Sci U S A (2003) 1.37
Primary cilia and coordination of receptor tyrosine kinase (RTK) signalling. J Pathol (2011) 1.27
Characterization of primary cilia and Hedgehog signaling during development of the human pancreas and in human pancreatic duct cancer cell lines. Dev Dyn (2008) 1.27
Cell shrinkage as a signal to apoptosis in NIH 3T3 fibroblasts. J Physiol (2005) 1.23
Concentrations of AMH and inhibin-B in relation to follicular diameter in normal human small antral follicles. Hum Reprod (2010) 1.22
Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer. Reproduction (2005) 1.21
Production of embryonic and fetal-like red blood cells from human induced pluripotent stem cells. PLoS One (2011) 1.19
DNA methylation supports intrinsic epigenetic memory in mammalian cells. PLoS Genet (2006) 1.17
Enzymatically active ADAMTS13 variants are not inhibited by anti-ADAMTS13 autoantibodies: a novel therapeutic strategy? J Biol Chem (2005) 1.16
Zinc-finger nuclease-mediated correction of α-thalassemia in iPS cells. Blood (2012) 1.15
An IAP retrotransposon in the mouse ADAMTS13 gene creates ADAMTS13 variant proteins that are less effective in cleaving von Willebrand factor multimers. Blood (2007) 1.14
Autophagy driven by a master regulator of hematopoiesis. Mol Cell Biol (2011) 1.13
The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation. J Cell Sci (2009) 1.12
The Na+/H+ exchanger NHE1 is required for directional migration stimulated via PDGFR-alpha in the primary cilium. J Cell Biol (2009) 1.12
EB1 and EB3 promote cilia biogenesis by several centrosome-related mechanisms. J Cell Sci (2011) 1.11
High-resolution mapping of h1 linker histone variants in embryonic stem cells. PLoS Genet (2013) 1.11
Estradiol and regulation of anti-Müllerian hormone, inhibin-A, and inhibin-B secretion: analysis of small antral and preovulatory human follicles' fluid. J Clin Endocrinol Metab (2006) 1.09
EB1 is required for primary cilia assembly in fibroblasts. Curr Biol (2007) 1.09
Decreased replication origin activity in temporal transition regions. J Cell Biol (2009) 1.09
Regulation of early endocytic vesicle motility and fission in a reconstituted system. J Cell Sci (2003) 1.08
Transcriptional interference among the murine beta-like globin genes. Blood (2006) 1.06
Expression and localization of the progesterone receptor in mouse and human reproductive organs. J Endocrinol (2006) 1.06
Maternal smoking during pregnancy and age at menarche of premenopausal and post-menopausal daughters. Hum Reprod (2012) 1.06
Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs. Mol Reprod Dev (2005) 1.04
Insulin receptor-like proteins in Tetrahymena thermophila ciliary membranes. Curr Biol (2003) 1.04
Two-step mechanism of homogeneous nucleation of sickle cell hemoglobin polymers. Biophys J (2007) 1.02
Efficient generation of lens progenitor cells and lentoid bodies from human embryonic stem cells in chemically defined conditions. FASEB J (2010) 0.98
Isolation of pre-antral follicles from human ovarian medulla tissue. Hum Reprod (2010) 0.97
Cloning, localization, and axonemal function of Tetrahymena centrin. Mol Biol Cell (2003) 0.97
PDGFRα signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1/2-ERK1/2-p90RSK and AKT signaling pathways. J Cell Sci (2012) 0.96
GenPlay, a multipurpose genome analyzer and browser. Bioinformatics (2011) 0.95
Intermolecular interactions, nucleation, and thermodynamics of crystallization of hemoglobin C. Biophys J (2002) 0.95
Exogenous iron increases hemoglobin in beta-thalassemic mice. Exp Hematol (2008) 0.94
Ovarian volume throughout life: a validated normative model. PLoS One (2013) 0.93
Gene specificity of suppression of transgene-mediated insertional transcriptional activation by the chicken HS4 insulator. PLoS One (2009) 0.92
Inversin/Nephrocystin-2 is required for fibroblast polarity and directional cell migration. PLoS One (2013) 0.92
YKL-40 is differentially expressed in human embryonic stem cells and in cell progeny of the three germ layers. J Histochem Cytochem (2011) 0.90
Orthotopic autotransplantation of cryopreserved ovarian tissue to a woman cured of cancer - follicular growth, steroid production and oocyte retrieval. Reprod Biomed Online (2004) 0.90
Evaluation in mammalian oocytes of gene transcripts linked to epigenetic reprogramming. Reproduction (2007) 0.90
Stem cell factor and c-Kit in human primordial germ cells and fetal ovaries. Mol Cell Endocrinol (2005) 0.90
Primary cilia and aberrant cell signaling in epithelial ovarian cancer. Cilia (2012) 0.89
Anti-Müllerian hormone in pregnant women in relation to other hormones, fetal sex and in circulation of second trimester fetuses. Reprod Biomed Online (2009) 0.89
The migration and loss of human primordial germ stem cells from the hind gut epithelium towards the gonadal ridge. Int J Dev Biol (2012) 0.89
Acellular invertebrate hemoglobins as model therapeutic oxygen carriers: unique redox potentials. Artif Cells Blood Substit Immobil Biotechnol (2007) 0.88
Number of germ cells and somatic cells in human fetal testes during the first weeks after sex differentiation. Hum Reprod (2003) 0.88
Cloning and characterization of Kin5, a novel Tetrahymena ciliary kinesin II. Cell Motil Cytoskeleton (2004) 0.87
Novel, high-yield red blood cell production methods from CD34-positive cells derived from human embryonic stem, yolk sac, fetal liver, cord blood, and peripheral blood. Stem Cells Transl Med (2012) 0.87
Embryonic stem cells or induced pluripotent stem cells? A DNA integrity perspective. Curr Gene Ther (2013) 0.87
Promoters of the murine embryonic beta-like globin genes Ey and betah1 do not compete for interaction with the beta-globin locus control region. Proc Natl Acad Sci U S A (2003) 0.86
Transgenic mice and hemoglobinopathies. Methods Mol Med (2003) 0.86