Identification of RIP1 kinase as a specific cellular target of necrostatins.

PubWeight™: 9.24‹?› | Rank: Top 0.1%

🔗 View Article (PMID 18408713)

Published in Nat Chem Biol on May 01, 2008

Authors

Alexei Degterev1, Junichi Hitomi, Megan Germscheid, Irene L Ch'en, Olga Korkina, Xin Teng, Derek Abbott, Gregory D Cuny, Chengye Yuan, Gerhard Wagner, Stephen M Hedrick, Scott A Gerber, Alexey Lugovskoy, Junying Yuan

Author Affiliations

1: Tufts University, School of Medicine, Department of Biochemistry, 136 Harrison Avenue, Boston, Massachusetts 02111, USA. alexei.degterev@tufts.edu

Articles citing this

(truncated to the top 100)

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell (2009) 11.26

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ (2008) 10.45

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ (2011) 9.44

Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol (2010) 9.06

Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell (2008) 7.61

Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol (2008) 6.78

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature (2011) 6.31

NF-κB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev (2012) 5.77

cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell (2011) 4.78

Regulated necrosis: the expanding network of non-apoptotic cell death pathways. Nat Rev Mol Cell Biol (2014) 4.28

Virus inhibition of RIP3-dependent necrosis. Cell Host Microbe (2010) 3.70

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis. Nature (2011) 3.61

Necroptosis as an alternative form of programmed cell death. Curr Opin Cell Biol (2010) 3.51

DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA. Cell Host Microbe (2012) 3.23

Necroptosis and its role in inflammation. Nature (2015) 3.01

Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets. Nat Rev Drug Discov (2010) 2.90

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation. Cell Res (2010) 2.82

Cellular stress responses: cell survival and cell death. Int J Cell Biol (2010) 2.74

Necroptosis. N Engl J Med (2014) 2.71

TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species. Cell (2013) 2.71

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ (2014) 2.66

Many stimuli pull the necrotic trigger, an overview. Cell Death Differ (2011) 2.55

FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells. Proc Natl Acad Sci U S A (2008) 2.52

Mechanisms of necroptosis in T cells. J Exp Med (2011) 2.51

Caspases and kinases in a death grip. Cell (2009) 2.47

Caspase 8 inhibits programmed necrosis by processing CYLD. Nat Cell Biol (2011) 2.37

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production. Cell Death Differ (2010) 2.26

Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium. Nat Immunol (2012) 2.25

Antigen-mediated T cell expansion regulated by parallel pathways of death. Proc Natl Acad Sci U S A (2008) 2.20

Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis. Proc Natl Acad Sci U S A (2010) 2.20

Hepatocyte death: a clear and present danger. Physiol Rev (2010) 2.18

Alternative cell death mechanisms in development and beyond. Genes Dev (2010) 2.14

Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2013) 2.10

RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3. Cell (2014) 2.06

RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts. Mol Cell (2011) 2.06

Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment. J Cell Biol (2009) 2.02

Old, new and emerging functions of caspases. Cell Death Differ (2014) 2.01

Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance. J Clin Invest (2010) 1.97

RIP3: a molecular switch for necrosis and inflammation. Genes Dev (2013) 1.94

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models. Cell Death Dis (2012) 1.94

Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death. Nat Rev Mol Cell Biol (2013) 1.89

It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival. Nat Rev Mol Cell Biol (2011) 1.76

Caspase-independent cell death: leaving the set without the final cut. Oncogene (2008) 1.74

TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation. Cell Death Differ (2012) 1.72

Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: role for reactive oxygen species-enhanced MEK/ERK activation. J Allergy Clin Immunol (2013) 1.69

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis. EMBO Mol Med (2012) 1.68

Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice. J Immunol (2014) 1.67

Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis. Proc Natl Acad Sci U S A (2010) 1.67

Retracted Mitoneet mediates TNFα-induced necroptosis promoted by exposure to fructose and ethanol. J Cell Sci (2013) 1.67

HMGB1 in health and disease. Mol Aspects Med (2014) 1.67

A novel role for RIP1 kinase in mediating TNFα production. Cell Death Dis (2012) 1.67

Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes. Gastroenterology (2016) 1.65

Mechanisms of cell death in heart disease. Arterioscler Thromb Vasc Biol (2012) 1.63

An extracellular bacterial pathogen modulates host metabolism to regulate its own sensing and proliferation. Cell (2014) 1.61

IAPs limit activation of RIP kinases by TNF receptor 1 during development. EMBO J (2012) 1.61

Tumor necrosis factor and cancer, buddies or foes? Acta Pharmacol Sin (2008) 1.60

Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases. Proc Natl Acad Sci U S A (2013) 1.59

Necroptosis drives motor neuron death in models of both sporadic and familial ALS. Neuron (2014) 1.56

The molecular regulation of programmed necrotic cell injury. Trends Biochem Sci (2010) 1.55

zVAD-induced necroptosis in L929 cells depends on autocrine production of TNFα mediated by the PKC-MAPKs-AP-1 pathway. Cell Death Differ (2010) 1.54

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition. Proc Natl Acad Sci U S A (2014) 1.54

TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members. Cell Death Dis (2011) 1.53

Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase. Cell Death Differ (2012) 1.53

Perispinal etanercept for post-stroke neurological and cognitive dysfunction: scientific rationale and current evidence. CNS Drugs (2014) 1.49

Neuronal cell death in neonatal hypoxia-ischemia. Ann Neurol (2011) 1.47

Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors. Blood (2015) 1.47

TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1. Cell Death Dis (2013) 1.46

Modulatory profiling identifies mechanisms of small molecule-induced cell death. Proc Natl Acad Sci U S A (2011) 1.45

Necrostatin decreases oxidative damage, inflammation, and injury after neonatal HI. J Cereb Blood Flow Metab (2010) 1.44

Retracted The NAD-dependent deacetylase SIRT2 is required for programmed necrosis. Nature (2012) 1.44

Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death. Proc Natl Acad Sci U S A (2012) 1.41

In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8. J Biol Chem (2011) 1.40

RIPK3 Restricts Viral Pathogenesis via Cell Death-Independent Neuroinflammation. Cell (2017) 1.39

Neuroprotective strategies targeting apoptotic and necrotic cell death for stroke. Apoptosis (2009) 1.39

The two faces of receptor interacting protein kinase-1. Mol Cell (2014) 1.37

Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition. PLoS One (2012) 1.37

Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration. Proc Natl Acad Sci U S A (2012) 1.37

RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition. Cell Death Differ (2013) 1.36

Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development. J Cell Mol Med (2013) 1.36

Going up in flames: necrotic cell injury and inflammatory diseases. Cell Mol Life Sci (2010) 1.35

The complex interplay between autophagy, apoptosis, and necrotic signals promotes T-cell homeostasis. Immunol Rev (2010) 1.35

Glutaminolysis and Transferrin Regulate Ferroptosis. Mol Cell (2015) 1.35

Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo. J Immunol (2014) 1.34

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis. Cell Death Dis (2014) 1.33

RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis. Cell Death Differ (2014) 1.33

RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation. PLoS One (2011) 1.33

Dichotomy between RIP1- and RIP3-mediated necroptosis in tumor necrosis factor-α-induced shock. Mol Med (2012) 1.31

Nitration of the mitochondrial complex I subunit NDUFB8 elicits RIP1- and RIP3-mediated necrosis. Free Radic Biol Med (2009) 1.30

A plug release mechanism for membrane permeation by MLKL. Structure (2014) 1.29

cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation. Cell Death Differ (2012) 1.29

Distinct roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating necroptosis. Cell Death Differ (2014) 1.29

Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production. Blood (2012) 1.28

Programmed necrosis in the cross talk of cell death and inflammation. Annu Rev Immunol (2014) 1.27

How chemoproteomics can enable drug discovery and development. Chem Biol (2012) 1.27

The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage. Proc Natl Acad Sci U S A (2009) 1.27

NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis. Mol Cell Biol (2011) 1.25

Requirement of FADD, NEMO, and BAX/BAK for aberrant mitochondrial function in tumor necrosis factor alpha-induced necrosis. Mol Cell Biol (2011) 1.24

The convergence of radiation and immunogenic cell death signaling pathways. Front Oncol (2012) 1.24

MAPK signaling in inflammation-associated cancer development. Protein Cell (2010) 1.23

Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury. Brain Res (2010) 1.23

Articles cited by this

Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol (1993) 64.61

Apoptosis in the pathogenesis and treatment of disease. Science (1995) 20.24

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell (2004) 19.51

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol (2005) 11.63

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell (2003) 11.07

Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science (2004) 10.77

Structural mechanism for STI-571 inhibition of abelson tyrosine kinase. Science (2000) 9.29

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex. Nature (1995) 9.03

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol (2000) 8.49

Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae. Nat Biotechnol (2002) 8.37

RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell (1995) 5.73

TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death. Mol Cell (2007) 4.53

RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis. EMBO J (1996) 4.33

Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571). Cancer Res (2002) 4.19

Selective isolation at the femtomole level of phosphopeptides from proteolytic digests using 2D-NanoLC-ESI-MS/MS and titanium oxide precolumns. Anal Chem (2004) 4.06

Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae. J Proteome Res (2007) 3.13

Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2. Nat Immunol (2003) 2.90

The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2. J Biol Chem (2004) 2.65

Necrostatin: a potentially novel cardioprotective agent? Cardiovasc Drugs Ther (2007) 2.50

Cell death in pancreatitis: caspases protect from necrotizing pancreatitis. J Biol Chem (2005) 2.40

Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activation. J Biol Chem (2000) 2.37

Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction. Immunity (2004) 2.36

Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-kappaB activation. J Biol Chem (2006) 2.32

Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601. EMBO J (2000) 2.17

Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling. Curr Biol (2007) 2.15

Interdigital cell death can occur through a necrotic and caspase-independent pathway. Curr Biol (1999) 2.11

The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice. Immunity (1999) 1.98

Distinct signaling pathways in TRAIL- versus tumor necrosis factor-induced apoptosis. Mol Cell Biol (2006) 1.88

Necrostatin-1 protects against glutamate-induced glutathione depletion and caspase-independent cell death in HT-22 cells. J Neurochem (2007) 1.88

Sitosterol-containing lipoproteins trigger free sterol-induced caspase-independent death in ACAT-competent macrophages. J Biol Chem (2006) 1.80

Structure-activity relationship study of novel necroptosis inhibitors. Bioorg Med Chem Lett (2005) 1.72

Programmed cell death of developing mammalian neurons after genetic deletion of caspases. J Neurosci (2001) 1.47

Identification of a cdk-activating kinase in fission yeast. EMBO J (1995) 1.45

A biochemical rationale for the anticancer effects of Hsp90 inhibitors: slow, tight binding inhibition by geldanamycin and its analogues. Proc Natl Acad Sci U S A (2006) 1.38

Structure-activity relationship study of tricyclic necroptosis inhibitors. J Med Chem (2007) 1.27

Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5. Bioorg Med Chem Lett (2006) 1.26

Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-kappaB, JNK1, p53 and WOX1 during stress response. BMC Mol Biol (2007) 1.26

Cell death in the absence of Bax and Bak. Cell Death Differ (2006) 1.24

Inhibition of RIP2/RIck/CARDIAK activity by pyridinyl imidazole inhibitors of p38 MAPK. Mol Cell Biochem (2005) 1.22

Caspase-3 deficiency during development increases vulnerability to hypoxic-ischemic injury through caspase-3-independent pathways. Neurobiol Dis (2006) 1.17

Mutagenesis of p38alpha MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-OUT state. Biochemistry (2007) 1.15

RIP death domain structural interactions implicated in TNF-mediated proliferation and survival. Proteins (2006) 1.06

SU9516: biochemical analysis of cdk inhibition and crystal structure in complex with cdk2. Biochem Biophys Res Commun (2003) 0.98

Focal adhesion kinase determines the fate of death or survival of cells in response to TNFalpha in the presence of actinomycin D. Biochim Biophys Acta (2006) 0.98

Articles by these authors

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J (2008) 12.89

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat Biotechnol (2006) 12.13

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol (2005) 11.63

Autophagy in cell death: an innocent convict? J Clin Invest (2005) 10.70

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science (2005) 7.98

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix. Science (2004) 7.63

Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell (2008) 7.61

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet (2011) 6.89

Large-scale phosphorylation analysis of mouse liver. Proc Natl Acad Sci U S A (2007) 6.08

Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science (2010) 5.44

Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs. Cell (2004) 4.34

Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nat Immunol (2009) 4.31

Optimization and use of peptide mass measurement accuracy in shotgun proteomics. Mol Cell Proteomics (2006) 4.25

BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med (2008) 4.20

Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor. J Immunol (2005) 4.18

Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A. Nat Chem Biol (2006) 3.89

Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem (2006) 3.77

The absolute quantification strategy: a general procedure for the quantification of proteins and post-translational modifications. Methods (2005) 3.71

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis. Nature (2011) 3.61

Expansion and evolution of cell death programmes. Nat Rev Mol Cell Biol (2008) 3.59

A decade of caspases. Oncogene (2003) 3.55

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. J Cell Biol (2003) 3.52

Necroptosis as an alternative form of programmed cell death. Curr Opin Cell Biol (2010) 3.51

Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E. Cell (2003) 3.46

Solution structure of the integral human membrane protein VDAC-1 in detergent micelles. Science (2008) 3.38

Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc Natl Acad Sci U S A (2007) 3.37

The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell (2003) 3.36

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha. Proc Natl Acad Sci U S A (2002) 3.28

Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2. Genes Dev (2005) 3.25

An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Nature (2006) 3.23

Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell (2007) 3.21

Foxo transcription factors control regulatory T cell development and function. Immunity (2010) 3.17

The CD95 receptor: apoptosis revisited. Cell (2007) 3.13

Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae. J Proteome Res (2007) 3.13

Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. Proc Natl Acad Sci U S A (2008) 3.03

HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane. Immunity (2008) 3.01

A nuclear receptor-like pathway regulating multidrug resistance in fungi. Nature (2008) 3.00

Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival. Cell (2011) 2.98

What is stochastic resonance? Definitions, misconceptions, debates, and its relevance to biology. PLoS Comput Biol (2009) 2.98

The role of erk1 and erk2 in multiple stages of T cell development. Immunity (2005) 2.96

Steps in assembly of silent chromatin in yeast: Sir3-independent binding of a Sir2/Sir4 complex to silencers and role for Sir2-dependent deacetylation. Mol Cell Biol (2002) 2.93

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev (2013) 2.90

MAPK3/1 (ERK1/2) in ovarian granulosa cells are essential for female fertility. Science (2009) 2.86

Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity (2006) 2.77

Position of eukaryotic initiation factor eIF1 on the 40S ribosomal subunit determined by directed hydroxyl radical probing. Genes Dev (2003) 2.77

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. EMBO J (2009) 2.72

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders. Nature (2003) 2.60

Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation. Cell (2009) 2.60

Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell (2011) 2.58

A proteomic strategy for gaining insights into protein sumoylation in yeast. Mol Cell Proteomics (2004) 2.58

Negative regulation of Vps34 by Cdk mediated phosphorylation. Mol Cell (2010) 2.57

Cell death assays for drug discovery. Nat Rev Drug Discov (2011) 2.51

Mechanisms of necroptosis in T cells. J Exp Med (2011) 2.51

The alphabeta T cell receptor is an anisotropic mechanosensor. J Biol Chem (2009) 2.41

The rhesus rotavirus VP4 sialic acid binding domain has a galectin fold with a novel carbohydrate binding site. EMBO J (2002) 2.41

Ultrahigh-resolution (1)H-(13)C HSQC spectra of metabolite mixtures using nonlinear sampling and forward maximum entropy reconstruction. J Am Chem Soc (2007) 2.40

A semisynthetic epitope for kinase substrates. Nat Methods (2007) 2.40

A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions. Dev Cell (2010) 2.40

Dynamic thiolation-thioesterase structure of a non-ribosomal peptide synthetase. Nature (2008) 2.39

The mRNA cap-binding protein eIF4E in post-transcriptional gene expression. Nat Struct Mol Biol (2004) 2.37

Quantitative phosphoproteomics identifies substrates and functional modules of Aurora and Polo-like kinase activities in mitotic cells. Sci Signal (2011) 2.33

Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells. Nat Immunol (2009) 2.32

Translation initiation: structures, mechanisms and evolution. Q Rev Biophys (2005) 2.31

Accelerated acquisition of high resolution triple-resonance spectra using non-uniform sampling and maximum entropy reconstruction. J Magn Reson (2004) 2.30

Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a. Biochemistry (2002) 2.29

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis. J Biol Chem (2006) 2.26

Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors. Proc Natl Acad Sci U S A (2005) 2.23

Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2. Nat Struct Biol (2003) 2.23

In situ observation of protein phosphorylation by high-resolution NMR spectroscopy. Nat Struct Mol Biol (2008) 2.23

Antigen-mediated T cell expansion regulated by parallel pathways of death. Proc Natl Acad Sci U S A (2008) 2.20

A general framework for development and data analysis of competitive high-throughput screens for small-molecule inhibitors of protein-protein interactions by fluorescence polarization. Biochemistry (2004) 2.20

Cutting edge: innate immunity conferred by B cells is regulated by caspase-8. J Immunol (2005) 2.18

Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75. Nat Struct Mol Biol (2005) 2.17

NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2. J Biol Chem (2007) 2.13

The impact of peptide abundance and dynamic range on stable-isotope-based quantitative proteomic analyses. J Proteome Res (2008) 2.11

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proc Natl Acad Sci U S A (2010) 2.10

Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell (2010) 2.08

Mammalian SCAN domain dimer is a domain-swapped homolog of the HIV capsid C-terminal domain. Mol Cell (2005) 2.07

Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice. J Cereb Blood Flow Metab (2008) 2.06

Identification and characterization of mefloquine efficacy against JC virus in vitro. Antimicrob Agents Chemother (2009) 2.02

Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization. Nat Cell Biol (2007) 2.01

Progressive multifocal leukoencephalopathy (PML) development is associated with mutations in JC virus capsid protein VP1 that change its receptor specificity. J Infect Dis (2011) 1.96

Radiation-induced IFN-gamma production within the tumor microenvironment influences antitumor immunity. J Immunol (2008) 1.93

Autophagy limits Listeria monocytogenes intracellular growth in the early phase of primary infection. Autophagy (2007) 1.92

Automated neurite extraction using dynamic programming for high-throughput screening of neuron-based assays. Neuroimage (2007) 1.92

Optimized phospholipid bilayer nanodiscs facilitate high-resolution structure determination of membrane proteins. J Am Chem Soc (2013) 1.90

Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model. J Neurosci Res (2010) 1.89

Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death. Nat Rev Mol Cell Biol (2013) 1.89

The Jekyll and Hyde functions of caspases. Dev Cell (2009) 1.87

Ufd1 exhibits the AAA-ATPase fold with two distinct ubiquitin interaction sites. Structure (2005) 1.86