Published in J Biol Chem on November 15, 2006
FoxO transcription factors in the maintenance of cellular homeostasis during aging. Curr Opin Cell Biol (2008) 3.70
How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited. Diabetes (2011) 1.74
Uncoupling of acetylation from phosphorylation regulates FoxO1 function independent of its subcellular localization. J Biol Chem (2010) 1.68
Forkhead homeobox type O transcription factors in the responses to oxidative stress. Antioxid Redox Signal (2010) 1.59
FSH and FOXO1 regulate genes in the sterol/steroid and lipid biosynthetic pathways in granulosa cells. Mol Endocrinol (2009) 1.27
Hepatic FoxO1 ablation exacerbates lipid abnormalities during hyperglycemia. J Biol Chem (2010) 1.21
Insulin and JNK: optimizing metabolic homeostasis and lifespan. Trends Endocrinol Metab (2009) 1.19
Conditional ablation of Gsk-3β in islet beta cells results in expanded mass and resistance to fat feeding-induced diabetes in mice. Diabetologia (2010) 1.15
FoxO1 and HNF-4 are involved in regulation of hepatic glucokinase gene expression by resveratrol. J Biol Chem (2009) 1.07
JNK signaling in insulin-producing cells is required for adaptive responses to stress in Drosophila. Aging Cell (2009) 1.06
Aging induces a distinct gene expression program in mouse islets. Islets (2010) 1.03
Metabolic inflexibility impairs insulin secretion and results in MODY-like diabetes in triple FoxO-deficient mice. Cell Metab (2014) 0.96
Cardiomyocyte ATP production, metabolic flexibility, and survival require calcium flux through cardiac ryanodine receptors in vivo. J Biol Chem (2013) 0.96
Insulin receptor substrate-2 regulates aerobic glycolysis in mouse mammary tumor cells via glucose transporter 1. J Biol Chem (2008) 0.95
Genetic analysis of type-1 insulin-like growth factor receptor signaling through insulin receptor substrate-1 and -2 in pancreatic beta cells. J Biol Chem (2010) 0.94
Nucleo-cytosolic shuttling of FoxO1 directly regulates mouse Ins2 but not Ins1 gene expression in pancreatic beta cells (MIN6). J Biol Chem (2011) 0.92
Over-stimulation of insulin/IGF-1 signaling by western diet may promote diseases of civilization: lessons learnt from laron syndrome. Nutr Metab (Lond) (2011) 0.92
Effects of beta-cell rest on beta-cell function: a review of clinical and preclinical data. Pediatr Diabetes (2008) 0.91
Control of Foxo1 gene expression by co-activator P300. J Biol Chem (2013) 0.90
The new biology of diabetes. Diabetologia (2015) 0.89
The B55α-containing PP2A holoenzyme dephosphorylates FOXO1 in islet β-cells under oxidative stress. Biochem J (2012) 0.88
The interplay of prolactin and the glucocorticoids in the regulation of beta-cell gene expression, fatty acid oxidation, and glucose-stimulated insulin secretion: implications for carbohydrate metabolism in pregnancy. Endocrinology (2008) 0.87
Novel insulin sensitizer modulates nutrient sensing pathways and maintains β-cell phenotype in human islets. PLoS One (2013) 0.87
Differential and complementary effects of glucose and prolactin on islet DNA synthesis and gene expression. Endocrinology (2011) 0.85
Glucagon-like peptide 1 inhibits the sirtuin deacetylase SirT1 to stimulate pancreatic β-cell mass expansion. Diabetes (2011) 0.84
Adult-onset deletion of Pten increases islet mass and beta cell proliferation in mice. Diabetologia (2013) 0.84
A mutant allele encoding DNA binding-deficient FoxO1 differentially regulates hepatic glucose and lipid metabolism. Diabetes (2015) 0.83
Transcriptional regulation of glucose sensors in pancreatic β-cells and liver: an update. Sensors (Basel) (2010) 0.82
New insights into ovarian function. Handb Exp Pharmacol (2010) 0.81
Update on the protective molecular pathways improving pancreatic beta-cell dysfunction. Mediators Inflamm (2013) 0.81
FoxO1 Plays an Important Role in Regulating β-Cell Compensation for Insulin Resistance in Male Mice. Endocrinology (2016) 0.80
Reconstitution of insulin action in muscle, white adipose tissue, and brain of insulin receptor knock-out mice fails to rescue diabetes. J Biol Chem (2011) 0.78
FoxO1 Deacetylation Decreases Fatty Acid Oxidation in β-Cells and Sustains Insulin Secretion in Diabetes. J Biol Chem (2016) 0.78
Antioxidant effect of mogrosides against oxidative stress induced by palmitic acid in mouse insulinoma NIT-1 cells. Braz J Med Biol Res (2013) 0.78
Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics. J Proteome Res (2015) 0.76
When β-cells fail: lessons from dedifferentiation. Diabetes Obes Metab (2016) 0.75
Nov/Ccn3, a novel transcriptional target of FoxO1, impairs pancreatic β-cell function. PLoS One (2013) 0.75
Pdcd2l Promotes Palmitate-Induced Pancreatic Beta-Cell Apoptosis as a FoxO1 Target Gene. PLoS One (2016) 0.75
Rpl13a small nucleolar RNAs regulate systemic glucose metabolism. J Clin Invest (2016) 0.75
A high-resolution recombination map of the human genome. Nat Genet (2002) 28.66
Mutational processes molding the genomes of 21 breast cancers. Cell (2012) 11.22
The life history of 21 breast cancers. Cell (2012) 10.59
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature (2003) 9.77
Clinical and biological implications of driver mutations in myelodysplastic syndromes. Blood (2013) 6.50
The forkhead transcription factor Foxo1 regulates adipocyte differentiation. Dev Cell (2003) 5.59
SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab (2008) 4.89
Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure. Cell (2012) 4.88
Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat Genet (2002) 4.76
Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. Cell Metab (2007) 4.74
FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab (2005) 4.14
Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes. J Biol Chem (2005) 4.13
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest (2002) 4.05
Structure-based prediction of protein-protein interactions on a genome-wide scale. Nature (2012) 3.37
Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nat Med (2006) 3.24
Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism. J Clin Invest (2006) 3.21
Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions. Cell Metab (2006) 3.14
BioJava: an open-source framework for bioinformatics in 2012. Bioinformatics (2012) 2.94
Generation of functional insulin-producing cells in the gut by Foxo1 ablation. Nat Genet (2012) 2.75
Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. J Clin Invest (2002) 2.65
A Foxo/Notch pathway controls myogenic differentiation and fiber type specification. J Clin Invest (2007) 2.57
Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ. Cell (2012) 2.46
Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proc Natl Acad Sci U S A (2009) 2.31
Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor. Diabetes (2003) 2.16
Mouse models of insulin resistance. Physiol Rev (2004) 2.16
Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity. J Biol Chem (2004) 2.15
Hormonal regulation of hepatic glucose production in health and disease. Cell Metab (2011) 2.12
Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice. Am J Physiol Endocrinol Metab (2003) 2.06
FoxO1 target Gpr17 activates AgRP neurons to regulate food intake. Cell (2012) 2.03
Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors. J Cell Biol (2003) 1.94
Testis determination requires insulin receptor family function in mice. Nature (2003) 1.94
Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor. J Clin Invest (2002) 1.93
Signalling through IGF-I and insulin receptors: where is the specificity? Growth Horm IGF Res (2002) 1.91
Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: a prospective observational study. Lancet Oncol (2011) 1.85
Recurrent focal copy-number changes and loss of heterozygosity implicate two noncoding RNAs and one tumor suppressor gene at chromosome 3q13.31 in osteosarcoma. Cancer Res (2010) 1.81
Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha. J Clin Invest (2005) 1.76
Increased CD36 protein as a response to defective insulin signaling in macrophages. J Clin Invest (2004) 1.76
How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited. Diabetes (2011) 1.74
Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance. J Clin Invest (2006) 1.74
Insulin receptor knockout mice. Annu Rev Physiol (2002) 1.70
Aberrant 3' oligoadenylation of spliceosomal U6 small nuclear RNA in poikiloderma with neutropenia. Blood (2012) 1.68
Uncoupling of acetylation from phosphorylation regulates FoxO1 function independent of its subcellular localization. J Biol Chem (2010) 1.68
FoxOs function synergistically to promote glucose production. J Biol Chem (2010) 1.66
Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. J Clin Invest (2007) 1.60
Whole exome sequencing of adenoid cystic carcinoma. J Clin Invest (2013) 1.58
Transgenic rescue of insulin receptor-deficient mice. J Clin Invest (2004) 1.57
Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner. Nat Med (2011) 1.55
Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action. J Clin Invest (2005) 1.55
The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake. Nat Med (2009) 1.55
The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models. Genome Biol (2013) 1.54
The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities. Endocr Rev (2008) 1.52
Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity. Cell Metab (2012) 1.51
Toward a more uniform sampling of human genetic diversity: a survey of worldwide populations by high-density genotyping. Genomics (2010) 1.47
Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons. Diabetes (2009) 1.46
FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis. Cell Metab (2012) 1.46
Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass. Diabetes (2006) 1.45
Adiponectin resistance exacerbates insulin resistance in insulin receptor transgenic/knockout mice. Diabetes (2007) 1.42
Human insulin resistance is associated with increased plasma levels of 12α-hydroxylated bile acids. Diabetes (2013) 1.41
Genome-wide expression profiling implicates a MAST3-regulated gene set in colonic mucosal inflammation of ulcerative colitis patients. Inflamm Bowel Dis (2011) 1.41
New insights into the integrated physiology of insulin action. Rev Endocr Metab Disord (2004) 1.40
The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells. Gastroenterology (2007) 1.40
The impact of macrophage insulin resistance on advanced atherosclerotic plaque progression. Circ Res (2010) 1.29
Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress. Diabetes (2008) 1.26
The double life of Irs. Cell Metab (2008) 1.26
Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1. Mol Cell Biol (2009) 1.24
Increased hepatic levels of the insulin receptor inhibitor, PC-1/NPP1, induce insulin resistance and glucose intolerance. Diabetes (2005) 1.24
Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through Creb deacetylation. Cell Metab (2011) 1.23
Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability. Nat Med (2013) 1.23
Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice. J Clin Invest (2009) 1.22
Hepatic FoxO1 ablation exacerbates lipid abnormalities during hyperglycemia. J Biol Chem (2010) 1.21
Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice. Cell Metab (2011) 1.18
Diabetes in mice with selective impairment of insulin action in Glut4-expressing tissues. Diabetes (2011) 1.18
Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans. J Clin Invest (2005) 1.14
Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia. Am J Physiol Endocrinol Metab (2005) 1.14
Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice. J Clin Invest (2012) 1.14
Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia. Cell Metab (2011) 1.14
A proteomic chronology of gene expression through the cell cycle in human myeloid leukemia cells. Elife (2014) 1.10
Hypoxia converts the myogenic action of insulin-like growth factors into mitogenic action by differentially regulating multiple signaling pathways. Proc Natl Acad Sci U S A (2010) 1.09
Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor. Proc Natl Acad Sci U S A (2011) 1.08
Mechanisms of disease: using genetically altered mice to study concepts of type 2 diabetes. Nat Clin Pract Endocrinol Metab (2008) 1.07
Post-translational modifications, a key process in CD36 function: lessons from the spontaneously hypertensive rat heart. J Mol Cell Cardiol (2011) 1.03
Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance. J Biol Chem (2002) 1.02
Inactivation of arf-bp1 induces p53 activation and diabetic phenotypes in mice. J Biol Chem (2011) 1.00
New variants at 10q26 and 15q21 are associated with aggressive prostate cancer in a genome-wide association study from a prostate biopsy screening cohort. Cancer Biol Ther (2011) 0.98
Foxo1 links hyperglycemia to LDL oxidation and endothelial nitric oxide synthase dysfunction in vascular endothelial cells. Diabetes (2009) 0.98
TP53 alterations determine clinical subgroups and survival of patients with choroid plexus tumors. J Clin Oncol (2010) 0.97
Mouse models of insulin resistance. Am J Physiol Endocrinol Metab (2002) 0.97
Respective contributions of maternal insulin resistance and diet to metabolic and hypothalamic phenotypes of progeny. Obesity (Silver Spring) (2010) 0.96
The tangled path to glucose production. Nat Med (2006) 0.96
Mosaic analysis of insulin receptor function. J Clin Invest (2004) 0.95
EGF receptor transactivation is obligatory for protein synthesis stimulation by G protein-coupled receptors. Am J Physiol Cell Physiol (2002) 0.95
Cell biology. Selective insulin sensitizers. Science (2011) 0.94
Genetic analysis of type-1 insulin-like growth factor receptor signaling through insulin receptor substrate-1 and -2 in pancreatic beta cells. J Biol Chem (2010) 0.94
In vivo mutagenesis of the insulin receptor. J Biol Chem (2003) 0.91
All roads lead to FoxO. Cell Metab (2005) 0.91
Expanded granulocyte/monocyte compartment in myeloid-specific triple FoxO knockout increases oxidative stress and accelerates atherosclerosis in mice. Circ Res (2013) 0.91
FoxO feedback control of basal IRS-2 expression in pancreatic β-cells is distinct from that in hepatocytes. Diabetes (2011) 0.91
Increased atherosclerosis and endothelial dysfunction in mice bearing constitutively deacetylated alleles of Foxo1 gene. J Biol Chem (2012) 0.90
Liver sinusoidal endothelial cells link hyperinsulinemia to hepatic insulin resistance. Diabetes (2013) 0.89
The effect of insulin signaling on female reproductive function independent of adiposity and hyperglycemia. Endocrinology (2010) 0.89