Published in J Biol Chem on December 20, 2011
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Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15. Genes Dev (2013) 1.30
Limiting the power of p53 through the ubiquitin proteasome pathway. Genes Dev (2014) 1.10
HUWE1 ubiquitylates and degrades the RAC activator TIAM1 promoting cell-cell adhesion disassembly, migration, and invasion. Cell Rep (2014) 0.90
USP7S-dependent inactivation of Mule regulates DNA damage signalling and repair. Nucleic Acids Res (2012) 0.85
It Takes 15 to Tango: Making Sense of the Many Ubiquitin Ligases of p53. Genes Cancer (2012) 0.83
Characterization of ARF-BP1/HUWE1 interactions with CTCF, MYC, ARF and p53 in MYC-driven B cell neoplasms. Int J Mol Sci (2012) 0.81
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A specific E3 ligase/deubiquitinase pair modulates TBP protein levels during muscle differentiation. Elife (2015) 0.78
Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation. Cell Stem Cell (2016) 0.77
Homeostatic defects in B cells deficient in the E3 ubiquitin ligase ARF-BP1 are restored by enhanced expression of MYC. Leuk Res (2013) 0.76
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The ubiquitin ligase COP1 is a critical negative regulator of p53. Nature (2004) 5.05
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ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell (2005) 4.60
Signaling to p53: ribosomal proteins find their way. Cancer Cell (2009) 3.84
Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus. Genes Dev (2009) 3.02
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Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage. Mol Biol Cell (2007) 1.65
Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice. J Clin Invest (2011) 1.59
Prospective therapeutic applications of p53 inhibitors. Biochem Biophys Res Commun (2005) 1.40
p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress. J Biol Chem (2010) 1.39
Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1. EMBO J (2008) 1.36
USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1. EMBO J (2011) 1.26
Requirement of the ATM/p53 tumor suppressor pathway for glucose homeostasis. Mol Cell Biol (2010) 1.23
E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alpha. Proc Natl Acad Sci U S A (2010) 1.23
Regulated expression of the ubiquitin protein ligase, E3(Histone)/LASU1/Mule/ARF-BP1/HUWE1, during spermatogenesis. Dev Dyn (2007) 1.07
The ARF-B23 connection: implications for growth control and cancer treatment. Cell Cycle (2004) 0.98
p53 and MDM2: antagonists or partners in crime? Cancer Cell (2009) 0.96
Tumor suppression by p53: making cells senescent. Histol Histopathol (2010) 0.96
Δ40 Isoform of p53 controls β-cell proliferation and glucose homeostasis in mice. Diabetes (2011) 0.87
Genotypes of p53 codon 72 correlate with age at onset of type 1 diabetes in a sex-specific manner. J Pediatr Endocrinol Metab (2011) 0.83
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature (2003) 9.77
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Mammalian SIRT1 represses forkhead transcription factors. Cell (2004) 8.89
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature (2002) 7.71
Acetylation is indispensable for p53 activation. Cell (2008) 5.70
Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell (2006) 5.64
The forkhead transcription factor Foxo1 regulates adipocyte differentiation. Dev Cell (2003) 5.59
p53 ubiquitination: Mdm2 and beyond. Mol Cell (2006) 5.57
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SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell (2007) 5.30
Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science (2003) 5.23
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell (2005) 5.04
Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell (2012) 4.96
SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab (2008) 4.89
Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure. Cell (2012) 4.88
Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat Genet (2002) 4.76
Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. Cell Metab (2007) 4.74
ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell (2005) 4.60
Non-transcriptional control of DNA replication by c-Myc. Nature (2007) 4.55
Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. Cell (2002) 4.33
Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29
FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab (2005) 4.14
Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes. J Biol Chem (2005) 4.13
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest (2002) 4.05
A dynamic role of HAUSP in the p53-Mdm2 pathway. Mol Cell (2004) 4.05
Acetylation of p53 inhibits its ubiquitination by Mdm2. J Biol Chem (2002) 3.37
Structure-based prediction of protein-protein interactions on a genome-wide scale. Nature (2012) 3.37
Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nat Med (2006) 3.24
Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism. J Clin Invest (2006) 3.21
How does SIRT1 affect metabolism, senescence and cancer? Nat Rev Cancer (2008) 3.17
Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions. Cell Metab (2006) 3.14
Non-invasive prenatal measurement of the fetal genome. Nature (2012) 3.11
Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09
Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A (2004) 3.06
Parc: a cytoplasmic anchor for p53. Cell (2003) 3.06
Acetylation inactivates the transcriptional repressor BCL6. Nat Genet (2002) 3.00
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol (2006) 2.85
Generation of functional insulin-producing cells in the gut by Foxo1 ablation. Nat Genet (2012) 2.75
Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity. Mol Cell Biol (2005) 2.72
Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. J Clin Invest (2002) 2.65
A local mechanism mediates NAD-dependent protection of axon degeneration. J Cell Biol (2005) 2.64
SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem (2005) 2.59
A Foxo/Notch pathway controls myogenic differentiation and fiber type specification. J Clin Invest (2007) 2.57
p53 post-translational modification: deregulated in tumorigenesis. Trends Mol Med (2010) 2.54
Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ. Cell (2012) 2.46
Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. PLoS Biol (2006) 2.35
Nearly finished genomes produced using gel microdroplet culturing reveal substantial intraspecies genomic diversity within the human microbiome. Genome Res (2013) 2.29
Mouse models of insulin resistance. Physiol Rev (2004) 2.16
Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity. J Biol Chem (2004) 2.15
Hormonal regulation of hepatic glucose production in health and disease. Cell Metab (2011) 2.12
Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes. Mol Cell Biol (2007) 2.12
Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice. Am J Physiol Endocrinol Metab (2003) 2.06
Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML. Blood (2006) 2.06
FoxO1 target Gpr17 activates AgRP neurons to regulate food intake. Cell (2012) 2.03
Microfluidics for flow cytometric analysis of cells and particles. Physiol Meas (2005) 2.00
C/EBPalpha and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor gamma agonists. Mol Cell Biol (2009) 1.98
Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors. J Cell Biol (2003) 1.94
Testis determination requires insulin receptor family function in mice. Nature (2003) 1.94
Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor. J Clin Invest (2002) 1.93
Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J Biol Chem (2003) 1.92
Hormonal control of androgen receptor function through SIRT1. Mol Cell Biol (2006) 1.91
Signalling through IGF-I and insulin receptors: where is the specificity? Growth Horm IGF Res (2002) 1.91
Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell (2011) 1.87
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest (2012) 1.82
Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha. J Clin Invest (2005) 1.76
Increased CD36 protein as a response to defective insulin signaling in macrophages. J Clin Invest (2004) 1.76
SnapShot: p53 posttranslational modifications. Cell (2008) 1.75
How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited. Diabetes (2011) 1.74
Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance. J Clin Invest (2006) 1.74
Suppression of cancer cell growth by promoting cyclin D1 degradation. Mol Cell (2009) 1.72
Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses. Nature (2010) 1.71
Improving genome assemblies by sequencing PCR products with PacBio. Biotechniques (2012) 1.70
Insulin receptor knockout mice. Annu Rev Physiol (2002) 1.70
Computer-controlled microcirculatory support system for endothelial cell culture and shearing. Anal Chem (2005) 1.70
Uncoupling of acetylation from phosphorylation regulates FoxO1 function independent of its subcellular localization. J Biol Chem (2010) 1.68
Differential effects on ARF stability by normal versus oncogenic levels of c-Myc expression. Mol Cell (2013) 1.67
The impact of acetylation and deacetylation on the p53 pathway. Protein Cell (2011) 1.66
FoxOs function synergistically to promote glucose production. J Biol Chem (2010) 1.66
Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. J Clin Invest (2007) 1.60
Transgenic rescue of insulin receptor-deficient mice. J Clin Invest (2004) 1.57
Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action. J Clin Invest (2005) 1.55
Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner. Nat Med (2011) 1.55
The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake. Nat Med (2009) 1.55
Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Mol Cell Proteomics (2012) 1.54
The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities. Endocr Rev (2008) 1.52
α-adducin Gly460Trp polymorphism and essential hypertension risk in Chinese: a meta-analysis. Hypertens Res (2011) 1.51
Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity. Cell Metab (2012) 1.51
p53 regulation by ubiquitin. FEBS Lett (2011) 1.51
Translation of ASH1 mRNA is repressed by Puf6p-Fun12p/eIF5B interaction and released by CK2 phosphorylation. Genes Dev (2008) 1.50
p53-Dependent and p53-independent activation of autophagy by ARF. Cancer Res (2008) 1.50
Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons. Diabetes (2009) 1.46
FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis. Cell Metab (2012) 1.46
Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass. Diabetes (2006) 1.45