Published in Mol Cell Biol on November 20, 2006
Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell (2010) 23.97
Pioneer transcription factors: establishing competence for gene expression. Genes Dev (2011) 6.01
Transcription factors: from enhancer binding to developmental control. Nat Rev Genet (2012) 5.00
PU.1 and C/EBPalpha/beta convert fibroblasts into macrophage-like cells. Proc Natl Acad Sci U S A (2008) 3.35
A recurrent network involving the transcription factors PU.1 and Gfi1 orchestrates innate and adaptive immune cell fates. Immunity (2009) 1.55
Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies. Nucleic Acids Res (2012) 1.38
RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis. EMBO J (2012) 1.37
Epigenetic silencing of the oncogenic miR-17-92 cluster during PU.1-directed macrophage differentiation. EMBO J (2011) 1.30
The Pu.1 locus is differentially regulated at the level of chromatin structure and noncoding transcription by alternate mechanisms at distinct developmental stages of hematopoiesis. Mol Cell Biol (2007) 1.23
Endoglin expression in blood and endothelium is differentially regulated by modular assembly of the Ets/Gata hemangioblast code. Blood (2008) 1.16
CSF-1 receptor signaling in myeloid cells. Cold Spring Harb Perspect Biol (2014) 1.10
Inflammatory monocytes and the pathogenesis of viral encephalitis. J Neuroinflammation (2012) 1.08
Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation. Dev Cell (2016) 0.96
Differential regulation of NAB corepressor genes in Schwann cells. BMC Mol Biol (2007) 0.94
Molecular control of monocyte development. Cell Immunol (2014) 0.92
Mast cell transcriptional networks. Blood Cells Mol Dis (2008) 0.90
Krox20/EGR2 deficiency accelerates cell growth and differentiation in the monocytic lineage and decreases bone mass. Blood (2010) 0.89
Origin, development, and homeostasis of tissue-resident macrophages. Immunol Rev (2014) 0.88
The Interplay between Chromatin and Transcription Factor Networks during B Cell Development: Who Pulls the Trigger First? Front Immunol (2014) 0.85
Colony-stimulating factor-1-responsive macrophage precursors reside in the amphibian (Xenopus laevis) bone marrow rather than the hematopoietic subcapsular liver. J Innate Immun (2013) 0.83
MicroRNA-Mediated Down-Regulation of M-CSF Receptor Contributes to Maturation of Mouse Monocyte-Derived Dendritic Cells. Front Immunol (2013) 0.81
Lymphoid to myeloid cell trans-differentiation is determined by C/EBPβ structure and post-translational modifications. PLoS One (2013) 0.81
Cell-Type Specific Determinants of NRAMP1 Expression in Professional Phagocytes. Biology (Basel) (2013) 0.79
Proteomic biosignatures for monocyte-macrophage differentiation. Cell Immunol (2011) 0.79
Amphibian macrophage development and antiviral defenses. Dev Comp Immunol (2015) 0.77
Macrophage production and activation are dependent on TRIM33. Oncotarget (2016) 0.75
Protein kinase A inhibition of macrophage maturation is accompanied by an increase in DNA methylation of the colony-stimulating factor 1 receptor gene. Immunology (2016) 0.75
Enforced Expression of Hoxa3 Inhibits Classical and Promotes Alternative Activation of Macrophages In Vitro and In Vivo. J Immunol (2016) 0.75
PU.1 acts as tumor suppressor for myeloma cells through direct transcriptional repression of IRF4. Oncogene (2017) 0.75
Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity. Mol Cell (2003) 11.78
Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science (1994) 7.60
Multilineage transcriptional priming and determination of alternate hematopoietic cell fates. Cell (2006) 5.39
Multilineage gene expression precedes commitment in the hemopoietic system. Genes Dev (1997) 5.21
Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J (1996) 5.17
Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment. Dev Cell (2002) 4.37
A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood (2002) 4.06
Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPalpha ratio and granulocyte colony-stimulating factor. Nat Immunol (2003) 3.24
Cooperative and antagonistic interplay between PU.1 and GATA-2 in the specification of myeloid cell fates. Immunity (2002) 2.99
Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with "zinc-binding finger" structure. Proc Natl Acad Sci U S A (1988) 2.73
Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages. Nature (2004) 2.49
A lipopolysaccharide-specific enhancer complex involving Ets, Elk-1, Sp1, and CREB binding protein and p300 is recruited to the tumor necrosis factor alpha promoter in vivo. Mol Cell Biol (2000) 2.33
Differentiation plasticity of hematopoietic cells. Blood (2002) 2.17
The role of enhancers as centres for general transcription factor recruitment. Trends Biochem Sci (2005) 2.14
Interaction and functional collaboration of p300 and C/EBPbeta. Mol Cell Biol (1997) 2.12
PU.1 regulates expression of the interleukin-7 receptor in lymphoid progenitors. Immunity (2002) 2.10
The granulocyte-macrophage colony-stimulating factor/interleukin 3 locus is regulated by an inducible cyclosporin A-sensitive enhancer. Proc Natl Acad Sci U S A (1993) 2.01
Chromatin domain activation via GATA-1 utilization of a small subset of dispersed GATA motifs within a broad chromosomal region. Proc Natl Acad Sci U S A (2005) 1.96
Activation of the beta-globin locus control region precedes commitment to the erythroid lineage. Proc Natl Acad Sci U S A (1992) 1.87
PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors. EMBO J (1998) 1.84
Loops, lineage, and leukemia. Cell (1998) 1.73
Isolation of intact nuclei for nuclear extract preparation from a fragile B-lymphocyte cell line. Biotechniques (1995) 1.66
Formation of an active tissue-specific chromatin domain initiated by epigenetic marking at the embryonic stem cell stage. Mol Cell Biol (2005) 1.62
c-Jun is a JNK-independent coactivator of the PU.1 transcription factor. J Biol Chem (1999) 1.49
Chromatin fine structure profiles for a developmentally regulated gene: reorganization of the lysozyme locus before trans-activator binding and gene expression. Genes Dev (2000) 1.40
Transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during maturation of myeloid precursor cells. Genes Dev (2002) 1.34
Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible. EMBO J (2004) 1.28
Differentiation-dependent alterations in histone methylation and chromatin architecture at the inducible chicken lysozyme gene. J Biol Chem (2005) 1.26
A highly conserved c-fms gene intronic element controls macrophage-specific and regulated expression. J Leukoc Biol (2001) 1.18
Expression of the early growth response 1 and 2 zinc finger genes during induction of monocytic differentiation. J Clin Invest (1991) 1.18
Physical and functional interactions between the transcription factor PU.1 and the coactivator CBP. Oncogene (1999) 1.16
Developmentally regulated recruitment of transcription factors and chromatin modification activities to chicken lysozyme cis-regulatory elements in vivo. Mol Cell Biol (2003) 1.15
Interaction between PU.1 and another Ets family transcription factor promotes macrophage-specific Basal transcription initiation. J Biol Chem (1998) 1.04
The mechanism of repression of the myeloid-specific c-fms gene by Pax5 during B lineage restriction. EMBO J (2006) 0.98
Differential transcription factor occupancy but evolutionarily conserved chromatin features at the human and mouse M-CSF (CSF-1) receptor loci. Nucleic Acids Res (2003) 0.97
Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell (2010) 23.97
Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development. Science (2002) 5.47
Multilineage transcriptional priming and determination of alternate hematopoietic cell fates. Cell (2006) 5.39
Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation. Immunity (2006) 3.41
Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPalpha ratio and granulocyte colony-stimulating factor. Nat Immunol (2003) 3.24
Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression. J Exp Med (2002) 3.16
IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity. J Immunol (2005) 3.15
Cooperative and antagonistic interplay between PU.1 and GATA-2 in the specification of myeloid cell fates. Immunity (2002) 2.99
Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling. Immunity (2008) 2.72
Assembling a gene regulatory network for specification of the B cell fate. Dev Cell (2004) 2.46
The distal V(H) gene cluster of the Igh locus contains distinct regulatory elements with Pax5 transcription factor-dependent activity in pro-B cells. Immunity (2011) 2.41
Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros. Nat Immunol (2008) 2.40
A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes. Science (2012) 2.30
Compensatory dendritic cell development mediated by BATF-IRF interactions. Nature (2012) 2.25
DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina. Cell (2012) 2.20
Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5. Nat Immunol (2008) 2.19
IRF-4,8 orchestrate the pre-B-to-B transition in lymphocyte development. Genes Dev (2003) 2.12
PU.1 regulates expression of the interleukin-7 receptor in lymphoid progenitors. Immunity (2002) 2.10
The replacement histone H2A.Z in a hyperacetylated form is a feature of active genes in the chicken. Nucleic Acids Res (2005) 2.08
IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. Nat Immunol (2011) 1.95
Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma. Nat Med (2010) 1.93
PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element. Genes Dev (2008) 1.90
Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia. Cancer Cell (2013) 1.89
Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription. Nat Immunol (2004) 1.82
The LPS-induced transcriptional upregulation of the chicken lysozyme locus involves CTCF eviction and noncoding RNA transcription. Mol Cell (2008) 1.81
Initiation of allelic exclusion by stochastic interaction of Tcrb alleles with repressive nuclear compartments. Nat Immunol (2008) 1.78
Regulation of interleukin 7-dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5. Nat Immunol (2005) 1.76
Use of sputum eosinophil counts to guide management in children with severe asthma. Thorax (2011) 1.73
Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis. Immunity (2009) 1.67
Sputum inflammatory phenotypes are not stable in children with asthma. Thorax (2012) 1.65
Crystal structure of PU.1/IRF-4/DNA ternary complex. Mol Cell (2002) 1.64
Repeatability of sodium and chloride in exhaled breath condensates. Pediatr Pulmonol (2004) 1.63
Clinical use of noninvasive measurements of airway inflammation in steroid reduction in children. Am J Respir Crit Care Med (2005) 1.56
Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire. Immunity (2013) 1.56
A recurrent network involving the transcription factors PU.1 and Gfi1 orchestrates innate and adaptive immune cell fates. Immunity (2009) 1.55
Transcriptional regulation of germinal center B and plasma cell fates by dynamical control of IRF4. Immunity (2013) 1.52
The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis. EMBO J (2012) 1.50
Thyroid hormone-regulated enhancer blocking: cooperation of CTCF and thyroid hormone receptor. EMBO J (2003) 1.49
Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development. Nat Immunol (2009) 1.48
Runx proteins regulate Foxp3 expression. J Exp Med (2009) 1.45
Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells. Blood (2011) 1.41
Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in T(H)17 cells. Nat Immunol (2011) 1.41
Evolution in action: following function in duplicated floral homeotic genes. Curr Biol (2005) 1.38
Pax5: a master regulator of B cell development and leukemogenesis. Adv Immunol (2011) 1.37
RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis. EMBO J (2012) 1.37
Transcription factor PU.1 controls transcription start site positioning and alternative TLR4 promoter usage. J Biol Chem (2007) 1.36
Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling. Nat Immunol (2012) 1.35
Transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during maturation of myeloid precursor cells. Genes Dev (2002) 1.34
Wellington: a novel method for the accurate identification of digital genomic footprints from DNase-seq data. Nucleic Acids Res (2013) 1.33
Epigenetic silencing of the oncogenic miR-17-92 cluster during PU.1-directed macrophage differentiation. EMBO J (2011) 1.30
Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible. EMBO J (2004) 1.28
Genetic networks that regulate B lymphopoiesis. Curr Opin Hematol (2005) 1.26
Differentiation-dependent alterations in histone methylation and chromatin architecture at the inducible chicken lysozyme gene. J Biol Chem (2005) 1.26
Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1. Nat Immunol (2013) 1.24
The Pu.1 locus is differentially regulated at the level of chromatin structure and noncoding transcription by alternate mechanisms at distinct developmental stages of hematopoiesis. Mol Cell Biol (2007) 1.23
The transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells. EMBO J (2011) 1.22
Macrophage development from HSCs requires PU.1-coordinated microRNA expression. Blood (2011) 1.22
CPPsite: a curated database of cell penetrating peptides. Database (Oxford) (2012) 1.21
Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver. Blood (2008) 1.21
IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid mouse progenitors. Blood (2012) 1.19
A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation. Nat Immunol (2012) 1.18
An incoherent regulatory network architecture that orchestrates B cell diversification in response to antigen signaling. Mol Syst Biol (2011) 1.17
Developmentally regulated recruitment of transcription factors and chromatin modification activities to chicken lysozyme cis-regulatory elements in vivo. Mol Cell Biol (2003) 1.15
Lymphodepletion in the ApcMin/+ mouse model of intestinal tumorigenesis. Blood (2003) 1.14
Gene regulatory networks directing myeloid and lymphoid cell fates within the immune system. Semin Immunol (2008) 1.14
Epigenetic consequences of AML1-ETO action at the human c-FMS locus. EMBO J (2003) 1.14
POU/TBP cooperativity: a mechanism for enhancer action from a distance. Mol Cell (2002) 1.14
PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2. Nat Med (2010) 1.12
NPACT: Naturally Occurring Plant-based Anti-cancer Compound-Activity-Target database. Nucleic Acids Res (2012) 1.11
CCDB: a curated database of genes involved in cervix cancer. Nucleic Acids Res (2010) 1.09
Altered chromosomal positioning, compaction, and gene expression with a lamin A/C gene mutation. PLoS One (2010) 1.08
GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment. Blood (2012) 1.08
TumorHoPe: a database of tumor homing peptides. PLoS One (2012) 1.07
An extended set of PRDM1/BLIMP1 target genes links binding motif type to dynamic repression. Nucleic Acids Res (2010) 1.07
Regulation of the interleukin-7 receptor alpha promoter by the Ets transcription factors PU.1 and GA-binding protein in developing B cells. J Biol Chem (2007) 1.06
Decitabine maintains hematopoietic precursor self-renewal by preventing repression of stem cell genes by a differentiation-inducing stimulus. Mol Cancer Ther (2010) 1.05