Published in FEBS Lett on July 08, 1991
Inflammation and Alzheimer's disease. Neurobiol Aging (2000) 12.56
Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proc Natl Acad Sci U S A (1993) 2.79
Interleukin-6, a major cytokine in the central nervous system. Int J Biol Sci (2012) 2.01
Glial cytokines in Alzheimer's disease: review and pathogenic implications. Hum Pathol (1995) 1.53
Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain. Am J Pathol (1992) 1.47
Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain. Proc Natl Acad Sci U S A (1997) 1.46
Complement in the brain. Mol Immunol (2011) 1.41
Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway. Mol Psychiatry (2016) 1.40
Interleukin-1 in the genesis and progression of and risk for development of neuronal degeneration in Alzheimer's disease. J Leukoc Biol (2002) 1.38
Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model. J Immunol (2011) 1.36
Inflammatory processes induce beta-amyloid precursor protein changes in mouse brain. Proc Natl Acad Sci U S A (1995) 1.31
The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer's disease brain. Arch Immunol Ther Exp (Warsz) (2012) 1.23
Neuroinflammation in Alzheimer's disease: mechanisms, pathologic consequences, and potential for therapeutic manipulation. J Alzheimers Dis (2010) 1.19
The pervasiveness of interleukin-1 in alzheimer pathogenesis: a role for specific polymorphisms in disease risk. Exp Gerontol (2000) 1.06
Pro-inflammatory interleukin-18 increases Alzheimer's disease-associated amyloid-β production in human neuron-like cells. J Neuroinflammation (2012) 1.03
Systemic inflammation, blood-brain barrier vulnerability and cognitive/non-cognitive symptoms in Alzheimer disease: relevance to pathogenesis and therapy. Front Aging Neurosci (2014) 1.02
Whether, when and how chronic inflammation increases the risk of developing late-onset Alzheimer's disease. Alzheimers Res Ther (2012) 1.02
S100beta induction of the proinflammatory cytokine interleukin-6 in neurons. J Neurochem (2000) 1.02
Peptides and proteins in plasma and cerebrospinal fluid as biomarkers for the prediction, diagnosis, and monitoring of therapeutic efficacy of Alzheimer's disease. Biochim Biophys Acta (2008) 1.01
Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy. Ann N Y Acad Sci (2010) 0.99
Interleukin-6 is present in early stages of plaque formation and is restricted to the brains of Alzheimer's disease patients. Acta Neuropathol (1995) 0.96
The role of inflammasome in Alzheimer's disease. Ageing Res Rev (2014) 0.95
CSF Biomarkers for Alzheimer's Disease Diagnosis. Int J Alzheimers Dis (2010) 0.94
Heat shock proteins and amateur chaperones in amyloid-Beta accumulation and clearance in Alzheimer's disease. Mol Neurobiol (2007) 0.92
Rapid induction of tumor necrosis factor alpha in the cerebrospinal fluid after intracerebroventricular injection of lipopolysaccharide revealed by a sensitive capture immuno-PCR assay. Proc Natl Acad Sci U S A (1995) 0.91
Amyloid beta peptide potentiates cytokine secretion by interleukin-1 beta-activated human astrocytoma cells. Proc Natl Acad Sci U S A (1995) 0.90
Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease. J Neuroinflammation (2009) 0.89
Microglia in Alzheimer brain: a neuropathological perspective. Int J Alzheimers Dis (2012) 0.87
miR-155 is involved in Alzheimer's disease by regulating T lymphocyte function. Front Aging Neurosci (2015) 0.86
Isoprenoids and related pharmacological interventions: potential application in Alzheimer's disease. Mol Neurobiol (2012) 0.85
Pattern of interleukin-6 receptor complex immunoreactivity between cortical regions of rapid autopsy normal and Alzheimer's disease brain. Eur Arch Psychiatry Clin Neurosci (2004) 0.83
Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse model. Hum Mol Genet (2015) 0.83
Sporadic Alzheimer disease fibroblasts display an oxidative stress phenotype. Free Radic Biol Med (2012) 0.83
Distribution of neuronal growth-promoting factors and cytoskeletal proteins in altered neurites in Alzheimer's disease and non-demented elderly. Acta Neuropathol (1995) 0.82
C/T conversion alters interleukin-1A promoter function in a human astrocyte cell line. Life Sci (2006) 0.81
Serine protease inhibitor antithrombin III and its messenger RNA in the pathogenesis of Alzheimer's disease. Am J Pathol (1993) 0.81
Clinical significance of neurobiochemical profiles in the lumbar cerebrospinal fluid of Alzheimer's disease patients. J Neural Transm (Vienna) (2001) 0.80
Brain omega-3 polyunsaturated fatty acids modulate microglia cell number and morphology in response to intracerebroventricular amyloid-β 1-40 in mice. J Neuroinflammation (2016) 0.79
Menopause, obesity and inflammation: interactive risk factors for Alzheimer's disease. Front Aging Neurosci (2015) 0.78
Brain Atrophy, Anti-Smooth Muscle Antibody and Cognitive Impairment: An Association Study. Aging Dis (2015) 0.77
The role of the innate immune system in Alzheimer's disease and frontotemporal lobar degeneration: an eye on microglia. Clin Dev Immunol (2013) 0.77
Neuroinflammation and brain functional disconnection in Alzheimer's disease. Front Aging Neurosci (2013) 0.77
The Distinct Role of ADAM17 in APP Proteolysis and Microglial Activation Related to Alzheimer's Disease. Cell Mol Neurobiol (2015) 0.76
Are there roles for brain cell senescence in aging and neurodegenerative disorders? Biogerontology (2014) 0.76
Insulin resistance in Alzheimer's disease. Transl Res (2016) 0.75
Wnt/TLR Dialog in Neuroinflammation, Relevance in Alzheimer's Disease. Front Immunol (2017) 0.75
Pharmacotherapy in the treatment of Alzheimer's disease: an update. World Psychiatry (2004) 0.75
Brain energy metabolism and neuroinflammation in ageing APP/PS1-21 mice using longitudinal 18F-FDG and 18F-DPA-714 PET imaging. J Cereb Blood Flow Metab (2016) 0.75
Patients with prior fractures have an increased risk of future fractures: a summary of the literature and statistical synthesis. J Bone Miner Res (2000) 7.29
Cortical language localization in left, dominant hemisphere. An electrical stimulation mapping investigation in 117 patients. J Neurosurg (1989) 4.18
T lymphocyte-directed gene therapy for ADA- SCID: initial trial results after 4 years. Science (1995) 3.87
Attainment and adjustment in two geographical areas. I--The prevalence of psychiatric disorder. Br J Psychiatry (1975) 3.79
Adaptation to ischemia during percutaneous transluminal coronary angioplasty. Clinical, hemodynamic, and metabolic features. Circulation (1990) 3.52
Hypoglycemic symptoms and frequency of severe hypoglycemia in patients treated with human and animal insulin preparations. Diabetes Care (1991) 3.51
Quantitative assessment of pulmonary hypertension in patients with tricuspid regurgitation using continuous wave Doppler ultrasound. J Am Coll Cardiol (1985) 3.50
Inflammatory cytokines in cystic fibrosis lungs. Am J Respir Crit Care Med (1995) 3.47
Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation. Am J Respir Crit Care Med (1994) 3.24
Human neutrophils increase expression of C3bi as well as C3b receptors upon activation. J Clin Invest (1984) 2.88
c-Jun and p53 activity is modulated by SUMO-1 modification. J Biol Chem (2000) 2.71
Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2. EMBO J (1999) 2.64
Absorption kinetics and biologic effects of subcutaneously injected insulin preparations. Diabetes Care (1987) 2.50
Association of asthma control with health care utilization and quality of life. Am J Respir Crit Care Med (1999) 2.36
[Repression by glucose of alcohol dehydrogenase, malate dehydrogenase, isocitrate lyase and malate synthase in yeast]. Biochim Biophys Acta (1966) 2.33
Bicentric evaluation of a teaching and treatment programme for type 1 (insulin-dependent) diabetic patients: improvement of metabolic control and other measures of diabetes care for up to 22 months. Diabetologia (1983) 2.18
Recombinant human B cell stimulatory factor 2 (BSF-2/IFN-beta 2) regulates beta-fibrinogen and albumin mRNA levels in Fao-9 cells. FEBS Lett (1987) 2.04
Sleep and depression--results from psychobiological studies: an overview. Biol Psychol (2001) 2.02
Effect of age on excess mortality in obesity. JAMA (1999) 2.01
Intensified insulin therapy and the risk of severe hypoglycaemia. Diabetologia (1997) 1.95
Oxidative damage to DNA: formation, measurement, and biological significance. Rev Physiol Biochem Pharmacol (1997) 1.91
The formation of glutamine and alanine in skeletal muscle. J Biol Chem (1974) 1.90
Glucose metabolism in perfused skeletal muscle. Effects of starvation, diabetes, fatty acids, acetoacetate, insulin and exercise on glucose uptake and disposition. Biochem J (1976) 1.90
Evaluation of an intensified insulin treatment and teaching programme as routine management of type 1 (insulin-dependent) diabetes. The Bucharest-Düsseldorf Study. Diabetologia (1987) 1.87
Do angiotensin converting enzyme inhibitors represent a progress in hypertension care in diabetes mellitus? Diabetologia (1990) 1.84
Normal bronchial epithelial cells constitutively produce the anti-inflammatory cytokine interleukin-10, which is downregulated in cystic fibrosis. Am J Respir Cell Mol Biol (1995) 1.82
Regulation of glucose and ketone-body metabolism in brain of anaesthetized rats. Biochem J (1974) 1.78
Regulation of interleukin-6 expression in cultured human blood monocytes and monocyte-derived macrophages. Blood (1988) 1.76
Glucose metabolism in perfused skeletal muscle. Interaction of insulin and exercise on glucose uptake. Biochem J (1975) 1.71
Current understanding of the inflammatory process in cystic fibrosis: onset and etiology. Pediatr Pulmonol (1997) 1.68
Pharmacokinetics and bioavailability of injected glucagon: differences between intramuscular, subcutaneous, and intravenous administration. Diabetes Care (1985) 1.67
Effective and safe translation of intensified insulin therapy to general internal medicine departments. Diabetologia (1993) 1.67
Issues in the measurement of satisfaction with treatment. Am J Manag Care (1997) 1.67
Neutrophil elastase cleaves C3bi on opsonized pseudomonas as well as CR1 on neutrophils to create a functionally important opsonin receptor mismatch. J Clin Invest (1990) 1.66
Cross-sectional and longitudinal studies of naturally occurring antibodies to Pseudomonas aeruginosa in cystic fibrosis indicate absence of antibody-mediated protection and decline in opsonic quality after infection. J Infect Dis (1995) 1.63
Polyunsaturated fatty acids inhibit T cell signal transduction by modification of detergent-insoluble membrane domains. J Cell Biol (1998) 1.63
IVC anomalies and right renal aplasia detected on CT: a possible link? Abdom Imaging (2003) 1.63
Assessment of excess mortality in obesity. Am J Epidemiol (1998) 1.62
Detection of human papillomavirus DNA on the fingers of patients with genital warts. Sex Transm Infect (1999) 1.61
Prevalence and treatment of insomnia in general practice. A longitudinal study. Eur Arch Psychiatry Clin Neurosci (1993) 1.61
Glucose metabolism in rat skeletal muscle at rest. Effect of starvation, diabetes, ketone bodies and free fatty acids. Diabetes (1974) 1.61
Health beliefs and compliance with inhaled corticosteroids by asthmatic patients in primary care practices. Respir Med (1999) 1.59
Lack of binding of human C3, in its native state, to C3b receptors. J Immunol (1981) 1.57
Evaluation of a structured treatment and teaching programme on non-insulin-dependent diabetes. Lancet (1988) 1.56
Nonproductive kappa immunoglobulin genes: recombinational abnormalities and other lesions affecting transcription, RNA processing, turnover, and translation. Mol Cell Biol (1985) 1.55
EEG coherence in Alzheimer disease. Electroencephalogr Clin Neurophysiol (1994) 1.53
Use of intravenously administered immune globulin to prevent nosocomial sepsis in low birth weight infants: report of a pilot study. J Pediatr (1989) 1.53
The neuropeptide substance P activates transcription factor NF-kappa B and kappa B-dependent gene expression in human astrocytoma cells. J Immunol (1997) 1.52
Localization of complement component 3 on Streptococcus pneumoniae: anti-capsular antibody causes complement deposition on the pneumococcal capsule. Infect Immun (1983) 1.51
Prevalence of insomnia in elderly general practice attenders and the current treatment modalities. Acta Psychiatr Scand (1994) 1.51
Uncontrolled-rate freezing and storage at -80 degrees C, with only 3.5-percent DMSO in cryoprotective solution for 109 autologous peripheral blood progenitor cell transplantations. Transfusion (2001) 1.51
Noninvasive estimation of pulmonary artery diastolic pressure in patients with tricuspid regurgitation by Doppler echocardiography. Chest (1999) 1.51
Flavanone synthase from Petroselinum hortense. Molecular weight, subunit composition, size of messenger RNA, and absence of pantetheinyl residue. Eur J Biochem (1979) 1.50
Action profiles of fast onset insulin analogues. Diabetologia (1990) 1.50
Sonographic healing stages of Achilles tendon after tenomuscular lengthening in children with cerebral palsy. J Pediatr Orthop (2001) 1.50
Obstructive sleep apnea is a risk factor for difficult endotracheal intubation. Minerva Anestesiol (2011) 1.49
Extensive amplification and self-renewal of human primitive hematopoietic stem cells from cord blood. Blood (1997) 1.48
Echocardiographic detection of transient right heart thrombus: now you see it, now you don't. Am Heart J (1991) 1.48
Unsuspected cardiac abnormalities in the acquired immune deficiency syndrome. An echocardiographic study. Chest (1989) 1.48
Functional differences between the 40 kDa and 50 to 70 kDa IgG Fc receptors on human neutrophils revealed by elastase treatment and antireceptor antibodies. J Immunol (1988) 1.48
Test-retest reliability and validity of the Structured Interview for Sleep Disorders According to DSM-III-R. Am J Psychiatry (1993) 1.46
Pyrimethamine concentrations in serum and cerebrospinal fluid during treatment of acute Toxoplasma encephalitis in patients with AIDS. J Infect Dis (1988) 1.45
Skeletal muscle glycolysis, oxidation, and storage of an oral glucose load. J Clin Invest (1988) 1.42
Possible risk of sulfonylureas in the treatment of non-insulin-dependent diabetes mellitus and coronary artery disease. Diabetologia (1997) 1.42
Captopril, blood pressure, and diabetic nephropathy. JAMA (1994) 1.42
[Chronic fatigue syndrome. Definition, diagnostic measures and therapeutic possibilities]. Nervenarzt (1996) 1.42
Prandial glycaemia after a carbohydrate-rich meal in type I diabetic patients: using the rapid acting insulin analogue [Lys(B28), Pro(B29)] human insulin. Diabet Med (1996) 1.41
Interleukin-6-(IL-6) plasma levels in depression and schizophrenia: comparison between the acute state and after remission. Eur Arch Psychiatry Clin Neurosci (1997) 1.41
Hemodialysis of children: a review. Tex Med (1976) 1.40
[Differential indications for psychotherapy exemplified by depression]. Nervenarzt (2011) 1.39
[Significance of historical and current hallucinogenic research in psychiatry]. Nervenarzt (1993) 1.39
Diabetes care in cats and dogs. Diabet Med (2002) 1.39
[The metabolic effects of beta-receptor blockers. What is of practical importance in antihypertensive therapy?]. Dtsch Med Wochenschr (1992) 1.39
Right-sided endocarditis in intravenous drug users. Prognostic features in 102 episodes. Ann Intern Med (1992) 1.38
HLA-DR2 and sleep onset REM periods in endogenous depression. Br J Psychiatry (1988) 1.38
Altered respiratory epithelial cell cytokine production in cystic fibrosis. J Allergy Clin Immunol (1999) 1.38
Reliability of causes of death in persons with Type I diabetes. Diabetologia (2002) 1.38
[Addressed to the Federal Professional Society of Rehabilitation on "Planning ambulatory rehabilitation of psychosomatic and psychiatric diseases" 15 January 2003]. Nervenarzt (2003) 1.37
Complement receptors. Clin Immunol Rev (1983) 1.37
Radiation-induced decomposition of the purine bases within DNA and related model compounds. Int J Radiat Biol Relat Stud Phys Chem Med (1985) 1.36
Evaluation of correlation between dose and clinical outcomes in subcutaneous immunoglobulin replacement therapy. Clin Exp Immunol (2012) 1.36
Neural attenuation of responses to emitted sounds in echolocating rats. Science (1972) 1.35
Functional and molecular aspects of voltage-gated K+ channel beta subunits. Ann N Y Acad Sci (1999) 1.34
Exercise and diabetes mellitus. Diabetes (1979) 1.34
Exercise-induced fall of blood glucose in insulin-treated diabetics unrelated to alteration of insulin mobilization. Diabetes (1979) 1.33
Classical complement pathway activation by antipneumococcal antibodies leads to covalent binding of C3b to antibody molecules. Infect Immun (1983) 1.31
Human pancreatic tissue concentration of bactericidal antibiotics. Gastroenterology (1992) 1.31
Noncontact fluorescence diffuse optical tomography of heterogeneous media. Appl Opt (2007) 1.31
Detection of interleukin-6 and alpha 2-macroglobulin immunoreactivity in cortex and hippocampus of Alzheimer's disease patients. Lab Invest (1992) 1.28
Studies on the mechanism of T cell inhibition by the Pseudomonas aeruginosa phenazine pigment pyocyanine. J Immunol (1987) 1.27
Mycobacterium tuberculosis 19-kDa lipoprotein promotes neutrophil activation. J Immunol (2001) 1.26
Cigarette-smoking as a risk factor for macroproteinuria and proliferative retinopathy in type 1 (insulin-dependent) diabetes. Diabetologia (1986) 1.26
A quantitative analysis of C3 binding to O-antigen capsule, lipopolysaccharide, and outer membrane protein of E. coli 0111B4. J Immunol (1984) 1.26
The nephrotic syndrome secondary to acute glomerulonephritis during falciparum malaria. Ann Intern Med (1967) 1.25
Effect of insulin concentration, subcutaneous fat thickness and skin temperature on subcutaneous insulin absorption in healthy subjects. Diabetologia (1994) 1.25
Attainment and adjustment in two geographical areas: III--Some factors accounting for area differences. Br J Psychiatry (1975) 1.25
Systematic review and validation of prediction rules for identifying children with serious infections in emergency departments and urgent-access primary care. Health Technol Assess (2012) 1.25
Molecular cloning and characterization of murine and human N-acetylglucosamine kinase. Eur J Biochem (2000) 1.25