Published in Ageing Res Rev on February 19, 2014
Low-grade inflammation, diet composition and health: current research evidence and its translation. Br J Nutr (2015) 1.50
Inflammasomes in neuroinflammation and changes in brain function: a focused review. Front Neurosci (2014) 1.26
Cardiovascular risk factors and future risk of Alzheimer's disease. BMC Med (2014) 1.00
Role of inflammasome activation in the pathophysiology of vascular diseases of the neurovascular unit. Antioxid Redox Signal (2014) 0.92
Osteoporosis and alzheimer pathology: Role of cellular stress response and hormetic redox signaling in aging and bone remodeling. Front Pharmacol (2014) 0.91
Metabolic Risk Factors of Sporadic Alzheimer's Disease: Implications in the Pathology, Pathogenesis and Treatment. Aging Dis (2015) 0.90
MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson's disease. Mol Neurodegener (2016) 0.88
Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer's disease. Cell Death Dis (2014) 0.87
Amyloid-β and proinflammatory cytokines utilize a prion protein-dependent pathway to activate NADPH oxidase and induce cofilin-actin rods in hippocampal neurons. PLoS One (2014) 0.85
Ceramides in Alzheimer's Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and Aβ Accumulation. Oxid Med Cell Longev (2015) 0.85
The Role of Damage-Associated Molecular Patterns (DAMPs) in Human Diseases: Part II: DAMPs as diagnostics, prognostics and therapeutics in clinical medicine. Sultan Qaboos Univ Med J (2015) 0.84
Inflammatory Response in the CNS: Friend or Foe? Mol Neurobiol (2016) 0.83
Inflammation Combined with Ischemia Produces Myelin Injury and Plaque-Like Aggregates of Myelin, Amyloid-β and AβPP in Adult Rat Brain. J Alzheimers Dis (2015) 0.83
Targeting Hsp90 and its co-chaperones to treat Alzheimer's disease. Expert Opin Ther Targets (2014) 0.81
The Expression Changes of Inflammasomes in the Aging Rat Kidneys. J Gerontol A Biol Sci Med Sci (2015) 0.80
Exposure to air pollution as a potential contributor to cognitive function, cognitive decline, brain imaging, and dementia: A systematic review of epidemiologic research. Neurotoxicology (2016) 0.79
Gene delivery of a viral anti-inflammatory protein to combat ocular inflammation. Hum Gene Ther (2015) 0.79
Evidence to Consider Angiotensin II Receptor Blockers for the Treatment of Early Alzheimer's Disease. Cell Mol Neurobiol (2016) 0.78
Alterations of the Neuroinflammatory Markers IL-6 and TRAIL in Alzheimer's Disease. Dement Geriatr Cogn Dis Extra (2015) 0.77
Perspectives on the Tertiary Prevention Strategy for Alzheimer's Disease. Curr Alzheimer Res (2016) 0.76
Mesenchymal stem cell transplantation inhibited high salt-induced activation of the NLRP3 inflammasome in the renal medulla in Dahl S rats. Am J Physiol Renal Physiol (2016) 0.76
Treating Alzheimer's disease with Yizhijiannao granules by regulating expression of multiple proteins in temporal lobe. Neural Regen Res (2014) 0.76
Palmitate Increases β-site AβPP-Cleavage Enzyme 1 Activity and Amyloid-β Genesis by Evoking Endoplasmic Reticulum Stress and Subsequent C/EBP Homologous Protein Activation. J Alzheimers Dis (2017) 0.75
Cytokines and Cytokine Receptors Involved in the Pathogenesis of Alzheimer's Disease. J Clin Cell Immunol (2016) 0.75
Association between TNF-α promoter -308 A/G polymorphism and Alzheimer's disease: a meta-analysis. Neurol Sci (2015) 0.75
Beneficial effects of liraglutide (GLP1 analog) in the hippocampal inflammation. Metab Brain Dis (2017) 0.75
The inflammasomes. Cell (2010) 19.37
Alzheimer's disease. N Engl J Med (2010) 13.13
The inflammasomes: guardians of the body. Annu Rev Immunol (2009) 12.89
The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol (2008) 10.39
Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet (2008) 8.51
Ischemic cell death in brain neurons. Physiol Rev (1999) 8.01
Frequent amyloid deposition without significant cognitive impairment among the elderly. Arch Neurol (2008) 7.95
2012 Alzheimer's disease facts and figures. Alzheimers Dement (2012) 5.43
Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study. BMJ (2005) 5.34
Alzheimer mechanisms and therapeutic strategies. Cell (2012) 5.24
Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist. Nature (1990) 4.87
Mediterranean diet and risk for Alzheimer's disease. Ann Neurol (2006) 4.38
Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist. Lancet (2004) 4.23
Immune function of astrocytes. Glia (2001) 4.05
Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice. J Neurosci (2008) 3.90
Interleukin-1-receptor antagonist in the Muckle-Wells syndrome. N Engl J Med (2003) 3.86
Inhibition of human caspases by peptide-based and macromolecular inhibitors. J Biol Chem (1998) 3.80
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature (2012) 3.67
Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4. Science (1993) 3.62
In-vivo measurement of activated microglia in dementia. Lancet (2001) 3.51
Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response. J Histochem Cytochem (2006) 3.20
Results of a high-resolution genome screen of 437 Alzheimer's disease families. Hum Mol Genet (2003) 3.00
Microglia: intrinsic immuneffector cell of the brain. Brain Res Brain Res Rev (1995) 2.92
The pannexin 1 channel activates the inflammasome in neurons and astrocytes. J Biol Chem (2009) 2.90
Interleukin-1 as a pathogenetic mediator of ischemic brain damage in rats. Stroke (1995) 2.81
Inflammasome activation and IL-1β and IL-18 processing during infection. Trends Immunol (2011) 2.75
Turnover of resident microglia in the normal adult mouse brain. Neuroscience (1992) 2.73
Automated MRI measures identify individuals with mild cognitive impairment and Alzheimer's disease. Brain (2009) 2.61
Linking lipids to Alzheimer's disease: cholesterol and beyond. Nat Rev Neurosci (2011) 2.60
Does NSAID use modify cognitive trajectories in the elderly? The Cache County study. Neurology (2007) 2.56
Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention. Exp Neurol (2007) 2.36
Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort. Neurology (2009) 2.32
Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study. Neurobiol Dis (2008) 2.27
Palmitate activates the NF-kappaB transcription factor and induces IL-6 and TNFalpha expression in 3T3-L1 adipocytes. J Nutr (2005) 2.20
Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients. Neurosci Lett (1995) 2.19
P38 MAP kinase is activated at early stages in Alzheimer's disease brain. Exp Neurol (2003) 2.14
Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice. Am J Pathol (2007) 2.05
A review: inflammatory process in Alzheimer's disease, role of cytokines. ScientificWorldJournal (2012) 2.03
The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective. J Neuroinflammation (2008) 2.03
Inhibition of the inflammasome complex reduces the inflammatory response after thromboembolic stroke in mice. J Cereb Blood Flow Metab (2008) 1.99
A molecular platform in neurons regulates inflammation after spinal cord injury. J Neurosci (2008) 1.93
Palmitate modulates intracellular signaling, induces endoplasmic reticulum stress, and causes apoptosis in mouse 3T3-L1 and rat primary preadipocytes. Am J Physiol Endocrinol Metab (2007) 1.90
Deregulation of sphingolipid metabolism in Alzheimer's disease. Neurobiol Aging (2008) 1.89
The control of neuron number. Annu Rev Neurosci (1988) 1.80
A cell biological perspective on Alzheimer's disease. Annu Rev Cell Dev Biol (2002) 1.79
Differential requirements for NAIP5 in activation of the NLRC4 inflammasome. Infect Immun (2011) 1.74
Role of complement in neurodegeneration and neuroinflammation. Mol Immunol (2006) 1.73
IL-1: discoveries, controversies and future directions. Eur J Immunol (2010) 1.73
Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis. J Biol Chem (2003) 1.73
Therapeutic neutralization of the NLRP1 inflammasome reduces the innate immune response and improves histopathology after traumatic brain injury. J Cereb Blood Flow Metab (2009) 1.69
Elevated circulating tumor necrosis factor levels in Alzheimer's disease. Neurosci Lett (1991) 1.63
Gene expression alterations in the sphingolipid metabolism pathways during progression of dementia and Alzheimer's disease: a shift toward ceramide accumulation at the earliest recognizable stages of Alzheimer's disease? Neurochem Res (2007) 1.61
Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils. Mol Biol Cell (2007) 1.61
Inflammation and Alzheimer's disease. Arch Pharm Res (2010) 1.60
Neutrophil proteinase 3-mediated induction of bioactive IL-18 secretion by human oral epithelial cells. J Immunol (2001) 1.60
In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis. Neurobiol Aging (1997) 1.60
Astrocytes: implications for neuroinflammatory pathogenesis of Alzheimer's disease. Curr Alzheimer Res (2011) 1.58
The microglial phagocytic role with specific plaque types in the Alzheimer disease brain. Neurobiol Aging (2004) 1.56
Inflammation in central nervous system injury. Philos Trans R Soc Lond B Biol Sci (2003) 1.56
Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis. Biochim Biophys Acta (2010) 1.56
Inflammation: a new candidate in modulating adult neurogenesis. J Neurosci Res (2008) 1.55
Neuropathologic changes in Alzheimer's disease. J Clin Psychiatry (2003) 1.53
Increased A beta peptides and reduced cholesterol and myelin proteins characterize white matter degeneration in Alzheimer's disease. Biochemistry (2002) 1.50
Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice. Neurobiol Dis (2006) 1.45
Astrocytes produce and release interleukin-1, interleukin-6, tumor necrosis factor alpha and interferon-gamma following traumatic and metabolic injury. J Neurotrauma (2001) 1.44
Decreased expression of CD200 and CD200 receptor in Alzheimer's disease: a potential mechanism leading to chronic inflammation. Exp Neurol (2008) 1.44
Fibrillar amyloid-beta-activated human astroglia kill primary human neurons via neutral sphingomyelinase: implications for Alzheimer's disease. J Neurosci (2010) 1.38
Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model. J Immunol (2011) 1.36
Cultures of astrocytes and microglia express interleukin 18. Brain Res Mol Brain Res (1999) 1.34
Interleukin-6 and alpha-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices. FEBS Lett (1991) 1.34
Astrocytic dysfunction: insights on the role in neurodegeneration. Brain Res Bull (2009) 1.34
Cell type-specific interleukin-1beta signaling in the CNS. J Neurosci (2004) 1.33
Annual review prize lecture cytokines - killers in the brain? J Physiol (1999) 1.31
Mechanisms of cell signaling and inflammation in Alzheimer's disease. Curr Drug Targets Inflamm Allergy (2005) 1.29
Inflammasome signaling at the heart of central nervous system pathology. J Neurosci Res (2010) 1.28
MicroRNA-137/181c regulates serine palmitoyltransferase and in turn amyloid β, novel targets in sporadic Alzheimer's disease. J Neurosci (2011) 1.27
Interleukin-1beta (IL-1beta) processing pathway. Sci Signal (2010) 1.26
Interleukin 18 in the CNS. J Neuroinflammation (2010) 1.26
High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model. Neurobiol Aging (2008) 1.26
Cellular and molecular biology of Alzheimer's disease and animal models. Annu Rev Med (1994) 1.24
The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer's disease brain. Arch Immunol Ther Exp (Warsz) (2012) 1.23
Human amyloid beta-induced neuroinflammation is an early event in neurodegeneration. Glia (2006) 1.22
Saturated long-chain fatty acids activate inflammatory signaling in astrocytes. J Neurochem (2012) 1.21
Non-steroidal anti-inflammatory drugs and Alzheimer's disease: the epidemiological evidence. CNS Neurol Disord Drug Targets (2010) 1.21
Assessment of α-synuclein secretion in mouse and human brain parenchyma. PLoS One (2011) 1.19
Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke. Cell Death Dis (2013) 1.19
De novo-synthesized ceramide signals apoptosis in astrocytes via extracellular signal-regulated kinase. FASEB J (2000) 1.19
Amyloid-beta oligomers set fire to inflammasomes and induce Alzheimer's pathology. J Cell Mol Med (2008) 1.16
Self-renewal and differentiation of reactive astrocyte-derived neural stem/progenitor cells isolated from the cortical peri-infarct area after stroke. J Neurosci (2012) 1.15
Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients. Neurobiol Aging (2007) 1.15
Costimulatory effects of interferon-gamma and interleukin-1beta or tumor necrosis factor alpha on the synthesis of Abeta1-40 and Abeta1-42 by human astrocytes. Neurobiol Dis (2000) 1.14
Interleukin-1 gene (IL1) assigned to long arm of human chromosome 2. Lymphokine Res (1986) 1.13
S100B-induced microglial and neuronal IL-1 expression is mediated by cell type-specific transcription factors. J Neurochem (2005) 1.13
Neuroinflammatory phenotype in early Alzheimer's disease. Neurobiol Aging (2012) 1.13
Assessing the contribution of inflammation in models of Alzheimer's disease. Biochem Soc Trans (2011) 1.12
Palmitic and stearic fatty acids induce Alzheimer-like hyperphosphorylation of tau in primary rat cortical neurons. Neurosci Lett (2005) 1.11
Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a beta-sheet breaker peptide. FASEB J (2002) 1.11
Increased brain fatty acid uptake in metabolic syndrome. Diabetes (2010) 1.10
The emerging role of interleukin-1β in autoinflammatory diseases. Arthritis Rheum (2011) 1.09
Neuroimmunomodulation in the pathogenesis of Alzheimer's disease. Neuroimmunomodulation (2010) 1.08