Published in J Biol Chem on December 04, 2006
An overview of sphingolipid metabolism: from synthesis to breakdown. Adv Exp Med Biol (2010) 2.33
Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas. J Biol Chem (2009) 1.58
Depletion of ceramides with very long chain fatty acids causes defective skin permeability barrier function, and neonatal lethality in ELOVL4 deficient mice. Int J Biol Sci (2007) 1.49
Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation. J Invest Dermatol (2008) 1.24
Multi-system disorders of glycosphingolipid and ganglioside metabolism. J Lipid Res (2010) 1.22
ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters. J Biol Chem (2008) 1.21
Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3. J Biol Chem (2008) 1.18
The outer frontier: the importance of lipid metabolism in the skin. J Lipid Res (2008) 1.16
E7 oncoprotein of novel human papillomavirus type 108 lacking the E6 gene induces dysplasia in organotypic keratinocyte cultures. J Virol (2009) 0.96
Ablation of neuronal ceramide synthase 1 in mice decreases ganglioside levels and expression of myelin-associated glycoprotein in oligodendrocytes. J Biol Chem (2012) 0.93
Ceramide signaling in mammalian epidermis. Biochim Biophys Acta (2013) 0.92
Epidermal expression of an Elovl4 transgene rescues neonatal lethality of homozygous Stargardt disease-3 mice. J Lipid Res (2011) 0.89
Metabolic changes in skin caused by Scd1 deficiency: a focus on retinol metabolism. PLoS One (2011) 0.89
Normal fur development and sebum production depends on fatty acid 2-hydroxylase expression in sebaceous glands. J Biol Chem (2011) 0.88
A world of sphingolipids and glycolipids in the brain--novel functions of simple lipids modified with glucose. Proc Jpn Acad Ser B Phys Biol Sci (2012) 0.84
Functional and genetic characterization of the non-lysosomal glucosylceramidase 2 as a modifier for Gaucher disease. Orphanet J Rare Dis (2013) 0.84
Regulation of retinoid-mediated signaling involved in skin homeostasis by RAR and RXR agonists/antagonists in mouse skin. PLoS One (2013) 0.83
Interruption of glycosphingolipid synthesis enhances osteoarthritis development in mice. Arthritis Rheum (2012) 0.82
Simplifying complexity: genetically resculpting glycosphingolipid synthesis pathways in mice to reveal function. Glycoconj J (2014) 0.80
1-O-acylceramides are natural components of human and mouse epidermis. J Lipid Res (2013) 0.80
My journey into the world of sphingolipids and sphingolipidoses. Proc Jpn Acad Ser B Phys Biol Sci (2012) 0.79
Circulating levels of sphingosine-1-phosphate are elevated in severe, but not mild psoriasis and are unresponsive to anti-TNF-α treatment. Sci Rep (2015) 0.77
Endogenous β-glucocerebrosidase activity in Abca12⁻/⁻epidermis elevates ceramide levels after topical lipid application but does not restore barrier function. J Lipid Res (2013) 0.76
Endoplasmic reticulum calcium, stress, and cell-to-cell adhesion. J Invest Dermatol (2014) 0.76
Sphingolipids in mitochondria. Biochim Biophys Acta (2016) 0.75
Glycosphingolipid-Protein Interaction in Signal Transduction. Int J Mol Sci (2016) 0.75
Intracellular metabolite β-glucosylceramide is an endogenous Mincle ligand possessing immunostimulatory activity. Proc Natl Acad Sci U S A (2017) 0.75
Renal sulfatides: sphingoid base-dependent localization and region-specific compensation of CerS2-dysfunction. J Lipid Res (2014) 0.75
Feeding filaggrin: effects of l-histidine supplementation in atopic dermatitis. Clin Cosmet Investig Dermatol (2017) 0.75
Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study. Front Immunol (2017) 0.75
Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med (2009) 6.72
Direct observation of the nanoscale dynamics of membrane lipids in a living cell. Nature (2008) 6.38
The human keratins: biology and pathology. Histochem Cell Biol (2008) 5.13
The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J Clin Invest (2005) 3.99
New consensus nomenclature for mammalian keratins. J Cell Biol (2006) 3.27
Vascular normalization in Rgs5-deficient tumours promotes immune destruction. Nature (2008) 3.05
Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing hormone neurons and fertility. Neuron (2006) 3.04
Modular activation of nuclear factor-kappaB transcriptional programs in human diabetic nephropathy. Diabetes (2006) 2.85
Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology. Nature (2010) 2.62
Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis. Immunity (2006) 2.61
Enhanced insulin sensitivity in mice lacking ganglioside GM3. Proc Natl Acad Sci U S A (2003) 2.56
Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Mol Cell (2005) 2.46
Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans. J Clin Invest (2008) 2.46
Principles of lysosomal membrane digestion: stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids. Annu Rev Cell Dev Biol (2005) 2.41
Group testing for pathway analysis improves comparability of different microarray datasets. Bioinformatics (2006) 2.37
The epidermal barrier function is dependent on the serine protease CAP1/Prss8. J Cell Biol (2005) 2.36
Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis. J Exp Med (2005) 2.25
Normal development and function of invariant natural killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency. Proc Natl Acad Sci U S A (2007) 2.24
TLR4 links podocytes with the innate immune system to mediate glomerular injury. J Am Soc Nephrol (2008) 2.23
Yes and PI3K bind CD95 to signal invasion of glioblastoma. Cancer Cell (2008) 2.21
Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors. J Biol Chem (2009) 2.12
An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice. Nat Med (2008) 2.12
Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev (2006) 2.10
Combinatorial ganglioside biosynthesis. J Biol Chem (2002) 2.06
A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression. Mol Cancer Res (2007) 2.03
Is the loose anagen hair syndrome a keratin disorder? A clinical and molecular study. Arch Dermatol (2002) 2.03
Sphingolipid metabolism diseases. Biochim Biophys Acta (2006) 2.01
Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury. J Clin Invest (2009) 2.01
Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1. Nat Med (2013) 1.98
Decrease and gain of gene expression are equally discriminatory markers for prostate carcinoma: a gene expression analysis on total and microdissected prostate tissue. Am J Pathol (2002) 1.96
Endostatin's antiangiogenic signaling network. Mol Cell (2004) 1.95
Tubular overexpression of transforming growth factor-beta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells. Am J Pathol (2010) 1.93
AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis. Nat Genet (2010) 1.89
E6 and E7 from beta HPV38 cooperate with ultraviolet light in the development of actinic keratosis-like lesions and squamous cell carcinoma in mice. PLoS Pathog (2011) 1.89
Saposin C is required for lipid presentation by human CD1b. Nat Immunol (2004) 1.88
Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. J Invest Dermatol (2005) 1.82
Parietal epithelial cells participate in the formation of sclerotic lesions in focal segmental glomerulosclerosis. J Am Soc Nephrol (2011) 1.80
Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy. J Cell Biol (2003) 1.73
Gene expression fingerprints in human tubulointerstitial inflammation and fibrosis as prognostic markers of disease progression. Kidney Int (2004) 1.72
Prediction of acute renal allograft rejection by urinary monokine induced by IFN-gamma (MIG). J Am Soc Nephrol (2005) 1.72
An unusual Ala12Thr polymorphism in the 1A alpha-helical segment of the companion layer-specific keratin K6hf: evidence for a risk factor in the etiology of the common hair disorder pseudofolliculitis barbae. J Invest Dermatol (2004) 1.72
A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation. J Clin Invest (2002) 1.70
Viral double-stranded RNA aggravates lupus nephritis through Toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells. J Am Soc Nephrol (2005) 1.69
Lineage specification of parietal epithelial cells requires β-catenin/Wnt signaling. J Am Soc Nephrol (2011) 1.64
Inhibition of alpha(v)beta3 integrin survival signaling enhances antiangiogenic and antitumor effects of radiotherapy. Clin Cancer Res (2005) 1.64
Integrin-linked kinase is required for epidermal and hair follicle morphogenesis. J Cell Biol (2007) 1.63
Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling. J Biol Chem (2005) 1.63
Trimodal cancer treatment: beneficial effects of combined antiangiogenesis, radiation, and chemotherapy. Cancer Res (2005) 1.62
Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice. FASEB J (2004) 1.60
Gnotobiotic piglets develop thrombotic microangiopathy after oral infection with enterohemorrhagic Escherichia coli. Am J Clin Pathol (2002) 1.59
Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas. J Biol Chem (2009) 1.58
Rac1 is crucial for hair follicle integrity but is not essential for maintenance of the epidermis. Mol Cell Biol (2006) 1.58
Hfe acts in hepatocytes to prevent hemochromatosis. Cell Metab (2008) 1.55
Gene expression profiles of podocyte-associated molecules as diagnostic markers in acquired proteinuric diseases. J Am Soc Nephrol (2003) 1.54
Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum. Cell Metab (2008) 1.54
Absence of decorin adversely influences tubulointerstitial fibrosis of the obstructed kidney by enhanced apoptosis and increased inflammatory reaction. Am J Pathol (2002) 1.52
Impairment of sodium balance in mice deficient in renal principal cell mineralocorticoid receptor. J Am Soc Nephrol (2007) 1.51
Lysosomal degradation of membrane lipids. FEBS Lett (2009) 1.50
Depletion of ceramides with very long chain fatty acids causes defective skin permeability barrier function, and neonatal lethality in ELOVL4 deficient mice. Int J Biol Sci (2007) 1.49
cDNA microarray analysis reveals new candidate genes possibly linked to side effects under mycophenolate mofetil therapy. Transplantation (2004) 1.48
Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis. PLoS Biol (2013) 1.48
The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7. Exp Cell Res (2005) 1.47
Principles of lysosomal membrane degradation: Cellular topology and biochemistry of lysosomal lipid degradation. Biochim Biophys Acta (2008) 1.46
Systemic inflammation in glucocerebrosidase-deficient mice with minimal glucosylceramide storage. J Clin Invest (2002) 1.45
Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth. Proc Natl Acad Sci U S A (2005) 1.44
Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels. Proc Natl Acad Sci U S A (2009) 1.44
Comparative promoter analysis allows de novo identification of specialized cell junction-associated proteins. Proc Natl Acad Sci U S A (2006) 1.43
Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions. Proc Natl Acad Sci U S A (2005) 1.43
Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept. Proc Natl Acad Sci U S A (2006) 1.41
Chemokine receptor CCR1 but not CCR5 mediates leukocyte recruitment and subsequent renal fibrosis after unilateral ureteral obstruction. J Am Soc Nephrol (2004) 1.41
Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation. Nat Cell Biol (2007) 1.40
Cardiac hypertrophy and fibrosis in chronic L-NAME-treated AT2 receptor-deficient mice. J Hypertens (2004) 1.39
Temporal Cre-mediated recombination exclusively in endothelial cells using Tie2 regulatory elements. Genesis (2002) 1.38
Effects of increased renal tubular vascular endothelial growth factor (VEGF) on fibrosis, cyst formation, and glomerular disease. Am J Pathol (2009) 1.37
Nrf2 links epidermal barrier function with antioxidant defense. EMBO Mol Med (2012) 1.35
High-accuracy amplification of nanogram total RNA amounts for gene profiling. Genomics (2004) 1.35
G-rich DNA suppresses systemic lupus. J Am Soc Nephrol (2005) 1.35
Human hair keratin-associated proteins (KAPs). Int Rev Cytol (2006) 1.30
Novel role of toll-like receptor 3 in hepatitis C-associated glomerulonephritis. Am J Pathol (2006) 1.28
Improved elucidation of biological processes linked to diabetic nephropathy by single probe-based microarray data analysis. PLoS One (2008) 1.27
Human nephrosclerosis triggers a hypoxia-related glomerulopathy. Am J Pathol (2009) 1.27
Loss of ceramide synthase 3 causes lethal skin barrier disruption. Hum Mol Genet (2011) 1.26
Lysosomal lipid storage diseases. Cold Spring Harb Perspect Biol (2011) 1.26
Bacterial CpG-DNA aggravates immune complex glomerulonephritis: role of TLR9-mediated expression of chemokines and chemokine receptors. J Am Soc Nephrol (2003) 1.25
Deficiency of epidermal protein-bound omega-hydroxyceramides in atopic dermatitis. J Invest Dermatol (2002) 1.25
Development of an assay for the intermembrane transfer of cholesterol by Niemann-Pick C2 protein. Biol Chem (2007) 1.25