Published in Cell Metab on January 01, 2008
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A general map of iron metabolism and tissue-specific subnetworks. Mol Biosyst (2009) 1.02
Regulation of divalent metal transporter 1 (DMT1) non-IRE isoform by the microRNA Let-7d in erythroid cells. Haematologica (2010) 0.99
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Iron absorption in Drosophila melanogaster. Nutrients (2013) 0.95
Retracted The role of ubiquitination in hepcidin-independent and hepcidin-dependent degradation of ferroportin. Cell Metab (2011) 0.94
SIREs: searching for iron-responsive elements. Nucleic Acids Res (2010) 0.93
HIF-1 regulates iron homeostasis in Caenorhabditis elegans by activation and inhibition of genes involved in iron uptake and storage. PLoS Genet (2011) 0.92
Protein degradation and iron homeostasis. Biochim Biophys Acta (2012) 0.90
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Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia. Nat Commun (2016) 0.88
Isoform specific regulation of divalent metal (ion) transporter (DMT1) by proteasomal degradation. Biometals (2012) 0.85
Molecular insights into the regulation of iron metabolism during the prenatal and early postnatal periods. Cell Mol Life Sci (2012) 0.84
Hypoxia-inducible factors link iron homeostasis and erythropoiesis. Gastroenterology (2013) 0.84
F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis. J Biol Chem (2012) 0.84
Divalent metal transporter 1 (Dmt1) mediates copper transport in the duodenum of iron-deficient rats and when overexpressed in iron-deprived HEK-293 cells. J Nutr (2013) 0.84
Duodenal cytochrome b (DCYTB) in iron metabolism: an update on function and regulation. Nutrients (2015) 0.82
Hypoxia inducible factor-2 α is translationally repressed in response to dietary iron deficiency in Sprague-Dawley rats. J Nutr (2011) 0.80
Iron Regulatory Proteins Mediate Host Resistance to Salmonella Infection. Cell Host Microbe (2015) 0.80
Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins. Neurobiol Dis (2015) 0.79
Regulation of iron metabolism in Hamp (-/-) mice in response to iron-deficient diet. Eur J Nutr (2012) 0.79
Duodenal cytochrome b (Cybrd 1) and HIF-2α expression during acute hypoxic exposure in mice. Eur J Nutr (2011) 0.79
Role of duodenal iron transporters and hepcidin in patients with alcoholic liver disease. J Cell Mol Med (2014) 0.78
Genetic polymorphism of the iron-regulatory protein-1 and -2 genes in age-related macular degeneration. Mol Biol Rep (2012) 0.77
Abnormal body iron distribution and erythropoiesis in a novel mouse model with inducible gain of iron regulatory protein (IRP)-1 function. J Mol Med (Berl) (2013) 0.76
Duodenal expression of iron transport molecules in patients with hereditary hemochromatosis or iron deficiency. J Cell Mol Med (2012) 0.76
Aging-related changes in the iron status of skeletal muscle. Exp Gerontol (2013) 0.76
Modelling Systemic Iron Regulation during Dietary Iron Overload and Acute Inflammation: Role of Hepcidin-Independent Mechanisms. PLoS Comput Biol (2017) 0.75
Transferrin receptor mRNA interactions contributing to iron homeostasis. RNA (2016) 0.75
Murine mutants in the study of systemic iron metabolism and its disorders: an update on recent advances. Biochim Biophys Acta (2012) 0.75
"Pumping iron"-how macrophages handle iron at the systemic, microenvironmental, and cellular levels. Pflugers Arch (2017) 0.75
Dietary hemoglobin rescues young piglets from severe iron deficiency anemia: Duodenal expression profile of genes involved in heme iron absorption. PLoS One (2017) 0.75
Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med (2009) 6.72
Molecular mechanisms of translational control. Nat Rev Mol Cell Biol (2004) 6.39
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell (2012) 6.22
Nonsense-mediated decay approaches the clinic. Nat Genet (2004) 5.12
The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J Clin Invest (2005) 3.99
Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation. Nature (2007) 3.77
A sensitive array for microRNA expression profiling (miChip) based on locked nucleic acids (LNA). RNA (2006) 3.71
A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain. Nat Struct Mol Biol (2007) 3.62
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Mol Cell (2003) 3.53
STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood (2006) 3.38
Y14 and hUpf3b form an NMD-activating complex. Mol Cell (2003) 3.17
Vascular normalization in Rgs5-deficient tumours promotes immune destruction. Nature (2008) 3.05
Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing hormone neurons and fertility. Neuron (2006) 3.04
Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network. Annu Rev Nutr (2008) 2.98
Modular activation of nuclear factor-kappaB transcriptional programs in human diabetic nephropathy. Diabetes (2006) 2.85
Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements. Mol Cell (2005) 2.79
Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles. Cell (2006) 2.77
3' end mRNA processing: molecular mechanisms and implications for health and disease. EMBO J (2008) 2.67
Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways. EMBO J (2008) 2.52
Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Mol Cell (2005) 2.46
Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans. J Clin Invest (2008) 2.46
Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. Nat Genet (2003) 2.43
Group testing for pathway analysis improves comparability of different microarray datasets. Bioinformatics (2006) 2.37
The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice. J Clin Invest (2011) 2.30
Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis. J Exp Med (2005) 2.25
Normal development and function of invariant natural killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency. Proc Natl Acad Sci U S A (2007) 2.24
TLR4 links podocytes with the innate immune system to mediate glomerular injury. J Am Soc Nephrol (2008) 2.23
Yes and PI3K bind CD95 to signal invasion of glioblastoma. Cancer Cell (2008) 2.21
Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD. J Mol Med (Berl) (2009) 2.15
The role of ABCE1 in eukaryotic posttermination ribosomal recycling. Mol Cell (2010) 2.14
The RNA-binding protein repertoire of embryonic stem cells. Nat Struct Mol Biol (2013) 2.12
Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors. J Biol Chem (2009) 2.12
An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice. Nat Med (2008) 2.12
NMD: RNA biology meets human genetic medicine. Biochem J (2010) 2.09
Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway. Blood (2010) 2.02
Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury. J Clin Invest (2009) 2.01
c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs. Mol Cell Biol (2002) 1.98
Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1. Nat Med (2013) 1.98
Decrease and gain of gene expression are equally discriminatory markers for prostate carcinoma: a gene expression analysis on total and microdissected prostate tissue. Am J Pathol (2002) 1.96
Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency. Nat Struct Mol Biol (2007) 1.96
Homodirectional changes in transcriptome composition and mRNA translation induced by rapamycin and heat shock. Nat Struct Biol (2003) 1.95
Endostatin's antiangiogenic signaling network. Mol Cell (2004) 1.95
Tubular overexpression of transforming growth factor-beta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells. Am J Pathol (2010) 1.93
PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding. Nat Struct Mol Biol (2012) 1.91
A dual inhibitory mechanism restricts msl-2 mRNA translation for dosage compensation in Drosophila. Cell (2005) 1.91
AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis. Nat Genet (2010) 1.89
E6 and E7 from beta HPV38 cooperate with ultraviolet light in the development of actinic keratosis-like lesions and squamous cell carcinoma in mice. PLoS Pathog (2011) 1.89
Drosophila miR2 primarily targets the m7GpppN cap structure for translational repression. Mol Cell (2009) 1.82
Parietal epithelial cells participate in the formation of sclerotic lesions in focal segmental glomerulosclerosis. J Am Soc Nephrol (2011) 1.80
Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function. Proc Natl Acad Sci U S A (2002) 1.77
Translational control via protein-regulated upstream open reading frames. Cell (2011) 1.76
Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells. Biochem J (2003) 1.74
Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1. Nat Med (2007) 1.73
Gene expression fingerprints in human tubulointerstitial inflammation and fibrosis as prognostic markers of disease progression. Kidney Int (2004) 1.72
Prediction of acute renal allograft rejection by urinary monokine induced by IFN-gamma (MIG). J Am Soc Nephrol (2005) 1.72
A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells. J Mol Med (Berl) (2008) 1.71
A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation. J Clin Invest (2002) 1.70
Disassembly of exon junction complexes by PYM. Cell (2009) 1.69
Viral double-stranded RNA aggravates lupus nephritis through Toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells. J Am Soc Nephrol (2005) 1.69
An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice. Nat Genet (2004) 1.68
microRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells. PLoS One (2009) 1.67
Lineage specification of parietal epithelial cells requires β-catenin/Wnt signaling. J Am Soc Nephrol (2011) 1.64
Inhibition of alpha(v)beta3 integrin survival signaling enhances antiangiogenic and antitumor effects of radiotherapy. Clin Cancer Res (2005) 1.64
Trimodal cancer treatment: beneficial effects of combined antiangiogenesis, radiation, and chemotherapy. Cancer Res (2005) 1.62
Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice. FASEB J (2004) 1.60
Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2). Blood (2005) 1.59
Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife. Genome Biol (2004) 1.59
Gnotobiotic piglets develop thrombotic microangiopathy after oral infection with enterohemorrhagic Escherichia coli. Am J Clin Pathol (2002) 1.59
Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway. Genome Biol (2002) 1.58
Hfe acts in hepatocytes to prevent hemochromatosis. Cell Metab (2008) 1.55
Gene expression profiles of podocyte-associated molecules as diagnostic markers in acquired proteinuric diseases. J Am Soc Nephrol (2003) 1.54
The abundance of RNPS1, a protein component of the exon junction complex, can determine the variability in efficiency of the Nonsense Mediated Decay pathway. Nucleic Acids Res (2007) 1.53
Absence of decorin adversely influences tubulointerstitial fibrosis of the obstructed kidney by enhanced apoptosis and increased inflammatory reaction. Am J Pathol (2002) 1.52
Using the lambdaN peptide to tether proteins to RNAs. Methods Mol Biol (2004) 1.52
Impairment of sodium balance in mice deficient in renal principal cell mineralocorticoid receptor. J Am Soc Nephrol (2007) 1.51
Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. Blood (2014) 1.50
cDNA microarray analysis reveals new candidate genes possibly linked to side effects under mycophenolate mofetil therapy. Transplantation (2004) 1.48
Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis. PLoS Biol (2013) 1.48
Mechanism of translational regulation by miR-2 from sites in the 5' untranslated region or the open reading frame. RNA (2010) 1.46
Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation. RNA (2006) 1.46
Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth. Proc Natl Acad Sci U S A (2005) 1.44
Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2. EMBO J (2009) 1.44
Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels. Proc Natl Acad Sci U S A (2009) 1.44
Abnormally spliced beta-globin mRNAs: a single point mutation generates transcripts sensitive and insensitive to nonsense-mediated mRNA decay. Blood (2002) 1.43
miChip: an array-based method for microRNA expression profiling using locked nucleic acid capture probes. Nat Protoc (2008) 1.43
Comparative promoter analysis allows de novo identification of specialized cell junction-associated proteins. Proc Natl Acad Sci U S A (2006) 1.43
Chemokine receptor CCR1 but not CCR5 mediates leukocyte recruitment and subsequent renal fibrosis after unilateral ureteral obstruction. J Am Soc Nephrol (2004) 1.41
Cardiac hypertrophy and fibrosis in chronic L-NAME-treated AT2 receptor-deficient mice. J Hypertens (2004) 1.39
RNA-binding proteins in Mendelian disease. Trends Genet (2013) 1.38
Temporal Cre-mediated recombination exclusively in endothelial cells using Tie2 regulatory elements. Genesis (2002) 1.38
Effects of increased renal tubular vascular endothelial growth factor (VEGF) on fibrosis, cyst formation, and glomerular disease. Am J Pathol (2009) 1.37
Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity. Mol Cell Biol (2004) 1.37
Eukaryotic translation initiation factor 4GI and p97 promote cellular internal ribosome entry sequence-driven translation. Proc Natl Acad Sci U S A (2005) 1.36
Enhancement of IRES-mediated translation of the c-myc and BiP mRNAs by the poly(A) tail is independent of intact eIF4G and PABP. Mol Cell (2004) 1.36
High-accuracy amplification of nanogram total RNA amounts for gene profiling. Genomics (2004) 1.35
G-rich DNA suppresses systemic lupus. J Am Soc Nephrol (2005) 1.35