Published in Mol Cell Biol on December 04, 2006
MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets. Clin Sci (Lond) (2008) 1.95
The p38 mitogen-activated protein kinase pathway--a potential target for intervention in infarction, hypertrophy, and heart failure. J Mol Cell Cardiol (2010) 1.22
14-3-3Tau regulates ubiquitin-independent proteasomal degradation of p21, a novel mechanism of p21 downregulation in breast cancer. Mol Cell Biol (2010) 1.06
Serine 58 of 14-3-3zeta is a molecular switch regulating ASK1 and oxidant stress-induced cell death. Mol Cell Biol (2009) 1.06
TRB3 function in cardiac endoplasmic reticulum stress. Circ Res (2010) 1.04
Heritability of submaximal exercise heart rate response to exercise training is accounted for by nine SNPs. J Appl Physiol (1985) (2011) 1.00
Human cord blood progenitors with high aldehyde dehydrogenase activity improve vascular density in a model of acute myocardial infarction. J Transl Med (2010) 0.99
The role of RIP2 in p38 MAPK activation in the stressed heart. J Biol Chem (2008) 0.96
Therapeutic targets in the ASK1-dependent stress signaling pathways. Proc Jpn Acad Ser B Phys Biol Sci (2012) 0.94
p38 MAPK in cardioprotection - are we there yet? Br J Pharmacol (2014) 0.90
14-3-3 regulates the LNK/JAK2 pathway in mouse hematopoietic stem and progenitor cells. J Clin Invest (2012) 0.87
Apoptosis signal regulating kinase 1 (ASK1): potential as a therapeutic target for Alzheimer's disease. Int J Mol Sci (2014) 0.85
PP2AC Level Determines Differential Programming of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer. EBioMedicine (2015) 0.83
14-3-3ε plays a role in cardiac ventricular compaction by regulating the cardiomyocyte cell cycle. Mol Cell Biol (2012) 0.83
Novel mouse model of left ventricular pressure overload and infarction causing predictable ventricular remodelling and progression to heart failure. Clin Exp Pharmacol Physiol (2015) 0.79
Human giant congenital melanocytic nevus exhibits potential proteomic alterations leading to melanotumorigenesis. Proteome Sci (2012) 0.78
A Characterization of the expression of 14-3-3 isoforms in psoriasis, basal cell carcinoma, atopic dermatitis and contact dermatitis. Dermatol Reports (2010) 0.75
Overexpression of 14-3-3θ promotes tumor metastasis and indicates poor prognosis in breast carcinoma. Oncotarget (2014) 0.75
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell (1999) 32.32
The structural basis for 14-3-3:phosphopeptide binding specificity. Cell (1997) 10.87
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L) Cell (1996) 10.83
Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine. Cell (1996) 7.81
14-3-3 proteins: structure, function, and regulation. Annu Rev Pharmacol Toxicol (2000) 6.94
Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J (1999) 3.46
14-3-3 proteins: regulation of subcellular localization by molecular interference. Cell Signal (2000) 3.06
Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins. Proc Natl Acad Sci U S A (1999) 2.41
The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy. Proc Natl Acad Sci U S A (2001) 2.36
JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3. J Cell Biol (2005) 2.06
14-3-3 proteins block apoptosis and differentially regulate MAPK cascades. EMBO J (2000) 2.06
14-3-3 proteins mediate an essential anti-apoptotic signal. J Biol Chem (2001) 2.04
p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload. Mol Cell Biol (2004) 1.95
Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion. Circulation (1999) 1.93
JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery. J Biol Chem (2002) 1.80
Phenylephrine promotes phosphorylation of Bad in cardiac myocytes through the extracellular signal-regulated kinases 1/2 and protein kinase A. J Mol Cell Cardiol (2002) 1.62
Navigating the signalling network in mouse cardiac myocytes. Nature (2002) 1.54
Activation of apoptosis signal-regulating kinase 1 by reactive oxygen species through dephosphorylation at serine 967 and 14-3-3 dissociation. J Biol Chem (2003) 1.45
Role of p38alpha MAPK in cardiac apoptosis and remodeling after myocardial infarction. J Mol Cell Cardiol (2005) 1.42
p38 mitogen-activated protein kinase inhibition improves cardiac function and attenuates left ventricular remodeling following myocardial infarction in the rat. J Am Coll Cardiol (2004) 1.28
Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse development. Mol Cell Biol (2006) 1.16
Critical appraisal of the mouse model of myocardial infarction. Exp Physiol (2004) 1.05
Disruption of a single copy of the p38alpha MAP kinase gene leads to cardioprotection against ischemia-reperfusion. Biochem Biophys Res Commun (2003) 1.05
Differential role of 14-3-3 family members in Xenopus development. Dev Dyn (2006) 1.00
Role of 14-3-3-mediated p38 mitogen-activated protein kinase inhibition in cardiac myocyte survival. Circ Res (2003) 0.92
Differential functions of 14-3-3 isoforms in vertebrate development. Curr Top Dev Biol (2005) 0.85
Akt1 is required for physiological cardiac growth. Circulation (2006) 4.25
The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus. J Clin Invest (2002) 4.22
Bipartite network projection and personal recommendation. Phys Rev E Stat Nonlin Soft Matter Phys (2007) 3.80
ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. Cell Metab (2006) 3.38
Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis. Nat Genet (2012) 3.34
A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content. Proc Natl Acad Sci U S A (2003) 2.68
Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J Clin Invest (2003) 2.68
Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart. Genes Dev (2008) 2.58
Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy. Circ Res (2004) 2.50
CD36 deficiency rescues lipotoxic cardiomyopathy. Circ Res (2007) 2.31
Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency. J Clin Invest (2003) 2.05
Uremic cardiac hypertrophy is reversed by rapamycin but not by lowering of blood pressure. Kidney Int (2009) 1.95
Controlling complex networks: how much energy is needed? Phys Rev Lett (2012) 1.80
RNAi promotes heterochromatic silencing through replication-coupled release of RNA Pol II. Nature (2011) 1.79
The role of the Grb2-p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis. J Clin Invest (2003) 1.61
Raf-1 kinase is required for cardiac hypertrophy and cardiomyocyte survival in response to pressure overload. Circulation (2004) 1.59
Liver-directed neonatal gene therapy prevents cardiac, bone, ear, and eye disease in mucopolysaccharidosis I mice. Mol Ther (2005) 1.58
Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice. Am J Physiol Heart Circ Physiol (2009) 1.56
Reduced vessel elasticity alters cardiovascular structure and function in newborn mice. Circ Res (2009) 1.51
RGS4, a GTPase activator, improves renal function in ischemia-reperfusion injury. Kidney Int (2011) 1.51
Recent advances in imaging the lungs of intact small animals. Am J Respir Cell Mol Biol (2004) 1.51
Time course of changes in collateral blood flow and isolated vessel size and gene expression after femoral artery occlusion in rats. Am J Physiol Heart Circ Physiol (2004) 1.50
Akt2 regulates cardiac metabolism and cardiomyocyte survival. J Biol Chem (2006) 1.50
Upregulation of elastase proteins results in aortic dilatation in mucopolysaccharidosis I mice. Mol Genet Metab (2008) 1.45
MDM2 SNP309 variation increases cervical cancer risk among Asians. Tumour Biol (2014) 1.45
Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease. J Clin Invest (2013) 1.42
Role of p38alpha MAPK in cardiac apoptosis and remodeling after myocardial infarction. J Mol Cell Cardiol (2005) 1.42
ZnT-1 protects HL-1 cells from simulated ischemia-reperfusion through activation of Ras-ERK signaling. J Mol Med (Berl) (2011) 1.40
Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice. J Clin Invest (2008) 1.32
Alignment-free sequence comparison based on next-generation sequencing reads. J Comput Biol (2013) 1.26
Myocardial dysfunction after electrical defibrillation. Resuscitation (2002) 1.25
Echocardiographic evaluation of ventricular remodeling in a mouse model of myocardial infarction. J Am Soc Echocardiogr (2002) 1.24
Dominant-negative p38alpha mitogen-activated protein kinase prevents cardiac apoptosis and remodeling after streptozotocin-induced diabetes mellitus. Am J Physiol Heart Circ Physiol (2009) 1.24
Reciprocity between abscisic acid and ethylene at the onset of berry ripening and after harvest. BMC Plant Biol (2010) 1.23
Improvements in mucopolysaccharidosis I mice after adult retroviral vector-mediated gene therapy with immunomodulation. Mol Ther (2007) 1.21
14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy. Biochem Pharmacol (2008) 1.17
Zinc ions and cation diffusion facilitator proteins regulate Ras-mediated signaling. Dev Cell (2002) 1.17
Suppression of 9-cis-epoxycarotenoid dioxygenase, which encodes a key enzyme in abscisic acid biosynthesis, alters fruit texture in transgenic tomato. Plant Physiol (2011) 1.17
Transcriptional regulation of SlPYL, SlPP2C, and SlSnRK2 gene families encoding ABA signal core components during tomato fruit development and drought stress. J Exp Bot (2011) 1.12
Chronic inhibition of pyruvate dehydrogenase in heart triggers an adaptive metabolic response. J Biol Chem (2011) 1.11
Comparison of metagenomic samples using sequence signatures. BMC Genomics (2012) 1.10
Delineation of hypoxia in canine myocardium using PET and copper(II)-diacetyl-bis(N(4)-methylthiosemicarbazone). J Nucl Med (2002) 1.09
Memory-based snowdrift game on networks. Phys Rev E Stat Nonlin Soft Matter Phys (2006) 1.08
New developments of alignment-free sequence comparison: measures, statistics and next-generation sequencing. Brief Bioinform (2013) 1.07
Ca2+-independent alterations in diastolic sarcomere length and relaxation kinetics in a mouse model of lipotoxic diabetic cardiomyopathy. Circ Res (2008) 1.07
[Identify nature N-acylethanolamide-hydrolyzing acid amide (NAAA) inhibitor: effect of angelicae pubescentis radix on anti-inflammation]. Zhongguo Zhong Yao Za Zhi (2011) 1.07
Targeted activation of c-Jun N-terminal kinase in vivo induces restrictive cardiomyopathy and conduction defects. J Biol Chem (2004) 1.07
Connexin43 as a determinant of myocardial infarct size following coronary occlusion in mice. J Am Coll Cardiol (2003) 1.06
Time course of alterations in myocardial glucose utilization in the Zucker diabetic fatty rat with correlation to gene expression of glucose transporters: a small-animal PET investigation. J Nucl Med (2008) 1.06
Serine 58 of 14-3-3zeta is a molecular switch regulating ASK1 and oxidant stress-induced cell death. Mol Cell Biol (2009) 1.06
The importance of elastin to aortic development in mice. Am J Physiol Heart Circ Physiol (2010) 1.05
TRB3 function in cardiac endoplasmic reticulum stress. Circ Res (2010) 1.04
Evidence for positive selection on a number of MicroRNA regulatory interactions during recent human evolution. PLoS Genet (2012) 1.03
A murine model of infantile neuronal ceroid lipofuscinosis-ultrastructural evaluation of storage in the central nervous system and viscera. Pediatr Dev Pathol (2007) 1.03
Liver fibrosis in chronic viral hepatitis: an ultrasonographic study. World J Gastroenterol (2003) 1.02
A multiscale investigation of bicoid-dependent transcriptional events in Drosophila embryos. PLoS One (2011) 1.01
FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium. Development (2011) 1.00
Vertebral artery injuries following cervical spine trauma: a prospective observational study. Eur Spine J (2011) 1.00
Differential role of 14-3-3 family members in Xenopus development. Dev Dyn (2006) 1.00
Human cord blood progenitors with high aldehyde dehydrogenase activity improve vascular density in a model of acute myocardial infarction. J Transl Med (2010) 0.99
Improved retroviral vector design results in sustained expression after adult gene therapy in mucopolysaccharidosis I mice. J Gene Med (2008) 0.99
Fatty acid synthase modulates homeostatic responses to myocardial stress. J Biol Chem (2011) 0.98
A self-inactivating gamma-retroviral vector reduces manifestations of mucopolysaccharidosis I in mice. Mol Ther (2009) 0.97
Prior exercise training produces NO-dependent increases in collateral blood flow after acute arterial occlusion. Am J Physiol Heart Circ Physiol (2002) 0.97
Vascular calcification and aortic fibrosis: a bifunctional role for osteopontin in diabetic arteriosclerosis. Arterioscler Thromb Vasc Biol (2011) 0.96
An NADPH sensor protein (HSCARG) down-regulates nitric oxide synthesis by association with argininosuccinate synthetase and is essential for epithelial cell viability. J Biol Chem (2008) 0.96
Protein kinase C-delta deficiency perturbs bone homeostasis by selective uncoupling of cathepsin K secretion and ruffled border formation in osteoclasts. J Bone Miner Res (2012) 0.96
Study on the multiple mechanisms underlying the reaction between hydroxyl radical and phenolic compounds by qualitative structure and activity relationship. Bioorg Med Chem (2002) 0.96
G-protein signaling participates in the development of diabetic cardiomyopathy. Diabetes (2004) 0.95
Monophyly or paraphyly--the taxonomy of Holcoglossum (Aeridinae: Orchidaceae). PLoS One (2012) 0.95
Exenatide improves glucose homeostasis and prolongs survival in a murine model of dilated cardiomyopathy. PLoS One (2011) 0.95
Cation diffusion facilitator proteins modulate Raf-1 activity. J Biol Chem (2004) 0.95
Beta3 integrin deficiency promotes cardiac hypertrophy and inflammation. J Mol Cell Cardiol (2006) 0.95
Modulation of doxorubicin-induced cardiac dysfunction in dominant-negative p38α mitogen-activated protein kinase mice. Free Radic Biol Med (2010) 0.94
Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J Clin Invest (2003) 0.94
Pseudohypoxic brain swelling (postoperative intracranial hypotension-associated venous congestion) after spinal surgery: report of 2 cases. Neurosurgery (2011) 0.93
Inactivation of 14-3-3 protein exacerbates cardiac hypertrophy and fibrosis through enhanced expression of protein kinase C beta 2 in experimental diabetes. Biol Pharm Bull (2005) 0.92
Establishment of a quantitative structure-activity relationship model for evaluating and predicting the protective potentials of phenolic antioxidants on lipid peroxidation. J Pharm Sci (2003) 0.92
Role of 14-3-3-mediated p38 mitogen-activated protein kinase inhibition in cardiac myocyte survival. Circ Res (2003) 0.92