Published in J Med Chem on December 14, 2006
Non-bisphosphonate inhibitors of isoprenoid biosynthesis identified via computer-aided drug design. Chem Biol Drug Des (2011) 1.13
Antibacterial drug leads: DNA and enzyme multitargeting. J Med Chem (2015) 0.94
Structures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthases. Proteins (2008) 0.92
Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site. Proc Natl Acad Sci U S A (2014) 0.87
HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis. ACS Med Chem Lett (2012) 0.85
Targeting DXP synthase in human pathogens: enzyme inhibition and antimicrobial activity of butylacetylphosphonate. J Antibiot (Tokyo) (2013) 0.84
An enzyme-coupled continuous fluorescence assay for farnesyl diphosphate synthases. Anal Biochem (2011) 0.81
Nuclear magnetic resonance-based quantification of organic diphosphates. Anal Biochem (2010) 0.79
Versatile (1)H-(31)P-(31)P COSY 2D NMR techniques for the characterization of polyphosphorylated small molecules. J Org Chem (2010) 0.79
Undecaprenyl diphosphate synthase inhibitors: antibacterial drug leads. J Med Chem (2014) 0.78
Isoprenoid Biosynthesis Inhibitors Targeting Bacterial Cell Growth. ChemMedChem (2016) 0.75
Sub-inhibitory fosmidomycin exposures elicits oxidative stress in Salmonella enterica serovar Typhimurium LT2. PLoS One (2014) 0.75
In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature (2012) 7.80
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity (2008) 7.60
iPS cells produce viable mice through tetraploid complementation. Nature (2009) 6.51
The draft genome of the transgenic tropical fruit tree papaya (Carica papaya Linnaeus). Nature (2008) 5.54
Increasing solar absorption for photocatalysis with black hydrogenated titanium dioxide nanocrystals. Science (2011) 3.89
Mutations in SYNGAP1 in autosomal nonsyndromic mental retardation. N Engl J Med (2009) 3.88
Hyperspectral remote sensing of foliar nitrogen content. Proc Natl Acad Sci U S A (2012) 3.87
An investigation of bone resorption and Dictyostelium discoideum growth inhibition by bisphosphonate drugs. J Med Chem (2002) 3.82
Direct measure of the de novo mutation rate in autism and schizophrenia cohorts. Am J Hum Genet (2010) 3.69
RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice. Neuron (2003) 3.58
Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury. Nat Med (2009) 3.32
MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors. Cell Stem Cell (2010) 3.18
Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus. Gastroenterology (2002) 3.02
Adaptive immune response of Vgamma2Vdelta2+ T cells during mycobacterial infections. Science (2002) 3.01
A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. Science (2008) 2.96
Percentage of subjects with no heavy drinking days: evaluation as an efficacy endpoint for alcohol clinical trials. Alcohol Clin Exp Res (2010) 2.89
Annotated expressed sequence tags and cDNA microarrays for studies of brain and behavior in the honey bee. Genome Res (2002) 2.78
Cell cycle regulation in the postmitotic neuron: oxymoron or new biology? Nat Rev Neurosci (2007) 2.75
Apatinib for chemotherapy-refractory advanced metastatic gastric cancer: results from a randomized, placebo-controlled, parallel-arm, phase II trial. J Clin Oncol (2013) 2.69
Human platelet dense granules contain polyphosphate and are similar to acidocalcisomes of bacteria and unicellular eukaryotes. J Biol Chem (2004) 2.41
Contribution of enteric infection, altered intestinal barrier function, and maternal malnutrition to infant malnutrition in Bangladesh. Clin Infect Dis (2011) 2.38
Chinese physicians and their smoking knowledge, attitudes, and practices. Am J Prev Med (2007) 2.32
Methods of the International Tobacco Control (ITC) China Survey. Tob Control (2009) 2.30
BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice. Clin Cancer Res (2012) 2.28
PD-1 blockade enhances T-cell migration to tumors by elevating IFN-γ inducible chemokines. Cancer Res (2012) 2.23
The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. Immunity (2009) 2.21
Prognostic significance of tumor-associated macrophages in solid tumor: a meta-analysis of the literature. PLoS One (2012) 2.14
The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury. PLoS One (2013) 2.14
Quality of life in chronic kidney disease (CKD): a cross-sectional analysis in the Renal Research Institute-CKD study. Am J Kidney Dis (2005) 2.05
Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state. Stem Cell Reports (2013) 2.05
Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proc Natl Acad Sci U S A (2007) 2.00
Insulin acutely decreases hepatic fatty acid synthase activity. Cell Metab (2005) 1.99
Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole. J Med Chem (2006) 1.98
An NMR investigation of CO tolerance in a Pt/Ru fuel cell catalyst. J Am Chem Soc (2002) 1.94
The Songbird Neurogenomics (SoNG) Initiative: community-based tools and strategies for study of brain gene function and evolution. BMC Genomics (2008) 1.93
Tissue inhibitor of metalloproteinase-3 downregulation in lymphangioleiomyomatosis: potential consequence of abnormal serum response factor expression. Am J Respir Cell Mol Biol (2003) 1.93
CEACAM1 regulates insulin clearance in liver. Nat Genet (2002) 1.92
A cattle-human comparative map built with cattle BAC-ends and human genome sequence. Genome Res (2003) 1.92
Forecasting global generation of obsolete personal computers. Environ Sci Technol (2010) 1.89
Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model. Nat Cell Biol (2012) 1.87
Broadband graphene terahertz modulators enabled by intraband transitions. Nat Commun (2012) 1.79
S-nitrosylating agents: a novel class of compounds that increase cystic fibrosis transmembrane conductance regulator expression and maturation in epithelial cells. Mol Pharmacol (2006) 1.79
Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation. J Am Chem Soc (2009) 1.75
Hematocrit is associated with fibrosis in patients with nonalcoholic steatohepatitis. Eur J Gastroenterol Hepatol (2014) 1.71
Extensive DNA damage-induced sumoylation contributes to replication and repair and acts in addition to the mec1 checkpoint. Mol Cell (2012) 1.70
Antibacterial drug leads targeting isoprenoid biosynthesis. Proc Natl Acad Sci U S A (2012) 1.69
Pharmacogenetic approach at the serotonin transporter gene as a method of reducing the severity of alcohol drinking. Am J Psychiatry (2011) 1.69
The Relationship between auxin transport and maize branching. Plant Physiol (2008) 1.68
Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors. Cell Res (2011) 1.67
Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation. Cell (2013) 1.66
Findings from 2010 Global Adult Tobacco Survey: implementation of MPOWER policy in China. Biomed Environ Sci (2010) 1.65
Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein. Cell Res (2012) 1.64
Prevalence of covert duplicate publications in Budd-Chiari syndrome articles in China: a systematic analysis. Am J Med (2013) 1.63
Effects of topiramate on methamphetamine-induced changes in attentional and perceptual-motor skills of cognition in recently abstinent methamphetamine-dependent individuals. Prog Neuropsychopharmacol Biol Psychiatry (2006) 1.62
UCA1, a long non-coding RNA up-regulated in colorectal cancer influences cell proliferation, apoptosis and cell cycle distribution. Pathology (2014) 1.61
Structure of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, the terminal enzyme of the non-mevalonate pathway. J Am Chem Soc (2008) 1.57
Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells. Int J Cancer (2006) 1.57
Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease. Proc Natl Acad Sci U S A (2009) 1.56
Down-regulation of myeloid cell leukemia-1 through inhibiting Erk/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer. Cancer Res (2008) 1.56
CD1-mediated gamma/delta T cell maturation of dendritic cells. J Exp Med (2002) 1.56
The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin 1-dependent and Beclin 1-independent cytoprotective autophagy in cancer cells. J Biol Chem (2010) 1.55
Construction of genetic linkage maps and comparative genome analysis of catfish using gene-associated markers. Genetics (2009) 1.55
Bioorganometallic mechanism of action, and inhibition, of IspH. Proc Natl Acad Sci U S A (2010) 1.54
Hydrogen peroxide inhibits mTOR signaling by activation of AMPKalpha leading to apoptosis of neuronal cells. Lab Invest (2010) 1.52
Aliskiren enhances protective effects of valsartan against type 2 diabetic nephropathy in mice. J Hypertens (2010) 1.52
Effect of intravenous proton pump inhibitor regimens and timing of endoscopy on clinical outcomes of peptic ulcer bleeding. J Gastroenterol Hepatol (2012) 1.51
Androgenetic haploid embryonic stem cells produce live transgenic mice. Nature (2012) 1.51
Resveratrol facilitates pain attenuation in a rat model of neuropathic pain through the activation of spinal Sirt1. Reg Anesth Pain Med (2013) 1.50
ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy. EMBO Rep (2014) 1.49
Demethylation of TNFSF7 contributes to CD70 overexpression in CD4+ T cells from patients with systemic sclerosis. Clin Immunol (2012) 1.48
A 1463 gene cattle-human comparative map with anchor points defined by human genome sequence coordinates. Genome Res (2004) 1.48
Solid-state NMR, crystallographic, and computational investigation of bisphosphonates and farnesyl diphosphate synthase-bisphosphonate complexes. J Am Chem Soc (2006) 1.48
Genetic sophistication of human complement components C4A and C4B and RP-C4-CYP21-TNX (RCCX) modules in the major histocompatibility complex. Am J Hum Genet (2002) 1.47
Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design. Proteins (2006) 1.47
Safety and efficacy of staple-mediated femoral arteriotomy closure: results from a randomized multicenter study. Catheter Cardiovasc Interv (2006) 1.47
Prognostic role of circulating tumor cells and disseminated tumor cells in patients with prostate cancer: a systematic review and meta-analysis. Tumour Biol (2014) 1.46
Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5. Free Radic Biol Med (2008) 1.45
Association of TLR4 gene non-missense single nucleotide polymorphisms with rheumatoid arthritis in Chinese Han population. Rheumatol Int (2012) 1.45
TRPA channels distinguish gravity sensing from hearing in Johnston's organ. Proc Natl Acad Sci U S A (2009) 1.45
Beta-adrenergic relaxation of mouse urinary bladder smooth muscle in the absence of large-conductance Ca2+-activated K+ channel. Am J Physiol Renal Physiol (2008) 1.45
Diagnostic utility of magnetic resonance imaging and radiography in juvenile spondyloarthritis: evaluation of the sacroiliac joints in controls and affected subjects. J Rheumatol (2014) 1.44
Posttreatment plasma VEGF levels may be associated with the overall survival of patients with advanced non-small cell lung cancer treated with bevacizumab plus chemotherapy. Med Oncol (2011) 1.44
Diastereoselective tetrahydropyrone synthesis through transition-metal-free oxidative carbon-hydrogen bond activation. Angew Chem Int Ed Engl (2008) 1.43
The role of matrix metalloproteinase-2 in the treatment of atrial fibrillation recurrence after a radiofrequency modified maze procedure. Cardiology (2013) 1.43
Experimental realization of self-guiding unidirectional electromagnetic edge states. Phys Rev Lett (2011) 1.42
Stimulation of beta3-adrenoceptors relaxes rat urinary bladder smooth muscle via activation of the large-conductance Ca2+-activated K+ channels. Am J Physiol Cell Physiol (2008) 1.41
Curcumin disrupts the Mammalian target of rapamycin-raptor complex. Cancer Res (2009) 1.41
Diterpene cyclases and the nature of the isoprene fold. Proteins (2010) 1.41
Retracted Rebamipide plus proton pump inhibitor versus proton pump inhibitor alone in the treatment of endoscopic submucosal dissection-induced gastric ulcer: a meta-analysis of randomized controlled trials. Medicine (Baltimore) (2014) 1.40
Metabolic profiling reveals distinct variations linked to nicotine consumption in humans--first results from the KORA study. PLoS One (2008) 1.40
Vgamma2Vdelta2 T Cell Receptor recognition of prenyl pyrophosphates is dependent on all CDRs. J Immunol (2010) 1.40
Population-based survey of secondhand smoke exposure in China. Biomed Environ Sci (2010) 1.40