Published in Biochemistry on December 19, 2006
Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation. Hum Mol Genet (2011) 1.72
Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases. J Neurosci (2011) 1.39
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Accumulation of aspartic acid421- and glutamic acid391-cleaved tau in neurofibrillary tangles correlates with progression in Alzheimer disease. J Neuropathol Exp Neurol (2008) 1.11
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Model Hirano bodies protect against tau-independent and tau-dependent cell death initiated by the amyloid precursor protein intracellular domain. PLoS One (2012) 0.80
Cu, Zn-superoxide dismutase 1 (SOD1) is a novel target of Puromycin-sensitive aminopeptidase (PSA/NPEPPS): PSA/NPEPPS is a possible modifier of amyotrophic lateral sclerosis. Mol Neurodegener (2011) 0.80
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Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity. Biochim Biophys Acta (2013) 0.78
Aminopeptidases do not directly degrade tau protein. Mol Neurodegener (2010) 0.78
A new type of neuron-specific aminopeptidase NAP-2 in rat brain synaptosomes. Neurochem Int (2008) 0.77
Tau 6D and 6P isoforms inhibit polymerization of full-length tau in vitro. Biochemistry (2009) 0.76
Puromycin-sensitive aminopeptidase: an antiviral prodrug activating enzyme. Antiviral Res (2009) 0.76
Mary S. Easton Center of Alzheimer's Disease Research at UCLA: advancing the therapeutic imperative. J Alzheimers Dis (2010) 0.75
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Strong association of de novo copy number mutations with autism. Science (2007) 27.84
Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron (2011) 20.15
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Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66
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De novo mutations revealed by whole-exome sequencing are strongly associated with autism. Nature (2012) 13.61
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Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci U S A (2003) 10.56
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Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Common genetic variants on 5p14.1 associate with autism spectrum disorders. Nature (2009) 7.39
Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene. Am J Hum Genet (2008) 7.13
Functional organization of the transcriptome in human brain. Nat Neurosci (2008) 7.02
Conservation and evolution of gene coexpression networks in human and chimpanzee brains. Proc Natl Acad Sci U S A (2006) 5.69
Functional and evolutionary insights into human brain development through global transcriptome analysis. Neuron (2009) 5.46
Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders. Am J Hum Genet (2008) 5.44
A functional genetic link between distinct developmental language disorders. N Engl J Med (2008) 4.99
Elevated gene expression levels distinguish human from non-human primate brains. Proc Natl Acad Sci U S A (2003) 4.69
Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits. Cell (2011) 4.58
Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proc Natl Acad Sci U S A (2003) 3.85
FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains. Nat Neurosci (2006) 3.81
Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis. PLoS Genet (2008) 3.66
Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome. Nat Med (2011) 3.66
A unified genetic theory for sporadic and inherited autism. Proc Natl Acad Sci U S A (2007) 3.47
A genome-wide scan for common alleles affecting risk for autism. Hum Mol Genet (2010) 3.42
Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes. PLoS Genet (2009) 3.42
Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations. Nat Genet (2013) 3.19
Cytogenetic and molecular characterization of A2BP1/FOX1 as a candidate gene for autism. Am J Med Genet B Neuropsychiatr Genet (2007) 3.11
Tau is essential to beta -amyloid-induced neurotoxicity. Proc Natl Acad Sci U S A (2002) 3.04
Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis. Science (2004) 3.01
A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging. J Neurosci (2008) 2.97
PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci U S A (2005) 2.93
Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction. J Neurosci (2004) 2.89
Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism. Cell (2013) 2.87
Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways. Proc Natl Acad Sci U S A (2010) 2.85
Human-specific transcriptional networks in the brain. Neuron (2012) 2.80
Axonal transport defects in neurodegenerative diseases. J Neurosci (2009) 2.74
Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice. Nat Genet (2013) 2.62
Early asymmetry of gene transcription in embryonic human left and right cerebral cortex. Science (2005) 2.56
Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways. Hum Mol Genet (2007) 2.55
A genomewide screen of 345 families for autism-susceptibility loci. Am J Hum Genet (2003) 2.51
Heterogeneous dysregulation of microRNAs across the autism spectrum. Neurogenetics (2008) 2.50
Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis. J Neurosci (2007) 2.49
Individual common variants exert weak effects on the risk for autism spectrum disorderspi. Hum Mol Genet (2012) 2.46
Transcriptional architecture of the primate neocortex. Neuron (2012) 2.42
Human brain evolution: insights from microarrays. Nat Rev Genet (2004) 2.42
Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1. Brain (2010) 2.41
The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice. Proc Natl Acad Sci U S A (2008) 2.37
Human-specific transcriptional regulation of CNS development genes by FOXP2. Nature (2009) 2.33
Evidence for a language quantitative trait locus on chromosome 7q in multiplex autism families. Am J Hum Genet (2001) 2.29
Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila. Neuron (2002) 2.28
Evidence for sex-specific risk alleles in autism spectrum disorder. Am J Hum Genet (2004) 2.24
Mutations in SLC20A2 are a major cause of familial idiopathic basal ganglia calcification. Neurogenetics (2013) 2.11
Sex differences in autism spectrum disorders. Curr Opin Neurol (2013) 2.11
A quantitative trait locus analysis of social responsiveness in multiplex autism families. Am J Psychiatry (2007) 2.09
Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain. Am J Hum Genet (2007) 2.08
Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology (2012) 2.08
HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model. PLoS One (2008) 2.08
An evaluation of tyramide signal amplification and archived fixed and frozen tissue in microarray gene expression analysis. Nucleic Acids Res (2002) 2.06
Identification of process-localized mRNAs from cultured rodent hippocampal neurons. J Neurosci (2006) 2.02
High-throughput analysis of promoter occupancy reveals direct neural targets of FOXP2, a gene mutated in speech and language disorders. Am J Hum Genet (2007) 2.01
In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. J Neurosci (2011) 2.00
Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells. J Neurosci Res (2008) 1.96
Strategies for aggregating gene expression data: the collapseRows R function. BMC Bioinformatics (2011) 1.96
X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment. Nat Genet (2008) 1.95
An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke. Nat Neurosci (2010) 1.89
Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia. J Biol Chem (2011) 1.88
ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo. J Exp Med (2008) 1.86
Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPARgamma pathway as a therapeutic target in Friedreich's ataxia. Hum Mol Genet (2009) 1.85
A common X-linked inborn error of carnitine biosynthesis may be a risk factor for nondysmorphic autism. Proc Natl Acad Sci U S A (2012) 1.85
Tau, tangles, and Alzheimer's disease. Biochim Biophys Acta (2005) 1.82
Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau. Sci Rep (2012) 1.77
Conformational changes and truncation of tau protein during tangle evolution in Alzheimer's disease. J Alzheimers Dis (2003) 1.76
TDP-43 frontotemporal lobar degeneration and autoimmune disease. J Neurol Neurosurg Psychiatry (2013) 1.74
Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation. J Cell Biol (2005) 1.74
The organization of the transcriptional network in specific neuronal classes. Mol Syst Biol (2009) 1.74
Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease. Neurobiol Aging (2004) 1.73
Altered functional connectivity in frontal lobe circuits is associated with variation in the autism risk gene CNTNAP2. Sci Transl Med (2010) 1.72
Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation. Hum Mol Genet (2011) 1.72
Genetic advances in autism: heterogeneity and convergence on shared pathways. Curr Opin Genet Dev (2009) 1.71
Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease. J Biol Chem (2011) 1.71
Autism genetics: searching for specificity and convergence. Genome Biol (2012) 1.70
Identification of oligomers at early stages of tau aggregation in Alzheimer's disease. FASEB J (2012) 1.70
Frontotemporal dementia due to C9ORF72 mutations: clinical and imaging features. Neurology (2012) 1.69
Explaining human uniqueness: genome interactions with environment, behaviour and culture. Nat Rev Genet (2008) 1.67
Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice. Mol Neurodegener (2011) 1.67
The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity. J Neurosci Res (2009) 1.65
Replication of autism linkage: fine-mapping peak at 17q21. Am J Hum Genet (2005) 1.65
Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons. Genome Res (2011) 1.61
Gene expression study on peripheral blood identifies progranulin mutations. Ann Neurol (2008) 1.59