Structural basis for the inhibition of M1 family aminopeptidases by the natural product actinonin: Crystal structure in complex with E. coli aminopeptidase N.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 25644575)

Published in Protein Sci on April 08, 2015

Authors

Roopa Jones Ganji1, Ravikumar Reddi, Rajesh Gumpena, Anil Kumar Marapaka, Tarun Arya, Priyanka Sankoju, Supriya Bhukya, Anthony Addlagatta

Author Affiliations

1: Center for Chemical Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500007, Telangana, India.

Articles cited by this

Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01

Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr (1997) 137.43

PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr (2010) 108.52

The Protein Data Bank: a computer-based archival file for macromolecular structures. J Mol Biol (1977) 90.57

Features and development of Coot. Acta Crystallogr D Biol Crystallogr (2010) 89.46

Announcing the worldwide Protein Data Bank. Nat Struct Biol (2003) 17.06

HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutes. Acta Crystallogr D Biol Crystallogr (2006) 13.29

LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. J Chem Inf Model (2011) 6.49

MEROPS: the peptidase database. Nucleic Acids Res (2007) 4.32

Evolutionary families of metallopeptidases. Methods Enzymol (1995) 3.48

MEROPS: the protease database. Nucleic Acids Res (2002) 2.21

Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor. Biochemistry (2000) 2.03

Antibiotics in the clinical pipeline in 2013. J Antibiot (Tokyo) (2013) 1.93

The moonlighting enzyme CD13: old and new functions to target. Trends Mol Med (2008) 1.70

Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors. Biochem J (2004) 1.48

Binding of hydroxamic acid inhibitors to crystalline thermolysin suggests a pentacoordinate zinc intermediate in catalysis. Biochemistry (1981) 1.46

Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes. J Med Chem (1984) 1.44

Structure of aminopeptidase N from Escherichia coli suggests a compartmentalized, gated active site. Proc Natl Acad Sci U S A (2006) 1.33

Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors. J Biol Chem (2009) 1.33

Crystal structure of aminopeptidase N (proteobacteria alanyl aminopeptidase) from Escherichia coli and conformational change of methionine 260 involved in substrate recognition. J Biol Chem (2006) 1.28

The X-ray crystal structure of human aminopeptidase N reveals a novel dimer and the basis for peptide processing. J Biol Chem (2012) 1.12

A new human peptide deformylase inhibitable by actinonin. Biochem Biophys Res Commun (2003) 1.07

Structural basis for the unusual specificity of Escherichia coli aminopeptidase N. Biochemistry (2008) 1.06

Production of actinonin, an inhibitor of aminopeptidase M, by actinomycetes. J Antibiot (Tokyo) (1985) 1.04

Degradation of tropoelastin by matrix metalloproteinases--cleavage site specificities and release of matrikines. FEBS J (2010) 1.02

Degradation of tau protein by puromycin-sensitive aminopeptidase in vitro. Biochemistry (2006) 1.02

Comparative analysis of the antibacterial activity of a novel peptide deformylase inhibitor, GSK1322322. Antimicrob Agents Chemother (2013) 1.00

A study of the substrate specificity of aminopeptidase N from Lactococcus lactis subsp. cremoris Wg2. Appl Microbiol Biotechnol (1995) 0.99

A glutamate residue contributes to the exopeptidase specificity in aminopeptidase A. Biochem J (1998) 0.96

Cloning and characterization of a leucyl aminopeptidase from three pathogenic Leishmania species. J Biol Chem (2002) 0.94

Refolding and recovery of recombinant human matrix metalloproteinase 7 (matrilysin) from inclusion bodies expressed by Escherichia coli. J Biochem (1999) 0.94

Discovery and refinement of a new structural class of potent peptide deformylase inhibitors. J Med Chem (2007) 0.93

Substrate recognition and selectivity of peptide deformylase. Similarities and differences with metzincins and thermolysin. J Mol Biol (1999) 0.93

Cell-based evidence for aminopeptidase N/CD13 inhibitor actinonin targeting of MT1-MMP-mediated proMMP-2 activation. Cancer Lett (2009) 0.92

Antitumor activity of actinonin in vitro and in vivo. Clin Cancer Res (1998) 0.91

The Caenorhabditis elegans orthologue of mammalian puromycin-sensitive aminopeptidase has roles in embryogenesis and reproduction. J Biol Chem (2003) 0.90

A novel neuron-specific aminopeptidase in rat brain synaptosomes. Its identification, purification, and characterization. J Biol Chem (1998) 0.88

Glu121-Lys319 salt bridge between catalytic and N-terminal domains is pivotal for the activity and stability of Escherichia coli aminopeptidase N. Protein Sci (2012) 0.81

A naturally variable residue in the S1 subsite of M1 family aminopeptidases modulates catalytic properties and promotes functional specialization. J Biol Chem (2013) 0.81

Differential regulation of aminopeptidase N (CD13) by transendothelial migration and cytokines on human eosinophils. Exp Lung Res (2003) 0.78

Identification, biochemical and structural evaluation of species-specific inhibitors against type I methionine aminopeptidases. J Med Chem (2013) 0.78

Metalloenzyme inhibitors for the treatment of Gram-negative bacterial infections: a patent review (2009-2012). Expert Opin Ther Pat (2013) 0.77

Structure of the Ni(II) complex of Escherichia coli peptide deformylase and suggestions on deformylase activities depending on different metal(II) centres. J Biol Inorg Chem (2010) 0.76

Articles by these authors

Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. Proc Natl Acad Sci U S A (2006) 1.14

Rational proteomics I. Fingerprint identification and cofactor specificity in the short-chain oxidoreductase (SCOR) enzyme family. Proteins (2003) 1.10

Structure/function relationships responsible for coenzyme specificity and the isomerase activity of human type 1 3 beta-hydroxysteroid dehydrogenase/isomerase. J Biol Chem (2003) 1.07

4,4-Diphenyl-2,5-cyclohexadienone: four polymorphs and nineteen crystallographically independent molecular conformations. Angew Chem Int Ed Engl (2002) 0.97

Identification of pyridinylpyrimidines as inhibitors of human methionine aminopeptidases. Angew Chem Int Ed Engl (2006) 0.95

Structure activity relationship studies of imidazo[1,2-a]pyrazine derivatives against cancer cell lines. Eur J Med Chem (2010) 0.88

Determining structure and function of steroid dehydrogenase enzymes by sequence analysis, homology modeling, and rational mutational analysis. Ann N Y Acad Sci (2005) 0.85

Discovery of α,β- and α,γ-diamino acid scaffolds for the inhibition of M1 family aminopeptidases. ChemMedChem (2011) 0.81

Glu121-Lys319 salt bridge between catalytic and N-terminal domains is pivotal for the activity and stability of Escherichia coli aminopeptidase N. Protein Sci (2012) 0.81

Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents. Eur J Med Chem (2012) 0.78

Structure/function aspects of human 3beta-hydroxysteroid dehydrogenase. Mol Cell Endocrinol (2004) 0.78

Identification, biochemical and structural evaluation of species-specific inhibitors against type I methionine aminopeptidases. J Med Chem (2013) 0.78

Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents. Bioorg Med Chem (2012) 0.78

Rational genomics I: antisense open reading frames and codon bias in short-chain oxido reductase enzymes and the evolution of the genetic code. Proteins (2005) 0.78

Structural characterization of the protein cce_0567 from Cyanothece 51142, a metalloprotein associated with nitrogen fixation in the DUF683 family. Biochim Biophys Acta (2009) 0.78

Discovery of a new genetic variant of methionine aminopeptidase from Streptococci with possible post-translational modifications: biochemical and structural characterization. PLoS One (2013) 0.77

Three-dimensional structure of homodimeric cholesterol esterase-ligand complex at 1.4 A resolution. Acta Crystallogr D Biol Crystallogr (2002) 0.77

Design and synthesis of resveratrol-based nitrovinylstilbenes as antimitotic agents. J Med Chem (2011) 0.76

Identification of the molecular basis of inhibitor selectivity between the human and streptococcal type I methionine aminopeptidases. J Med Chem (2015) 0.76

Association of glutamate carboxypeptidase II (GCPII) haplotypes with breast and prostate cancer risk. Gene (2012) 0.76

Design and synthesis of biaryl aryl stilbenes/ethylenes as antimicrotubule agents. Eur J Med Chem (2012) 0.75

3-substituted 2-phenylimidazo[2,1-b]benzothiazoles: synthesis, anticancer activity, and inhibition of tubulin polymerization. ChemMedChem (2012) 0.75

Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents. FEBS J (2014) 0.75

Paradoxical role of C1561T glutamate carboxypeptidase II (GCPII) genetic polymorphism in altering disease susceptibility. Gene (2012) 0.75

Iodine-catalyzed condensation of isatin with indoles: a facile synthesis of di(indolyl)indolin-2-ones and evaluation of their cytotoxicity. Bioorg Med Chem Lett (2012) 0.75

Synthesis and biological evaluation of imidazopyridine-oxindole conjugates as microtubule-targeting agents. ChemMedChem (2013) 0.75