Published in Mol Ther on January 01, 2007
Escaping the valley of death. Mol Ther (2012) 0.75
Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature (2004) 8.87
Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases. Science (2003) 3.70
Fibromyalgia after motor vehicle collision: evidence and implications. Traffic Inj Prev (2005) 3.35
Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling. Cell (2008) 3.02
Evidence of augmented central pain processing in idiopathic chronic low back pain. Arthritis Rheum (2004) 2.88
Subgrouping of fibromyalgia patients on the basis of pressure-pain thresholds and psychological factors. Arthritis Rheum (2003) 2.72
Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization. Nat Med (2005) 2.63
mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Proc Natl Acad Sci U S A (2008) 2.48
Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling. Science (2003) 2.46
Side effects of retroviral gene transfer into hematopoietic stem cells. Blood (2003) 2.35
Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M. Blood (2009) 2.33
Truncation of the GABA(A)-receptor gamma2 subunit in a family with generalized epilepsy with febrile seizures plus. Am J Hum Genet (2001) 2.32
Cognitive behavioral therapy and aerobic exercise for Gulf War veterans' illnesses: a randomized controlled trial. JAMA (2003) 2.26
Identifying the clinical domains of fibromyalgia: contributions from clinician and patient Delphi exercises. Arthritis Rheum (2008) 2.22
CTC1 Mutations in a patient with dyskeratosis congenita. Pediatr Blood Cancer (2012) 2.14
Overcoming reprogramming resistance of Fanconi anemia cells. Blood (2012) 2.07
Signaling and cytoskeletal requirements in erythroblast enucleation. Blood (2012) 2.05
Momentary relationship between cortisol secretion and symptoms in patients with fibromyalgia. Arthritis Rheum (2005) 1.98
Lentiviral vectors pseudotyped with murine ecotropic envelope: increased biosafety and convenience in preclinical research. Exp Hematol (2006) 1.95
Characterization and consequences of pain variability in individuals with fibromyalgia. Arthritis Rheum (2005) 1.88
Fibromyalgia syndrome module at OMERACT 9: domain construct. J Rheumatol (2009) 1.87
Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells. J Clin Invest (2003) 1.85
Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells. Mol Ther (2005) 1.82
Stem cell collection and gene transfer in Fanconi anemia. Mol Ther (2007) 1.81
Upping the ante: recent advances in direct reprogramming. Mol Ther (2009) 1.73
Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease. Cancer Cell (2007) 1.72
The relationship between depression, clinical pain, and experimental pain in a chronic pain cohort. Arthritis Rheum (2005) 1.66
Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly. J Biol Chem (2006) 1.66
Chance or necessity? Insertional mutagenesis in gene therapy and its consequences. Mol Ther (2004) 1.65
Comparison of three retroviral vector systems for transduction of nonobese diabetic/severe combined immunodeficiency mice repopulating human CD34+ cord blood cells. Hum Gene Ther (2003) 1.58
Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils. Nat Immunol (2004) 1.56
The MAPP research network: design, patient characterization and operations. BMC Urol (2014) 1.56
Gene therapy continues to mature and to face challenges. Mol Ther (2009) 1.54
FIP1L1/PDGFRalpha synergizes with SCF to induce systemic mastocytosis in a murine model of chronic eosinophilic leukemia/hypereosinophilic syndrome. Blood (2008) 1.53
TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells. J Clin Invest (2007) 1.53
Ambulatory monitoring of physical activity and symptoms in fibromyalgia and chronic fatigue syndrome. Arthritis Rheum (2005) 1.52
Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment. Blood (2005) 1.52
Intrathecal opioids for chronic pain: a call for evidence. Pain Med (2014) 1.50
Fibromyalgia syndrome. J Rheumatol (2005) 1.49
A rapid method for retrovirus-mediated identification of complementation groups in Fanconi anemia patients. Mol Ther (2005) 1.48
P2X7 receptor cell surface expression and cytolytic pore formation are regulated by a distal C-terminal region. J Biol Chem (2002) 1.48
Treatment of fibromyalgia with formula acupuncture: investigation of needle placement, needle stimulation, and treatment frequency. J Altern Complement Med (2005) 1.45
A modified γ-retrovirus vector for X-linked severe combined immunodeficiency. N Engl J Med (2014) 1.42
Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton. Blood (2006) 1.41
Inflammatory ROS promote and cooperate with the Fanconi anemia mutation for hematopoietic senescence. J Cell Sci (2007) 1.40
The P2X7 receptor drives microglial activation and proliferation: a trophic role for P2X7R pore. J Neurosci (2009) 1.40
Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera. Blood (2013) 1.38
Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in T-cell development. Blood (2008) 1.37
Survey criteria for fibromyalgia independently predict increased postoperative opioid consumption after lower-extremity joint arthroplasty: a prospective, observational cohort study. Anesthesiology (2013) 1.37
Rac1 and a GTPase-activating protein, MgcRacGAP, are required for nuclear translocation of STAT transcription factors. J Cell Biol (2006) 1.36
The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes. J Immunol (2002) 1.35
Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen. Haematologica (2010) 1.34
The Apc(min) mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS. Blood (2010) 1.33
Differential niche and Wnt requirements during acute myeloid leukemia progression. Blood (2011) 1.32
Phenotypic correction of primary Fanconi anemia T cells with retroviral vectors as a diagnostic tool. Exp Hematol (2002) 1.31
Structure-function based design of small molecule inhibitors targeting Rho family GTPases. Curr Top Med Chem (2006) 1.31
Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis. Blood (2007) 1.28
Methylguanine methyltransferase-mediated in vivo selection and chemoprotection of allogeneic stem cells in a large-animal model. J Clin Invest (2003) 1.27
Inflammatory reactive oxygen species-mediated hemopoietic suppression in Fancc-deficient mice. J Immunol (2007) 1.27
Efficacy of milnacipran in patients with fibromyalgia. J Rheumatol (2005) 1.26
A psychophysical study of auditory and pressure sensitivity in patients with fibromyalgia and healthy controls. J Pain (2008) 1.25
Sleeping beauty vector system moves toward human trials in the United States. Mol Ther (2008) 1.24
Subgroups of older adults with osteoarthritis based upon differing comorbid symptom presentations and potential underlying pain mechanisms. Arthritis Res Ther (2011) 1.22
Rational design and applications of a Rac GTPase-specific small molecule inhibitor. Methods Enzymol (2006) 1.22
Defective homing is associated with altered Cdc42 activity in cells from patients with Fanconi anemia group A. Blood (2008) 1.21
Chromosome-specific microsatellite multiplex sets for linkage studies in the domestic dog. Genomics (2004) 1.20
Promoting student-centered active learning in lectures with a personal response system. Adv Physiol Educ (2009) 1.19
Inhibition of RhoA GTPase activity enhances hematopoietic stem and progenitor cell proliferation and engraftment. Blood (2006) 1.19
Structural brain anomalies and chronic pain: a quantitative meta-analysis of gray matter volume. J Pain (2013) 1.18
RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development. Nat Immunol (2006) 1.17
The role of chemokine activation of Rac GTPases in hematopoietic stem cell marrow homing, retention, and peripheral mobilization. Exp Hematol (2006) 1.17
Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors. Blood (2012) 1.16
Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways. J Immunol (2005) 1.15
Development and analytic validation of an enzyme-linked immunosorbent assay for the measurement of canine pancreatic lipase immunoreactivity in serum. Can J Vet Res (2003) 1.14
Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy. Proc Natl Acad Sci U S A (2002) 1.14
Comorbid somatic symptoms and functional status in patients with fibromyalgia and chronic fatigue syndrome: sensory amplification as a common mechanism. Psychosomatics (2008) 1.14
Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo. Blood (2010) 1.13
Cross-talk between RhoH and Rac1 in regulation of actin cytoskeleton and chemotaxis of hematopoietic progenitor cells. Blood (2007) 1.13
Rac deletion in osteoclasts causes severe osteopetrosis. J Cell Sci (2011) 1.10
Rac1 is essential for intraembryonic hematopoiesis and for the initial seeding of fetal liver with definitive hematopoietic progenitor cells. Blood (2007) 1.10
Differences in unpleasantness induced by experimental pressure pain between patients with fibromyalgia and healthy controls. Eur J Pain (2005) 1.09
Rac2-deficient hematopoietic stem cells show defective interaction with the hematopoietic microenvironment and long-term engraftment failure. Stem Cells (2005) 1.07
Ectopic HOXB4 overcomes the inhibitory effect of tumor necrosis factor-{alpha} on Fanconi anemia hematopoietic stem and progenitor cells. Blood (2009) 1.07
Microglia: proliferation and activation driven by the P2X7 receptor. Int J Biochem Cell Biol (2010) 1.07
Rac2, a hematopoiesis-specific Rho GTPase, specifically regulates mast cell protease gene expression in bone marrow-derived mast cells. Mol Cell Biol (2002) 1.06
A phase III, randomized, controlled trial of the fully human IL-12/23 mAb briakinumab in moderate-to-severe psoriasis. J Invest Dermatol (2011) 1.06
The association between experimental and clinical pain measures among persons with fibromyalgia and chronic fatigue syndrome. Eur J Pain (2006) 1.05
Clinical characterization of a familial degenerative myelopathy in Pembroke Welsh Corgi dogs. J Vet Intern Med (2008) 1.05
Measuring health in patients with fibromyalgia: content comparison of questionnaires based on the International Classification of Functioning, Disability and Health. Arthritis Rheum (2008) 1.04
Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in T(H)1 responses. Immunol Cell Biol (2002) 1.04
Decreases in HCN mRNA expression in the hippocampus after kindling and status epilepticus in adult rats. Epilepsia (2008) 1.02
Rapid lentiviral transduction preserves the engraftment potential of Fanca(-/-) hematopoietic stem cells. Mol Ther (2008) 1.02
Hematopoietic-specific Rho GTPases Rac2 and RhoH and human blood disorders. Exp Cell Res (2013) 1.01
Comparison of clinical and evoked pain measures in fibromyalgia. J Pain (2006) 1.00
Characteristics of fibromyalgia independently predict poorer long-term analgesic outcomes following total knee and hip arthroplasty. Arthritis Rheumatol (2015) 1.00
Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections. J Clin Invest (2012) 1.00
Content and criterion validity of the preliminary core dataset for clinical trials in fibromyalgia syndrome. J Rheumatol (2009) 0.99
In vivo selection of human hematopoietic cells in a xenograft model using combined pharmacologic and genetic manipulations. Hum Gene Ther (2003) 0.99