Published in Nature on March 21, 2004
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Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction. Proc Natl Acad Sci U S A (2005) 6.16
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Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines. J Clin Invest (2006) 4.51
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Allogeneic mesenchymal stem cells restore cardiac function in chronic ischemic cardiomyopathy via trilineage differentiating capacity. Proc Natl Acad Sci U S A (2009) 4.21
Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function. Proc Natl Acad Sci U S A (2005) 4.13
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Bone marrow cells adopt the cardiomyogenic fate in vivo. Proc Natl Acad Sci U S A (2007) 3.06
Formation of human myocardium in the rat heart from human embryonic stem cells. Am J Pathol (2005) 2.60
Cardiomyogenic potential of C-kit(+)-expressing cells derived from neonatal and adult mouse hearts. Circulation (2010) 2.52
Cells expressing early cardiac markers reside in the bone marrow and are mobilized into the peripheral blood after myocardial infarction. Circ Res (2004) 2.50
Tissue-engineered vascular grafts transform into mature blood vessels via an inflammation-mediated process of vascular remodeling. Proc Natl Acad Sci U S A (2010) 2.49
c-kit+ precursors support postinfarction myogenesis in the neonatal, but not adult, heart. Proc Natl Acad Sci U S A (2012) 2.35
Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment. Biochem Biophys Res Commun (2007) 2.35
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Comparison of different adult stem cell types for treatment of myocardial ischemia. Circulation (2008) 2.22
Strategies to promote donor cell survival: combining preconditioning approach with stem cell transplantation. J Mol Cell Cardiol (2008) 2.16
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Development of a network to test strategies in cardiovascular cell delivery: the NHLBI-sponsored Cardiovascular Cell Therapy Research Network (CCTRN). J Cardiovasc Transl Res (2010) 1.84
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In vivo functional and transcriptional profiling of bone marrow stem cells after transplantation into ischemic myocardium. Arterioscler Thromb Vasc Biol (2011) 1.80
Evolution of the c-kit-positive cell response to pathological challenge in the myocardium. Stem Cells (2008) 1.80
Stem cells: lost in translation. Nature (2004) 1.79
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Cardiac regenerative capacity and mechanisms. Annu Rev Cell Dev Biol (2012) 1.70
Endothelial-cardiomyocyte interactions in cardiac development and repair. Annu Rev Physiol (2006) 1.68
Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction. Circulation (2008) 1.68
Increased cardiac myocyte progenitors in failing human hearts. Circulation (2008) 1.68
Perspectives on Trypanosoma cruzi-induced heart disease (Chagas disease). Prog Cardiovasc Dis (2009) 1.60
Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration. J Clin Invest (2010) 1.57
The origin of interstitial myofibroblasts in chronic kidney disease. Pediatr Nephrol (2011) 1.55
Cardiogenic differentiation and transdifferentiation of progenitor cells. Circ Res (2008) 1.54
A tissue engineering approach to progenitor cell delivery results in significant cell engraftment and improved myocardial remodeling. Stem Cells (2007) 1.53
Bone marrow-derived circulating progenitor cells fail to transdifferentiate into adipocytes in adult adipose tissues in mice. J Clin Invest (2007) 1.52
LateTIME: a phase-II, randomized, double-blinded, placebo-controlled, pilot trial evaluating the safety and effect of administration of bone marrow mononuclear cells 2 to 3 weeks after acute myocardial infarction. Tex Heart Inst J (2010) 1.52
An emerging consensus on cardiac regeneration. Nat Med (2014) 1.50
Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease. Science (2014) 1.49
Gender differences in injury induced mesenchymal stem cell apoptosis and VEGF, TNF, IL-6 expression: role of the 55 kDa TNF receptor (TNFR1). J Mol Cell Cardiol (2006) 1.48
Cultured human bone marrow-derived CD31(+) cells are effective for cardiac and vascular repair through enhanced angiogenic, adhesion, and anti-inflammatory effects. J Am Coll Cardiol (2014) 1.47
Evidence that bone marrow cells do not contribute to the alveolar epithelium. Am J Respir Cell Mol Biol (2005) 1.47
FGF-2 controls the differentiation of resident cardiac precursors into functional cardiomyocytes. J Clin Invest (2005) 1.46
Injection of bone marrow cell extract into infarcted hearts results in functional improvement comparable to intact cell therapy. Mol Ther (2009) 1.45
Genetic enhancement of stem cell engraftment, survival, and efficacy. Circ Res (2008) 1.42
Imaging gene expression in human mesenchymal stem cells: from small to large animals. Radiology (2009) 1.37
Hierarchy of molecular-pathway usage in bone marrow homing and its shift by cytokines. Blood (2005) 1.37
Bones of contention: marrow-derived cells in myocardial regeneration. J Mol Cell Cardiol (2008) 1.37
Cell-based therapies and imaging in cardiology. Eur J Nucl Med Mol Imaging (2005) 1.36
Cell therapy for ischaemic heart disease: focus on the role of resident cardiac stem cells. Neth Heart J (2009) 1.35
Bone-derived stem cells repair the heart after myocardial infarction through transdifferentiation and paracrine signaling mechanisms. Circ Res (2013) 1.33
Heterogeneity of engrafted bone-lining cells after systemic and local transplantation. Blood (2005) 1.32
Adult bone marrow-derived cells: regenerative potential, plasticity, and tissue commitment. Basic Res Cardiol (2005) 1.32
Cell-based therapy for prevention and reversal of myocardial remodeling. Am J Physiol Heart Circ Physiol (2012) 1.31
Donor myocardial infarction impairs the therapeutic potential of bone marrow cells by an interleukin-1-mediated inflammatory response. Sci Transl Med (2011) 1.31
Biomimetic approach to cardiac tissue engineering. Philos Trans R Soc Lond B Biol Sci (2007) 1.31
Imaging stem cells implanted in infarcted myocardium. J Am Coll Cardiol (2006) 1.28
Regeneration of the heart. EMBO Mol Med (2011) 1.27
Mesenchymal stem cells rescue cardiomyoblasts from cell death in an in vitro ischemia model via direct cell-to-cell connections. BMC Cell Biol (2010) 1.27
Empowering adult stem cells for myocardial regeneration. Circ Res (2011) 1.25
Capturing the stem cell paracrine effect using heparin-presenting nanofibres to treat cardiovascular diseases. J Tissue Eng Regen Med (2010) 1.23
Bone marrow mesenchymal stem cells are progenitors in vitro for inner ear hair cells. Mol Cell Neurosci (2006) 1.23
Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction. Proc Natl Acad Sci U S A (2006) 1.23
Transplanted hematopoietic stem cells demonstrate impaired sarcoglycan expression after engraftment into cardiac and skeletal muscle. J Clin Invest (2004) 1.23
Mechanical derivation of functional myotubes from adipose-derived stem cells. Biomaterials (2011) 1.22
Bone marrow-derived stromal cells home to and remain in the infarcted rat heart but fail to improve function: an in vivo cine-MRI study. Am J Physiol Heart Circ Physiol (2008) 1.22
Lineage tracing of cardiac explant derived cells. PLoS One (2008) 1.22
CD34-positive stem cells: in the treatment of heart and vascular disease in human beings. Tex Heart Inst J (2011) 1.21
Very small embryonic-like (VSEL) stem cells in adult organs and their potential role in rejuvenation of tissues and longevity. Exp Gerontol (2008) 1.20
Genetic engineering of mesenchymal stem cells and its application in human disease therapy. Hum Gene Ther (2010) 1.19
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"Small stem cells" in adult tissues: very small embryonic-like stem cells stand up! Cytometry A (2009) 1.18
Cardiac regeneration. Curr Top Dev Biol (2012) 1.17
Extracellular vesicles: potential roles in regenerative medicine. Front Immunol (2014) 1.17
Role of endothelial progenitor cells during ischemia-induced vasculogenesis and collateral formation. Microvasc Res (2010) 1.16
Cardiac repair and regeneration: the Rubik's cube of cell therapy for heart disease. Dis Model Mech (2009) 1.16
Human embryonic stem cells and cardiac repair. Transplant Rev (Orlando) (2008) 1.15
CD34+ cells represent highly functional endothelial progenitor cells in murine bone marrow. PLoS One (2011) 1.15
G-CSF/SCF reduces inducible arrhythmias in the infarcted heart potentially via increased connexin43 expression and arteriogenesis. J Exp Med (2006) 1.13
Bone marrow mononuclear cell therapy for acute myocardial infarction: a perspective from the cardiovascular cell therapy research network. Circ Res (2014) 1.12
Cardiac regeneration and stem cell therapy. Curr Opin Organ Transplant (2008) 1.11
A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods. J Transl Med (2014) 1.10
Interrogating functional integration between injected pluripotent stem cell-derived cells and surrogate cardiac tissue. Proc Natl Acad Sci U S A (2009) 1.10
The bone marrow--cardiac axis of myocardial regeneration. Prog Cardiovasc Dis (2007) 1.10
Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat Biotechnol (2007) 14.48
Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature (2008) 10.27
Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response. FASEB J (2007) 4.32
Biphasic role for Wnt/beta-catenin signaling in cardiac specification in zebrafish and embryonic stem cells. Proc Natl Acad Sci U S A (2007) 3.90
Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases. Science (2003) 3.70
Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts. Nature (2012) 3.63
Fibromyalgia after motor vehicle collision: evidence and implications. Traffic Inj Prev (2005) 3.35
Increased vulnerability to atrial fibrillation in transgenic mice with selective atrial fibrosis caused by overexpression of TGF-beta1. Circ Res (2004) 3.30
Growth of engineered human myocardium with mechanical loading and vascular coculture. Circ Res (2011) 3.25
A hierarchical network controls protein translation during murine embryonic stem cell self-renewal and differentiation. Cell Stem Cell (2008) 3.18
Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling. Cell (2008) 3.02
Cardiomyocyte cell cycle regulation. Circ Res (2002) 2.99
Cardiac regeneration: repopulating the heart. Annu Rev Physiol (2006) 2.92
Targeted expression of cyclin D2 results in cardiomyocyte DNA synthesis and infarct regression in transgenic mice. Circ Res (2004) 2.92
Evidence of augmented central pain processing in idiopathic chronic low back pain. Arthritis Rheum (2004) 2.88
A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development. Cell (2012) 2.81
Subgrouping of fibromyalgia patients on the basis of pressure-pain thresholds and psychological factors. Arthritis Rheum (2003) 2.72
Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization. Nat Med (2005) 2.63
Systems approaches to preventing transplanted cell death in cardiac repair. J Mol Cell Cardiol (2008) 2.60
Cardiomyogenic potential of C-kit(+)-expressing cells derived from neonatal and adult mouse hearts. Circulation (2010) 2.52
mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Proc Natl Acad Sci U S A (2008) 2.48
Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling. Science (2003) 2.46
Side effects of retroviral gene transfer into hematopoietic stem cells. Blood (2003) 2.35
Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M. Blood (2009) 2.33
Truncation of the GABA(A)-receptor gamma2 subunit in a family with generalized epilepsy with febrile seizures plus. Am J Hum Genet (2001) 2.32
Skeletal muscle stem cells do not transdifferentiate into cardiomyocytes after cardiac grafting. J Mol Cell Cardiol (2002) 2.29
Cognitive behavioral therapy and aerobic exercise for Gulf War veterans' illnesses: a randomized controlled trial. JAMA (2003) 2.26
Cell-based cardiac repair: reflections at the 10-year point. Circulation (2005) 2.25
Identifying the clinical domains of fibromyalgia: contributions from clinician and patient Delphi exercises. Arthritis Rheum (2008) 2.22
Differential cardiac remodeling in preload versus afterload. Circulation (2010) 2.20
Physiological coupling of donor and host cardiomyocytes after cellular transplantation. Circ Res (2003) 2.14
CTC1 Mutations in a patient with dyskeratosis congenita. Pediatr Blood Cancer (2012) 2.14
Regeneration gaps: observations on stem cells and cardiac repair. J Am Coll Cardiol (2006) 2.13
Overcoming reprogramming resistance of Fanconi anemia cells. Blood (2012) 2.07
Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells. PLoS One (2010) 2.06
Signaling and cytoskeletal requirements in erythroblast enucleation. Blood (2012) 2.05
Momentary relationship between cortisol secretion and symptoms in patients with fibromyalgia. Arthritis Rheum (2005) 1.98
Lentiviral vectors pseudotyped with murine ecotropic envelope: increased biosafety and convenience in preclinical research. Exp Hematol (2006) 1.95
Cardiomyocyte cell cycle activation improves cardiac function after myocardial infarction. Cardiovasc Res (2007) 1.90
Characterization and consequences of pain variability in individuals with fibromyalgia. Arthritis Rheum (2005) 1.88
Fibromyalgia syndrome module at OMERACT 9: domain construct. J Rheumatol (2009) 1.87
Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells. J Clin Invest (2003) 1.85
Expression of mutant p193 and p53 permits cardiomyocyte cell cycle reentry after myocardial infarction in transgenic mice. Circ Res (2004) 1.84
Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells. Mol Ther (2005) 1.82
Stem cell collection and gene transfer in Fanconi anemia. Mol Ther (2007) 1.81
Adult bone marrow-derived cells do not acquire functional attributes of cardiomyocytes when transplanted into peri-infarct myocardium. Mol Ther (2008) 1.75
The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation. Mol Cell (2008) 1.73
Upping the ante: recent advances in direct reprogramming. Mol Ther (2009) 1.73
Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease. Cancer Cell (2007) 1.72
The relationship between depression, clinical pain, and experimental pain in a chronic pain cohort. Arthritis Rheum (2005) 1.66
Myocyte and myogenic stem cell transplantation in the heart. Cardiovasc Res (2003) 1.66
Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly. J Biol Chem (2006) 1.66
Chance or necessity? Insertional mutagenesis in gene therapy and its consequences. Mol Ther (2004) 1.65
Two-photon molecular excitation imaging of Ca2+ transients in Langendorff-perfused mouse hearts. Am J Physiol Cell Physiol (2003) 1.62
Acute doxorubicin cardiotoxicity is associated with p53-induced inhibition of the mammalian target of rapamycin pathway. Circulation (2008) 1.61
Comparison of three retroviral vector systems for transduction of nonobese diabetic/severe combined immunodeficiency mice repopulating human CD34+ cord blood cells. Hum Gene Ther (2003) 1.58
Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils. Nat Immunol (2004) 1.56
The MAPP research network: design, patient characterization and operations. BMC Urol (2014) 1.56
Gene therapy continues to mature and to face challenges. Mol Ther (2009) 1.54
FIP1L1/PDGFRalpha synergizes with SCF to induce systemic mastocytosis in a murine model of chronic eosinophilic leukemia/hypereosinophilic syndrome. Blood (2008) 1.53
TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells. J Clin Invest (2007) 1.53
Ambulatory monitoring of physical activity and symptoms in fibromyalgia and chronic fatigue syndrome. Arthritis Rheum (2005) 1.52
Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment. Blood (2005) 1.52
Intrathecal opioids for chronic pain: a call for evidence. Pain Med (2014) 1.50
Fibromyalgia syndrome. J Rheumatol (2005) 1.49
A rapid method for retrovirus-mediated identification of complementation groups in Fanconi anemia patients. Mol Ther (2005) 1.48
P2X7 receptor cell surface expression and cytolytic pore formation are regulated by a distal C-terminal region. J Biol Chem (2002) 1.48
Treatment of fibromyalgia with formula acupuncture: investigation of needle placement, needle stimulation, and treatment frequency. J Altern Complement Med (2005) 1.45
A modified γ-retrovirus vector for X-linked severe combined immunodeficiency. N Engl J Med (2014) 1.42
Neural modulation of cardiac arrhythmias and sudden cardiac death. Heart Rhythm (2006) 1.42
Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton. Blood (2006) 1.41
Inflammatory ROS promote and cooperate with the Fanconi anemia mutation for hematopoietic senescence. J Cell Sci (2007) 1.40
The P2X7 receptor drives microglial activation and proliferation: a trophic role for P2X7R pore. J Neurosci (2009) 1.40
In vitro generation of differentiated cardiac myofibers on micropatterned laminin surfaces. J Biomed Mater Res (2002) 1.38
Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera. Blood (2013) 1.38
Spontaneous and evoked intracellular calcium transients in donor-derived myocytes following intracardiac myoblast transplantation. J Clin Invest (2004) 1.38