Published in J Biol Chem on December 17, 2006
Connexin43 phosphorylation: structural changes and biological effects. Biochem J (2009) 2.75
Structural and molecular mechanisms of gap junction remodeling in epicardial border zone myocytes following myocardial infarction. Circ Res (2009) 1.63
Gap junctions. Compr Physiol (2012) 1.59
Cx43 CT domain influences infarct size and susceptibility to ventricular tachyarrhythmias in acute myocardial infarction. Cardiovasc Res (2009) 1.51
Connexins: a myriad of functions extending beyond assembly of gap junction channels. Cell Commun Signal (2009) 1.49
Paracrine signaling through plasma membrane hemichannels. Biochim Biophys Acta (2012) 1.28
Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Basic Res Cardiol (2012) 1.17
pH-dependent modulation of voltage gating in connexin45 homotypic and connexin45/connexin43 heterotypic gap junctions. Proc Natl Acad Sci U S A (2010) 1.11
Gap junction protein Cx37 interacts with endothelial nitric oxide synthase in endothelial cells. Arterioscler Thromb Vasc Biol (2010) 1.02
Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles. Front Pharmacol (2013) 1.02
Characterization of the structure and intermolecular interactions between the connexin40 and connexin43 carboxyl-terminal and cytoplasmic loop domains. J Biol Chem (2009) 1.01
Regulation of neuronal connexin-36 channels by pH. Proc Natl Acad Sci U S A (2008) 1.00
Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels. Basic Res Cardiol (2013) 1.00
Voltage-dependent conformational changes in connexin channels. Biochim Biophys Acta (2011) 0.99
Novel pharmacophores of connexin43 based on the "RXP" series of Cx43-binding peptides. Circ Res (2009) 0.96
Cardiac to cancer: connecting connexins to clinical opportunity. FEBS Lett (2014) 0.96
Manipulating connexin communication channels: use of peptidomimetics and the translational outputs. J Membr Biol (2012) 0.95
Purification and reconstitution of the connexin43 carboxyl terminus attached to the 4th transmembrane domain in detergent micelles. Protein Expr Purif (2008) 0.91
Trifluoroethanol reveals helical propensity at analogous positions in cytoplasmic domains of three connexins. Biopolymers (2009) 0.90
Cytoplasmic amino acids within the membrane interface region influence connexin oligomerization. J Membr Biol (2012) 0.89
An electrostatic mechanism for Ca(2+)-mediated regulation of gap junction channels. Nat Commun (2016) 0.89
Structure and functional studies of N-terminal Cx43 mutants linked to oculodentodigital dysplasia. Mol Biol Cell (2012) 0.88
Neurological manifestations of oculodentodigital dysplasia: a Cx43 channelopathy of the central nervous system? Front Pharmacol (2013) 0.87
Optimizing the solution conditions to solve the structure of the Connexin43 carboxyl terminus attached to the 4(th) transmembrane domain in detergent micelles. Cell Commun Adhes (2010) 0.86
Intracellular Cleavage of the Cx43 C-Terminal Domain by Matrix-Metalloproteases: A Novel Contributor to Inflammation? Mediators Inflamm (2015) 0.85
Mechanism for modulation of gating of connexin26-containing channels by taurine. J Gen Physiol (2011) 0.85
Amino acid residue Val362 plays a critical role in maintaining the structure of C terminus of connexin 50 and in lens epithelial-fiber differentiation. J Biol Chem (2010) 0.84
Cx43-hemichannel function and regulation in physiology and pathophysiology: insights from the bovine corneal endothelial cell system and beyond. Front Physiol (2014) 0.84
Structural changes in the carboxyl terminus of the gap junction protein connexin 40 caused by the interaction with c-Src and zonula occludens-1. Cell Commun Adhes (2008) 0.83
Carboxy terminus and pore-forming domain properties specific to Cx37 are necessary for Cx37-mediated suppression of insulinoma cell proliferation. Am J Physiol Cell Physiol (2013) 0.83
Characterization of the connexin45 carboxyl-terminal domain structure and interactions with molecular partners. Biophys J (2014) 0.82
Gap junction regulation by calmodulin. FEBS Lett (2014) 0.80
Junctional proteins of the blood-brain barrier: New insights into function and dysfunction. Tissue Barriers (2016) 0.80
Fast proton exchange in histidine: measurement of rate constants through indirect detection by NMR spectroscopy. Chemistry (2014) 0.79
Particle tracking model of electrophoretic morphogen movement reveals stochastic dynamics of embryonic gradient. Dev Dyn (2009) 0.79
Structural order in Pannexin 1 cytoplasmic domains. Channels (Austin) (2014) 0.78
Helicobacter pylori VacA induces apoptosis by accumulation of connexin 43 in autophagic vesicles via a Rac1/ERK-dependent pathway. Cell Death Discov (2015) 0.78
Intracellular spermine prevents acid-induced uncoupling of Cx43 gap junction channels. Neuroreport (2015) 0.78
The carboxyl terminal residues 220-283 are not required for voltage gating of a chimeric connexin32 hemichannel. Biophys J (2013) 0.77
Determinants of Cx43 Channel Gating and Permeation: The Amino Terminus. Biophys J (2016) 0.77
Structural Studies of the Nedd4 WW Domains and Their Selectivity for the Connexin43 (Cx43) Carboxyl Terminus. J Biol Chem (2016) 0.77
Not what you thought: how H+ ions combine with taurine or other aminosulfonates to close Cx26 channels. J Gen Physiol (2011) 0.76
Specific functional pathologies of Cx43 mutations associated with oculodentodigital dysplasia. Mol Biol Cell (2016) 0.76
A history of gap junction structure: hexagonal arrays to atomic resolution. Cell Commun Adhes (2013) 0.76
Polyamines preserve connexin 43-mediated gap junctional communication during intracellular hypercalcemia and acidosis. Neuroreport (2017) 0.75
Connexinopathies: a structural and functional glimpse. BMC Cell Biol (2016) 0.75
Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications. Pharmacol Rev (2017) 0.75
Connexin43 remodeling caused by inhibition of plakophilin-2 expression in cardiac cells. Circ Res (2007) 3.16
Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes. Circ Res (2009) 2.48
Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice. Heart Rhythm (2011) 2.21
Subcellular heterogeneity of sodium current properties in adult cardiac ventricular myocytes. Heart Rhythm (2011) 2.10
Structural changes in the carboxyl terminus of the gap junction protein connexin43 indicates signaling between binding domains for c-Src and zonula occludens-1. J Biol Chem (2004) 2.03
An evaluation of detergents for NMR structural studies of membrane proteins. J Biomol NMR (2004) 1.99
Interactions between ankyrin-G, Plakophilin-2, and Connexin43 at the cardiac intercalated disc. Circ Res (2011) 1.95
Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy. Heart Rhythm (2012) 1.91
Molecular composition of the intercalated disc in a spontaneous canine animal model of arrhythmogenic right ventricular dysplasia/cardiomyopathy. Heart Rhythm (2007) 1.70
Loss of electrical communication, but not plaque formation, after mutations in the cytoplasmic loop of connexin43. Heart Rhythm (2004) 1.70
Phosphorylation at S365 is a gatekeeper event that changes the structure of Cx43 and prevents down-regulation by PKC. J Cell Biol (2007) 1.70
Remodeling of mechanical junctions and of microtubule-associated proteins accompany cardiac connexin43 lateralization. Heart Rhythm (2012) 1.69
Characterization of the molecular phenotype of two arrhythmogenic right ventricular cardiomyopathy (ARVC)-related plakophilin-2 (PKP2) mutations. Heart Rhythm (2008) 1.67
Structural and molecular mechanisms of gap junction remodeling in epicardial border zone myocytes following myocardial infarction. Circ Res (2009) 1.63
Missense mutations in plakophilin-2 cause sodium current deficit and associate with a Brugada syndrome phenotype. Circulation (2013) 1.61
Phosphorylation of connexin43 on serine 306 regulates electrical coupling. Heart Rhythm (2009) 1.60
Gap junctions. Compr Physiol (2012) 1.59
pH-dependent intramolecular binding and structure involving Cx43 cytoplasmic domains. J Biol Chem (2002) 1.59
High incidence of cardiac malformations in connexin40-deficient mice. Circ Res (2003) 1.54
Cx43 CT domain influences infarct size and susceptibility to ventricular tachyarrhythmias in acute myocardial infarction. Cardiovasc Res (2009) 1.51
C-terminal truncation of connexin43 changes number, size, and localization of cardiac gap junction plaques. Circ Res (2007) 1.46
Regulation of connexin43 protein complexes by intracellular acidification. Circ Res (2003) 1.43
Design and characterization of the first peptidomimetic molecule that prevents acidification-induced closure of cardiac gap junctions. Heart Rhythm (2010) 1.43
Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency. Cardiovasc Res (2012) 1.38
Eps15 homology domain 1-associated tubules contain phosphatidylinositol-4-phosphate and phosphatidylinositol-(4,5)-bisphosphate and are required for efficient recycling. Mol Biol Cell (2009) 1.34
Role of the carboxyl terminal of connexin43 in transjunctional fast voltage gating. Circ Res (2002) 1.32
Functional characterization of connexin43 mutations found in patients with oculodentodigital dysplasia. Circ Res (2005) 1.31
EHD1 and Eps15 interact with phosphatidylinositols via their Eps15 homology domains. J Biol Chem (2007) 1.28
pH-dependent dimerization of the carboxyl terminal domain of Cx43. Biophys J (2004) 1.26
Mechanism for the selective interaction of C-terminal Eps15 homology domain proteins with specific Asn-Pro-Phe-containing partners. J Biol Chem (2010) 1.24
EH domain of EHD1. J Biomol NMR (2007) 1.21
RXP-E: a connexin43-binding peptide that prevents action potential propagation block. Circ Res (2008) 1.15
Plakophilins: multifunctional scaffolds for adhesion and signaling. Curr Opin Cell Biol (2009) 1.13
Identification of a novel peptide that interferes with the chemical regulation of connexin43. Circ Res (2006) 1.12
Modifications in the biophysical properties of connexin43 channels by a peptide of the cytoplasmic loop region. Circ Res (2004) 1.11
Formation of the gap junction nexus: binding partners for connexins. J Physiol Paris (2002) 1.08
Sequence-specific resonance assignment of the carboxyl terminal domain of Connexin43. J Biomol NMR (2002) 1.04
Gap junction protein Cx37 interacts with endothelial nitric oxide synthase in endothelial cells. Arterioscler Thromb Vasc Biol (2010) 1.02
Differential roles of C-terminal Eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes. J Biol Chem (2013) 1.02
Characterization of the structure and intermolecular interactions between the connexin40 and connexin43 carboxyl-terminal and cytoplasmic loop domains. J Biol Chem (2009) 1.01
Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels. Basic Res Cardiol (2013) 1.00
Ultrastructural changes in cardiac myocytes from Boxer dogs with arrhythmogenic right ventricular cardiomyopathy. J Vet Cardiol (2011) 0.99
Super-resolution fluorescence microscopy of the cardiac connexome reveals plakophilin-2 inside the connexin43 plaque. Cardiovasc Res (2013) 0.98
Epithelial interactions and local engraftment of lung-resident mesenchymal stem cells. Am J Respir Cell Mol Biol (2011) 0.98
Rabankyrin-5 interacts with EHD1 and Vps26 to regulate endocytic trafficking and retromer function. Traffic (2012) 0.97
Novel pharmacophores of connexin43 based on the "RXP" series of Cx43-binding peptides. Circ Res (2009) 0.96
Ordered assembly of the adhesive and electrochemical connections within newly formed intercalated disks in primary cultures of adult rat cardiomyocytes. J Biomed Biotechnol (2010) 0.96
The gap junction protein connexin32 interacts with the Src homology 3/hook domain of discs large homolog 1. J Biol Chem (2007) 0.93
Effects of phosphorylation on the structure and backbone dynamics of the intrinsically disordered connexin43 C-terminal domain. J Biol Chem (2013) 0.93
Structural insight into the interaction of proteins containing NPF, DPF, and GPF motifs with the C-terminal EH-domain of EHD1. Protein Sci (2009) 0.93
A connexin40 mutation associated with a malignant variant of progressive familial heart block type I. Circ Arrhythm Electrophysiol (2012) 0.91
Purification and reconstitution of the connexin43 carboxyl terminus attached to the 4th transmembrane domain in detergent micelles. Protein Expr Purif (2008) 0.91
Scn1b deletion leads to increased tetrodotoxin-sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts. J Physiol (2014) 0.90
The intercalated disk as a single functional unit. Heart Rhythm (2004) 0.90
PCP4 regulates Purkinje cell excitability and cardiac rhythmicity. J Clin Invest (2014) 0.90
The noncanonical functions of Cx43 in the heart. J Membr Biol (2012) 0.90
Heterogeneity of ATP-sensitive K+ channels in cardiac myocytes: enrichment at the intercalated disk. J Biol Chem (2012) 0.90
Characterization of the structure and intermolecular interactions between the connexin 32 carboxyl-terminal domain and the protein partners synapse-associated protein 97 and calmodulin. J Biol Chem (2012) 0.89
Relative contribution of changes in sodium current versus intercellular coupling on reentry initiation in 2-dimensional preparations of plakophilin-2-deficient cardiac cells. Heart Rhythm (2011) 0.89
Well-defined cross-linked antioxidant nanozymes for treatment of ischemic brain injury. J Control Release (2012) 0.88
Effect of charge substitutions at residue his-142 on voltage gating of connexin43 channels. Biophys J (2006) 0.88
Cardiomyocyte ATP release through pannexin 1 aids in early fibroblast activation. Am J Physiol Heart Circ Physiol (2012) 0.87
Evidence for the presence of a free C-terminal fragment of cx43 in cultured cells. Cell Commun Adhes (2007) 0.87
Optimizing the solution conditions to solve the structure of the Connexin43 carboxyl terminus attached to the 4(th) transmembrane domain in detergent micelles. Cell Commun Adhes (2010) 0.86
A model for the role of EHD1-containing membrane tubules in endocytic recycling. Commun Integr Biol (2009) 0.85
Mechanism for modulation of gating of connexin26-containing channels by taurine. J Gen Physiol (2011) 0.85
Regulation of cardiovascular connexins by mechanical forces and junctions. Cardiovasc Res (2013) 0.84
Connexin43 regulates sodium current; ankyrin-G modulates gap junctions: the intercalated disc exchanger. Cardiovasc Res (2011) 0.84
Structural changes in the carboxyl terminus of the gap junction protein connexin 40 caused by the interaction with c-Src and zonula occludens-1. Cell Commun Adhes (2008) 0.83
¹H, ¹³C, and ¹⁵N backbone resonance assignments of the connexin43 carboxyl terminal domain attached to the 4th transmembrane domain in detergent micelles. Biomol NMR Assign (2012) 0.83
Carboxy terminus and pore-forming domain properties specific to Cx37 are necessary for Cx37-mediated suppression of insulinoma cell proliferation. Am J Physiol Cell Physiol (2013) 0.83
(1)H, (13)C, and (15)N backbone resonance assignments of the carboxyl terminal domain of Connexin40. Biomol NMR Assign (2007) 0.81
Chemical shift assignments of the connexin45 carboxyl terminal domain: monomer and dimer conformations. Biomol NMR Assign (2012) 0.81
NMR structure note: UBA domain of CIP75. J Biomol NMR (2010) 0.81
Stabilization of a G-Quadruplex from Unfolding by Replication Protein A Using Potassium and the Porphyrin TMPyP4. J Nucleic Acids (2011) 0.81
An Escherichia coli strain for expression of the connexin45 carboxyl terminus attached to the 4th transmembrane domain. Front Pharmacol (2013) 0.80
Plakophilin-2 and the migration, differentiation and transformation of cells derived from the epicardium of neonatal rat hearts. Cell Commun Adhes (2011) 0.80
Transcription factor ETV1 is essential for rapid conduction in the heart. J Clin Invest (2016) 0.77
Erratum: Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc. Nat Commun (2016) 0.77
The year in arrhythmias--2009: part I. Heart Rhythm (2009) 0.76
Gap junction remodeling in the failing heart: different connexins--different message? J Cardiovasc Electrophysiol (2003) 0.76
A history of gap junction structure: hexagonal arrays to atomic resolution. Cell Commun Adhes (2013) 0.76