Published in Circ Res on August 02, 2007
Mechanisms of disease: molecular genetics of arrhythmogenic right ventricular dysplasia/cardiomyopathy. Nat Clin Pract Cardiovasc Med (2008) 3.19
Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes. Circ Res (2009) 2.48
Remodelling of gap junctions and connexin expression in diseased myocardium. Cardiovasc Res (2008) 2.43
Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice. Heart Rhythm (2011) 2.21
Interactions between ankyrin-G, Plakophilin-2, and Connexin43 at the cardiac intercalated disc. Circ Res (2011) 1.95
Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy. Heart Rhythm (2012) 1.91
Characterization of the molecular phenotype of two arrhythmogenic right ventricular cardiomyopathy (ARVC)-related plakophilin-2 (PKP2) mutations. Heart Rhythm (2008) 1.67
Compound heterozygous desmoplakin mutations result in a phenotype with a combination of myocardial, skin, hair, and enamel abnormalities. J Invest Dermatol (2009) 1.62
Missense mutations in plakophilin-2 cause sodium current deficit and associate with a Brugada syndrome phenotype. Circulation (2013) 1.61
A novel desmocollin-2 mutation reveals insights into the molecular link between desmosomes and gap junctions. Heart Rhythm (2011) 1.54
Biological role of connexin intercellular channels and hemichannels. Arch Biochem Biophys (2012) 1.45
Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency. Cardiovasc Res (2012) 1.38
The tight junction protein CAR regulates cardiac conduction and cell-cell communication. J Exp Med (2008) 1.23
Abnormal connexin43 in arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 mutations. J Cell Mol Med (2008) 1.18
Loss of αT-catenin alters the hybrid adhering junctions in the heart and leads to dilated cardiomyopathy and ventricular arrhythmia following acute ischemia. J Cell Sci (2012) 1.16
RXP-E: a connexin43-binding peptide that prevents action potential propagation block. Circ Res (2008) 1.15
Plakophilins: multifunctional scaffolds for adhesion and signaling. Curr Opin Cell Biol (2009) 1.13
The biology of the desmosome-like junction a versatile anchoring junction and signal transducer in the seminiferous epithelium. Int Rev Cell Mol Biol (2011) 1.12
The connexin43 carboxyl terminus and cardiac gap junction organization. Biochim Biophys Acta (2011) 1.05
The junctions that don't fit the scheme: special symmetrical cell-cell junctions of their own kind. Cell Tissue Res (2009) 1.03
Mechanisms of gap junction traffic in health and disease. J Cardiovasc Pharmacol (2009) 1.00
Super-resolution fluorescence microscopy of the cardiac connexome reveals plakophilin-2 inside the connexin43 plaque. Cardiovasc Res (2013) 0.98
Connexin43 and the regulation of intercalated disc function. Heart Rhythm (2011) 0.98
Regulation of cardiac inward rectifier potassium current (I(K1)) by synapse-associated protein-97. J Biol Chem (2010) 0.97
Arrhythmogenic cardiomyopathy and Brugada syndrome: diseases of the connexome. FEBS Lett (2014) 0.97
Novel pharmacophores of connexin43 based on the "RXP" series of Cx43-binding peptides. Circ Res (2009) 0.96
Ordered assembly of the adhesive and electrochemical connections within newly formed intercalated disks in primary cultures of adult rat cardiomyocytes. J Biomed Biotechnol (2010) 0.96
Assembly of the cardiac intercalated disk during pre- and postnatal development of the human heart. PLoS One (2014) 0.95
Gap junctions and blood-tissue barriers. Adv Exp Med Biol (2012) 0.92
Arrhythmogenic cardiomyopathy: diagnosis, genetic background, and risk management. Neth Heart J (2014) 0.91
Molecular crosstalk between mechanical and electrical junctions at the intercalated disc. Circ Res (2007) 0.90
The noncanonical functions of Cx43 in the heart. J Membr Biol (2012) 0.90
Desmosome-ion channel interactions and their possible role in arrhythmogenic cardiomyopathy. Pediatr Cardiol (2012) 0.90
A new perspective on intercalated disc organization: implications for heart disease. Dermatol Res Pract (2010) 0.89
Relative contribution of changes in sodium current versus intercellular coupling on reentry initiation in 2-dimensional preparations of plakophilin-2-deficient cardiac cells. Heart Rhythm (2011) 0.89
Xin proteins and intercalated disc maturation, signaling and diseases. Front Biosci (Landmark Ed) (2012) 0.88
ZO-1 determines adherens and gap junction localization at intercalated disks. Am J Physiol Heart Circ Physiol (2010) 0.88
Connexin defects underlie arrhythmogenic right ventricular cardiomyopathy in a novel mouse model. Hum Mol Genet (2013) 0.87
Novel missense mutations in exon 15 of desmoglein-2: role of the intracellular cadherin segment in arrhythmogenic right ventricular cardiomyopathy? Heart Rhythm (2010) 0.87
Cardiac mesenchymal stromal cells are a source of adipocytes in arrhythmogenic cardiomyopathy. Eur Heart J (2015) 0.87
Gap junctions and arrhythmogenic cardiomyopathy. Heart Rhythm (2011) 0.86
The desmosomal plaque proteins of the plakophilin family. Dermatol Res Pract (2010) 0.86
Desmosomal molecules in and out of adhering junctions: normal and diseased States of epidermal, cardiac and mesenchymally derived cells. Dermatol Res Pract (2010) 0.86
Value of the signal-averaged electrocardiogram in arrhythmogenic right ventricular cardiomyopathy/dysplasia. Heart Rhythm (2010) 0.84
Diagnostic dilemmas: overlapping features of brugada syndrome and arrhythmogenic right ventricular cardiomyopathy. Front Physiol (2012) 0.84
Changes in Cx43 and NaV1.5 expression precede the occurrence of substantial fibrosis in calcineurin-induced murine cardiac hypertrophy. PLoS One (2014) 0.84
Regulation of cardiovascular connexins by mechanical forces and junctions. Cardiovasc Res (2013) 0.84
The plaque protein myozap identified as a novel major component of adhering junctions in endothelia of the blood and the lymph vascular systems. J Cell Mol Med (2012) 0.83
TMEM43 mutation p.S358L alters intercalated disc protein expression and reduces conduction velocity in arrhythmogenic right ventricular cardiomyopathy. PLoS One (2014) 0.83
The spatiotemporal development of intercalated disk in three-dimensional engineered heart tissues based on collagen/matrigel matrix. PLoS One (2013) 0.81
Mena associates with Rac1 and modulates connexin 43 remodeling in cardiomyocytes. Am J Physiol Heart Circ Physiol (2013) 0.81
Genetic variants related to gap junctions and hormone secretion influence conception rates in cows. Proc Natl Acad Sci U S A (2013) 0.81
Congenital Long QT Syndrome: An Update and Present Perspective in Saudi Arabia. Front Pediatr (2013) 0.81
Trafficking highways to the intercalated disc: new insights unlocking the specificity of connexin 43 localization. Cell Commun Adhes (2014) 0.80
New functions for alpha-catenins in health and disease: from cancer to heart regeneration. Cell Tissue Res (2015) 0.80
Plakophilin-2 and the migration, differentiation and transformation of cells derived from the epicardium of neonatal rat hearts. Cell Commun Adhes (2011) 0.80
Function of a novel plakophilin-2 mutation in the abnormal expression of connexin43 in a patient with arrhythmogenic right ventricular cardiomyopathy. Exp Ther Med (2014) 0.79
Plakophilin-2: a cell-cell adhesion plaque molecule of selective and fundamental importance in cardiac functions and tumor cell growth. Cell Tissue Res (2012) 0.78
Cardiac autoantibodies from patients affected by a new variant of endemic pemphigus foliaceus in Colombia, South America. J Clin Immunol (2011) 0.78
Impact of new electrocardiographic criteria in arrhythmogenic cardiomyopathy. Front Physiol (2012) 0.77
Cardiovascular health, part 1: preparticipation cardiovascular screening. Sports Health (2009) 0.77
Deficiency of cyclase-associated protein 2 promotes arrhythmias associated with connexin43 maldistribution and fibrosis. Arch Med Sci (2016) 0.76
Cell models of arrhythmogenic cardiomyopathy: advances and opportunities. Dis Model Mech (2017) 0.75
Plakophilin-2 loss promotes TGF-β1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes. J Cell Biol (2016) 0.75
A change of heart: heterogeneous remodeling in heart failure. Heart Rhythm (2008) 0.75
Arrhythmogenic right ventricular cardiomyopathy: considerations from in silico experiments. Front Physiol (2012) 0.75
Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications. Pharmacol Rev (2017) 0.75
Toward early diagnosis in arrhythmogenic right ventricular dysplasia/cardiomyopathy. J Interv Card Electrophysiol (2009) 0.75
Unmasking the molecular link between arrhythmogenic cardiomyopathy and Brugada syndrome. Nat Rev Cardiol (2017) 0.75
Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes. Circ Res (2009) 2.48
Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice. Heart Rhythm (2011) 2.21
Breast-cancer screening with trained volunteers in a rural area of Sudan: a pilot study. Lancet Oncol (2013) 2.16
Subcellular heterogeneity of sodium current properties in adult cardiac ventricular myocytes. Heart Rhythm (2011) 2.10
Structural changes in the carboxyl terminus of the gap junction protein connexin43 indicates signaling between binding domains for c-Src and zonula occludens-1. J Biol Chem (2004) 2.03
Interactions between ankyrin-G, Plakophilin-2, and Connexin43 at the cardiac intercalated disc. Circ Res (2011) 1.95
Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy. Heart Rhythm (2012) 1.91
Electrotonic myofibroblast-to-myocyte coupling increases propensity to reentrant arrhythmias in two-dimensional cardiac monolayers. Biophys J (2008) 1.90
Blockade of the inward rectifying potassium current terminates ventricular fibrillation in the guinea pig heart. J Cardiovasc Electrophysiol (2003) 1.71
Molecular composition of the intercalated disc in a spontaneous canine animal model of arrhythmogenic right ventricular dysplasia/cardiomyopathy. Heart Rhythm (2007) 1.70
Loss of electrical communication, but not plaque formation, after mutations in the cytoplasmic loop of connexin43. Heart Rhythm (2004) 1.70
Unique Kir2.x properties determine regional and species differences in the cardiac inward rectifier K+ current. Circ Res (2004) 1.70
Remodeling of mechanical junctions and of microtubule-associated proteins accompany cardiac connexin43 lateralization. Heart Rhythm (2012) 1.69
Characterization of the molecular phenotype of two arrhythmogenic right ventricular cardiomyopathy (ARVC)-related plakophilin-2 (PKP2) mutations. Heart Rhythm (2008) 1.67
Missense mutations in plakophilin-2 cause sodium current deficit and associate with a Brugada syndrome phenotype. Circulation (2013) 1.61
Phosphorylation of connexin43 on serine 306 regulates electrical coupling. Heart Rhythm (2009) 1.60
Gap junctions. Compr Physiol (2012) 1.59
pH-dependent intramolecular binding and structure involving Cx43 cytoplasmic domains. J Biol Chem (2002) 1.59
The ionic bases of the action potential in isolated mouse cardiac Purkinje cell. Heart Rhythm (2012) 1.59
Elevated pre-operative serum peptides for collagen I and III synthesis result in post-surgical atrial fibrillation. J Am Coll Cardiol (2012) 1.59
Dynamic reciprocity of sodium and potassium channel expression in a macromolecular complex controls cardiac excitability and arrhythmia. Proc Natl Acad Sci U S A (2012) 1.58
Kir2.3 isoform confers pH sensitivity to heteromeric Kir2.1/Kir2.3 channels in HEK293 cells. Heart Rhythm (2006) 1.56
High incidence of cardiac malformations in connexin40-deficient mice. Circ Res (2003) 1.54
Cholinergic atrial fibrillation: I(K,ACh) gradients determine unequal left/right atrial frequencies and rotor dynamics. Cardiovasc Res (2003) 1.54
Cx43 CT domain influences infarct size and susceptibility to ventricular tachyarrhythmias in acute myocardial infarction. Cardiovasc Res (2009) 1.51
Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells. J Biol Chem (2004) 1.50
C-terminal truncation of connexin43 changes number, size, and localization of cardiac gap junction plaques. Circ Res (2007) 1.46
Characterization of the pH-dependent interaction between the gap junction protein connexin43 carboxyl terminus and cytoplasmic loop domains. J Biol Chem (2006) 1.45
Adenoviral expression of IKs contributes to wavebreak and fibrillatory conduction in neonatal rat ventricular cardiomyocyte monolayers. Circ Res (2007) 1.44
Regulation of connexin43 protein complexes by intracellular acidification. Circ Res (2003) 1.43
Design and characterization of the first peptidomimetic molecule that prevents acidification-induced closure of cardiac gap junctions. Heart Rhythm (2010) 1.43
Structural bases for the chemical regulation of Connexin43 channels. Cardiovasc Res (2004) 1.43
Connexin 43 interacts with zona occludens-1 and -2 proteins in a cell cycle stage-specific manner. J Biol Chem (2005) 1.38
Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency. Cardiovasc Res (2012) 1.38
Role of the carboxyl terminal of connexin43 in transjunctional fast voltage gating. Circ Res (2002) 1.32
Functional characterization of connexin43 mutations found in patients with oculodentodigital dysplasia. Circ Res (2005) 1.31
pH-dependent dimerization of the carboxyl terminal domain of Cx43. Biophys J (2004) 1.26
Involvement of the cytoplasmic C-terminal domain of connexin43 in neuronal migration. J Neurosci (2009) 1.23
RXP-E: a connexin43-binding peptide that prevents action potential propagation block. Circ Res (2008) 1.15
Plakophilins: multifunctional scaffolds for adhesion and signaling. Curr Opin Cell Biol (2009) 1.13
Identification of a novel peptide that interferes with the chemical regulation of connexin43. Circ Res (2006) 1.12
Modifications in the biophysical properties of connexin43 channels by a peptide of the cytoplasmic loop region. Circ Res (2004) 1.11
Formation of the gap junction nexus: binding partners for connexins. J Physiol Paris (2002) 1.08
Dominant frequency increase rate predicts transition from paroxysmal to long-term persistent atrial fibrillation. Circulation (2014) 1.07
Sequence-specific resonance assignment of the carboxyl terminal domain of Connexin43. J Biomol NMR (2002) 1.04
Gap junction protein Cx37 interacts with endothelial nitric oxide synthase in endothelial cells. Arterioscler Thromb Vasc Biol (2010) 1.02
Left versus right atrial difference in dominant frequency, K(+) channel transcripts, and fibrosis in patients developing atrial fibrillation after cardiac surgery. Heart Rhythm (2009) 1.00
Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels. Basic Res Cardiol (2013) 1.00
Ultrastructural changes in cardiac myocytes from Boxer dogs with arrhythmogenic right ventricular cardiomyopathy. J Vet Cardiol (2011) 0.99
Super-resolution fluorescence microscopy of the cardiac connexome reveals plakophilin-2 inside the connexin43 plaque. Cardiovasc Res (2013) 0.98
Epithelial interactions and local engraftment of lung-resident mesenchymal stem cells. Am J Respir Cell Mol Biol (2011) 0.98
The connexin43 C-terminal region mediates neuroprotection during stroke. J Neuropathol Exp Neurol (2010) 0.98
Regulation of cardiac inward rectifier potassium current (I(K1)) by synapse-associated protein-97. J Biol Chem (2010) 0.97
Novel pharmacophores of connexin43 based on the "RXP" series of Cx43-binding peptides. Circ Res (2009) 0.96
Ordered assembly of the adhesive and electrochemical connections within newly formed intercalated disks in primary cultures of adult rat cardiomyocytes. J Biomed Biotechnol (2010) 0.96
Connexin43 modulates neutrophil recruitment to the lung. J Cell Mol Med (2009) 0.96
Expression and function of connexins in the epidermis, analyzed with transgenic mouse mutants. Eur J Cell Biol (2004) 0.92
A connexin40 mutation associated with a malignant variant of progressive familial heart block type I. Circ Arrhythm Electrophysiol (2012) 0.91
Scn1b deletion leads to increased tetrodotoxin-sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts. J Physiol (2014) 0.90
TGF-β1, released by myofibroblasts, differentially regulates transcription and function of sodium and potassium channels in adult rat ventricular myocytes. PLoS One (2013) 0.90
The intercalated disk as a single functional unit. Heart Rhythm (2004) 0.90
Loss of connexin 26 in mammary epithelium during early but not during late pregnancy results in unscheduled apoptosis and impaired development. Dev Biol (2004) 0.90
PCP4 regulates Purkinje cell excitability and cardiac rhythmicity. J Clin Invest (2014) 0.90
The noncanonical functions of Cx43 in the heart. J Membr Biol (2012) 0.90
Heterogeneity of ATP-sensitive K+ channels in cardiac myocytes: enrichment at the intercalated disk. J Biol Chem (2012) 0.90