Published in J Cell Sci on January 01, 2007
Basal cell carcinomas: attack of the hedgehog. Nat Rev Cancer (2008) 4.34
Cancer stem cells and the ontogeny of lung cancer. J Clin Oncol (2008) 1.51
Targeting the Hedgehog pathway in cancer. Ther Adv Med Oncol (2010) 1.35
Hedgehog signalling in breast cancer. Carcinogenesis (2009) 1.18
Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway. Hum Mol Genet (2009) 1.16
Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment. Cancer Res (2011) 1.15
tsunami, the Dictyostelium homolog of the Fused kinase, is required for polarization and chemotaxis. Genes Dev (2008) 1.03
Gli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation. Hum Mol Genet (2010) 1.03
Activation of the Hedgehog pathway in chronic myelogeneous leukemia patients. J Exp Clin Cancer Res (2011) 1.00
Cooperative Hedgehog-EGFR signaling. Front Biosci (Landmark Ed) (2012) 0.95
Vsx2/Chx10 ensures the correct timing and magnitude of Hedgehog signaling in the mouse retina. Dev Biol (2008) 0.95
Opposing roles of voltage-gated Ca2+ channels in neuronal control of regenerative patterning. J Neurosci (2011) 0.94
Oxysterols and their cellular effectors. Biomolecules (2012) 0.92
An old friend with new skills: Imiquimod as novel inhibitor of Hedgehog signaling in basal cell carcinoma. Oncoscience (2014) 0.91
The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκB activity. J Cell Sci (2015) 0.90
Redundant and differential roles of transcription factors Gli1 and Gli2 in the development of mouse fetal Leydig cells. Biol Reprod (2011) 0.90
GLI2 inhibition abrogates human leukemia stem cell dormancy. J Transl Med (2015) 0.86
Hedgehog signaling pathway and ovarian cancer. Chin J Cancer Res (2013) 0.83
Sonic hedgehog pathway contributes to gastric cancer cell growth and proliferation. Biores Open Access (2014) 0.83
Autocrine Sonic hedgehog signaling promotes gastric cancer proliferation through induction of phospholipase Cγ1 and the ERK1/2 pathway. J Exp Clin Cancer Res (2016) 0.80
In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors. Oncotarget (2016) 0.80
A novel signaling pathway mediated by the nuclear targeting of C-terminal fragments of mammalian Patched 1. PLoS One (2011) 0.78
Structural and logical analysis of a comprehensive hedgehog signaling pathway to identify alternative drug targets for glioma, colon and pancreatic cancer. PLoS One (2013) 0.77
Design and characterization of a photo-activatable hedgehog probe that mimics the natural lipidated form. Arch Biochem Biophys (2014) 0.75
Hedgehog signaling pathway and its targets for treatment in basal cell carcinoma. J Exp Pharmacol (2012) 0.75
Oxidative stress contributes to the impaired sonic hedgehog pathway in type 1 diabetic mice with myocardial infarction. Exp Ther Med (2015) 0.75
Control of inflammation by stromal Hedgehog pathway activation restrains colitis. Proc Natl Acad Sci U S A (2016) 0.75
Quantitative differential proteomics of yeast extracellular matrix: there is more to it than meets the eye. BMC Microbiol (2015) 0.75
The Hedgehog-GLI pathway in embryonic development and cancer: implications for pulmonary oncology therapy. Oncotarget (2017) 0.75
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev (2002) 8.56
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol (2003) 7.42
Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A (2002) 6.55
Medulloblastoma growth inhibition by hedgehog pathway blockade. Science (2002) 6.53
Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity. Cell (2006) 6.49
Minimizing the risk of reporting false positives in large-scale RNAi screens. Nat Methods (2006) 5.96
Hedgehog: functions and mechanisms. Genes Dev (2008) 5.69
The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling. Nat Genet (2009) 5.65
DNA-binding specificities of human transcription factors. Cell (2013) 5.14
Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J (2010) 4.78
Counting absolute numbers of molecules using unique molecular identifiers. Nat Methods (2011) 4.18
Identification of pathways regulating cell size and cell-cycle progression by RNAi. Nature (2006) 3.60
Multiplexed massively parallel SELEX for characterization of human transcription factor binding specificities. Genome Res (2010) 3.46
MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas. Science (2011) 3.17
Transcription factor binding in human cells occurs in dense clusters formed around cohesin anchor sites. Cell (2013) 2.98
Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors. Science (2012) 2.58
A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis. Nat Genet (2003) 2.29
Divergence of hedgehog signal transduction mechanism between Drosophila and mammals. Dev Cell (2006) 2.12
Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Mol Cell (2003) 2.02
Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype. Cancer Cell (2008) 1.82
Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched. Cell (2002) 1.77
Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling. Cell (2008) 1.58
Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos. Mol Cell Biol (2008) 1.47
High-throughput assay for determining specificity and affinity of protein-DNA binding interactions. Nat Protoc (2006) 1.34
A versatile platform for creating a comprehensive UAS-ORFeome library in Drosophila. Development (2013) 1.25
Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia. J Cell Sci (2011) 1.24
Loss of SUFU function in familial multiple meningioma. Am J Hum Genet (2012) 1.21
Locating potential enhancer elements by comparative genomics using the EEL software. Nat Protoc (2006) 1.13
Frequent L1 retrotranspositions originating from TTC28 in colorectal cancer. Oncotarget (2014) 1.04
Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation. Cancer Res (2010) 1.04
Lessons from functional analysis of genome-wide association studies. Cancer Res (2013) 1.03
Exome sequencing reveals frequent inactivating mutations in ARID1A, ARID1B, ARID2 and ARID4A in microsatellite unstable colorectal cancer. Int J Cancer (2014) 1.02
KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA. PLoS Pathog (2009) 1.01
Eleven candidate susceptibility genes for common familial colorectal cancer. PLoS Genet (2013) 0.98
FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex. Proc Natl Acad Sci U S A (2010) 0.94
Mutations in the circadian gene CLOCK in colorectal cancer. Mol Cancer Res (2010) 0.93
Identification of candidate oncogenes in human colorectal cancers with microsatellite instability. Gastroenterology (2013) 0.92
Systematic screening of a Drosophila ORF library in vivo uncovers Wnt/Wg pathway components. Dev Cell (2013) 0.92
Transcriptional networks controlling the cell cycle. G3 (Bethesda) (2013) 0.85
Methods for Analysis of Transcription Factor DNA-Binding Specificity In Vitro. Subcell Biochem (2011) 0.83
Beyond the balance of activator and repressor. Sci Signal (2011) 0.79
Human kinome analysis reveals novel kinases contributing to virus infection and retinoic-acid inducible gene I-induced type I and type III IFN gene expression. Innate Immun (2013) 0.77
Jussi Taipale: for the love of data. Interview by Caitlin Sedwick. J Cell Biol (2008) 0.75
[Epithelial stem cell and cancer]. Duodecim (2004) 0.75