Published in J Cell Sci on March 15, 2011
miR-23a promotes the transition from indolent to invasive colorectal cancer. Cancer Discov (2012) 1.49
Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures. Nat Struct Mol Biol (2011) 1.12
Innovations in phenotyping of mouse models in the German Mouse Clinic. Mamm Genome (2012) 1.09
Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice. Sci Signal (2015) 0.95
The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance. J Transl Med (2011) 0.94
Mice deficient in MIM expression are predisposed to lymphomagenesis. Oncogene (2011) 0.94
Mtss1 promotes cell-cell junction assembly and stability through the small GTPase Rac1. PLoS One (2012) 0.93
Murine missing in metastasis (MIM) mediates cell polarity and regulates the motility response to growth factors. PLoS One (2011) 0.92
Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis. J Biol Chem (2013) 0.90
Identification of the Adapter Molecule MTSS1 as a Potential Oncogene-Specific Tumor Suppressor in Acute Myeloid Leukemia. PLoS One (2015) 0.89
MIM regulates the trafficking of bone marrow cells via modulating surface expression of CXCR4. Leukemia (2016) 0.88
Anti-miR182 reduces ovarian cancer burden, invasion, and metastasis: an in vivo study in orthotopic xenografts of nude mice. Mol Cancer Ther (2014) 0.85
Dimerization is necessary for MIM-mediated membrane deformation and endocytosis. Biochem J (2012) 0.81
The BAR Domain Superfamily Proteins from Subcellular Structures to Human Diseases. Membranes (Basel) (2012) 0.79
Phosphorylation of the Bin, Amphiphysin, and RSV161/167 (BAR) domain of ACAP4 regulates membrane tubulation. Proc Natl Acad Sci U S A (2013) 0.79
Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function. J Clin Invest (2017) 0.75
MTSS1 is epigenetically regulated in glioma cells and inhibits glioma cell motility. Transl Oncol (2016) 0.75
Missing-in-metastasis protein downregulates CXCR4 by promoting ubiquitylation and interaction with small Rab GTPases. J Cell Sci (2017) 0.75
Redundant functions of I-BAR family members, IRSp53 and IRTKS, are essential for embryonic development. Sci Rep (2017) 0.75
Mtss1((CSC156)) mutant mice fail to display efficient Mtss1 protein depletion. Leukemia (2017) 0.75
Rapid transcriptome characterization for a nonmodel organism using 454 pyrosequencing. Mol Ecol (2008) 9.09
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev (2002) 8.56
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol (2003) 7.42
Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A (2002) 6.55
Medulloblastoma growth inhibition by hedgehog pathway blockade. Science (2002) 6.53
Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity. Cell (2006) 6.49
Filopodia: molecular architecture and cellular functions. Nat Rev Mol Cell Biol (2008) 6.40
Minimizing the risk of reporting false positives in large-scale RNAi screens. Nat Methods (2006) 5.96
Hedgehog: functions and mechanisms. Genes Dev (2008) 5.69
The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling. Nat Genet (2009) 5.65
Stress fibers are generated by two distinct actin assembly mechanisms in motile cells. J Cell Biol (2006) 5.54
DNA-binding specificities of human transcription factors. Cell (2013) 5.14
A genome-wide perspective of genetic variation in human metabolism. Nat Genet (2009) 5.00
Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J (2010) 4.78
Mutations in dynein link motor neuron degeneration to defects in retrograde transport. Science (2003) 4.40
Counting absolute numbers of molecules using unique molecular identifiers. Nat Methods (2011) 4.18
Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects. Nat Genet (2008) 4.02
Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases. Proc Natl Acad Sci U S A (2010) 3.90
The European dimension for the mouse genome mutagenesis program. Nat Genet (2004) 3.84
A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell (2009) 3.63
Identification of pathways regulating cell size and cell-cycle progression by RNAi. Nature (2006) 3.60
Multiplexed massively parallel SELEX for characterization of human transcription factor binding specificities. Genome Res (2010) 3.46
MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas. Science (2011) 3.17
Actin-depolymerizing factor and cofilin-1 play overlapping roles in promoting rapid F-actin depolymerization in mammalian nonmuscle cells. Mol Biol Cell (2004) 3.15
Effects of G-protein mutations on skin color. Nat Genet (2004) 3.08
Missing-in-metastasis and IRSp53 deform PI(4,5)P2-rich membranes by an inverse BAR domain-like mechanism. J Cell Biol (2007) 3.05
An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice. Nat Genet (2009) 3.05
Transcription factor binding in human cells occurs in dense clusters formed around cohesin anchor sites. Cell (2013) 2.98
WH2 domain: a small, versatile adapter for actin monomers. FEBS Lett (2002) 2.85
EuroPhenome: a repository for high-throughput mouse phenotyping data. Nucleic Acids Res (2009) 2.72
Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration. PLoS Biol (2010) 2.72
Pathbase: a database of mutant mouse pathology. Nucleic Acids Res (2004) 2.66
Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer. Cancer Cell (2013) 2.64
Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors. Science (2012) 2.58
Molecular mechanisms of membrane deformation by I-BAR domain proteins. Curr Biol (2009) 2.47
Novel biomarkers for pre-diabetes identified by metabolomics. Mol Syst Biol (2012) 2.39
The epidermal growth factor receptor ligands at a glance. J Cell Physiol (2009) 2.35
Actin stress fibers--assembly, dynamics and biological roles. J Cell Sci (2012) 2.33
Beethoven, a mouse model for dominant, progressive hearing loss DFNA36. Nat Genet (2002) 2.31
A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis. Nat Genet (2003) 2.29
Regulation of the actin cytoskeleton-plasma membrane interplay by phosphoinositides. Physiol Rev (2010) 2.25
A molecular pathway for myosin II recruitment to stress fibers. Curr Biol (2011) 2.25
Rapamycin extends murine lifespan but has limited effects on aging. J Clin Invest (2013) 2.23
Defining mechanisms of actin polymerization and depolymerization during dendritic spine morphogenesis. J Cell Biol (2009) 2.21
Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity. Gastroenterology (2007) 2.15
Epigenetic marking correlates with developmental potential in cloned bovine preimplantation embryos. Curr Biol (2003) 2.14
Divergence of hedgehog signal transduction mechanism between Drosophila and mammals. Dev Cell (2006) 2.12
Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project. Mamm Genome (2012) 2.12
StellaTUM: current consensus and discussion on pancreatic stellate cell research. Gut (2011) 2.07
A mutation in hairless dogs implicates FOXI3 in ectodermal development. Science (2008) 2.06
The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma. Clin Gastroenterol Hepatol (2008) 2.05
Leiomodin is an actin filament nucleator in muscle cells. Science (2008) 2.05
A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains. Genome Biol (2013) 2.04
Regulation of cytoskeletal dynamics by actin-monomer-binding proteins. Trends Cell Biol (2004) 2.02
Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Mol Cell (2003) 2.02
Active delivery of trefoil factors by genetically modified Lactococcus lactis prevents and heals acute colitis in mice. Gastroenterology (2004) 1.99
IRSp53: crossing the road of membrane and actin dynamics in the formation of membrane protrusions. Trends Cell Biol (2008) 1.99
Introducing the German Mouse Clinic: open access platform for standardized phenotyping. Nat Methods (2005) 1.93
Liver mitochondrial membrane crosslinking and destruction in a rat model of Wilson disease. J Clin Invest (2011) 1.86
The three mouse actin-depolymerizing factor/cofilins evolved to fulfill cell-type-specific requirements for actin dynamics. Mol Biol Cell (2002) 1.85
Transcriptional network governing the angiogenic switch in human pancreatic cancer. Proc Natl Acad Sci U S A (2007) 1.85
Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype. Cancer Cell (2008) 1.82
RET tyrosine kinase signaling in development and cancer. Cytokine Growth Factor Rev (2005) 1.82
Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development. Mol Cell Biol (2005) 1.80
Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain. J Biol Chem (2002) 1.80
Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor. FASEB J (2003) 1.80
Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched. Cell (2002) 1.77
EMMA--mouse mutant resources for the international scientific community. Nucleic Acids Res (2009) 1.75
Structure of the actin-depolymerizing factor homology domain in complex with actin. J Cell Biol (2008) 1.75