Developmental and regional expression in the rat brain and functional properties of four NMDA receptors.

PubWeight™: 11.44‹?› | Rank: Top 0.1%

🔗 View Article (PMID 7512349)

Published in Neuron on March 01, 1994

Authors

H Monyer1, N Burnashev, D J Laurie, B Sakmann, P H Seeburg

Author Affiliations

1: Laboratory of Molecular Neuroscience, Heidelberg University, Federal Republic of Germany.

Articles citing this

(truncated to the top 100)

Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol (2007) 16.81

Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev (2010) 11.25

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease. Nat Rev Neurosci (2013) 4.35

Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132. Neuron (2010) 3.96

Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticity. Neuropharmacology (2008) 3.30

Dendritic glutamate receptor channels in rat hippocampal CA3 and CA1 pyramidal neurons. J Physiol (1995) 3.20

Synaptic control of motoneuronal excitability. Physiol Rev (2000) 2.93

Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles. J Physiol (2005) 2.90

Synaptic connections between layer 4 spiny neurone-layer 2/3 pyramidal cell pairs in juvenile rat barrel cortex: physiology and anatomy of interlaminar signalling within a cortical column. J Physiol (2002) 2.70

Fractional calcium currents through recombinant GluR channels of the NMDA, AMPA and kainate receptor subtypes. J Physiol (1995) 2.67

Reliable synaptic connections between pairs of excitatory layer 4 neurones within a single 'barrel' of developing rat somatosensory cortex. J Physiol (1999) 2.60

Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation. Nat Neurosci (2007) 2.56

Increased contribution of NR2A subunit to synaptic NMDA receptors in developing rat cortical neurons. J Physiol (1998) 2.50

NMDA receptor surface mobility depends on NR2A-2B subunits. Proc Natl Acad Sci U S A (2006) 2.31

Single-channel activations and concentration jumps: comparison of recombinant NR1a/NR2A and NR1a/NR2D NMDA receptors. J Physiol (1998) 2.26

Ionotropic and metabotropic glutamate receptor structure and pharmacology. Psychopharmacology (Berl) (2005) 2.25

Regulation of NMDA receptors by phosphorylation. Neuropharmacology (2007) 2.20

Control of NMDA receptor function by the NR2 subunit amino-terminal domain. J Neurosci (2009) 2.19

Balanced amplification: a new mechanism of selective amplification of neural activity patterns. Neuron (2009) 2.17

The impact of NMDA receptor hypofunction on GABAergic neurons in the pathophysiology of schizophrenia. Schizophr Res (2015) 2.14

The molecular and cellular biology of enhanced cognition. Nat Rev Neurosci (2009) 2.12

In vivo cocaine experience generates silent synapses. Neuron (2009) 2.11

Classification of fusiform neocortical interneurons based on unsupervised clustering. Proc Natl Acad Sci U S A (2000) 2.03

Triheteromeric NMDA receptors at hippocampal synapses. J Neurosci (2013) 2.01

Bidirectional, experience-dependent regulation of N-methyl-D-aspartate receptor subunit composition in the rat visual cortex during postnatal development. Proc Natl Acad Sci U S A (1999) 1.99

The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults. Neuron (2012) 1.97

NMDA di-heteromeric receptor populations and associated proteins in rat hippocampus. J Neurosci (2007) 1.95

Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential. Br J Pharmacol (2009) 1.94

Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit. EMBO J (2009) 1.92

Control of hippocampal gamma oscillation frequency by tonic inhibition and excitation of interneurons. Nat Neurosci (2009) 1.83

Bidirectional synaptic mechanisms of ocular dominance plasticity in visual cortex. Philos Trans R Soc Lond B Biol Sci (2009) 1.83

Dual palmitoylation of NR2 subunits regulates NMDA receptor trafficking. Neuron (2009) 1.81

NMDA receptors activated by subventricular zone astrocytic glutamate are critical for neuroblast survival prior to entering a synaptic network. Neuron (2010) 1.78

Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: single-cell NMDA receptor subunit deletion in vivo. Neuron (2011) 1.78

Metaplasticity at single glutamatergic synapses. Neuron (2010) 1.74

Tonic activation of NMDA receptors by ambient glutamate of non-synaptic origin in the rat hippocampus. J Physiol (2006) 1.74

Obligatory role of NR2A for metaplasticity in visual cortex. Neuron (2007) 1.72

Dimensions of the narrow portion of a recombinant NMDA receptor channel. Biophys J (1995) 1.72

Mg2+ imparts NMDA receptor subtype selectivity to the Alzheimer's drug memantine. J Neurosci (2009) 1.72

Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape 'superslow' afterburst EPSC in rat hippocampus. J Physiol (2004) 1.70

Differential trafficking of AMPA and NMDA receptors by SAP102 and PSD-95 underlies synapse development. Proc Natl Acad Sci U S A (2008) 1.68

A silent synapse-based mechanism for cocaine-induced locomotor sensitization. J Neurosci (2011) 1.68

Identification of a native low-conductance NMDA channel with reduced sensitivity to Mg2+ in rat central neurones. J Physiol (1996) 1.65

Triheteromeric NR1/NR2A/NR2B receptors constitute the major N-methyl-D-aspartate receptor population in adult hippocampal synapses. J Biol Chem (2010) 1.63

Synapse-specific expression of functional presynaptic NMDA receptors in rat somatosensory cortex. J Neurosci (2008) 1.61

Activation of the genetically defined m1 muscarinic receptor potentiates N-methyl-D-aspartate (NMDA) receptor currents in hippocampal pyramidal cells. Proc Natl Acad Sci U S A (1998) 1.61

NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1. Proc Natl Acad Sci U S A (2002) 1.59

Regulation of spine morphology and spine density by NMDA receptor signaling in vivo. Proc Natl Acad Sci U S A (2007) 1.58

Synaptic plasticity and phosphorylation. Pharmacol Ther (2006) 1.58

Treatment advances in neonatal neuroprotection and neurointensive care. Lancet Neurol (2011) 1.57

Activation of recombinant NR1/NR2C NMDA receptors. J Physiol (2008) 1.57

Age matters. Eur J Neurosci (2009) 1.56

Extrasynaptic and synaptic NMDA receptors form stable and uniform pools in rat hippocampal slices. J Physiol (2007) 1.56

Casein kinase 2 regulates the NR2 subunit composition of synaptic NMDA receptors. Neuron (2010) 1.55

GABAergic interneuron origin of schizophrenia pathophysiology. Neuropharmacology (2011) 1.55

Diversity in NMDA receptor composition: many regulators, many consequences. Neuroscientist (2012) 1.55

Mechanistic Insight into NMDA Receptor Dysregulation by Rare Variants in the GluN2A and GluN2B Agonist Binding Domains. Am J Hum Genet (2016) 1.54

Neuronal transporters regulate glutamate clearance, NMDA receptor activation, and synaptic plasticity in the hippocampus. J Neurosci (2009) 1.54

Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression. Prog Neuropsychopharmacol Biol Psychiatry (2008) 1.54

Control of assembly and function of glutamate receptors by the amino-terminal domain. Mol Pharmacol (2010) 1.54

The postsynaptic organization of synapses. Cold Spring Harb Perspect Biol (2011) 1.53

Rapid, bidirectional remodeling of synaptic NMDA receptor subunit composition by A-type K+ channel activity in hippocampal CA1 pyramidal neurons. Neuron (2008) 1.52

NMDA receptor subunit composition controls synaptogenesis and synapse stabilization. Proc Natl Acad Sci U S A (2011) 1.52

Presynaptic NMDA receptors: newly appreciated roles in cortical synaptic function and plasticity. Neuroscientist (2008) 1.51

Modulating synaptic NMDA receptors. Neuropharmacology (2016) 1.51

Molecular determinants of coordinated proton and zinc inhibition of N-methyl-D-aspartate NR1/NR2A receptors. Proc Natl Acad Sci U S A (2000) 1.50

Enhanced tyrosine phosphorylation of the 2B subunit of the N-methyl-D-aspartate receptor in long-term potentiation. Proc Natl Acad Sci U S A (1996) 1.50

Mechanisms of specificity in neuronal activity-regulated gene transcription. Prog Neurobiol (2011) 1.49

Revisiting the role of neurons in neurovascular coupling. Front Neuroenergetics (2010) 1.48

Synaptic NMDA receptors in developing mouse hippocampal neurones: functional properties and sensitivity to ifenprodil. J Physiol (1996) 1.48

mGluR5 and NMDA receptors drive the experience- and activity-dependent NMDA receptor NR2B to NR2A subunit switch. Neuron (2011) 1.45

MPX-004 and MPX-007: New Pharmacological Tools to Study the Physiology of NMDA Receptors Containing the GluN2A Subunit. PLoS One (2016) 1.45

Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl) piperazine-2,3-dicarboxylic acid. Br J Pharmacol (2004) 1.45

Uncoupling dendrite growth and patterning: single-cell knockout analysis of NMDA receptor 2B. Neuron (2009) 1.45

Cell type-specific development of NMDA receptors in the interneurons of rat prefrontal cortex. Neuropsychopharmacology (2009) 1.43

Deep molecular diversity of mammalian synapses: why it matters and how to measure it. Nat Rev Neurosci (2012) 1.40

NR2B- and NR2D-containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones. J Physiol (2007) 1.40

A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors. Nat Commun (2010) 1.38

Identification of subunits contributing to synaptic and extrasynaptic NMDA receptors in Golgi cells of the rat cerebellum. J Physiol (2000) 1.37

Distinct synaptic and extrasynaptic NMDA receptors identified in dorsal horn neurones of the adult rat spinal cord. J Physiol (2000) 1.37

Rethinking schizophrenia in the context of normal neurodevelopment. Front Cell Neurosci (2013) 1.33

NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. EMBO J (2006) 1.32

Mitochondrial mechanisms of cell death and neuroprotection in pediatric ischemic and traumatic brain injury. Exp Neurol (2009) 1.31

Dysbindin regulates hippocampal LTP by controlling NMDA receptor surface expression. Proc Natl Acad Sci U S A (2009) 1.31

Slow deactivation kinetics of NMDA receptors containing NR1 and NR2D subunits in rat cerebellar Purkinje cells. J Physiol (2000) 1.31

Functional insights from glutamate receptor ion channel structures. Annu Rev Physiol (2012) 1.30

Functional analysis of a de novo GRIN2A missense mutation associated with early-onset epileptic encephalopathy. Nat Commun (2014) 1.29

Switch to Ca2+-permeable AMPA and reduced NR2B NMDA receptor-mediated neurotransmission at dorsal horn nociceptive synapses during inflammatory pain in the rat. J Physiol (2007) 1.29

The unipolar brush cell: a remarkable neuron finally receiving deserved attention. Brain Res Rev (2010) 1.29

GRIN2A mutation and early-onset epileptic encephalopathy: personalized therapy with memantine. Ann Clin Transl Neurol (2014) 1.29

Dehydroepiandrosterone: a potential signalling molecule for neocortical organization during development. Proc Natl Acad Sci U S A (1998) 1.29

Allosteric modulators for the treatment of schizophrenia: targeting glutamatergic networks. Curr Top Med Chem (2013) 1.28

NMDA receptor activation by spontaneous glutamatergic neurotransmission. J Neurophysiol (2009) 1.28

Inhibition of NMDARs in the Nucleus Reticularis of the Thalamus Produces Delta Frequency Bursting. Front Neural Circuits (2009) 1.28

Genetic enhancement of memory and long-term potentiation but not CA1 long-term depression in NR2B transgenic rats. PLoS One (2009) 1.27

Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors. Nat Commun (2011) 1.26

The ratio of NR2A/B NMDA receptor subunits determines the qualities of ocular dominance plasticity in visual cortex. Proc Natl Acad Sci U S A (2009) 1.26

Hypoxia enhances S-nitrosylation-mediated NMDA receptor inhibition via a thiol oxygen sensor motif. Neuron (2007) 1.26

Cell-specific alterations of glutamate receptor expression in tuberous sclerosis complex cortical tubers. Ann Neurol (2008) 1.26

Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior. Nat Neurosci (2012) 1.25

Articles by these authors

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch (1981) 134.60

A system for shotgun DNA sequencing. Nucleic Acids Res (1981) 52.99

Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. DNA (1985) 40.01

Single-channel currents recorded from membrane of denervated frog muscle fibres. Nature (1976) 13.78

Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs. Science (1997) 13.11

Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin. Nature (1985) 13.04

Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue. Nature (1983) 10.64

Fast events in single-channel currents activated by acetylcholine and its analogues at the frog muscle end-plate. J Physiol (1985) 9.25

Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. Science (1985) 9.12

Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science (1995) 8.61

Nucleotide sequence and amplification in bacteria of structural gene for rat growth hormone. Nature (1977) 7.97

The primary structure and genetic organization of the bovine papillomavirus type 1 genome. Nature (1982) 7.24

Mechanism of anion permeation through channels gated by glycine and gamma-aminobutyric acid in mouse cultured spinal neurones. J Physiol (1987) 7.23

Fluctuations in the microsecond time range of the current through single acetylcholine receptor ion channels. Nature (1981) 7.16

A thin slice preparation for patch clamp recordings from neurones of the mammalian central nervous system. Pflugers Arch (1989) 6.98

RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell (1991) 6.97

Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist. Nature (1980) 6.83

Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2. Nature (2000) 6.67

Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science (1992) 6.49

Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance. Nature (1988) 6.35

Biological properties of human c-Ha-ras1 genes mutated at codon 12. Nature (1984) 6.21

Patch clamp measurements on Xenopus laevis oocytes: currents through endogenous channels and implanted acetylcholine receptor and sodium channels. Pflugers Arch (1986) 6.15

Physiology and anatomy of synaptic connections between thick tufted pyramidal neurones in the developing rat neocortex. J Physiol (1997) 5.94

Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene. Nature (1983) 5.90

Human leukocyte interferon produced by E. coli is biologically active. Nature (1980) 5.86

Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. EMBO J (1989) 5.66

RNA editing of AMPA receptor subunit GluR-B: a base-paired intron-exon structure determines position and efficiency. Cell (1993) 5.62

Patch-clamp recordings from the soma and dendrites of neurons in brain slices using infrared video microscopy. Pflugers Arch (1993) 5.33

Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli. Nature (1983) 5.27

Control of kinetic properties of AMPA receptor channels by nuclear RNA editing. Science (1994) 5.21

The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon. J Neurosci (1992) 5.02

Tripartite structure of the avian erythroblastosis virus E26 transforming gene. Nature (1984) 4.99

Interaction of RNA polymerase with promoters from bacteriophage fd. Eur J Biochem (1977) 4.94

Target-cell-specific facilitation and depression in neocortical circuits. Nat Neurosci (1998) 4.88

Active propagation of somatic action potentials into neocortical pyramidal cell dendrites. Nature (1994) 4.87

Multiple conductance states of single acetylcholine receptor channels in embryonic muscle cells. Nature (1981) 4.81

Conductance properties of single inwardly rectifying potassium channels in ventricular cells from guinea-pig heart. J Physiol (1984) 4.70

Ca2+ buffering and action potential-evoked Ca2+ signaling in dendrites of pyramidal neurons. Biophys J (1996) 4.58

Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning. Science (1999) 4.56

Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit. Neuron (1992) 4.53

The structure of eight distinct cloned human leukocyte interferon cDNAs. Nature (1981) 4.50

The distribution of thirteen GABAA receptor subunit mRNAs in the rat brain. III. Embryonic and postnatal development. J Neurosci (1992) 4.45

Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology. Nature (1989) 4.45

The extracellular patch clamp: a method for resolving currents through individual open channels in biological membranes. Pflugers Arch (1978) 4.42

Calcium influx and transmitter release in a fast CNS synapse. Nature (1996) 4.39

Expression of active human factor VIII from recombinant DNA clones. Nature (1984) 4.36

Molecular distinction between fetal and adult forms of muscle acetylcholine receptor. Nature (1986) 4.30

Activity-dependent action potential invasion and calcium influx into hippocampal CA1 dendrites. Science (1995) 4.29

Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS. Neuron (1995) 4.24

Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations. Nature (1983) 4.15

A new cellular mechanism for coupling inputs arriving at different cortical layers. Nature (1999) 4.10

Voltage-dependent inactivation of inward-rectifying single-channel currents in the guinea-pig heart cell membrane. J Physiol (1984) 4.08

Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. J Physiol (1993) 3.92

A mammalian RNA editing enzyme. Nature (1996) 3.90

A family of AMPA-selective glutamate receptors. Science (1990) 3.85

Direct expression in Escherichia coli of a DNA sequence coding for human growth hormone. Nature (1979) 3.80

Action potential initiation and backpropagation in neurons of the mammalian CNS. Trends Neurosci (1997) 3.69

Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. Science (1990) 3.53

Differential signal transduction by five splice variants of the PACAP receptor. Nature (1993) 3.38

Acetylcholine activation of single muscarinic K+ channels in isolated pacemaker cells of the mammalian heart. Nature (1983) 3.34

Activation of multiple-conductance state chloride channels in spinal neurones by glycine and GABA. Nature (1983) 3.32

Dendritic glutamate receptor channels in rat hippocampal CA3 and CA1 pyramidal neurons. J Physiol (1995) 3.20

Voltage-dependence of drug-induced conductance in frog neuromuscular junction. Proc Natl Acad Sci U S A (1975) 3.18

Action potential initiation and propagation in rat neocortical pyramidal neurons. J Physiol (1997) 3.18

Structural determinants of ion flow through recombinant glutamate receptor channels. Science (1991) 3.18

Construction and analysis of recombinant DNA for human chorionic somatomammotropin. Nature (1977) 3.13

Determinants of Ca2+ permeability in both TM1 and TM2 of high affinity kainate receptor channels: diversity by RNA editing. Neuron (1993) 3.08

Action of brief pulses of glutamate on AMPA/kainate receptors in patches from different neurones of rat hippocampal slices. J Physiol (1992) 3.06

Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family. Science (1989) 3.03

Pre- and postsynaptic whole-cell recordings in the medial nucleus of the trapezoid body of the rat. J Physiol (1995) 3.02

Dendritic calcium transients evoked by single back-propagating action potentials in rat neocortical pyramidal neurons. J Physiol (1995) 3.00

Calcium sensitivity of glutamate release in a calyx-type terminal. Science (2000) 2.98

The sequence of human serum albumin cDNA and its expression in E. coli. Nucleic Acids Res (1981) 2.97

Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA. Nature (1982) 2.96

Quantal analysis of inhibitory synaptic transmission in the dentate gyrus of rat hippocampal slices: a patch-clamp study. J Physiol (1990) 2.96

Effects of proteolytic enzymes on function and structure of frog neuromuscular junctions. J Physiol (1973) 2.95

Codon-improved Cre recombinase (iCre) expression in the mouse. Genesis (2002) 2.92

Patch clamp techniques for studying ionic channels in excitable membranes. Annu Rev Physiol (1984) 2.86

Heteromultimeric channels formed by rat brain potassium-channel proteins. Nature (1990) 2.83

Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice. Science (1995) 2.78

Calcium channel types with distinct presynaptic localization couple differentially to transmitter release in single calyx-type synapses. J Neurosci (1999) 2.77

Calcium action potentials restricted to distal apical dendrites of rat neocortical pyramidal neurons. J Physiol (1997) 2.77

The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor. EMBO J (1984) 2.77

Functional properties of recombinant rat GABAA receptors depend upon subunit composition. Neuron (1990) 2.75