Published in J Comb Chem on January 08, 2007
Scaling out by microwave-assisted, continuous flow organic synthesis (MACOS): multi-gram synthesis of bromo- and fluoro-benzofused sultams benzthiaoxazepine-1,1-dioxides. Chemistry (2010) 1.02
Application of a Double Aza-Michael Reaction in a 'Click, Click, Cy-Click' Strategy: From Bench to Flow. Synthesis (Stuttg) (2011) 0.92
Synthesis of amino-benzothiaoxazepine-1,1-dioxides utilizing a microwave-assisted, S(N)Ar protocol. ACS Comb Sci (2011) 0.84
Lithium-acetate-mediated Biginelli one-pot multicomponent synthesis under solvent-free conditions and cytotoxic activity against the human lung cancer cell line A549 and breast cancer cell line MCF7. ScientificWorldJournal (2012) 0.84
The development of a general strategy for the synthesis of tyramine-based natural products by using continuous flow techniques. Chemistry (2010) 0.83
Gold film-catalysed benzannulation by microwave-assisted, continuous flow organic synthesis (MACOS). Beilstein J Org Chem (2009) 0.78
In situ generation and intramolecular Schmidt reaction of keto azides in a microwave-assisted flow format. Chemistry (2011) 0.77
Synthesis of an Isoindoline-Annulated, Tricyclic Sultam Library via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS). Synthesis (Stuttg) (2012) 0.75
A new paradigm for designing ring construction strategies for green organic synthesis: implications for the discovery of multicomponent reactions to build molecules containing a single ring. Beilstein J Org Chem (2016) 0.75
Palladium complexes of N-heterocyclic carbenes as catalysts for cross-coupling reactions--a synthetic chemist's perspective. Angew Chem Int Ed Engl (2007) 2.11
Easily prepared air- and moisture-stable Pd-NHC (NHC=N-heterocyclic carbene) complexes: a reliable, user-friendly, highly active palladium precatalyst for the Suzuki-Miyaura reaction. Chemistry (2006) 1.55
The development of bulky palladium NHC complexes for the most-challenging cross-coupling reactions. Angew Chem Int Ed Engl (2012) 1.28
The first Negishi cross-coupling reaction of two alkyl centers utilizing a Pd-N-heterocyclic carbene (NHC) catalyst. Org Lett (2005) 1.15
Catalysis in capillaries by Pd thin films using microwave-assisted continuous-flow organic synthesis (MACOS). Angew Chem Int Ed Engl (2006) 1.12
A microreactor for microwave-assisted capillary (continuous flow) organic synthesis. J Am Chem Soc (2005) 1.06
Scaling out by microwave-assisted, continuous flow organic synthesis (MACOS): multi-gram synthesis of bromo- and fluoro-benzofused sultams benzthiaoxazepine-1,1-dioxides. Chemistry (2010) 1.02
Structure-activity relationship analysis of Pd-PEPPSI complexes in cross-couplings: a close inspection of the catalytic cycle and the precatalyst activation model. Chemistry (2010) 1.01
A microcapillary system for simultaneous, parallel microwave-assisted synthesis. Chemistry (2005) 0.98
Gold-film-catalysed hydrosilylation of alkynes by microwave-assisted, continuous-flow organic synthesis (MACOS). Chemistry (2008) 0.97
Regioselective cross-coupling of allylboronic acid pinacol ester derivatives with aryl halides via Pd-PEPPSI-IPent. J Am Chem Soc (2012) 0.97
Pd-PEPPSI-IPent(Cl): a highly effective catalyst for the selective cross-coupling of secondary organozinc reagents. Angew Chem Int Ed Engl (2012) 0.96
Diels-Alder cycloadditions by microwave-assisted, continuous flow organic synthesis (MACOS): the role of metal films in the flow tube. Chem Commun (Camb) (2007) 0.96
Pd PEPPSI-IPr-mediated reactions in metal-coated capillaries under MACOS: the synthesis of indoles by sequential aryl amination/Heck coupling. Chemistry (2008) 0.95
Propargyl amine synthesis catalysed by gold and copper thin films by using microwave-assisted continuous-flow organic synthesis (MACOS). Chemistry (2010) 0.94
Application of a Double Aza-Michael Reaction in a 'Click, Click, Cy-Click' Strategy: From Bench to Flow. Synthesis (Stuttg) (2011) 0.92
Higher-order zincates as transmetalators in alkyl-alkyl negishi cross-coupling. Angew Chem Int Ed Engl (2012) 0.89
Use of olefin templates in queued chemical transformations using late transition metal catalysis. Total synthesis of cis and trans bupleurynol via a single multireaction sequence. Org Lett (2004) 0.87
A 2.13 A structure of E. coli dihydrofolate reductase bound to a novel competitive inhibitor reveals a new binding surface involving the M20 loop region. J Med Chem (2006) 0.86
Synthesis of a unique isoindoline/tetrahydroisoquinoline-based tricyclic sultam library utilizing a Heck-aza-Michael strategy. ACS Comb Sci (2012) 0.85
Negishi cross-coupling of secondary alkylzinc halides with aryl/heteroaryl halides using Pd-PEPPSI-IPent. Chem Commun (Camb) (2011) 0.85
Synthesis of amino-benzothiaoxazepine-1,1-dioxides utilizing a microwave-assisted, S(N)Ar protocol. ACS Comb Sci (2011) 0.84
Amination with Pd-NHC complexes: rate and computational studies on the effects of the oxidative addition partner. Chemistry (2011) 0.83
The development of a general strategy for the synthesis of tyramine-based natural products by using continuous flow techniques. Chemistry (2010) 0.83
High yielding alkylations of unactivated sp3 and sp2 centres with alkyl-9-BBN reagents using an NHC-based catalyst: Pd-PEPPSI-IPrf. Chem Commun (Camb) (2008) 0.82
Room-temperature Negishi cross-coupling of unactivated alkyl bromides with alkyl organozinc reagents utilizing a Pd/N-heterocyclic carbene catalyst. J Org Chem (2005) 0.82
An efficient low-temperature Stille-Migita cross-coupling reaction for heteroaromatic compounds by Pd-PEPPSI-IPent. Chemistry (2010) 0.82
Pd-PEPPSI-IPent: low-temperature negishi cross-coupling for the preparation of highly functionalized, tetra-ortho-substituted biaryls. Angew Chem Int Ed Engl (2010) 0.79
Allylic ionization versus oxidative addition into vinyl C-X bonds by Pd with polyfunctional olefin templates. J Am Chem Soc (2004) 0.79
An expedient and facile one-step synthesis of a biguanide library by microwave irradiation coupled with simple product filtration. Inhibitors of dihydrofolate reductase. J Comb Chem (2004) 0.79
On the remarkably different role of salt in the cross-coupling of arylzincs from that seen with alkylzincs. Angew Chem Int Ed Engl (2014) 0.79
Facile (triazolyl)methylation of MACOS-derived benzofused sultams utilizing ROMP-derived OTP reagents. ACS Comb Sci (2012) 0.79
Electronic nature of N-heterocyclic carbene ligands: effect on the Suzuki reaction. Org Lett (2005) 0.78
Automated synthesis of a library of triazolated 1,2,5-thiadiazepane 1,1-dioxides via a double aza-Michael strategy. ACS Comb Sci (2012) 0.78
Gold film-catalysed benzannulation by microwave-assisted, continuous flow organic synthesis (MACOS). Beilstein J Org Chem (2009) 0.78
Differentiating C-Br and C-Cl bond activation by using solvent polarity: applications to orthogonal alkyl-alkyl Negishi reactions. Angew Chem Int Ed Engl (2011) 0.78
Potassium 2,2,5,7,8-pentamethylchroman-6-oxide: a rationally designed base for Pd-catalysed amination. Chemistry (2011) 0.77
In situ generation and intramolecular Schmidt reaction of keto azides in a microwave-assisted flow format. Chemistry (2011) 0.77
Room-temperature amination of deactivated aniline and aryl halide partners with carbonate base using a Pd-PEPPSI-IPentCl-o-picoline catalyst. Angew Chem Int Ed Engl (2014) 0.77
Pd-PEPPSI-IPent(Cl): an effective catalyst for the preparation of triarylamines. Chemistry (2012) 0.77
Amination with Pd-NHC complexes: rate and computational studies involving substituted aniline substrates. Chemistry (2011) 0.76
On the role of additives in alkyl-alkyl Negishi cross-couplings. Chem Commun (Camb) (2010) 0.76
[(IPent)PdCl2(morpholine)]: a readily activated precatalyst for room-temperature, additive-free carbon-sulfur coupling. Chemistry (2014) 0.76
Sulfination by using Pd-PEPPSI complexes: studies into precatalyst activation, cationic and solvent effects and the role of butoxide base. Chemistry (2013) 0.75
Synthesis of an Isoindoline-Annulated, Tricyclic Sultam Library via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS). Synthesis (Stuttg) (2012) 0.75
Potassium isopropoxide: for sulfination it is the only base you need! Chemistry (2013) 0.75
Pronounced solvent effect on the hydrostannylation of propargylic alcohol derivatives with nBu3SnH/Et3B at room temperature. Chemistry (2013) 0.75
Formation of substituted pyrroles via an imine condensation/Aza-Claisen rearrangement/imine-allene cyclization process by MAOS. J Comb Chem (2007) 0.75
Sterically demanding imidazolinium salts through the activation and cyclization of formamides. Chem Commun (Camb) (2012) 0.75
Assessing synthetic strategies: total syntheses of (+/-)-neodolabellane-type diterpenoids. Chemistry (2008) 0.75
Kinetic versus thermodynamic stereoselectivity in the hydrostannylation of propargylic alcohol derivatives using AIBN and Et3B as promotors. Chemistry (2012) 0.75
Multicomponent, flow diazotization/Mizoroki-Heck coupling protocol: dispelling myths about working with diazonium salts. Chemistry (2014) 0.75
Studies on the mechanism of B(C6F5)3-catalyzed hydrostannylation of propargylic alcohol derivatives. Angew Chem Int Ed Engl (2012) 0.75
Thermodynamic and NMR analysis of inhibitor binding to dihydrofolate reductase. Bioorg Med Chem (2010) 0.75
Solvent choice and kinetic isotope effects (KIEs) dramatically alter regioselectivity in the directed ortho metalation (DoM) of 1,5-dichloro-2,4-dimethoxybenzene. Chemistry (2014) 0.75
On the hydrostannylation of aryl propargylic alcohols and their derivatives: remarkable differences in both regio- and stereoselectivity in radical- and nonradical-mediated transformations. Chemistry (2014) 0.75
Cross-coupling of primary amides to aryl- and heteroaryl-partners using (DiMeIHeptCl)Pd promoted by trialkylboranes or BCF. J Am Chem Soc (2017) 0.75
Highly stereo- and regioselective hydrostannylation of internal alkynes promoted by simple boric acid in air. Chemistry (2012) 0.75
Carbon-sulfur bond formation of challenging substrates at low temperature by using Pd-PEPPSI-IPent. Chemistry (2011) 0.75
2,2'-Azobis(2-methylpropionitrile)-mediated alkyne hydrostannylation: reaction mechanism. Angew Chem Int Ed Engl (2013) 0.75
Density functional theory investigation of the alkyl-alkyl Negishi cross-coupling reaction catalyzed by N-heterocyclic carbene (NHC)-Pd complexes. Chemistry (2009) 0.75
Identification of a higher-order organozincate intermediate involved in Negishi cross-coupling reactions by mass spectrometry and NMR spectroscopy. Chemistry (2011) 0.75
Quantitative affinity electrophoresis of RNA-small molecule interactions by cross-linking the ligand to acrylamide. Anal Biochem (2013) 0.75