Published in Chemistry on April 12, 2010
Highly reactive, single-component nickel catalyst precursor for Suzuki-Miyuara cross-coupling of heteroaryl boronic acids with heteroaryl halides. Angew Chem Int Ed Engl (2012) 0.98
Stille coupling via C-N bond cleavage. Nat Commun (2016) 0.88
Transitioning organic synthesis from organic solvents to water. What's your E Factor? Green Chem (2014) 0.79
Palladium complexes of N-heterocyclic carbenes as catalysts for cross-coupling reactions--a synthetic chemist's perspective. Angew Chem Int Ed Engl (2007) 2.11
Easily prepared air- and moisture-stable Pd-NHC (NHC=N-heterocyclic carbene) complexes: a reliable, user-friendly, highly active palladium precatalyst for the Suzuki-Miyaura reaction. Chemistry (2006) 1.55
The development of bulky palladium NHC complexes for the most-challenging cross-coupling reactions. Angew Chem Int Ed Engl (2012) 1.28
The first Negishi cross-coupling reaction of two alkyl centers utilizing a Pd-N-heterocyclic carbene (NHC) catalyst. Org Lett (2005) 1.15
Catalysis in capillaries by Pd thin films using microwave-assisted continuous-flow organic synthesis (MACOS). Angew Chem Int Ed Engl (2006) 1.12
A microreactor for microwave-assisted capillary (continuous flow) organic synthesis. J Am Chem Soc (2005) 1.06
Multicomponent reactions to form heterocycles by microwave-assisted continuous flow organic synthesis. J Comb Chem (2007) 1.05
Scaling out by microwave-assisted, continuous flow organic synthesis (MACOS): multi-gram synthesis of bromo- and fluoro-benzofused sultams benzthiaoxazepine-1,1-dioxides. Chemistry (2010) 1.02
Structure-activity relationship analysis of Pd-PEPPSI complexes in cross-couplings: a close inspection of the catalytic cycle and the precatalyst activation model. Chemistry (2010) 1.01
A microcapillary system for simultaneous, parallel microwave-assisted synthesis. Chemistry (2005) 0.98
Gold-film-catalysed hydrosilylation of alkynes by microwave-assisted, continuous-flow organic synthesis (MACOS). Chemistry (2008) 0.97
Regioselective cross-coupling of allylboronic acid pinacol ester derivatives with aryl halides via Pd-PEPPSI-IPent. J Am Chem Soc (2012) 0.97
Pd-PEPPSI-IPent(Cl): a highly effective catalyst for the selective cross-coupling of secondary organozinc reagents. Angew Chem Int Ed Engl (2012) 0.96
Diels-Alder cycloadditions by microwave-assisted, continuous flow organic synthesis (MACOS): the role of metal films in the flow tube. Chem Commun (Camb) (2007) 0.96
Pd PEPPSI-IPr-mediated reactions in metal-coated capillaries under MACOS: the synthesis of indoles by sequential aryl amination/Heck coupling. Chemistry (2008) 0.95
Propargyl amine synthesis catalysed by gold and copper thin films by using microwave-assisted continuous-flow organic synthesis (MACOS). Chemistry (2010) 0.94
Application of a Double Aza-Michael Reaction in a 'Click, Click, Cy-Click' Strategy: From Bench to Flow. Synthesis (Stuttg) (2011) 0.92
Higher-order zincates as transmetalators in alkyl-alkyl negishi cross-coupling. Angew Chem Int Ed Engl (2012) 0.89
Use of olefin templates in queued chemical transformations using late transition metal catalysis. Total synthesis of cis and trans bupleurynol via a single multireaction sequence. Org Lett (2004) 0.87
A 2.13 A structure of E. coli dihydrofolate reductase bound to a novel competitive inhibitor reveals a new binding surface involving the M20 loop region. J Med Chem (2006) 0.86
Synthesis of a unique isoindoline/tetrahydroisoquinoline-based tricyclic sultam library utilizing a Heck-aza-Michael strategy. ACS Comb Sci (2012) 0.85
Negishi cross-coupling of secondary alkylzinc halides with aryl/heteroaryl halides using Pd-PEPPSI-IPent. Chem Commun (Camb) (2011) 0.85
Synthesis of amino-benzothiaoxazepine-1,1-dioxides utilizing a microwave-assisted, S(N)Ar protocol. ACS Comb Sci (2011) 0.84
Amination with Pd-NHC complexes: rate and computational studies on the effects of the oxidative addition partner. Chemistry (2011) 0.83
The development of a general strategy for the synthesis of tyramine-based natural products by using continuous flow techniques. Chemistry (2010) 0.83
Room-temperature Negishi cross-coupling of unactivated alkyl bromides with alkyl organozinc reagents utilizing a Pd/N-heterocyclic carbene catalyst. J Org Chem (2005) 0.82
High yielding alkylations of unactivated sp3 and sp2 centres with alkyl-9-BBN reagents using an NHC-based catalyst: Pd-PEPPSI-IPrf. Chem Commun (Camb) (2008) 0.82
Allylic ionization versus oxidative addition into vinyl C-X bonds by Pd with polyfunctional olefin templates. J Am Chem Soc (2004) 0.79
Facile (triazolyl)methylation of MACOS-derived benzofused sultams utilizing ROMP-derived OTP reagents. ACS Comb Sci (2012) 0.79
An expedient and facile one-step synthesis of a biguanide library by microwave irradiation coupled with simple product filtration. Inhibitors of dihydrofolate reductase. J Comb Chem (2004) 0.79
Pd-PEPPSI-IPent: low-temperature negishi cross-coupling for the preparation of highly functionalized, tetra-ortho-substituted biaryls. Angew Chem Int Ed Engl (2010) 0.79
On the remarkably different role of salt in the cross-coupling of arylzincs from that seen with alkylzincs. Angew Chem Int Ed Engl (2014) 0.79
Differentiating C-Br and C-Cl bond activation by using solvent polarity: applications to orthogonal alkyl-alkyl Negishi reactions. Angew Chem Int Ed Engl (2011) 0.78
Electronic nature of N-heterocyclic carbene ligands: effect on the Suzuki reaction. Org Lett (2005) 0.78
Automated synthesis of a library of triazolated 1,2,5-thiadiazepane 1,1-dioxides via a double aza-Michael strategy. ACS Comb Sci (2012) 0.78
Gold film-catalysed benzannulation by microwave-assisted, continuous flow organic synthesis (MACOS). Beilstein J Org Chem (2009) 0.78
Potassium 2,2,5,7,8-pentamethylchroman-6-oxide: a rationally designed base for Pd-catalysed amination. Chemistry (2011) 0.77
In situ generation and intramolecular Schmidt reaction of keto azides in a microwave-assisted flow format. Chemistry (2011) 0.77
Room-temperature amination of deactivated aniline and aryl halide partners with carbonate base using a Pd-PEPPSI-IPentCl-o-picoline catalyst. Angew Chem Int Ed Engl (2014) 0.77
Pd-PEPPSI-IPent(Cl): an effective catalyst for the preparation of triarylamines. Chemistry (2012) 0.77
Amination with Pd-NHC complexes: rate and computational studies involving substituted aniline substrates. Chemistry (2011) 0.76
On the role of additives in alkyl-alkyl Negishi cross-couplings. Chem Commun (Camb) (2010) 0.76
[(IPent)PdCl2(morpholine)]: a readily activated precatalyst for room-temperature, additive-free carbon-sulfur coupling. Chemistry (2014) 0.76
Sulfination by using Pd-PEPPSI complexes: studies into precatalyst activation, cationic and solvent effects and the role of butoxide base. Chemistry (2013) 0.75
Synthesis of an Isoindoline-Annulated, Tricyclic Sultam Library via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS). Synthesis (Stuttg) (2012) 0.75
Carbon-sulfur bond formation of challenging substrates at low temperature by using Pd-PEPPSI-IPent. Chemistry (2011) 0.75
Thermodynamic and NMR analysis of inhibitor binding to dihydrofolate reductase. Bioorg Med Chem (2010) 0.75
Multicomponent, flow diazotization/Mizoroki-Heck coupling protocol: dispelling myths about working with diazonium salts. Chemistry (2014) 0.75
Density functional theory investigation of the alkyl-alkyl Negishi cross-coupling reaction catalyzed by N-heterocyclic carbene (NHC)-Pd complexes. Chemistry (2009) 0.75
Potassium isopropoxide: for sulfination it is the only base you need! Chemistry (2013) 0.75
Studies on the mechanism of B(C6F5)3-catalyzed hydrostannylation of propargylic alcohol derivatives. Angew Chem Int Ed Engl (2012) 0.75
Identification of a higher-order organozincate intermediate involved in Negishi cross-coupling reactions by mass spectrometry and NMR spectroscopy. Chemistry (2011) 0.75
Assessing synthetic strategies: total syntheses of (+/-)-neodolabellane-type diterpenoids. Chemistry (2008) 0.75
Kinetic versus thermodynamic stereoselectivity in the hydrostannylation of propargylic alcohol derivatives using AIBN and Et3B as promotors. Chemistry (2012) 0.75
2,2'-Azobis(2-methylpropionitrile)-mediated alkyne hydrostannylation: reaction mechanism. Angew Chem Int Ed Engl (2013) 0.75
Sterically demanding imidazolinium salts through the activation and cyclization of formamides. Chem Commun (Camb) (2012) 0.75
Quantitative affinity electrophoresis of RNA-small molecule interactions by cross-linking the ligand to acrylamide. Anal Biochem (2013) 0.75
Formation of substituted pyrroles via an imine condensation/Aza-Claisen rearrangement/imine-allene cyclization process by MAOS. J Comb Chem (2007) 0.75
Highly stereo- and regioselective hydrostannylation of internal alkynes promoted by simple boric acid in air. Chemistry (2012) 0.75
Pronounced solvent effect on the hydrostannylation of propargylic alcohol derivatives with nBu3SnH/Et3B at room temperature. Chemistry (2013) 0.75
Solvent choice and kinetic isotope effects (KIEs) dramatically alter regioselectivity in the directed ortho metalation (DoM) of 1,5-dichloro-2,4-dimethoxybenzene. Chemistry (2014) 0.75
Cross-coupling of primary amides to aryl- and heteroaryl-partners using (DiMeIHeptCl)Pd promoted by trialkylboranes or BCF. J Am Chem Soc (2017) 0.75
On the hydrostannylation of aryl propargylic alcohols and their derivatives: remarkable differences in both regio- and stereoselectivity in radical- and nonradical-mediated transformations. Chemistry (2014) 0.75