Published in Mol Cell Neurosci on January 10, 2007
Generation of dopamine neurons with improved cell survival and phenotype maintenance using a degradation-resistant nurr1 mutant. Stem Cells (2009) 0.92
Conditions for tumor-free and dopamine neuron-enriched grafts after transplanting human ES cell-derived neural precursor cells. Mol Ther (2009) 0.89
In vitro and in vivo enhanced generation of human A9 dopamine neurons from neural stem cells by Bcl-XL. J Biol Chem (2010) 0.88
Immortalization of neuronal progenitors using SV40 large T antigen and differentiation towards dopaminergic neurons. J Cell Mol Med (2012) 0.76
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation. Nat Med (2008) 6.90
The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg. Neuron (2003) 4.49
α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells. J Clin Invest (2011) 3.53
Caspase signalling controls microglia activation and neurotoxicity. Nature (2011) 3.44
Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease. Neuron (2002) 3.15
Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein. Nat Rev Neurosci (2002) 2.93
A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease. J Exp Med (2008) 2.78
Beyond the brain: widespread pathology in Huntington's disease. Lancet Neurol (2009) 1.83
Dyskinesias following neural transplantation in Parkinson's disease. Nat Neurosci (2002) 1.74
Involvement of Ngn2, Tbr and NeuroD proteins during postnatal olfactory bulb neurogenesis. Eur J Neurosci (2009) 1.71
Neural transplantation for the treatment of Parkinson's disease. Lancet Neurol (2003) 1.64
Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line. J Biol Chem (2002) 1.64
Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in mice. Behav Brain Res (2005) 1.56
Are synucleinopathies prion-like disorders? Lancet Neurol (2010) 1.54
Stem cells: hype or hope? Drug Discov Today (2002) 1.48
Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease. Mov Disord (2010) 1.47
No evidence for new dopaminergic neurons in the adult mammalian substantia nigra. Proc Natl Acad Sci U S A (2004) 1.39
Critical issues of clinical human embryonic stem cell therapy for brain repair. Trends Neurosci (2008) 1.37
Parkinson's disease and alpha synuclein: is Parkinson's disease a prion-like disorder? Mov Disord (2013) 1.34
Orexin loss in Huntington's disease. Hum Mol Genet (2004) 1.33
The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies. NeuroRx (2005) 1.33
Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease. Hum Mol Genet (2002) 1.33
Neuronal properties, in vivo effects, and pathology of a Huntington's disease patient-derived induced pluripotent stem cells. Stem Cells (2012) 1.32
Reproductive health surveillance in the US-Mexico border region, 2003-2006: the Brownsville-Matamoros Sister City Project for Women's Health. Prev Chronic Dis (2008) 1.31
Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway. J Neurosci (2005) 1.31
Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice. Acta Neuropathol (2013) 1.30
The adult human brain harbors multipotent perivascular mesenchymal stem cells. PLoS One (2012) 1.30
Endothelial proliferation and increased blood-brain barrier permeability in the basal ganglia in a rat model of 3,4-dihydroxyphenyl-L-alanine-induced dyskinesia. J Neurosci (2006) 1.28
Hsa-miR-34b is a plasma-stable microRNA that is elevated in pre-manifest Huntington's disease. Hum Mol Genet (2011) 1.25
Alpha-synuclein transfers from neurons to oligodendrocytes. Glia (2013) 1.25
The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient beta-cell mass and exocytosis. Hum Mol Genet (2005) 1.24
Stage-specific modulation of cortical neuronal development by Mmu-miR-134. Cereb Cortex (2011) 1.19
Neurogenin2 directs granule neuroblast production and amplification while NeuroD1 specifies neuronal fate during hippocampal neurogenesis. PLoS One (2009) 1.19
Cholinergic neuronal defect without cell loss in Huntington's disease. Hum Mol Genet (2006) 1.17
Huntington's disease: a synaptopathy? Trends Mol Med (2003) 1.16
Progressive alterations in the hypothalamic-pituitary-adrenal axis in the R6/2 transgenic mouse model of Huntington's disease. Hum Mol Genet (2006) 1.15
Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo. PLoS One (2012) 1.15
The effect of alpha-synuclein knockdown on MPP+ toxicity in models of human neurons. Eur J Neurosci (2008) 1.13
Reduced hippocampal neurogenesis in R6/2 transgenic Huntington's disease mice. Neurobiol Dis (2005) 1.12
Increased metabolism in the R6/2 mouse model of Huntington's disease. Neurobiol Dis (2007) 1.11
Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression. Brain Res (2003) 1.10
Can Parkinson's disease pathology be propagated from one neuron to another? Prog Neurobiol (2011) 1.08
Dissecting the potential molecular mechanisms underlying alpha-synuclein cell-to-cell transfer in Parkinson's disease. Parkinsonism Relat Disord (2009) 1.07
Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing. ALTEX (2010) 1.06
Foxa2 and Nurr1 synergistically yield A9 nigral dopamine neurons exhibiting improved differentiation, function, and cell survival. Stem Cells (2010) 1.06
Emerging restorative treatments for Parkinson's disease. Prog Neurobiol (2008) 1.06
Inflammation and α-synuclein's prion-like behavior in Parkinson's disease--is there a link? Mol Neurobiol (2012) 1.04
From bench to bed: the potential of stem cells for the treatment of Parkinson's disease. Cell Tissue Res (2007) 1.03
Failure of transdifferentiation of adult hematopoietic stem cells into neurons. Stem Cells (2006) 1.02
Effects on differentiation of embryonic ventral midbrain progenitors by Lmx1a, Msx1, Ngn2, and Pitx3. J Neurosci (2008) 1.02
α-Synuclein: the long distance runner. Brain Pathol (2013) 0.99
Membrane interaction of α-synuclein in different aggregation states. J Parkinsons Dis (2011) 0.98
Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment. Proc Natl Acad Sci U S A (2009) 0.98
Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor. Bioorg Med Chem Lett (2011) 0.98
Loss of SNAP-25 and rabphilin 3a in sensory-motor cortex in Huntington's disease. J Neurochem (2007) 0.97
Reduced neurogenesis in the rat hippocampus following high fructose consumption. Regul Pept (2010) 0.96
Signs of degeneration in 12-22-year old grafts of mesencephalic dopamine neurons in patients with Parkinson's disease. J Parkinsons Dis (2011) 0.95
Disparities in fetal death and first day death: the influence of risk factors in 2 time periods. Am J Public Health (2012) 0.94
Systemic administration of neuregulin-1β1 protects dopaminergic neurons in a mouse model of Parkinson's disease. J Neurochem (2011) 0.94
The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy. ALTEX (2008) 0.93
Nitric oxide stimulates the proliferation of neural stem cells bypassing the epidermal growth factor receptor. Stem Cells (2010) 0.92
GABAergic differentiation induced by Mash1 is compromised by the bHLH proteins Neurogenin2, NeuroD1, and NeuroD2. Cereb Cortex (2009) 0.92
Induction of dopaminergic neurons from growth factor expanded neural stem/progenitor cell cultures derived from human first trimester forebrain. Brain Res Bull (2006) 0.91
Calpain activation is involved in early caspase-independent neurodegeneration in the hippocampus following status epilepticus. J Neurochem (2007) 0.91
Reduction of GnRH and infertility in the R6/2 mouse model of Huntington's disease. Eur J Neurosci (2005) 0.90
Enriched environment attenuates cell genesis in subventricular zone after focal ischemia in mice and decreases migration of newborn cells to the striatum. Stroke (2006) 0.90
Microchannel acoustophoresis does not impact survival or function of microglia, leukocytes or tumor cells. PLoS One (2013) 0.90
Gastrointestinal dysfunction contributes to weight loss in Huntington's disease mice. Neurobiol Dis (2011) 0.89
Mutant huntingtin interacts with {beta}-tubulin and disrupts vesicular transport and insulin secretion. Hum Mol Genet (2009) 0.89
Adsorption of α-synuclein to supported lipid bilayers: positioning and role of electrostatics. ACS Chem Neurosci (2013) 0.89
Midbrain expression of Delta-like 1 homologue is regulated by GDNF and is associated with dopaminergic differentiation. Exp Neurol (2007) 0.88
Increased thirst and drinking in Huntington's disease and the R6/2 mouse. Brain Res Bull (2008) 0.88
Low pregnancy weight gain and small for gestational age: a comparison of the association using 3 different measures of small for gestational age. Am J Obstet Gynecol (2009) 0.88
"NeuroStem Chip": a novel highly specialized tool to study neural differentiation pathways in human stem cells. BMC Genomics (2007) 0.88
Rasagiline ameliorates olfactory deficits in an alpha-synuclein mouse model of Parkinson's disease. PLoS One (2013) 0.87
Asialoerythropoietin is not effective in the R6/2 line of Huntington's disease mice. BMC Neurosci (2004) 0.87
Large stem cell grafts could lead to erroneous interpretations of behavioral results? Nat Med (2007) 0.87
Stem cell-based therapy for Parkinson's disease. Ann Med (2005) 0.87
The Importance of Graft Placement and Task Complexity for Transplant-Induced Recovery of Simple and Complex Sensorimotor Deficits in Dopamine Denervated Rats. Eur J Neurosci (1990) 0.86
Mind the gut: secretion of α-synuclein by enteric neurons. J Neurochem (2013) 0.86
Cervical cancer screening in the US-Mexico border region: a binational analysis. Matern Child Health J (2012) 0.86
Cell transplantation in Parkinson's disease: problems and perspectives. Curr Opin Neurol (2010) 0.85
What's to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease? Prion (2013) 0.85
Lentiviral gene delivery of GDNF into the striatum of R6/2 Huntington mice fails to attenuate behavioral and neuropathological changes. Exp Neurol (2005) 0.85
Propagation of host disease to grafted neurons: accumulating evidence. Exp Neurol (2009) 0.85
Proteolysis of NR2B by calpain in the hippocampus of epileptic rats. Neuroreport (2005) 0.85
Fibroblast growth factor-20 increases the yield of midbrain dopaminergic neurons derived from human embryonic stem cells. Front Neuroanat (2007) 0.84
Absence of striatal newborn neurons with mature phenotype following defined striatal and cortical excitotoxic brain injuries. Exp Neurol (2009) 0.84
Depletion of rabphilin 3A in a transgenic mouse model (R6/1) of Huntington's disease, a possible culprit in synaptic dysfunction. Neurobiol Dis (2005) 0.84
Identification of molecules derived from human fibroblast feeder cells that support the proliferation of human embryonic stem cells. Cell Mol Biol Lett (2010) 0.84
Decreased VIP and VPAC2 receptor expression in the biological clock of the R6/2 Huntington's disease mouse. J Mol Neurosci (2007) 0.84