Published in J Biol Chem on January 27, 2010
Optimization of the magnetic labeling of human neural stem cells and MRI visualization in the hemiparkinsonian rat brain. J Nanobiotechnology (2015) 0.85
Tracking of iron-labeled human neural stem cells by magnetic resonance imaging in cell replacement therapy for Parkinson's disease. Neural Regen Res (2016) 0.84
Intermediate progenitors are increased by lengthening of the cell cycle through calcium signaling and p53 expression in human neural progenitors. Mol Biol Cell (2012) 0.84
Clonal human fetal ventral mesencephalic dopaminergic neuron precursors for cell therapy research. PLoS One (2012) 0.80
Mineralocorticoid receptor overexpression facilitates differentiation and promotes survival of embryonic stem cell-derived neurons. Endocrinology (2012) 0.79
Influence of oxygen tension on dopaminergic differentiation of human fetal stem cells of midbrain and forebrain origin. PLoS One (2014) 0.79
Adult human olfactory epithelial-derived progenitors: a potential autologous source for cell-based treatment for Parkinson's disease. Stem Cells Transl Med (2012) 0.77
Midbrain dopamine neurons in Parkinson's disease exhibit a dysregulated miRNA and target-gene network. Brain Res (2015) 0.76
Immortalization of neuronal progenitors using SV40 large T antigen and differentiation towards dopaminergic neurons. J Cell Mol Med (2012) 0.76
bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell (1993) 14.39
The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radic Biol Med (1989) 5.10
Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease. Nat Med (2002) 3.31
Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms. Cell (2001) 2.93
BLOCKADE OF ENDOGENOUS NOREPINEPHRINE SYNTHESIS BY ALPHA-METHYL-TYROSINE, AN INHIBITOR OF TYROSINE HYDROXYLASE. J Pharmacol Exp Ther (1965) 2.82
Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years. Nat Med (2008) 2.80
Targeting programmed cell death in neurodegenerative diseases. Nat Rev Neurosci (2003) 2.31
A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b. Nat Neurosci (2000) 2.20
Differential development of neuronal physiological responsiveness in two human neural stem cell lines. BMC Neurosci (2007) 1.88
Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype. Proc Natl Acad Sci U S A (2006) 1.69
Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections. J Neurosci (2005) 1.67
Neural stem cell differentiation is dependent upon endogenous caspase 3 activity. FASEB J (2005) 1.65
Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line. J Biol Chem (2002) 1.64
Neurogenin 2 is required for the development of ventral midbrain dopaminergic neurons. Development (2006) 1.58
Strengths and limitations of the neurosphere culture system. Mol Neurobiol (2006) 1.56
Prospects of stem cell therapy for replacing dopamine neurons in Parkinson's disease. Trends Pharmacol Sci (2009) 1.51
Cell transplantation in Parkinson's disease: how can we make it work? Trends Neurosci (2005) 1.51
Establishment and properties of a growth factor-dependent, perpetual neural stem cell line from the human CNS. Exp Neurol (2000) 1.46
bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death. Proc Natl Acad Sci U S A (1995) 1.40
Engrailed genes are cell-autonomously required to prevent apoptosis in mesencephalic dopaminergic neurons. Development (2004) 1.37
Regional specification of rodent and human neurospheres. Brain Res Dev Brain Res (2002) 1.34
Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway. J Neurosci (2005) 1.31
Bcl-x is required for proper development of the mouse substantia nigra. J Neurosci (2005) 1.30
Bcl-xL is an antiapoptotic regulator for postnatal CNS neurons. J Neurosci (1998) 1.29
BCL2 regulates neural differentiation. Proc Natl Acad Sci U S A (1996) 1.22
Neural precursors derived from human embryonic stem cells maintain long-term proliferation without losing the potential to differentiate into all three neural lineages, including dopaminergic neurons. J Neurochem (2007) 1.22
Long-term proliferation and dopaminergic differentiation of human mesencephalic neural precursor cells. Exp Neurol (2001) 1.21
p38 mitogen-activated protein kinase activity commits embryonic stem cells to either neurogenesis or cardiomyogenesis. Stem Cells (2006) 1.21
Survival and differentiation of rat and human epidermal growth factor-responsive precursor cells following grafting into the lesioned adult central nervous system. Exp Neurol (1996) 1.18
Is caspase-dependent apoptosis only cell differentiation taken to the extreme? FASEB J (2006) 1.17
Caspase-dependent and -independent neuronal death: two distinct pathways to neuronal injury. Neuroscientist (2005) 1.14
Transcriptional regulation of mesencephalic dopaminergic neurons: the full circle of life and death. Mov Disord (2008) 1.07
Neural precursors derived from embryonic stem cells, but not those from fetal ventral mesencephalon, maintain the potential to differentiate into dopaminergic neurons after expansion in vitro. Stem Cells (2006) 1.05
Bcl-2-related protein family gene expression during oligodendroglial differentiation. J Neurochem (2003) 1.05
From bench to bed: the potential of stem cells for the treatment of Parkinson's disease. Cell Tissue Res (2007) 1.03
Control of neurogenesis and tyrosine hydroxylase expression in neural progenitor cells through bHLH proteins and Nurr1. Exp Neurol (2006) 1.02
Apoptosis and differentiation commitment: novel insights revealed by gene profiling studies in mouse embryonic stem cells. Cell Death Differ (2006) 1.00
Enhanced in vitro midbrain dopamine neuron differentiation, dopaminergic function, neurite outgrowth, and 1-methyl-4-phenylpyridium resistance in mouse embryonic stem cells overexpressing Bcl-XL. J Neurosci (2004) 0.96
BCL-2 and BCL-XL restrict lineage choice during hematopoietic differentiation. J Biol Chem (2003) 0.96
Long-term molecular and cellular stability of human neural stem cell lines. Exp Cell Res (2004) 0.94
Mash1 and neurogenin 2 enhance survival and differentiation of neural precursor cells after transplantation to rat brains via distinct modes of action. Mol Ther (2008) 0.93
Bcl-XL/Bax proteins direct the fate of embryonic cortical precursor cells. Mol Cell Biol (2007) 0.92
Ngn2 and Nurr1 act in synergy to induce midbrain dopaminergic neurons from expanded neural stem and progenitor cells. Exp Cell Res (2006) 0.92
Induction of dopaminergic neurons from growth factor expanded neural stem/progenitor cell cultures derived from human first trimester forebrain. Brain Res Bull (2006) 0.91
Bcl2, a transcriptional target of p38alpha, is critical for neuronal commitment of mouse embryonic stem cells. Cell Death Differ (2008) 0.91
Genetically perpetuated human neural stem cells engraft and differentiate into the adult mammalian brain. Mol Cell Neurosci (2000) 0.90
Bcl-XL modulates the differentiation of immortalized human neural stem cells. Cell Death Differ (2007) 0.89
Conditions for tumor-free and dopamine neuron-enriched grafts after transplanting human ES cell-derived neural precursor cells. Mol Ther (2009) 0.89
The generation of dopaminergic neurons by human neural stem cells is enhanced by Bcl-XL, both in vitro and in vivo. J Neurosci (2004) 0.88
HDAC inhibition amplifies gap junction communication in neural progenitors: potential for cell-mediated enzyme prodrug therapy. Exp Cell Res (2007) 0.87
Apoptotic natural cell death in developing primate dopamine midbrain neurons occurs during a restricted period in the second trimester of gestation. Exp Neurol (2007) 0.86
Bcl-2 accelerates the neuronal differentiation: new evidence approaching to the biofunction of bcl-2 in the neuronal system. Brain Res (1998) 0.85
Heparin, but not other proteoglycans potentiates the mitogenic effects of FGF-2 on mesencephalic precursor cells. Exp Neurol (1998) 0.85
Generation and properties of a new human ventral mesencephalic neural stem cell line. Exp Cell Res (2009) 0.84
One year survival and significant reversal of motor deficits in parkinsonian rats transplanted with hESC derived dopaminergic neurons. Biochem Biophys Res Commun (2008) 0.82
Tyrosine hydroxylase expression is unstable in a human immortalized mesencephalic cell line--studies in vitro and after intracerebral grafting in vivo. Mol Cell Neurosci (2007) 0.80
Expansion and characterization of ventral mesencephalic precursor cells: effect of mitogens and investigation of FA1 as a potential dopaminergic marker. J Neurosci Res (2007) 0.80
Inhibition of JNK increases survival of transplanted dopamine neurons in Parkinsonian rats. Cell Death Differ (2006) 0.79
Schwann cell precursors from nerve innervation are a cellular origin of melanocytes in skin. Cell (2009) 2.53
Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells. Cell Stem Cell (2009) 1.84
Reduced N-acetylaspartate levels in mice lacking aralar, a brain- and muscle-type mitochondrial aspartate-glutamate carrier. J Biol Chem (2005) 1.42
[QFT utility in health personal]. Rev Chilena Infectol (2014) 1.39
Developmental changes in the Ca2+-regulated mitochondrial aspartate-glutamate carrier aralar1 in brain and prominent expression in the spinal cord. Brain Res Dev Brain Res (2003) 1.16
Wnt/beta-catenin signaling blockade promotes neuronal induction and dopaminergic differentiation in embryonic stem cells. Stem Cells (2009) 1.08
Essential role of aralar in the transduction of small Ca2+ signals to neuronal mitochondria. J Biol Chem (2005) 1.05
Neural progenitors organize in small-world networks to promote cell proliferation. Proc Natl Acad Sci U S A (2013) 1.01
Mesenchymal stem cells rescue Purkinje cells and improve motor functions in a mouse model of cerebellar ataxia. Neurobiol Dis (2010) 1.00
Role of aralar, the mitochondrial transporter of aspartate-glutamate, in brain N-acetylaspartate formation and Ca(2+) signaling in neuronal mitochondria. J Neurosci Res (2007) 0.99
Pyruvate protection against beta-amyloid-induced neuronal death: role of mitochondrial redox state. J Neurosci Res (2003) 0.98
Estradiol selectively stimulates endothelial prostacyclin production through estrogen receptor-{alpha}. J Mol Endocrinol (2010) 0.96
Intraneuronal trafficking of G-protein-coupled receptors in vivo. Trends Neurosci (2006) 0.94
Long-term molecular and cellular stability of human neural stem cell lines. Exp Cell Res (2004) 0.94
Ca2+ and cAMP signaling in human embryonic stem cell-derived dopamine neurons. Stem Cells Dev (2010) 0.94
Transcription of genes encoding synaptic vesicle proteins in human neural stem cells: chromatin accessibility, histone methylation pattern, and the essential role of rest. J Biol Chem (2008) 0.92
Mammalian target of rapamycin complex 1 is involved in differentiation of regenerating myofibers in vivo. Muscle Nerve (2010) 0.91
Impact of early developmental arsenic exposure on promotor CpG-island methylation of genes involved in neuronal plasticity. Neurochem Int (2011) 0.91
The generation of dopaminergic neurons by human neural stem cells is enhanced by Bcl-XL, both in vitro and in vivo. J Neurosci (2004) 0.88
Long term behavioral effects of functional dopaminergic neurons generated from human neural stem cells in the rat 6-OH-DA Parkinson's disease model. Effects of the forced expression of BCL-X(L). Behav Brain Res (2012) 0.88
Antiproliferative, cytotoxic and hemolytic activities of a triterpene glycoside from Psolus patagonicus and its desulfated analog. Chemotherapy (2008) 0.86
Gathering of aging and estrogen withdrawal in vascular dysfunction of senescent accelerated mice. Exp Gerontol (2010) 0.85
Intermediate progenitors are increased by lengthening of the cell cycle through calcium signaling and p53 expression in human neural progenitors. Mol Biol Cell (2012) 0.84
Dramatic depletion of cell surface m2 muscarinic receptor due to limited delivery from intracytoplasmic stores in neurons of acetylcholinesterase-deficient mice. Mol Cell Neurosci (2003) 0.84
Generation and properties of a new human ventral mesencephalic neural stem cell line. Exp Cell Res (2009) 0.84
Wnt signal specifies the intrathalamic limit and its organizer properties by regulating Shh induction in the alar plate. J Neurosci (2013) 0.83
Systemic delivery of human mesenchymal stromal cells combined with IGF-1 enhances muscle functional recovery in LAMA2 dy/2j dystrophic mice. Stem Cell Rev (2013) 0.82
In vivo inhibition of the mitochondrial H+-ATP synthase in neurons promotes metabolic preconditioning. EMBO J (2014) 0.82
Human adipose stem cell-conditioned medium increases survival of Friedreich's ataxia cells submitted to oxidative stress. Stem Cells Dev (2012) 0.82
Genetic perpetuation of in vitro expanded human neural stem cells: cellular properties and therapeutic potential. Brain Res Bull (2002) 0.81
Enhanced dopaminergic differentiation of human neural stem cells by synergistic effect of Bcl-xL and reduced oxygen tension. J Neurochem (2009) 0.80
Clonal human fetal ventral mesencephalic dopaminergic neuron precursors for cell therapy research. PLoS One (2012) 0.80
Human midbrain precursors activate the expected developmental genetic program and differentiate long-term to functional A9 dopamine neurons in vitro. Enhancement by Bcl-X(L). Exp Cell Res (2012) 0.80
Modulation of the generation of dopaminergic neurons from human neural stem cells by Bcl-X(L): mechanisms of action. Vitam Horm (2011) 0.79
Gene marking of human neural stem/precursor cells using green fluorescent proteins. J Gene Med (2005) 0.79
Pallial origin of basal forebrain cholinergic neurons in the nucleus basalis of Meynert and horizontal limb of the diagonal band nucleus. Development (2011) 0.78
Dose and latency effects of leucine supplementation in modulating glucose homeostasis: opposite effects in healthy and glucocorticoid-induced insulin-resistance states. Nutrients (2012) 0.78
Low-level tyrosine hydroxylase (TH) expression allows for the generation of stable TH+ cell lines of human neural stem cells. Hum Gene Ther (2004) 0.76
Stem cells as in vitro model of Parkinson's disease. Stem Cells Int (2012) 0.75
Functional properties of the human ventral mesencephalic neural stem cell line hVM1. Exp Neurol (2010) 0.75
Resolving the NFκB hetero-dimer binding paradox: Strain and frustration guide the binding of dimeric transcription factors. J Am Chem Soc (2017) 0.75
Strategies for the development of cell lines for ex vivo gene therapy in the central nervous system. Cell Transplant (2010) 0.75
Evaluation of bioaccumulation kinetics of gold nanorods in vital mammalian organs by means of total reflection X-ray fluorescence spectrometry. Anal Chem (2014) 0.75
Effects of local infusion of methylmercury on the rat brain: GFAP immunohistochemistry and water maze learning. Proc West Pharmacol Soc (2003) 0.75
Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus. Nat Prod Res (2012) 0.75