Published in Genes Dev on January 15, 2007
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Functional interaction between poly(ADP-Ribose) polymerase 2 (PARP-2) and TRF2: PARP activity negatively regulates TRF2. Mol Cell Biol (2004) 1.27
TRF2 inhibition triggers apoptosis and reduces tumourigenicity of human melanoma cells. Eur J Cancer (2006) 1.04
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A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol (2008) 2.43
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XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer. Nat Genet (2005) 2.26
Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination. J Cell Biol (2007) 2.24
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Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation. EMBO J (2003) 1.66
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Transformation of normal human cells in the absence of telomerase activation. Cancer Cell (2002) 1.47
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Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development. Mol Cell Biol (2002) 1.32
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Genome-wide CTCF distribution in vertebrates defines equivalent sites that aid the identification of disease-associated genes. Nat Struct Mol Biol (2011) 1.31
RAP1 protects from obesity through its extratelomeric role regulating gene expression. Cell Rep (2013) 1.31
Telomere shortening in neural stem cells disrupts neuronal differentiation and neuritogenesis. J Neurosci (2009) 1.31
Increased p53 activity does not accelerate telomere-driven ageing. EMBO Rep (2006) 1.30
The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation. Genes Dev (2013) 1.29
Many ways to telomere dysfunction: in vivo studies using mouse models. Oncogene (2002) 1.27
The rate of increase of short telomeres predicts longevity in mammals. Cell Rep (2012) 1.26
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A role for the Rb family of proteins in controlling telomere length. Nat Genet (2002) 1.19
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The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression. EMBO Rep (2005) 1.09
TRF1 controls telomere length and mitotic fidelity in epithelial homeostasis. Mol Cell Biol (2009) 1.09
Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion. EMBO J (2012) 1.08
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Constitutive expression of tert in thymocytes leads to increased incidence and dissemination of T-cell lymphoma in Lck-Tert mice. Mol Cell Biol (2004) 1.05
Telomere shortening and oxidative stress in aged macrophages results in impaired STAT5a phosphorylation. J Immunol (2009) 1.04
Telomerase reverses epidermal hair follicle stem cell defects and loss of long-term survival associated with critically short telomeres. J Cell Biol (2007) 1.03
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Mice deficient in telomerase activity develop hypertension because of an excess of endothelin production. Circulation (2006) 1.00
Role of the TRF2 telomeric protein in cancer and ageing. Cell Cycle (2006) 0.99
Role of mammalian Rad54 in telomere length maintenance. Mol Cell Biol (2003) 0.99