Published in EMBO J on May 01, 2002
High-throughput telomere length quantification by FISH and its application to human population studies. Proc Natl Acad Sci U S A (2007) 2.15
Visualizing telomere dynamics in living mammalian cells using PNA probes. EMBO J (2003) 1.99
Defective DNA repair and increased genomic instability in Artemis-deficient murine cells. J Exp Med (2003) 1.98
The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres. EMBO J (2010) 1.83
Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells. Genes Dev (2004) 1.77
Molecular analysis of telomere fusions in Arabidopsis: multiple pathways for chromosome end-joining. EMBO J (2004) 1.72
Targeted deletion reveals an essential function for the telomere length regulator Trf1. Mol Cell Biol (2003) 1.69
Telomeres, chromosome instability and cancer. Nucleic Acids Res (2006) 1.67
Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation. EMBO J (2003) 1.66
Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer. Mol Cell Biol (2007) 1.65
Ku86 represses lethal telomere deletion events in human somatic cells. Proc Natl Acad Sci U S A (2009) 1.63
Ku is required for telomeric C-rich strand maintenance but not for end-to-end chromosome fusions in Arabidopsis. Proc Natl Acad Sci U S A (2003) 1.42
DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse. Mol Cell Biol (2006) 1.39
Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging. EMBO J (2005) 1.38
Telomeres in cancer and ageing. Philos Trans R Soc Lond B Biol Sci (2011) 1.36
Functional interaction between DNA-PKcs and telomerase in telomere length maintenance. EMBO J (2002) 1.32
End resection initiates genomic instability in the absence of telomerase. Mol Cell Biol (2003) 1.32
Increased p53 activity does not accelerate telomere-driven ageing. EMBO Rep (2006) 1.30
The Ku heterodimer performs separable activities at double-strand breaks and chromosome termini. Mol Cell Biol (2003) 1.28
Functional interaction between poly(ADP-Ribose) polymerase 2 (PARP-2) and TRF2: PARP activity negatively regulates TRF2. Mol Cell Biol (2004) 1.27
Comparative biology of telomeres: where plants stand. FEBS Lett (2010) 1.23
Healthy lifestyle and leukocyte telomere length in U.S. women. PLoS One (2012) 1.23
Regulation of telomere length and suppression of genomic instability in human somatic cells by Ku86. Mol Cell Biol (2004) 1.20
Human Ku70/80 interacts directly with hTR, the RNA component of human telomerase. Nucleic Acids Res (2005) 1.18
Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice. EMBO Rep (2004) 1.18
An increase in telomere sister chromatid exchange in murine embryonic stem cells possessing critically shortened telomeres. Proc Natl Acad Sci U S A (2005) 1.17
Sister telomeres rendered dysfunctional by persistent cohesion are fused by NHEJ. J Cell Biol (2009) 1.11
TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends. EMBO J (2010) 1.11
Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs. J Cell Biol (2004) 1.11
Telomerase dependence of telomere lengthening in Ku80 mutant Arabidopsis. Plant Cell (2003) 1.11
DNA double-strand breaks: a potential causative factor for mammalian aging? Mech Ageing Dev (2008) 1.10
Rearrangements of ribosomal DNA clusters in late generation telomerase-deficient Arabidopsis. Chromosoma (2003) 1.10
PARP1 Is a TRF2-associated poly(ADP-ribose)polymerase and protects eroded telomeres. Mol Biol Cell (2006) 1.07
Telomere structure, function and maintenance in Arabidopsis. Chromosome Res (2003) 1.07
Constitutive expression of tert in thymocytes leads to increased incidence and dissemination of T-cell lymphoma in Lck-Tert mice. Mol Cell Biol (2004) 1.05
Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein. Hum Genet (2003) 1.04
The Ku protein complex is involved in length regulation of Drosophila telomeres. Genetics (2005) 1.02
Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling. Aging (Albany NY) (2011) 1.01
End joining at Caenorhabditis elegans telomeres. Genetics (2008) 1.01
Role of mammalian Rad54 in telomere length maintenance. Mol Cell Biol (2003) 0.99
Targeting signaling pathways in epithelial ovarian cancer. Int J Mol Sci (2013) 0.98
Depletion of Ku70/80 reduces the levels of extrachromosomal telomeric circles and inhibits proliferation of ALT cells. Aging (Albany NY) (2011) 0.96
Making the most of a little: dosage effects in eukaryotic telomere length maintenance. Chromosome Res (2005) 0.95
OsKu70 is associated with developmental growth and genome stability in rice. Plant Physiol (2009) 0.92
Telomere biology: integrating chromosomal end protection with DNA damage response. Chromosoma (2005) 0.92
Ku80 facilitates chromatin binding of the telomere binding protein, TRF2. Cell Cycle (2010) 0.89
DNA repair and recombination functions in Arabidopsis telomere maintenance. Chromosome Res (2005) 0.88
Mechanisms of telomere loss and their consequences for chromosome instability. Front Oncol (2012) 0.87
Genome integrity, stem cells and hyaluronan. Aging (Albany NY) (2012) 0.87
Defending the end zone: studying the players involved in protecting chromosome ends. FEBS Lett (2010) 0.86
The role of RecQ helicases in non-homologous end-joining. Crit Rev Biochem Mol Biol (2014) 0.81
A conserved and species-specific functional interaction between the Werner syndrome-like exonuclease atWEX and the Ku heterodimer in Arabidopsis. Nucleic Acids Res (2005) 0.81
Mating type influences chromosome loss and replicative senescence in telomerase-deficient budding yeast by Dnl4-dependent telomere fusion. Mol Microbiol (2008) 0.78
Fungal Ku prevents permanent cell cycle arrest by suppressing DNA damage signaling at telomeres. Nucleic Acids Res (2015) 0.78
Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis. Clin Exp Gastroenterol (2011) 0.77
Ku70 Serine 155 mediates Aurora B inhibition and activation of the DNA damage response. Sci Rep (2016) 0.77
Controlled somatic and germline copy number variation in the mouse model. Curr Genomics (2010) 0.76
The Candida albicans Ku70 modulates telomere length and structure by regulating both telomerase and recombination. PLoS One (2011) 0.76
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell (1997) 13.34
Mammalian telomeres end in a large duplex loop. Cell (1999) 12.12
Switching and signaling at the telomere. Cell (2001) 11.25
A survey of telomerase activity in human cancer. Eur J Cancer (1997) 10.84
TRF2 protects human telomeres from end-to-end fusions. Cell (1998) 10.13
Control of telomere length by the human telomeric protein TRF1. Nature (1997) 7.62
Essential role of mouse telomerase in highly proliferative organs. Nature (1998) 7.23
Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell (1999) 6.98
Pot1, the putative telomere end-binding protein in fission yeast and humans. Science (2001) 6.95
The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell (2001) 5.98
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell (1999) 5.93
Telomere states and cell fates. Nature (2000) 5.71
Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats. Proc Natl Acad Sci U S A (1997) 4.88
Hypervariable ultra-long telomeres in mice. Nature (1990) 4.76
Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry. Nat Biotechnol (1998) 4.68
TIN2, a new regulator of telomere length in human cells. Nat Genet (1999) 4.66
Control of human telomere length by TRF1 and TRF2. Mol Cell Biol (2000) 4.54
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nat Genet (2000) 4.30
Yeast Ku as a regulator of chromosomal DNA end structure. Science (1998) 3.86
Disease states associated with telomerase deficiency appear earlier in mice with short telomeres. EMBO J (1999) 3.29
Telomeric localization of TRF2, a novel human telobox protein. Nat Genet (1997) 3.23
Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang. EMBO Rep (2000) 3.00
DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes. Proc Natl Acad Sci U S A (1999) 2.97
Deletion of Ku86 causes early onset of senescence in mice. Proc Natl Acad Sci U S A (1999) 2.97
Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat Genet (2001) 2.92
Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. EMBO J (2001) 2.83
Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis. Nat Genet (2000) 2.68
Strand-specific postreplicative processing of mammalian telomeres. Science (2001) 2.64
Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres. EMBO Rep (2001) 2.59
Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse. Cell (1999) 2.46
Ku acts in a unique way at the mammalian telomere to prevent end joining. Genes Dev (2000) 2.38
Ku is associated with the telomere in mammals. Proc Natl Acad Sci U S A (1999) 2.36
The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang. Mol Cell Biol (2001) 1.94
Telomere dysfunction triggers developmentally regulated germ cell apoptosis. Mol Biol Cell (2001) 1.85
Mammalian telomeres and telomerase. Curr Opin Cell Biol (2000) 1.70
Interaction of human Ku70 with TRF2. FEBS Lett (2000) 1.55
Ku binds telomeric DNA in vitro. J Biol Chem (1999) 1.55
Telomere length abnormalities in mammalian radiosensitive cells. Cancer Res (2001) 1.54
Telomere shortening in mTR-/- embryos is associated with failure to close the neural tube. EMBO J (1999) 1.49
Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals. J Exp Med (2000) 1.49
Impaired germinal center reaction in mice with short telomeres. EMBO J (2000) 1.39
G-strand overhangs on telomeres in telomerase-deficient mouse cells. Nucleic Acids Res (1999) 1.31
Normal telomere length and chromosomal end capping in poly(ADP-ribose) polymerase-deficient mice and primary cells despite increased chromosomal instability. J Cell Biol (2001) 1.19
Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A (2005) 15.46
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell (2006) 8.48
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell (2006) 6.09
IgH class switching and translocations use a robust non-classical end-joining pathway. Nature (2007) 6.05
DNA repair, genome stability, and aging. Cell (2005) 5.52
Retracted Spontaneous human adult stem cell transformation. Cancer Res (2005) 4.95
DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Nat Cell Biol (2006) 4.38
"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J (2002) 4.17
Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression. Cancer Cell (2008) 4.01
Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia. Cancer Cell (2008) 3.79
Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases. Nat Genet (2003) 3.64
Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metab (2005) 3.15
Effects of telomerase and telomere length on epidermal stem cell behavior. Science (2005) 3.05
Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis. FASEB J (2002) 2.96
Evolution of the immunoglobulin heavy chain class switch recombination mechanism. Adv Immunol (2007) 2.94
Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins. Nat Rev Cancer (2011) 2.66
POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia. Nat Genet (2013) 2.62
Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy. Nat Genet (2013) 2.44
Systematic review and meta-analysis of circulatory disease from exposure to low-level ionizing radiation and estimates of potential population mortality risks. Environ Health Perspect (2012) 2.42
The longest telomeres: a general signature of adult stem cell compartments. Genes Dev (2008) 2.38
Risks associated with low doses and low dose rates of ionizing radiation: why linearity may be (almost) the best we can do. Radiology (2009) 2.37
Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres. Nat Genet (2007) 2.37
Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin. Nat Cell Biol (2005) 2.27
XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer. Nat Genet (2005) 2.26
Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination. J Cell Biol (2007) 2.24
High-throughput telomere length quantification by FISH and its application to human population studies. Proc Natl Acad Sci U S A (2007) 2.15
AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development. J Exp Med (2008) 2.10
Genomic and expression profiling identifies the B-cell associated tyrosine kinase Syk as a possible therapeutic target in mantle cell lymphoma. Br J Haematol (2006) 2.09
Genetic unmasking of epigenetically silenced tumor suppressor genes in colon cancer cells deficient in DNA methyltransferases. Hum Mol Genet (2003) 1.93
Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination. Mol Cell (2008) 1.91
Telomere maintenance requires the RAD51D recombination/repair protein. Cell (2004) 1.89
Cyclin D1 gene (CCND1) mutations in endometrial cancer. Oncogene (2003) 1.74
Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres. EMBO J (2012) 1.73
Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation. EMBO J (2003) 1.66
Identification of overexpressed genes in frequently gained/amplified chromosome regions in multiple myeloma. Haematologica (2006) 1.65
Oligonucleotide array-CGH identifies genomic subgroups and prognostic markers for tumor stage mycosis fungoides. J Invest Dermatol (2009) 1.65
Melanoma proliferation and chemoresistance controlled by the DEK oncogene. Cancer Res (2009) 1.61
Cytogenetic risk stratification in chronic myelomonocytic leukemia. Haematologica (2010) 1.60
The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer. Hum Mol Genet (2009) 1.47
Transformation of normal human cells in the absence of telomerase activation. Cancer Cell (2002) 1.47
Phenotypic characterization of BRCA1 and BRCA2 tumors based in a tissue microarray study with 37 immunohistochemical markers. Breast Cancer Res Treat (2005) 1.45
Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability. J Exp Med (2009) 1.40
Immunohistochemical characteristics defined by tissue microarray of hereditary breast cancer not attributable to BRCA1 or BRCA2 mutations: differences from breast carcinomas arising in BRCA1 and BRCA2 mutation carriers. Clin Cancer Res (2003) 1.39
Nuclear envelope defects cause stem cell dysfunction in premature-aging mice. J Cell Biol (2008) 1.36
Comparative genome profiling across subtypes of low-grade B-cell lymphoma identifies type-specific and common aberrations that target genes with a role in B-cell neoplasia. Haematologica (2008) 1.34
Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis. Genes Dev (2007) 1.33
Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development. Mol Cell Biol (2002) 1.32
Functional interaction between DNA-PKcs and telomerase in telomere length maintenance. EMBO J (2002) 1.32
Genome-wide CTCF distribution in vertebrates defines equivalent sites that aid the identification of disease-associated genes. Nat Struct Mol Biol (2011) 1.31
Telomere shortening in neural stem cells disrupts neuronal differentiation and neuritogenesis. J Neurosci (2009) 1.31
Increased p53 activity does not accelerate telomere-driven ageing. EMBO Rep (2006) 1.30
Variability in the expression of polycomb proteins in different normal and tumoral tissues. A pilot study using tissue microarrays. Mod Pathol (2006) 1.27
Many ways to telomere dysfunction: in vivo studies using mouse models. Oncogene (2002) 1.27
53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis. Proc Natl Acad Sci U S A (2006) 1.27
Telomere shortening and chromosomal instability abrogates proliferation of adult but not embryonic neural stem cells. Development (2004) 1.25
Role of Rb family in the epigenetic definition of chromatin. Cell Cycle (2005) 1.23
Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells. Blood (2002) 1.22
Retraction: Spontaneous human adult stem cell transformation. Cancer Res (2010) 1.21
p53 prevents entry into mitosis with uncapped telomeres. Curr Biol (2010) 1.21
Telomere length predicts embryo fragmentation after in vitro fertilization in women--toward a telomere theory of reproductive aging in women. Am J Obstet Gynecol (2005) 1.20
A role for the Rb family of proteins in controlling telomere length. Nat Genet (2002) 1.19
Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice. EMBO Rep (2004) 1.18
Comment on "dose-responses from multi-model inference for the non-cancer disease mortality of atomic bomb survivors" (Radiat. Environ. Biophys (2012) 51:165-178) by Schöllnberger et al. Radiat Environ Biophys (2013) 1.16
DNA methylation profiles and their relationship with cytogenetic status in adult acute myeloid leukemia. PLoS One (2010) 1.15
Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations. Oncogene (2004) 1.13
Porphyrin derivatives for telomere binding and telomerase inhibition. Chembiochem (2005) 1.13
Antagonistic effects of telomerase on cancer and aging in K5-mTert transgenic mice. Oncogene (2005) 1.12
Multiple stages of malignant transformation of human endothelial cells modelled by co-expression of telomerase reverse transcriptase, SV40 T antigen and oncogenic N-ras. Oncogene (2002) 1.12
Differential gene expression profile in endometrioid and nonendometrioid endometrial carcinoma: STK15 is frequently overexpressed and amplified in nonendometrioid carcinomas. Cancer Res (2003) 1.11
Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs. J Cell Biol (2004) 1.11
Radiation leukemogenesis in mice: loss of PU.1 on chromosome 2 in CBA and C57BL/6 mice after irradiation with 1 GeV/nucleon 56Fe ions, X rays or gamma rays. Part I. Experimental observations. Radiat Res (2009) 1.10
Response to lenalidomide in myelodysplastic syndromes with del(5q): influence of cytogenetics and mutations. Br J Haematol (2013) 1.10
Breaks at telomeres and TRF2-independent end fusions in Fanconi anemia. Hum Mol Genet (2002) 1.10
The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression. EMBO Rep (2005) 1.09
Similar patterns of genomic alterations characterize primary mediastinal large-B-cell lymphoma and diffuse large-B-cell lymphoma. Genes Chromosomes Cancer (2002) 1.09
Irregular telomeres impair meiotic synapsis and recombination in mice. Proc Natl Acad Sci U S A (2004) 1.09
Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion. EMBO J (2012) 1.08
Intrafollicular neoplasia/in situ follicular lymphoma: review of a series of 13 cases. Histopathology (2010) 1.08
Constitutive expression of tert in thymocytes leads to increased incidence and dissemination of T-cell lymphoma in Lck-Tert mice. Mol Cell Biol (2004) 1.05
Clinical evidences of GM3 (NeuGc) ganglioside expression in human breast cancer using the 14F7 monoclonal antibody labelled with (99m)Tc. Breast Cancer Res Treat (2005) 1.05
Telomere shortening and oxidative stress in aged macrophages results in impaired STAT5a phosphorylation. J Immunol (2009) 1.04
Role of human Ku86 in telomere length maintenance and telomere capping. Cancer Res (2004) 1.03
Epigenetic loss of the familial tumor-suppressor gene exostosin-1 (EXT1) disrupts heparan sulfate synthesis in cancer cells. Hum Mol Genet (2004) 1.03
Cyclin E gene (CCNE) amplification and hCDC4 mutations in endometrial carcinoma. J Pathol (2003) 1.02
Mice deficient in telomerase activity develop hypertension because of an excess of endothelin production. Circulation (2006) 1.00
Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epidermal tumors. Proc Natl Acad Sci U S A (2010) 1.00
Role of the TRF2 telomeric protein in cancer and ageing. Cell Cycle (2006) 0.99
Role of mammalian Rad54 in telomere length maintenance. Mol Cell Biol (2003) 0.99
Differential requirement for H2AX and 53BP1 in organismal development and genome maintenance in the absence of poly(ADP)ribosyl polymerase 1. Mol Cell Biol (2010) 0.99
Determining the profiles and parameters for gene amplification testing of growth factor receptors in lung cancer. Int J Cancer (2013) 0.97
Gains, losses and complex karyotypes in myeloid disorders: a light at the end of the tunnel. Hematol Oncol (2005) 0.97
Aberrant Bcl6 protein expression in mantle cell lymphoma. Am J Surg Pathol (2004) 0.97
B-cell receptor cross-linking delays activation-induced cytidine deaminase induction and inhibits class-switch recombination to IgE. J Allergy Clin Immunol (2007) 0.95
Short telomeres protect from diet-induced atherosclerosis in apolipoprotein E-null mice. FASEB J (2003) 0.95