Shelterin: the protein complex that shapes and safeguards human telomeres.

PubWeight™: 15.19‹?› | Rank: Top 0.1% | All-Time Top 10000

🔗 View Article (PMID 16166375)

Published in Genes Dev on September 15, 2005

Authors

Titia de Lange1

Author Affiliations

1: The Rockefeller University, New York, New York 10021, USA. delange@mail.rockfeller.edu

Articles citing this

(truncated to the top 100)

The DNA-damage response in human biology and disease. Nature (2009) 17.86

Quadruplex DNA: sequence, topology and structure. Nucleic Acids Res (2006) 6.42

Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell (2009) 5.74

Telomere diseases. N Engl J Med (2009) 5.68

How telomeres solve the end-protection problem. Science (2009) 4.54

Telomeres and telomerase in cancer. Carcinogenesis (2009) 4.28

Telomeres: protecting chromosomes against genome instability. Nat Rev Mol Cell Biol (2010) 4.23

TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita. Am J Hum Genet (2008) 4.12

The telomere syndromes. Nat Rev Genet (2012) 4.01

Telomere length is paternally inherited and is associated with parental lifespan. Proc Natl Acad Sci U S A (2007) 3.67

Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation. Cell (2008) 3.42

Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature (2011) 3.19

RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection. Mol Cell (2013) 3.05

TINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes. Blood (2008) 3.02

The biogenesis and regulation of telomerase holoenzymes. Nat Rev Mol Cell Biol (2006) 2.94

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice. Genes Dev (2009) 2.91

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence. Nat Commun (2012) 2.90

TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends. Cell (2012) 2.74

Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis. EMBO J (2007) 2.61

TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres. Mol Cell (2009) 2.60

Telomere dysfunction and tumour suppression: the senescence connection. Nat Rev Cancer (2008) 2.54

Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair. Cell (2011) 2.50

A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol (2008) 2.43

Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes. Am J Pathol (2011) 2.41

TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo. Mol Cell Biol (2010) 2.39

The longest telomeres: a general signature of adult stem cell compartments. Genes Dev (2008) 2.38

Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance. Mol Cell (2009) 2.29

Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination. J Cell Biol (2007) 2.24

TPP1 is required for TERT recruitment, telomere elongation during nuclear reprogramming, and normal skin development in mice. Dev Cell (2010) 2.24

Associations between diet, lifestyle factors, and telomere length in women. Am J Clin Nutr (2010) 2.23

The association between leukocyte telomere length and cigarette smoking, dietary and physical variables, and risk of prostate cancer. Aging Cell (2009) 2.22

Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly. Cell (2008) 2.20

Role of telomeres and telomerase in cancer. Semin Cancer Biol (2011) 2.20

Telomere length homeostasis. Chromosoma (2006) 2.12

Healthy aging and disease: role for telomere biology? Clin Sci (Lond) (2011) 2.10

Telomere and telomerase in stem cells. Br J Cancer (2007) 2.09

Rif1 and rif2 inhibit localization of tel1 to DNA ends. Mol Cell (2009) 2.09

Telomere maintenance and human bone marrow failure. Blood (2008) 2.09

TZAP: A telomere-associated protein involved in telomere length control. Science (2017) 2.06

Advances in the understanding of dyskeratosis congenita. Br J Haematol (2009) 2.05

A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly. Proc Natl Acad Sci U S A (2006) 2.04

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts. J Clin Invest (2011) 2.02

Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice. Cell (2007) 1.96

Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence. EMBO Rep (2007) 1.96

Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proc Natl Acad Sci U S A (2009) 1.96

A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres. J Am Chem Soc (2008) 1.91

Cycles of chromosome instability are associated with a fragile site and are increased by defects in DNA replication and checkpoint controls in yeast. Genes Dev (2005) 1.89

Molecular dissection of telomeric repeat-containing RNA biogenesis unveils the presence of distinct and multiple regulatory pathways. Mol Cell Biol (2010) 1.89

Functional dissection of human and mouse POT1 proteins. Mol Cell Biol (2008) 1.87

Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances. Genes Dev (2014) 1.85

Control of telomere length by a trimming mechanism that involves generation of t-circles. EMBO J (2009) 1.85

Human premature aging, DNA repair and RecQ helicases. Nucleic Acids Res (2007) 1.84

Novel roles for A-type lamins in telomere biology and the DNA damage response pathway. EMBO J (2009) 1.83

Human Dna2 is a nuclear and mitochondrial DNA maintenance protein. Mol Cell Biol (2009) 1.83

The G4 genome. PLoS Genet (2013) 1.83

Roles of Werner syndrome protein in protection of genome integrity. DNA Repair (Amst) (2010) 1.82

MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres. Genes Dev (2006) 1.81

Epigenetic regulation of heterochromatic DNA stability. Curr Opin Genet Dev (2008) 1.80

POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation. EMBO J (2010) 1.80

Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2. Genes Dev (2008) 1.80

Telomere length measurement-caveats and a critical assessment of the available technologies and tools. Mutat Res (2011) 1.79

DNA damage response at functional and dysfunctional telomeres. Genes Dev (2008) 1.75

Suppression of nonhomologous end joining repair by overexpression of HMGA2. Cancer Res (2009) 1.73

Engineered telomere degradation models dyskeratosis congenita. Genes Dev (2008) 1.72

Constitutional mutations in RTEL1 cause severe dyskeratosis congenita. Am J Hum Genet (2013) 1.71

Protection of telomeres by a conserved Stn1-Ten1 complex. Proc Natl Acad Sci U S A (2007) 1.71

Papillomavirus E6 proteins. Virology (2008) 1.70

Heterochromatic genome stability requires regulators of histone H3 K9 methylation. PLoS Genet (2009) 1.69

Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites. Nat Cell Biol (2010) 1.69

Genetic p53 deficiency partially rescues the adrenocortical dysplasia phenotype at the expense of increased tumorigenesis. Cancer Cell (2009) 1.67

Telomeres, chromosome instability and cancer. Nucleic Acids Res (2006) 1.67

POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination. EMBO J (2006) 1.66

Telomere protection by TPP1 is mediated by POT1a and POT1b. Mol Cell Biol (2009) 1.66

Dyskeratosis congenita, stem cells and telomeres. Biochim Biophys Acta (2009) 1.62

Increased association of telomerase with short telomeres in yeast. Genes Dev (2007) 1.62

ATM promotes the obligate XY crossover and both crossover control and chromosome axis integrity on autosomes. PLoS Genet (2008) 1.61

Functional interaction between telomere protein TPP1 and telomerase. Genes Dev (2010) 1.60

Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G1 and resection-mediated inhibition of NHEJ in G2. Mol Cell Biol (2009) 1.60

DNA damage in telomeres and mitochondria during cellular senescence: is there a connection? Nucleic Acids Res (2007) 1.60

Telomerase is required for zebrafish lifespan. PLoS Genet (2013) 1.59

Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2'-deoxyguanosine. Cancer Discov (2014) 1.59

G-quadruplex nucleic acids and human disease. FEBS J (2010) 1.58

A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrix. Cell Cycle (2009) 1.58

The telosome/shelterin complex and its functions. Genome Biol (2008) 1.57

Flap endonuclease 1 contributes to telomere stability. Curr Biol (2008) 1.56

The role of telomere biology in bone marrow failure and other disorders. Mech Ageing Dev (2007) 1.56

Microarray-based genetic screen defines SAW1, a gene required for Rad1/Rad10-dependent processing of recombination intermediates. Mol Cell (2008) 1.56

Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response. EMBO J (2008) 1.56

Human cancer cells harbor T-stumps, a distinct class of extremely short telomeres. Mol Cell (2007) 1.56

The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence. Aging Cell (2011) 1.55

RAP1 is essential for silencing telomeric variant surface glycoprotein genes in Trypanosoma brucei. Cell (2009) 1.55

Mitochondrial localization of telomeric protein TIN2 links telomere regulation to metabolic control. Mol Cell (2012) 1.55

Mutations in CTC1, encoding the CTS telomere maintenance complex component 1, cause cerebroretinal microangiopathy with calcifications and cysts. Am J Hum Genet (2012) 1.54

Telomerase insufficiency in rheumatoid arthritis. Proc Natl Acad Sci U S A (2009) 1.54

OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation. J Biol Chem (2009) 1.53

Telomere length influences cancer cell differentiation in vivo. Mol Cell Biol (2013) 1.52

Stress-induced activation of heterochromatic transcription. PLoS Genet (2010) 1.51

Telomere maintenance through spatial control of telomeric proteins. Mol Cell Biol (2007) 1.51

TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs. Nat Struct Mol Biol (2009) 1.51

SUMO: a multifaceted modifier of chromatin structure and function. Dev Cell (2013) 1.50