Published in Lab Invest on January 22, 2007
Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet-Biedl syndrome. Proc Natl Acad Sci U S A (2008) 1.78
Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activation. Hepatology (2009) 1.44
Magnetic resonance microscopy defines ethanol-induced brain abnormalities in prenatal mice: effects of acute insult on gestational day 7. Alcohol Clin Exp Res (2009) 1.32
Large-scale analysis of acute ethanol exposure in zebrafish development: a critical time window and resilience. PLoS One (2011) 1.11
Cleft lip and palate results from Hedgehog signaling antagonism in the mouse: Phenotypic characterization and clinical implications. Birth Defects Res A Clin Mol Teratol (2010) 1.06
The teratogenic effects of prenatal ethanol exposure are exacerbated by Sonic Hedgehog or GLI2 haploinsufficiency in the mouse. PLoS One (2014) 1.05
Cholesterol metabolism: the main pathway acting downstream of cytochrome P450 oxidoreductase in skeletal development of the limb. Mol Cell Biol (2009) 1.03
Cdon mutation and fetal ethanol exposure synergize to produce midline signaling defects and holoprosencephaly spectrum disorders in mice. PLoS Genet (2012) 0.98
Genesis of teratogen-induced holoprosencephaly in mice. Am J Med Genet C Semin Med Genet (2010) 0.97
A screen of zebrafish mutants identifies ethanol-sensitive genetic loci. Alcohol Clin Exp Res (2013) 0.95
Sonic hedgehog ligand partners with caveolin-1 for intracellular transport. Lab Invest (2009) 0.93
Agrin function associated with ocular development is a target of ethanol exposure in embryonic zebrafish. Birth Defects Res A Clin Mol Teratol (2011) 0.93
Ventromedian forebrain dysgenesis follows early prenatal ethanol exposure in mice. Neurotoxicol Teratol (2010) 0.93
Ethanol-induced microphthalmia is not mediated by changes in retinoic acid or sonic hedgehog signaling during retinal neurogenesis. Alcohol Clin Exp Res (2011) 0.92
Forebrain and hindbrain development in zebrafish is sensitive to ethanol exposure involving agrin, Fgf, and sonic hedgehog function. Birth Defects Res A Clin Mol Teratol (2012) 0.92
An evolutionarily conserved mechanism of calcium-dependent neurotoxicity in a zebrafish model of fetal alcohol spectrum disorders. Alcohol Clin Exp Res (2014) 0.91
Canonical and non-canonical Hedgehog signalling and the control of metabolism. Semin Cell Dev Biol (2014) 0.89
Using optical coherence tomography to rapidly phenotype and quantify congenital heart defects associated with prenatal alcohol exposure. Dev Dyn (2015) 0.85
Molecular mechanisms of ethanol-associated oro-esophageal squamous cell carcinoma. Cancer Lett (2015) 0.84
Alcohol-induced morphological deficits in the development of octavolateral organs of the zebrafish (Danio rerio). Zebrafish (2013) 0.84
Ethanol teratogenesis in Japanese medaka: effects at the cellular level. Comp Biochem Physiol B Biochem Mol Biol (2007) 0.83
Neural crest development in fetal alcohol syndrome. Birth Defects Res C Embryo Today (2014) 0.83
Glycosylation defects underlying fetal alcohol spectrum disorder: a novel pathogenetic model. "When the wine goes in, strange things come out" - S.T. Coleridge, The Piccolomini. J Inherit Metab Dis (2011) 0.81
Genomic factors that shape craniofacial outcome and neural crest vulnerability in FASD. Front Genet (2014) 0.80
Molecular and morphological changes in zebrafish following transient ethanol exposure during defined developmental stages. Neurotoxicol Teratol (2014) 0.80
The Genetics of Fetal Alcohol Spectrum Disorders. Alcohol Clin Exp Res (2016) 0.80
Developmental age strengthens barriers to ethanol accumulation in zebrafish. Alcohol (2014) 0.79
Fishing for Fetal Alcohol Spectrum Disorders: Zebrafish as a Model for Ethanol Teratogenesis. Zebrafish (2016) 0.79
Disruption of circulation by ethanol promotes fetal alcohol spectrum disorder (FASD) in medaka (Oryzias latipes) embryogenesis. Comp Biochem Physiol C Toxicol Pharmacol (2008) 0.79
Maternal periconceptional alcohol consumption and congenital limb deficiencies. Birth Defects Res A Clin Mol Teratol (2014) 0.78
Analysis of crosstalk between retinoic acid and sonic hedgehog pathways following ethanol exposure in embryonic zebrafish. Birth Defects Res A Clin Mol Teratol (2015) 0.77
5-Mehtyltetrahydrofolate rescues alcohol-induced neural crest cell migration abnormalities. Mol Brain (2014) 0.76
Dose-dependent teratogenicity of the synthetic cannabinoid CP-55,940 in mice. Neurotoxicol Teratol (2015) 0.76
Eye-specific gene expression following embryonic ethanol exposure in zebrafish: roles for heat shock factor 1. Reprod Toxicol (2013) 0.76
Design and characterization of a photo-activatable hedgehog probe that mimics the natural lipidated form. Arch Biochem Biophys (2014) 0.75
Holoprosencephaly-polydactyly/pseudotrisomy 13: a presentation of two new cases and a review of the literature. Clin Dysmorphol (2012) 0.75
Gene-environment interactions in cortical interneuron development and dysfunction: A review of preclinical studies. Neurotoxicology (2016) 0.75
Dhcr7 Regulates Palatal Shelf Fusion through Regulation of Shh and Bmp2 Expression. Biomed Res Int (2016) 0.75
Zebrafish: A Model for the Study of Toxicants Affecting Muscle Development and Function. Int J Mol Sci (2016) 0.75
Gene-environment interactions in development and disease. Wiley Interdiscip Rev Dev Biol (2016) 0.75
Prenatal ethanol exposure phenocopies Cdon mutation by impeding Shh function in the etiology of optic nerve hypoplasia. Dis Model Mech (2016) 0.75
Comparison of molecular marker expression in early zebrafish brain development following chronic ethanol or morpholino treatment. Exp Brain Res (2017) 0.75
Genetic vulnerabilities to prenatal alcohol exposure: Limb defects in sonic hedgehog and GLI2 heterozygous mice. Birth Defects Res (2017) 0.75
Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med (2010) 13.33
The prevalence and etiology of elevated aminotransferase levels in the United States. Am J Gastroenterol (2003) 8.23
Genomewide association study of leprosy. N Engl J Med (2009) 8.17
The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology (2012) 5.47
Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology (2007) 4.83
Nonalcoholic fatty liver disease. Gastroenterology (2002) 4.15
Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology (2003) 4.03
Gender and menopause impact severity of fibrosis among patients with nonalcoholic steatohepatitis. Hepatology (2014) 4.01
Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease. Hepatology (2010) 3.73
Nonalcoholic fatty liver disease: an underrecognized cause of cryptogenic cirrhosis. JAMA (2003) 3.51
Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease. Hepatology (2005) 3.35
Fructose consumption as a risk factor for non-alcoholic fatty liver disease. J Hepatol (2008) 3.33
Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease. Hepatology (2012) 2.93
Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. J Clin Invest (2008) 2.89
Clinical, laboratory and histological associations in adults with nonalcoholic fatty liver disease. Hepatology (2010) 2.86
Noninvasive evaluation of hepatic fibrosis using acoustic radiation force-based shear stiffness in patients with nonalcoholic fatty liver disease. J Hepatol (2011) 2.56
Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease. Hepatology (2013) 2.42
Hematopoietic stem cells convert into liver cells within days without fusion. Nat Cell Biol (2004) 2.41
Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis. Hepatology (2010) 2.37
Mechanisms of disease progression in nonalcoholic fatty liver disease. Semin Liver Dis (2008) 2.35
An enhanced two-step floating catchment area (E2SFCA) method for measuring spatial accessibility to primary care physicians. Health Place (2009) 2.31
Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease. Am J Pathol (2003) 2.27
Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease. Gastroenterology (2009) 2.25
Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers. Stem Cells (2008) 2.24
Treatment response in the PIVENS trial is associated with decreased Hedgehog pathway activity. Hepatology (2014) 2.23
Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis. Am J Physiol Gastrointest Liver Physiol (2009) 2.23
NAFLD, NASH and liver cancer. Nat Rev Gastroenterol Hepatol (2013) 2.20
Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells. J Hepatol (2007) 2.16
Physical activity recommendations, exercise intensity, and histological severity of nonalcoholic fatty liver disease. Am J Gastroenterol (2011) 2.15
Secondary heart field contributes myocardium and smooth muscle to the arterial pole of the developing heart. Dev Biol (2005) 2.15
Hedgehog-mediated mesenchymal-epithelial interactions modulate hepatic response to bile duct ligation. Lab Invest (2007) 2.03
The β-adrenoceptor agonist isoproterenol rescues acetaminophen-injured livers through increasing progenitor numbers by Wnt in mice. Hepatology (2014) 2.03
Hedgehog signaling maintains resident hepatic progenitors throughout life. Am J Physiol Gastrointest Liver Physiol (2005) 2.02
In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in rats. Gastroenterology (2003) 2.00
Epithelial-to-mesenchymal transitions in the liver. Hepatology (2009) 1.99
Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis. Carcinogenesis (2005) 1.91
Smoothened is a master regulator of adult liver repair. J Clin Invest (2013) 1.89
Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells. Gastroenterology (2008) 1.84
Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease. Hepatology (2010) 1.82
Hedgehog signaling in the liver. J Hepatol (2010) 1.80
Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis. Hepatology (2009) 1.79
Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease. Gastroenterology (2013) 1.75
Interleukin-15 increases hepatic regenerative activity. J Hepatol (2006) 1.72
Accumulation of hedgehog-responsive progenitors parallels alcoholic liver disease severity in mice and humans. Gastroenterology (2008) 1.71
Retracted A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities. Proc Natl Acad Sci U S A (2008) 1.69
Analyzing somatosensory axon projections with the sensory neuron-specific Advillin gene. J Neurosci (2007) 1.67
Signals from dying hepatocytes trigger growth of liver progenitors. Gut (2010) 1.67
Repair-related activation of hedgehog signaling promotes cholangiocyte chemokine production. Hepatology (2009) 1.65
Hepatic allograft-derived Kupffer cells regulate T cell response in rats. Liver Transpl (2003) 1.65
Hepatic triglyceride synthesis and nonalcoholic fatty liver disease. Curr Opin Lipidol (2008) 1.62
Role for hedgehog signaling in hepatic stellate cell activation and viability. Lab Invest (2005) 1.62
The diagnosis and management of non-alcoholic fatty liver disease: Practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Am J Gastroenterol (2012) 1.61
Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice. Hepatology (2010) 1.57
Hyperlactataemia syndromes associated with HIV therapy. Lancet Infect Dis (2003) 1.57
Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes. Hepatology (2012) 1.57
The adventures of sonic hedgehog in development and repair. II. Sonic hedgehog and liver development, inflammation, and cancer. Am J Physiol Gastrointest Liver Physiol (2008) 1.56
Macrophage-derived Hedgehog ligands promotes fibrogenic and angiogenic responses in human schistosomiasis mansoni. Liver Int (2012) 1.55
Increased production of sonic hedgehog by ballooned hepatocytes. J Pathol (2011) 1.48
Bile ductules and stromal cells express hedgehog ligands and/or hedgehog target genes in primary biliary cirrhosis. Hepatology (2007) 1.48
p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors. Proc Natl Acad Sci U S A (2006) 1.48
Gastric cancer. Curr Probl Cancer (2011) 1.47
Dietary composition and nonalcoholic fatty liver disease. Dig Dis Sci (2004) 1.46
NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease. Gut (2012) 1.46
Endoplasmic reticulum stress, hepatocyte CD1d and NKT cell abnormalities in murine fatty livers. Lab Invest (2007) 1.44
PPARgamma agonists prevent TGFbeta1/Smad3-signaling in human hepatic stellate cells. Biochem Biophys Res Commun (2006) 1.42
Cardiac neural crest is necessary for normal addition of the myocardium to the arterial pole from the secondary heart field. Dev Biol (2005) 1.41
Effect of a 12-month intensive lifestyle intervention on hepatic steatosis in adults with type 2 diabetes. Diabetes Care (2010) 1.40
Evidence for epithelial-mesenchymal transitions in adult liver cells. Am J Physiol Gastrointest Liver Physiol (2006) 1.38
Innate immunity in the liver. Curr Opin Gastroenterol (2003) 1.38
Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer. PLoS One (2011) 1.37
Hedgehog controls hepatic stellate cell fate by regulating metabolism. Gastroenterology (2012) 1.36
Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice. Hepatology (2006) 1.35
Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway. J Biol Chem (2010) 1.33
Blood-brain barrier (BBB) disruption using a diagnostic ultrasound scanner and Definity in Mice. Ultrasound Med Biol (2009) 1.30
Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease. Hepatology (2004) 1.30
Nonalcoholic fatty liver disease as a complication of insulin resistance. Med Clin North Am (2007) 1.29
Role of inflammation in nonalcoholic steatohepatitis. Curr Opin Gastroenterol (2005) 1.26
Murine leptin deficiency alters Kupffer cell production of cytokines that regulate the innate immune system. Gastroenterology (2002) 1.25
Defining nonalcoholic fatty liver disease: implications for epidemiologic studies. Gastroenterology (2003) 1.25
Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice. Lab Invest (2007) 1.24
Diacylglycerol acyltranferase 1 anti-sense oligonucleotides reduce hepatic fibrosis in mice with nonalcoholic steatohepatitis. Hepatology (2008) 1.24
Chronic ethanol exposure potentiates lipopolysaccharide liver injury despite inhibiting Jun N-terminal kinase and caspase 3 activation. J Biol Chem (2002) 1.23